公开(公告)号：US06621574B1

公开(公告)日：2003-09-16

申请号：US09578975

申请日：2000-05-25

Applicant: Robert W. Forney ,  Nancy T. Kawai

Inventor： Robert W. Forney ,  Nancy T. Kawai

IPC: G01J344

CPC classification number: G01N21/276 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0297 ,  G01J3/44 ,  G01J2003/2866 ,  G01N21/65

Abstract: This invention relates to an accessory for incorporation into Raman and other spectroscopic instruments for combining shuttering and spectroscopic calibration functions. The accessory is comprised of an assembly with at least two positions that may be inserted into the light path, one position allowing light to be directed to and from the sample, and another position containing a reference standard that blocks the beam and provides a shuttering function. When the light strikes the reference standard, a reference spectrum is produced that may be used to calibrate the spectrograph. The device is especially useful in combination with compact sampling accessories for Raman spectroscopy.

Abstract translation: 本发明涉及一种用于并入拉曼的附件和用于组合快门和光谱校准功能的其它光谱仪器。 附件由具有至少两个位置的组件组成，该组件可插入到光路中，一个位置允许光被引导到样本，另一个位置包含阻挡光束并提供光栅功能的参考标准 。 当光照参考标准时，产生可用于校准光谱仪的参考光谱。 该器件特别适用于拉曼光谱的紧凑采样附件。

公开(公告)号：US20030035301A1

公开(公告)日：2003-02-20

申请号：US10180643

申请日：2002-06-26

Inventor： Allan Gardiner ,  D.C. Constance Haber

IPC: F21V009/10 ,  A61B001/06

CPC classification number: G01J3/02 ,  A61B5/0488 ,  A61B5/0531 ,  A61N5/0619 ,  A61N2005/0663 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/10 ,  G01J2003/1213

Abstract: Illuminators and systems are provided that permit the production of a beam of electromagnetic radiation having selected peak wavelength, bandwidth, intensity, pulse frequency and pulse duration for a variety of analytical and therapeutic applications. Multiple beam illuminators use filter elements arranged into filter arrays, having characteristic wavelength absorption properties. By providing a series of filter arrays formed into tracks having defined wavelength offsets, radiation passing through a portion of a track can be modified to include selected peak wavelength and bandwidth. Selection of peak wavelength(s) and bandwidth can be accomplished using mechanical interrupters, mechanical shutters, or electro-optical devices including liquid crystal device. Multiple output beams permit the coordinated illumination of a target, and sensors provide feedback regarding the effects of illumination on a target. Computer storage devices, programs, and controllers can provide easy selection of the characteristics of the output beams. Output beams can have a variety of different shapes and configurations, depending on the desired application.

Abstract translation: 提供照明器和系统，其允许产生具有选择的峰值波长，带宽，强度，脉冲频率和脉冲持续时间的电磁辐射束用于各种分析和治疗应用。 多光束照明器使用排列成滤光片阵列的滤光片，具有特征波长吸收特性。 通过提供形成为具有限定的波长偏移的轨道的一系列滤波器阵列，可以修改通过轨道的一部分的辐射，以包括所选择的峰值波长和带宽。 可以使用机械断路器，机械快门或包括液晶装置的电光装置来实现峰值波长和带宽的选择。 多个输出光束允许目标的协调照明，并且传感器提供有关照明对目标的影响的反馈。 计算机存储设备，程序和控制器可以方便地选择输出光束的特性。 输出光束可以具有各种不同的形状和配置，这取决于所需的应用。

公开(公告)号：US20020193671A1

公开(公告)日：2002-12-19

申请号：US09932185

申请日：2001-08-17

Inventor： Emil W. Ciurczak ,  Kevin P. Bynum ,  Howard Mark

IPC: A61B005/00

CPC classification number: G01J3/28 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0237 ,  G01J3/0254 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/12 ,  G01J2003/1213 ,  G01J2003/1828 ,  G01J2003/2866 ,  G01N21/359 ,  G01N2201/065

Abstract: An individualized modeling equation for predicting a patient's blood glucose values is generated as a function of non-invasive spectral scans of a body part and an analysis of blood samples from the patient, and is stored on a central computer. The central computer predicts a blood glucose value for the patient as a function of the individualized modeling equation and a non-invasive spectral scan generated by a remote spectral device. If the spectral scan falls within the range of the modeling equation, the predicted blood glucose level is output to the patient. If the spectral scan falls outside the range of the modeling equation, regeneration of the model is required, and the patient takes a number of noninvasive scans and an invasive blood glucose level determination. The computer regenerates the individualized modeling equation as a function of the set of spectral scans and corresponding blood glucose values.

Abstract translation: 产生用于预测患者血糖值的个性化建模方程作为身体部位的非侵入性光谱扫描和来自患者的血液样本的分析的函数，并且存储在中央计算机上。 中央计算机根据个性化建模方程和由远程光谱装置产生的非侵入式光谱扫描来预测患者的血糖值。 如果光谱扫描落在建模方程的范围内，则将预测的血糖水平输出给患者。 如果光谱扫描超出建模方程的范围，则需要再生模型，并且患者进行多次无创扫描和侵入性血糖水平测定。 计算机根据光谱扫描集和对应的血糖值重新生成个性化建模方程。

公开(公告)号：US06487343B1

公开(公告)日：2002-11-26

申请号：US09585144

申请日：2000-06-01

Applicant: Mark S. Lewandowski ,  Kenneth R. Quast ,  Dean E. Myers ,  Mark A. Schmidt

Inventor： Mark S. Lewandowski ,  Kenneth R. Quast ,  Dean E. Myers ,  Mark A. Schmidt

IPC: G02B626

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0291 ,  G01N21/274 ,  G01N21/3151 ,  G01N21/3563 ,  G02B6/2808 ,  G02B6/3825 ,  G02B6/3885 ,  G02B6/4249 ,  G02B6/4298

Abstract: An optical structure for combining light from a plurality of individual optical fibers into a single optical transmission device. The structure can be incorporated into the optical probe of a spectrophotometric instrument and includes a plurality of optical send fibers having input and output ends and an optical light mixer having input and output ends. The output ends of the send fibers are secured in optical communication with the input end of the light mixer.

Abstract translation: 一种用于将来自多个单独光纤的光组合成单个光传输装置的光学结构。 该结构可以结合到分光光度计的光学探针中，并且包括具有输入和输出端的多个光学发送光纤和具有输入和输出端的光学混合器。 发送光纤的输出端与光混合器的输入端光连通地固定。

公开(公告)号：US06481899B1

公开(公告)日：2002-11-19

申请号：US09585487

申请日：2000-06-01

Applicant: Kenneth R. Quast ,  Mark A. Schmidt ,  Sergey I. Gritsenko ,  Mark S. Lewandowski ,  Dean E. Myers

Inventor： Kenneth R. Quast ,  Mark A. Schmidt ,  Sergey I. Gritsenko ,  Mark S. Lewandowski ,  Dean E. Myers

IPC: G02B636

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0291 ,  G01N21/274 ,  G01N21/3151 ,  G01N21/3563 ,  G02B6/3825 ,  G02B6/3878 ,  G02B6/3885 ,  G02B6/4249 ,  G02B6/4298

Abstract: An optical connector latch to optically couple at least one optical fiber ferrule on an interface housing with an optics receptacle mount on an instrument and a method of using the same. The optical connector latch comprises one or more shell pegs adapted to advance the interface housing into engagement with the optics receptacle mount. One or more ferrule pins are adapted to extend through latch holes in the interface housing and latch holes in the optics receptacle mount to engage with the optical fiber ferrule. A drive mechanism is provided to drive the shell pegs and the ferrule pins toward the optics receptacle mount.

Abstract translation: 一种光学连接器闩锁，用于将接口壳体上的至少一个光纤套圈光学耦合到仪器上的光学器件插座安装件及其使用方法。 光学连接器闩锁包括一个或多个壳钉，其适于将接口壳体推进与光学插座安装座接合。 一个或多个套圈销适于延伸通过接口壳体中的闩锁孔和光学插座安装件中的闩锁孔，以与光纤套圈啮合。 提供驱动机构以将壳钉和套圈销朝向光学插座安装座驱动。

公开(公告)号：US20020044272A1

公开(公告)日：2002-04-18

申请号：US09932844

申请日：2001-08-17

Applicant: Amnis Corporation

Inventor： David A. Basiji ,  William E. Ortyn

IPC: G01N021/00

CPC classification number: G06K9/00127 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0232 ,  G01J3/14 ,  G01J3/2823 ,  G01J3/2889 ,  G01N15/14 ,  G01N21/6458 ,  G01N2015/1497

Abstract: Light from an object moving through an imaging system is collected, dispersed, and imaged onto a time delay integration (TDI) detector that is inclined relative to an axis of motion of the object, producing a pixilated output signal. In one embodiment, the movement of the image object over the TDI detector is asynchronous with the movement of the output signal producing an output signal that is a composite of the image of the object at varying focal point along the focal plane. In another embodiment, light from the object is periodically incident on the inclined TDI detector, producing a plurality of spaced apart images and corresponding output signals that propagate across the TDI detector. The inclined plane enables images of FISH probes or other components within an object to be produced at different focal points, so that the 3D spatial relationship between the FISH probes or components can be resolved.

Abstract translation: 来自移动通过成像系统的物体的光被收集，分散和成像到相对于物体的运动轴线倾斜的时间延迟积分（TDI）检测器，产生像素化的输出信号。 在一个实施例中，图像对象在TDI检测器上的移动与产生输出信号的输出信号的移动是异步的，该输出信号是沿着焦平面的变化焦点处的物体的图像的复合。 在另一个实施例中，来自物体的光周期性地入射到倾斜的TDI检测器上，产生多个间隔开的图像和在TDI检测器上传播的对应的输出信号。 倾斜平面使得可以在不同焦点处产生物体内的FISH探针或其他部件的图像，从而可以解决FISH探针或部件之间的3D空间关系。

公开(公告)号：US20020039186A1

公开(公告)日：2002-04-04

申请号：US09803131

申请日：2001-03-09

Inventor： Charles W. Von Rosenberg

IPC: G01N021/01

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/28 ,  G01J3/502 ,  G01J2003/2866 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/8507 ,  G01N33/10

Abstract: The present invention relates to spectral analysis systems and methods for determining physical and chemical properties of a sample by measuring the optical characteristics of light emitted from the sample. In one embodiment, a probe head for use with a spectrometer includes a reflector for illuminating a sample volume disposed circumferentially about the light source of the probe head. In another embodiment, a probe head includes an optical blocking element for forcing the optical path between the light source and an optical pick-up optically connected to the spectrometer into the sample. The probe head also includes a reference shutter for selectively blocking light emitted from the sample from reaching the optical pick-up to facilitate calibration of the spectrometer.

Abstract translation: 本发明涉及通过测量从样品发射的光的光学特性来确定样品的物理和化学性质的光谱分析系统和方法。 在一个实施例中，用于光谱仪的探针头包括用于照亮围绕探头的光源周向设置的样品体积的反射器。 在另一个实施例中，探头包括用于迫使光源和光学连接到光谱仪的光学拾取器之间的光路进入样品的光学阻挡元件。 探头还包括用于选择性地阻挡从样品发射的光到达光学拾波器以便于校准光谱仪的参考快门。

公开(公告)号：US20010055116A1

公开(公告)日：2001-12-27

申请号：US09932210

申请日：2001-08-17

Inventor： Anthony K. Maczura ,  Erich R. Gross ,  Anthony S. Lee ,  David M. Mayes

IPC: G01J003/42

CPC classification number: G01N21/276 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0272 ,  G01J3/28 ,  G01J3/42 ,  G01J3/46 ,  G01J3/502 ,  G01J3/524 ,  G01J2003/2866 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/85

Abstract: The present invention relates to spectral analysis systems and methods for determining physical and chemical properties of a sample by measuring the optical characteristics of light emitted from the sample. In one embodiment, a probe head for use with a spectrometer includes an optical blocking element for forcing the optical path between the light source and an optical pick-up optically connected to the spectrometer into the sample. The probe head also includes a reference shutter for selectively blocking light emitted from the sample from reaching the optical pick-up to facilitate calibration of the spectrometer.

Abstract translation: 本发明涉及通过测量从样品发射的光的光学特性来确定样品的物理和化学性质的光谱分析系统和方法。 在一个实施例中，与光谱仪一起使用的探针头包括用于迫使光源和光学连接到光谱仪的光学拾取器之间的光路进入样品的光学阻挡元件。 探头还包括用于选择性地阻挡从样品发射的光到达光学拾波器以便于校准光谱仪的参考快门。

公开(公告)号：US5973787A

公开(公告)日：1999-10-26

申请号：US76673

申请日：1998-05-12

Applicant: David E. Aspnes ,  Jon Opsal

Inventor： David E. Aspnes ,  Jon Opsal

IPC: G01N21/21 ,  G01B11/06 ,  G01J3/02 ,  G01J3/447 ,  G01J4/00 ,  G01J4/04 ,  G02F1/01

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01N21/211 ,  G01N2021/213

Abstract: An ellipsometer, and a method of ellipsometry, for analyzing a sample using a broad range of wavelengths, includes a light source for generating a beam of polychromatic light having a range of wavelengths of light for interacting with the sample. A polarizer polarizes the light beam before the light beam interacts with the sample. A rotating compensator induces phase retardations of a polarization state of the light beam wherein the range of wavelengths and the compensator are selected such that at least a first phase retardation value is induced that is within a primary range of effective retardations of substantially 135.degree. to 225.degree., and at least a second phase retardation value is induced that is outside of the primary range. An analyzer interacts with the light beam after the light beam interacts with the sample. A detector measures the intensity of light after interacting with the analyzer as a function of compensator angle and of wavelength, preferably at all wavelengths simultaneously. A processor determines the polarization state of the beam as it impinges the analyzer from the light intensities measured by the detector.

公开(公告)号：US5959763A

公开(公告)日：1999-09-28

申请号：US31487

申请日：1998-02-26

Applicant: Carl O. Bozler ,  Steven Rabe

Inventor： Carl O. Bozler ,  Steven Rabe

IPC: G02B26/02 ,  G02B26/08 ,  G09F9/37 ,  H01H59/00 ,  G02B26/00 ,  G02F1/03

CPC classification number: G02B26/02 ,  G02B26/0833 ,  G02B26/0841 ,  G09F9/372 ,  G01J3/0232 ,  H01H2001/0042 ,  H01H2059/0018 ,  H01H2059/0081 ,  H01H59/0009

Abstract: A spatial light modulator formed of a moveable electrode which is disposed opposite a fixed electrode and is biased to roll in a preferred direction upon application of an electric field across the electrodes to produce a light valve or light shutter. In one embodiment, the moveable electrode is restrained at one end and coils about the fixed end in a preferential roll direction. The bias is achieved by inducing anisotropic stress or anisotropic stiffness.

Abstract translation: 由可移动电极形成的空间光调制器，所述可移动电极与固定电极相对设置，并且在跨过电极施加电场以偏置以在优选方向上滚动以产生光阀或光闸。 在一个实施例中，可移动电极被限制在一端并以优先的滚动方向围绕固定端盘绕。 通过诱发各向异性压力或各向异性刚度来实现偏置。