公开(公告)号：US08705043B2

公开(公告)日：2014-04-22

申请号：US12966207

申请日：2010-12-13

Applicant: Chau-Hwang Lee ,  Chun-Chieh Wang

Inventor： Chau-Hwang Lee ,  Chun-Chieh Wang

IPC: G01B9/021 ,  G01B11/24 ,  G01B11/30

CPC classification number: G01B11/25 ,  G01B11/0608 ,  G06T7/521 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/30004

Abstract: A method for imaging an object using a microscope includes obtaining axial response data, the axial response data representative of a relationship between a separation between a top surface of the object and an objective lens of the microscope and an intensity of light reflected by the top surface of the object; positioning the object at a distance from the objective lens that is within a linear region of the axial response data; sequentially illuminating the object with a plurality of periodic patterns; obtaining a plurality of images of the object, each image resulting from the illumination of the object with a corresponding one of the plurality of periodic patterns; determining a reconstructed image of the object based on the plurality of images of the object; and, based on variations in the intensity of the reconstructed image, determining a topographic profile of the top surface of the object.

Abstract translation: 使用显微镜成像物体的方法包括获得轴向响应数据，轴向响应数据表示物体的顶表面与显微镜的物镜之间的间隔与由顶表面反射的光的强度之间的关系 的对象; 将物体定位在与轴向响应数据的线性区域内的离开物镜的距离处; 以多个周期性图案依次照明物体; 获得所述对象的多个图像，所述每个图像由所述对象的照明产生，所述每个图像具有所述多个周期性图案中的对应的一个; 基于对象的多个图像确定对象的重建图像; 并且基于重建图像的强度的变化，确定对象的顶表面的地形轮廓。

公开(公告)号：US08703951B2

公开(公告)日：2014-04-22

申请号：US13549572

申请日：2012-07-16

Applicant: Tsann-Long Su ,  Ting-Chao Chou ,  Te-Chang Lee

Inventor： Tsann-Long Su ,  Ting-Chao Chou ,  Te-Chang Lee

IPC: C07D471/00 ,  C07D491/00 ,  C07D498/00 ,  C07D513/00 ,  C07D515/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00

CPC classification number: C07D513/04 ,  C07D471/14

Abstract: The present invention provides a series of 2,3-bis(hydroxymethyl)-4H-benzo[d]pyrrolo-[1,2-a]thiazoles and 1,2-bis(hydroxymethyl)indolizino[6,7-b]indole derivatives and their bis(alkylcarbamates) derivatives. These derivatives were designed as bi-functional DNA cross-linking agents. The in vitro cytotoxicity study of these compounds revealed that they exhibit significant anti-proliferative activity in inhibiting human lymphoblastic leukemia and various solid tumor cell growth. The compounds also exhibit therapeutic efficacy against human breast carcinoma and lung cancer in xenograft model. The compounds generally possess potent antitumor activity to kill various human solid tumors and have high potential for clinical applications.

Abstract translation: 本发明提供了一系列2,3-双（羟甲基）-4H-苯并[d]吡咯并[1,2-a]噻唑和1,2-双（羟甲基）吲哚并[6,7-b]吲哚 衍生物及其双（烷基氨基甲酸酯）衍生物。 这些衍生物被设计为双功能DNA交联剂。 这些化合物的体外细胞毒性研究表明，它们在抑制人淋巴细胞白血病和各种实体瘤细胞生长中表现出显着的抗增殖活性。 该化合物还在异种移植模型中表现出对人乳腺癌和肺癌的治疗功效。 该化合物通常具有有效的抗肿瘤活性，可杀死各种人体实体肿瘤，具有很高的临床应用潜力。

公开(公告)号：US08685923B2

公开(公告)日：2014-04-01

申请号：US13572652

申请日：2012-08-12

Applicant: Shu-Mei Liang ,  Chun-Yung Huang ,  Chi-Ming Liang

Inventor： Shu-Mei Liang ,  Chun-Yung Huang ,  Chi-Ming Liang

IPC: A61K38/38 ,  C07K14/76 ,  C07K1/16

CPC classification number: A61K31/7088 ,  A61K38/162 ,  A61K38/38 ,  A61K38/39 ,  A61K39/39 ,  A61K2039/55516

Abstract: A method for inhibiting survival of cancer cells in a subject is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of fibrillar albumin. The preparation of the fibrillar albumin comprises: (i) forming a solution comprising an isolated and/or purified globular albumin; (ii) adding a detergent to the solution containing the isolated and/or purified globular albumin, wherein the detergent is one selected from the group consisting of sodium dodecyl sulfate (SDS) and n-tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; (iii) applying the solution to a molecular sizing column with a pore size that permits separation of a protein with a molecular weight of at least about 70 kDa so as to promote column-induced formation of the fibrillar albumin from the isolated and/or purified globular albumin; and (iv) eluting the fibrillar albumin from the column, wherein the eluted albumin has a fibrillar structure.

Abstract translation: 公开了抑制受试者中癌细胞存活的方法。 该方法包括向有需要的受试者施用治疗有效量的原纤维白蛋白。 纤维状白蛋白的制备包括：（i）形成包含分离和/或纯化的球状白蛋白的溶液; （ii）向含有分离和/或纯化的球状白蛋白的溶液中加入洗涤剂，其中洗涤剂选自十二烷基硫酸钠（SDS）和正十四烷基-N，N-二甲基-3-氨基 -1-丙磺酸盐; （iii）将溶液施加到具有允许分离至少约70kDa的分子量的蛋白质的孔径的分子筛分柱，以便促进来自分离和/或纯化的柱状诱导的纤维状白蛋白的形成 球状白蛋白 和（iv）从柱中洗脱纤维状白蛋白，其中洗脱的白蛋白具有纤维状结构。

公开(公告)号：US08685843B2

公开(公告)日：2014-04-01

申请号：US13346152

申请日：2012-01-09

Applicant: Lain-Jong Li ,  Ching-Yuan Su ,  Ang-Yu Lu ,  Chih-Yu Wu ,  Keng-Ku Liu

Inventor： Lain-Jong Li ,  Ching-Yuan Su ,  Ang-Yu Lu ,  Chih-Yu Wu ,  Keng-Ku Liu

IPC: H01L21/04

CPC classification number: H01L21/0262 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/184 ,  H01L21/02381 ,  H01L21/0242 ,  H01L21/02422 ,  H01L21/02444 ,  H01L21/02488 ,  H01L21/02502 ,  H01L21/02527 ,  H01L21/02612

Abstract: Graphene layers can be formed on a dielectric substrate using a process that includes forming a copper thin film on a dielectric substrate; diffusing carbon atoms through the copper thin film; and forming a graphene layer at an interface between the copper thin film and the dielectric substrate.

Abstract translation: 可以使用包括在电介质基板上形成铜薄膜的工艺在电介质基板上形成石墨烯层; 通过铜薄膜扩散碳原子; 以及在所述铜薄膜和所述电介质基板之间的界面处形成石墨烯层。

公开(公告)号：US20140066762A1

公开(公告)日：2014-03-06

申请号：US14016060

申请日：2013-08-31

Applicant: ACADEMIA SINICA

Inventor： Yeu-Kuang Hwu ,  Chia-Chi Chien ,  Cheng-Liang Wang

IPC: A61B6/00

CPC classification number: A61B6/485 ,  A61B6/481 ,  A61B6/508 ,  A61K49/0065 ,  B82Y5/00 ,  B82Y15/00

Abstract: A method of tracking specific cells in vivo is disclosed. The method of the disclosure includes: providing fluorescent nanoparticles suitable for targeting of specific cells; administering the fluorescent nanoparticles to a subject; providing an X-ray source to irradiate the subject; and determining the distribution and growth of the specific cells by the fluorescent images from the fluorescent nanoparticles and X-ray images of the subject irradiated by the X-ray source.

Abstract translation: 公开了一种在体内追踪特定细胞的方法。 本公开的方法包括：提供适于靶向特定细胞的荧光纳米颗粒; 向受试者施用荧光纳米颗粒; 提供X射线源以照射受试者; 以及通过来自荧光纳米颗粒的荧光图像和由X射线源照射的被摄体的X射线图像确定特定细胞的分布和生长。

公开(公告)号：US20140066438A1

公开(公告)日：2014-03-06

申请号：US13974832

申请日：2013-08-23

Applicant: Academia Sinica

Inventor： YI-LING LIN

IPC: A61K31/5415 ,  A61K31/451

CPC classification number: A61K31/5415 ,  A61K31/451 ,  Y02A50/385 ,  Y02A50/389 ,  Y02A50/393

Abstract: Methods for preventing and/or treating flavivirus infection are disclosed. The method comprises administering to a subject in need thereof a composition comprising: a) a dopamine D2 receptor antagonist in an amount effective for preventing and/or treating flavivirus infection; and b) a pharmaceutically acceptable carrier. The dopamine D2 receptor antagonist may be selected from the group consisting of prochlorperazine or a salt thereof, and haloperidol.

Abstract translation: 公开了用于预防和/或治疗黄病毒感染的方法。 该方法包括向有需要的受试者施用组合物，其包含：a）有效预防和/或治疗黄病毒感染量的多巴胺D2受体拮抗剂; 和b）药学上可接受的载体。 多巴胺D2受体拮抗剂可以选自丙氯拉嗪或其盐和氟哌啶醇。

公开(公告)号：US20140051127A1

公开(公告)日：2014-02-20

申请号：US13971353

申请日：2013-08-20

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Tsung-I Tsai ,  Chung-Yi Wu

IPC: C12P19/18

CPC classification number: C12P19/18 ,  C12P19/04 ,  C12Y207/0701

Abstract: A novel UDP-Gal regeneration process and its combined use with a galactosyltransferase to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

Abstract translation: 一种新型的UDP-Gal再生过程及其与半乳糖基转移酶的组合使用，以将半乳糖加入合适的受体底物。 本文还描述了大规模生产Globo系列寡糖的合成方法，其中所述方法可涉及糖基转移酶反应和核苷酸糖再生过程的组合。

公开(公告)号：US20130342209A1

公开(公告)日：2013-12-26

申请号：US13887405

申请日：2013-05-06

Applicant: Academia Sinica

Inventor： TAI-HUANG HUANG ,  CHING-YU CHOU ,  MING-LEE CHU ,  CHI-FON CHANG

IPC: G01R33/30

CPC classification number: G01R33/307 ,  G01R33/445

Abstract: A precision high-speed shuttle device for transporting samples between different positions of a superconducting magnet with different magnetic field strength is provided. The sample equilibrated at the center of the magnet, where the magnetic field is the highest and homogeneous, is shuttled to a higher position above, where the fringe field is lower, for a defined period of time and shuttled back to the center for detection. By shuttling the sample to different positions in the magnet in different experiments one can obtain a field-dependent profile of particular physical parameters. The position and timing of the sample are precisely under the experimental controlled. In this way various magnetic field-dependent nuclear magnetic resonance (NMR) experiments can be conducted in a single high-field NMR spectrometer.

Abstract translation: 提供了一种用于在具有不同磁场强度的超导磁体的不同位置之间传送样品的精密高速穿梭装置。 在磁体中心处平衡的样品（其中磁场最高和均匀）在穿过定义的时间段内穿梭到上方的边缘区域较高的位置，并穿梭回中心进行检测。 通过在不同的实验中将样品穿过磁体中的不同位置，可以获得特定物理参数的场依赖性分布。 样品的位置和时间正好在实验控制之下。 以这种方式，可以在单个高场NMR光谱仪中进行各种磁场依赖核磁共振（NMR）实验。

公开(公告)号：US20130328018A1

公开(公告)日：2013-12-12

申请号：US13494888

申请日：2012-06-12

Applicant: Kuei-Hsien Chen ,  Hsieh-Cheng Han ,  Ching-Chun Chang ,  Li-Chyong Chen ,  Chan-Yi Du

Inventor： Kuei-Hsien Chen ,  Hsieh-Cheng Han ,  Ching-Chun Chang ,  Li-Chyong Chen ,  Chan-Yi Du

IPC: H01L51/48 ,  H01L51/56 ,  H01L51/46 ,  H01L51/40

CPC classification number: H01L51/424 ,  H01L51/0036 ,  H01L51/0043 ,  H01L51/0046 ,  H01L51/0047 ,  H01L51/005 ,  H01L51/0055 ,  H01L51/4246 ,  H01L51/44 ,  Y02E10/549 ,  Y02P70/521

Abstract: The present invention is related to a process for reducing surface energy of a hole transport layer. The disclosed process comprises providing a hole transport layer; and providing a fluorine-containing layer directly on said hole transport layer. The configuration of said fluorine-containing layer reduces the structural disorder of an active layer and is able to recover a moisture-degraded hole transport layer, and thereby improves the performance of an electric device containing the same.

公开(公告)号：US08597701B2

公开(公告)日：2013-12-03

申请号：US11386985

申请日：2006-03-21

Applicant: Pei-Wen Hsiao

Inventor： Pei-Wen Hsiao

IPC: A61K8/97 ,  A61K31/366 ,  A61K31/165

CPC classification number: A61K36/28

Abstract: Disclosed herein is a method for treating an androgen-stimulated disease in a subject in need thereof by administering to the subject a composition containing an effective amount of an inhibitor of IκB kinase subunit α activity. The composition can also be administered to a subject at high risk for prostate cancer as a method for reducing the subject's risk thereof. A further method relates to identifying a modulator of transcriptional activity regulated by IκB kinase subunit α. Still another method relates to determining the IκB kinase subunit α-regulated transcriptional activity regulated by in a non-human mammalian test subject.

Abstract translation: 本文公开了通过向受试者施用含有有效量的IkappaB激酶亚基α活性抑制剂的组合物来治疗有需要的受试者中的雄激素刺激的疾病的方法。 该组合物也可以作为降低受试者风险的方法施用于患有前列腺癌的高风险的受试者。 另一种方法涉及鉴定由IkappaB激酶亚基α调节的转录活性的调节剂。 另一种方法涉及确定由非人哺乳动物测试受试者调节的IkappaB激酶亚基α调节的转录活性。