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公开(公告)号：US09357772B2
公开(公告)日：2016-06-07
申请号：US13859048
申请日：2013-04-09
Applicant: International Business Machines Corporation , Agency For Science, Technology and Research
Inventor： Daniel J. Coady , Richard A. Dipietro , Amanda C. Engler , James L. Hedrick , Victor W. L. Ng , Zhan-Yuin Ong , Jeremy P. K. Tan , Yi Yan Yang
CPC classification number: C08G63/64 , A01N33/12 , A01N43/50 , A01N57/34 , A61K9/0019 , A61K31/765 , A61K2800/54 , A61K2800/542 , A61K2800/5426 , C08G64/0233 , C08G64/0241 , C08G64/025 , C08G64/0258 , C08G64/0291 , C08G64/30 , A01N45/00
Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
Abstract translation: 通过有机催化开环聚合制备具有一个或两个阳离子聚碳酸酯链的抗微生物阳离子聚合物。 一种抗微生物阳离子聚合物具有基本上由连接到一个或两个端基的阳离子碳酸酯重复单元组成的聚合物链。 末端基团可包含共价结合形式的生物活性化合物如胆固醇。 其它抗微生物阳离子聚合物具有无规共聚碳酸酯链，其包含具有共价结合形式的维生素E和/或维生素D2的疏水重复单元的较小摩尔分数。 阳离子聚合物对革兰氏阴性和革兰氏阳性微生物和真菌表现出高活性和选择性。
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公开(公告)号：US20160148391A1
公开(公告)日：2016-05-26
申请号：US14898346
申请日：2014-06-12
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Teck Wee CHUA , Nam Trung PHAM , Karianto LEMAN , Richard Philippe CHANG , Yue WANG
CPC classification number: G06T7/246 , G06K9/00342 , G06K9/00375 , G06K9/4642 , G06K9/4676 , G06K9/481 , G06K9/6223 , G06T7/50 , G06T2207/30196
Abstract: A system and method for human motion recognition are provided. The system includes a video sequence decomposer, a feature extractor, and a motion recognition module. The video sequence decomposer decomposes a video sequence into a plurality of atomic actions. The feature extractor extracts features from each of the plurality of atomic actions, the features including at least a motion feature and a shape feature. And the motion recognition module performs motion recognition for each of the plurality of atomic actions in response to the features.
Abstract translation: 提供了一种用于人体运动识别的系统和方法。 该系统包括视频序列分解器，特征提取器和运动识别模块。 视频序列分解器将视频序列分解成多个原子动作。 特征提取器从多个原子动作中的每一个提取特征，所述特征至少包括运动特征和形状特征。 并且运动识别模块响应于特征对多个原子动作中的每一个执行运动识别。
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公开(公告)号：US20160143955A1
公开(公告)日：2016-05-26
申请号：US14903672
申请日：2014-07-10
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Shigeki Sugii , Wee Kiat Ong
CPC classification number: A61K35/35 , A61K35/12 , A61K35/36 , C12N5/0653 , C12N5/0667 , C12N2527/00
Abstract: Disclosed is a method for recovering stromal vascular fraction from a sample. The method comprises providing a mechanical force capable of breaking the sample into a single cell suspension whilst maintaining intact stromal vascular fraction cells cellular structures, wherein the mechanical force is mincing and/or homogenization. Also disclosed are methods of using the stromal vascular fraction.
Abstract translation: 公开了一种从样品中回收基质血管部分的方法。 该方法包括提供能够将样品破碎成单细胞悬浮液同时保持完整的基质血管部分细胞细胞结构的机械力，其中机械力是切碎和/或均质化。 还公开了使用基质血管部分的方法。
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344.发明授权Refractive index sensor for analyzing an analyte, and method of fabricating thereof 有权用于分析分析物的折射率传感器及其制造方法公开(公告)号：US09341568B2
公开(公告)日：2016-05-17
申请号：US14434319
申请日：2013-10-08
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Qing Liu , Jack Sheng Kee , Mi Kyoung Park
CPC classification number: G01N21/41 , G01N21/45 , G01N21/55 , G01N21/648 , G01N21/7703 , G01N21/774 , G01N2021/458 , G01N2021/7776 , G02B6/10
Abstract: A refractive index sensor is provided for analyzing an analyte, the sensor including: a strip waveguide for receiving an input light signal therein and transmitting the light signal, subject to manipulation as it propagates through the strip waveguide, to a detector for analysis with respect to the analyte; and a slot waveguide for sensing the analyte disposed thereon and for receiving a sensing signal, corresponding to said manipulation of the light signal, from the strip waveguide, wherein a grating is formed on a surface of the strip waveguide to enable coupling of the sensing signal from the strip waveguide to the slot waveguide, and the sensor is configured with enhanced sensitivity based on a sensitivity difference between the slot waveguide and the strip waveguide, and/or a group index difference between the slot waveguide and the strip waveguide.
Abstract translation: 提供折射率传感器用于分析分析物，所述传感器包括：带状波导，用于在其中接收输入光信号，并将光信号传送到经由带状波导传播的操作时，传输到相对于 分析物; 以及用于感测设置在其上的分析物并且用于从条形波导接收对应于所述光信号的所述操纵的感测信号的槽波导，其中在所述带状波导的表面上形成光栅以使得能够耦合所述感测信号 从带状波导到槽波导，并且传感器被配置为基于槽波导和带状波导之间的灵敏度差异增强的灵敏度和/或槽波导与带状波导之间的组折射率差。
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345.发明授权Optical circuit for sensing a biological entity in a fluid and method of configuring the same 有权用于感测流体中的生物实体的光电路及其配置方法公开(公告)号：US09335263B2
公开(公告)日：2016-05-10
申请号：US13623353
申请日：2012-09-20
Applicant: Agency for Science, Technology and Research
Inventor： Xiaoguang Tu , Tsung-Yang Liow , Mingbin Yu , Guo-Qiang Lo
CPC classification number: G01N21/45 , G01N21/41 , G01N2021/458 , G02B6/12007 , G02B2006/12159
Abstract: An optical circuit for sensing a biological entity in a fluid and a method of configuring an optical circuit for sensing a biological entity in a fluid are provided. The optical circuit includes a sensing arrangement including a reference arm having a reference waveguide and a sensing arm having a waveguide; wherein lengths of the reference waveguide and the waveguide are configured in accordance with a temperature dependency reduction criterion.
Abstract translation: 提供了用于感测流体中的生物体的光学电路以及配置用于感测流体中的生物体的光学电路的方法。 光电路包括感测装置，其包括具有参考波导的参考臂和具有波导的感测臂; 其中参考波导和波导的长度根据温度依赖性降低标准配置。
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Patent Agency Ranking
公开(公告)号：US20160116937A1
公开(公告)日：2016-04-28
申请号：US14897134
申请日：2014-06-05
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
IPC: G06F1/08
CPC classification number: G06F1/08 , H03K3/0375
Abstract: A method for detecting and correcting an error in a circuit is provided. The circuit is configured to receive an input signal and clock the input signal with a rising and falling timing signal. The method includes detecting late arrival signal transition of the input signal, at an intermediate point of a path, the path being one through which the input signal transits. The method further includes predicting an error in the input signal in response to detecting the late arrival signal transition at the intermediate point of the path. In addition, the method includes correcting the error in the input signal by manipulating the timing signal and/or a supply voltage.
Abstract translation: 提供了一种用于检测和校正电路中的误差的方法。 电路被配置为接收输入信号并且通过上升和下降定时信号对输入信号进行时钟。 该方法包括检测输入信号的延迟到达信号转变，在路径的中间点，该路径是输入信号通过的路径。 该方法还包括响应于检测到在路径的中间点的迟到到达信号转变来预测输入信号中的误差。 此外，该方法包括通过操纵定时信号和/或电源电压来校正输入信号中的误差。
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347.发明授权公开(公告)号：US09321845B2
公开(公告)日：2016-04-26
申请号：US14218288
申请日：2014-03-18
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Qi Zeng
IPC: A61K39/395 , C07K16/40 , C07K16/18 , G01N33/574 , A61K39/00
CPC classification number: C07K16/40 , A61K39/39558 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , G01N33/57496 , G01N2333/916
Abstract: We provide an antibody capable of binding to an intracellular PRL-I or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-I or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-I positive patients.
Abstract translation: 我们提供能够结合细胞内PRL-1或PRL-3多肽的抗体，其中抗体能够结合抗体269，抗体223或抗体318结合的表位。这种抗PRL抗体可能能够 结合细胞内PRL-1或PRL-3。 它们可能适合用作抗癌或转移疗法，或临床诊断以鉴别PRL-3或PRL-1阳性患者。
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公开(公告)号：US20160095933A1
公开(公告)日：2016-04-07
申请号：US14506733
申请日：2014-10-06
Applicant: International Business Machines Corporation , Agency For Science, Technology and Research
Inventor： Daniel J. Coady , Amanda C. Engler , James L. Hedrick , Xiyu Ke , Yi Yan Yang
CPC classification number: C08G64/18 , A61K9/0019 , A61K9/146 , A61K45/06 , C08G64/0233 , C08G64/0241 , C08G64/30 , C08G64/42
Abstract: Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water-soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution.
Abstract translation: 通过有机酸催化的开环聚合（ROP）制备具有活性酯侧链的环状碳酸酯单体的水溶性可生物降解聚合物。 包含活性酯侧链的初始聚合物用氨基醇处理，氨基醇将活性酯基转变成带有单羟基烷基和/或二羟基烷基的N-取代酰胺基，从而形成水溶性聚合物。 水溶性聚合物是无毒的，并且在缓冲的血清溶液中表现出隐形性质。
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公开(公告)号：US20160083690A1
公开(公告)日：2016-03-24
申请号：US14783545
申请日：2014-04-10
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： William Birch , Shaul Reuveny , Steve Oh , Jian Li
CPC classification number: C12N5/0075 , A61L27/18 , A61L27/34 , A61L27/3834 , C12N5/0654 , C12N2506/1392 , C12N2531/00 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/52 , C08L67/04 , C08L89/00 , C08L5/00
Abstract: A method for manufacturing polycaprolactone microcarriers is disclosed together with uses of the microcarriers.
Abstract translation: 公开了用于制造聚己内酯微载体的方法以及微载体的用途。
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公开(公告)号：US20160052851A1
公开(公告)日：2016-02-25
申请号：US14780678
申请日：2014-03-28
Inventor： Kanaparthi Ramesh , Armando Borgna , Yi Ling Eileen Goh , Timothy John White
CPC classification number: C07C45/38 , B01J23/50 , B01J27/1806 , B01J27/1817 , B01J27/188 , B01J27/198 , B01J35/1014 , C07C47/06
Abstract: The present invention provides the use of a metal-doped hydroxyapatite catalyst for highly selective conversion of an alcohol to an aldehyde at low temperatures. More specifically, the invention provides the use of a silver-doped hydroxyapatite catalyst for the highly selective oxidative dehydrogenation of ethanol to acetaldehyde. The present invention also provides the method for converting ethanol to acetaldehyde using a silver-doped hydroxyapatite catalyst.
Abstract translation: 本发明提供了金属掺杂的羟基磷灰石催化剂在低温下将醇高效地转化为醛的用途。 更具体地说，本发明提供了使用掺杂银的羟基磷灰石催化剂用于将乙醇高度选择性氧化脱氢成乙醛。 本发明还提供了使用掺银羟基磷灰石催化剂将乙醇转化为乙醛的方法。
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