公开(公告)号：US11733163B2

公开(公告)日：2023-08-22

申请号：US17085487

申请日：2020-10-30

Applicant: Saudi Arabian Oil Company

Inventor： Ezzat Hegazi ,  Vincent Cunningham

IPC: G01N21/64 ,  G01N21/39 ,  G01N21/13 ,  G01N33/28 ,  G01N21/33

CPC classification number: G01N21/6428 ,  G01N21/645 ,  G01N21/33 ,  G01N21/6456 ,  G01N33/28 ,  G01N2021/135 ,  G01N2021/392 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/129

Abstract: A single-wavelength light source is configured to generate an excitation light source. A sample holder that defines an inner cavity is capable of holding a sample and includes a surface transparent to the excitation light source. One or more mounts are attached to at least one of the light source or the sample holder. The mounts are configured to change an incident angle of the excitation light source on the surface. One or more optical components are positioned in a path of a fluorescence emission emitted from the surface and guide the fluorescence emission to a detector. A detector detects an intensity of the fluorescence emission.

公开(公告)号：US11719628B2

公开(公告)日：2023-08-08

申请号：US17248867

申请日：2021-02-11

Applicant: VIAVI Solutions Inc.

Inventor： Chang Meng Hsiung ,  Lan Sun

IPC: G01N21/27 ,  G01J3/02

CPC classification number: G01N21/274 ,  G01J3/0275 ,  G01N2201/129

Abstract: A device may receive a master data set for a first spectroscopic model; receive a target data set for a target population associated with the first spectroscopic model to update the first spectroscopic model; generate a training data set that includes the master data set and first data from the target data set; generate a validation data set that includes second data from the target data set and not the master data set; generate, using cross-validation and using the training data set and the validation data set, a second spectroscopic model that is an update of the first spectroscopic model; and provide the second spectroscopic model.

公开(公告)号：US20230194415A1

公开(公告)日：2023-06-22

申请号：US17768431

申请日：2020-10-05

Applicant: Evonik Operations GmbH

Inventor： Ingolf REIMANN ,  Joachim REISING

IPC: G01N21/27 ,  G01N21/359 ,  G06F17/16 ,  G06F18/214 ,  G16C60/00 ,  G16C20/20 ,  G16C20/30

CPC classification number: G01N21/274 ,  G01N21/359 ,  G06F17/16 ,  G06F18/214 ,  G16C60/00 ,  G16C20/20 ,  G16C20/30 ,  G01N2201/129 ,  G01J2003/2866

Abstract: The present invention relates to a computer-implemented method for predicting a property value of interest in a sample investigated by infrared spectroscopy. The method aims at generating a calibration function. To this end, a set of calibration samples is selected, whereby outliers are identified and removed from the set of calibration samples. Outliers are determined using principal component analysis and singular value decomposition. The threshold value separating outliers from the remaining samples is calculated on the basis of a predetermined formulae. The threshold value may also be increased stepwise in order to dynamically set the threshold value, which is preferable for spectroscopic devices not operated under laboratory conditions.

公开(公告)号：US11656174B2

公开(公告)日：2023-05-23

申请号：US17248333

申请日：2021-01-20

Applicant: VIAVI Solutions Inc.

Inventor： Chang Meng Hsiung ,  Lan Sun

IPC: G16C20/70 ,  G01N21/35 ,  G16C20/20 ,  G06N20/00 ,  G01J3/10 ,  G01N21/25 ,  G01N21/359 ,  G06V20/69 ,  G06F18/2411 ,  G06F18/2433

CPC classification number: G01N21/35 ,  G01J3/108 ,  G01N21/253 ,  G01N21/359 ,  G06F18/2411 ,  G06F18/2433 ,  G06N20/00 ,  G06V20/698 ,  G16C20/20 ,  G16C20/70 ,  G01N2201/129

Abstract: In some implementations, a device may determine that an unknown sample is an outlier sample by using an aggregated classification model. The device may determine that one or more spectroscopic measurements are not performed accurately based on determining that the unknown sample is the outlier sample. The device may cause one or more actions based on determining the one or more spectroscopic measurements are not performed accurately.

公开(公告)号：US20180348192A1

公开(公告)日：2018-12-06

申请号：US16056020

申请日：2018-08-06

Applicant: Saudi Arabian Oil Company

Inventor： Ezzat Hegazi ,  Vincent Cunningham ,  Maha Nour

IPC: G01N33/28 ,  G01N21/64 ,  G01J3/46 ,  G01J3/44

CPC classification number: G01N33/2888 ,  G01J3/4406 ,  G01J3/46 ,  G01N21/6402 ,  G01N21/6408 ,  G01N21/643 ,  G01N2021/6482 ,  G01N2201/129

Abstract: Methods, systems, and apparatus to diagnose lubrication oil deterioration. In one aspect, a method includes irradiating a lubrication oil sample with a light beam to emit a light-induced fluorescence, detecting and processing the light-induced fluorescence signal to determine a temporal variation of a fluorescence intensity, identifying a steady state of the light-induced fluorescence signal, processing the temporal variation of the fluorescence intensity to determine a lubrication oil parameter, and correlating the oil parameter to a calibration curve to diagnose the lubrication oil deterioration.

公开(公告)号：US20180296097A1

公开(公告)日：2018-10-18

申请号：US16015737

申请日：2018-06-22

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  G01J3/28 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/39 ,  G06F19/00 ,  G01N21/88 ,  G16H40/67 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01N33/02 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/35 ,  G01N33/49 ,  G01N33/44 ,  G01N33/15 ,  G01J3/453 ,  G01J3/42 ,  G01J3/18 ,  G01J3/12 ,  G01M3/38 ,  G01N21/85 ,  G01N21/95 ,  H01S3/00 ,  H01S3/30 ,  H01S3/067

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302 ,  Y02A90/26

Abstract: A measurement system includes a light source having semiconductor sources, a multiplexer, and one or more fused silica fibers configured to form an output optical beam having one or more optical wavelengths modulated at a modulation frequency. A light beam set-up includes a monochromator forming a filtered optical beam. A measurement apparatus delivers the filtered optical beam to a sample. A receiver receives a spectroscopy output beam generated from the sample by the filtered optical beam. The receiver is configured to use a lock-in technique that detects the modulation frequency, and to generate first and second signals responsive to light received while the light source is off and on, respectively. The measurement system improves a signal-to-noise ratio of the spectroscopy output beam by differencing the first and second signals. The receiver processes the spectroscopy output beam using chemometrics or multivariate analysis to permit identification of materials within the sample.

公开(公告)号：US10082600B2

公开(公告)日：2018-09-25

申请号：US14364119

申请日：2011-12-16

Applicant: Jing Shen ,  Christopher Jones ,  Dingding Chen ,  Michael T. Pelletier ,  Robert Atkinson ,  David Perkins

Inventor： Jing Shen ,  Christopher Jones ,  Dingding Chen ,  Michael T. Pelletier ,  Robert Atkinson ,  David Perkins

IPC: G01V13/00 ,  G01N33/24 ,  G01N21/27

CPC classification number: G01V13/00 ,  G01N21/274 ,  G01N33/241 ,  G01N2201/129 ,  G01N2201/1296

Abstract: A method of calibration transfer for a testing instrument includes: collecting a first sample; generating a standard response of a first instrument based, at least in part, on the first sample; and performing instrument standardization of a second instrument based, at least in part, on the standard response of the first instrument. Data corresponding to a second sample is then obtained using the second instrument and a component of the second sample is identified based, at least in part, on a calibration model.

公开(公告)号：US20180136193A1

公开(公告)日：2018-05-17

申请号：US15846883

申请日：2017-12-19

Applicant: Nueon Inc.

Inventor： Robert G. Messerschmidt ,  Howland D.T. Jones

IPC: G01N33/49 ,  G01N21/35 ,  G01N33/80

CPC classification number: G01N33/492 ,  A61B5/0082 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/14546 ,  A61B5/1455 ,  G01J3/42 ,  G01N21/35 ,  G01N21/552 ,  G01N33/80 ,  G01N2201/129 ,  G01N2333/805 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52 ,  G16H10/40

Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.

公开(公告)号：US09952159B2

公开(公告)日：2018-04-24

申请号：US15235170

申请日：2016-08-12

Applicant: Sean Xiaolu Wang ,  Qun Li

Inventor： Sean Xiaolu Wang ,  Qun Li

IPC: G01J3/30 ,  G01N21/71 ,  G01J3/10 ,  G01J3/28 ,  G01J3/443 ,  G01J3/02

CPC classification number: G01N21/718 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/443 ,  G01N2201/0612 ,  G01N2201/129

Abstract: This invention discloses a laser induced breakdown spectroscopy (LIBS) apparatus based on high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz (or even higher) range. When the laser beam hits the biological sample, it generates several thousands of micro-plasmas per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasmas. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses. Hence the intensity of the obtained LIBS spectrum can be greatly improved to increase the signal-to-noise ratio (SNR) and lower the level of detection (LOD).

公开(公告)号：US09931039B2

公开(公告)日：2018-04-03

申请号：US14412053

申请日：2013-07-02

Applicant: National University of Singapore

Inventor： Zhiwei Huang ,  Khek Yu Ho ,  Mads Sylvest Bergholt ,  Wei Zheng ,  Khay Guan Yeoh ,  Shiyamala Duraipandian

IPC: A61B5/02 ,  A61B5/00 ,  A61B1/00 ,  G01N21/65 ,  G01N21/27 ,  G01J3/44

CPC classification number: A61B5/0075 ,  A61B1/00165 ,  A61B5/0084 ,  A61B2560/0233 ,  G01J2003/4424 ,  G01N21/274 ,  G01N21/65 ,  G01N2021/656 ,  G01N2201/08 ,  G01N2201/12753 ,  G01N2201/129

Abstract: A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.