公开(公告)号：US5132218A

公开(公告)日：1992-07-21

申请号：US467506

申请日：1990-01-19

申请人： Takao Isogai ,  Masaru Yoshida

发明人： Takao Isogai ,  Masaru Yoshida

IPC分类号： C12N15/09 ,  C12N1/20 ,  C12N1/21 ,  C12N15/00 ,  C12N15/68 ,  C12N15/80 ,  C12R1/19 ,  C12R1/645 ,  C12R1/865

CPC分类号： C12N15/80 ,  C12N15/68 ,  Y10S435/911 ,  Y10S435/942

摘要： The present invention relates to new hybrid plasmids useful as vectors in recombinant DNA technology, in which Acremonium chrysogenum or Saccharomyces cerevisiae is used as a host, and to microorganisms bearing the hybrid plasmids.partially digesting a chromosomal DNA of Acremonium chrysogenum ATCC 11550 with restriction enzyme Sau 3A, said autonomous replication sequence having a molecular size of about 1.39 Kbp, and having the restriction maps set forth in FIGS. 4-6.

公开(公告)号：US5081237A

公开(公告)日：1992-01-14

申请号：US472270

申请日：1990-01-30

申请人： Masayoshi Murata ,  Toshiyuki Chiba ,  Akira Yamada

发明人： Masayoshi Murata ,  Toshiyuki Chiba ,  Akira Yamada

IPC分类号： C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61P31/04 ,  C07D477/14

CPC分类号： C07D477/14

摘要： The invention relates to novel intermediate compounds for preparation of compounds of high antimicrobial activity, said intermediate compounds being of one of the formulas: ##STR1## wherein R.sup.1 is carboxy or protected carboxy,R.sup.2 is hydroxy(lower)alkyl or protected hyroxy(lower)alkyl,R.sup.3 and R.sup.4 are each hydrogen or lower alkyl,R.sup.5 is a saturated heterocyclic group, andR.sup.6 is aryl or lower alkoxy,or pharmaceutically acceptable salts thereof.

公开(公告)号：US5061718A

公开(公告)日：1991-10-29

申请号：US472231

申请日：1990-01-30

申请人： Teruo Oku ,  Yoshio Kawai ,  Hiroshi Kayakiri ,  Kazuyoshi Kuratani ,  Masashi Hashimoto

发明人： Teruo Oku ,  Yoshio Kawai ,  Hiroshi Kayakiri ,  Kazuyoshi Kuratani ,  Masashi Hashimoto

IPC分类号： C12N9/99 ,  A61K31/085 ,  A61K31/12 ,  A61K31/165 ,  A61K31/275 ,  A61K31/33 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/47 ,  A61P1/00 ,  A61P1/16 ,  A61P9/08 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C41/00 ,  C07C41/01 ,  C07C41/26 ,  C07C43/23 ,  C07C45/00 ,  C07C45/67 ,  C07C45/68 ,  C07C46/00 ,  C07C49/747 ,  C07C49/755 ,  C07C50/12 ,  C07C67/00 ,  C07C231/00 ,  C07C231/06 ,  C07C231/12 ,  C07C235/20 ,  C07C235/42 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/52 ,  C07C255/54 ,  C07D213/30 ,  C07D213/64 ,  C07D215/14 ,  C07D215/20 ,  C07D215/26 ,  C07D231/12 ,  C07D235/08 ,  C07D235/12 ,  C07D237/08 ,  C07D239/26 ,  C07D277/64 ,  C07D277/68 ,  C07D521/00 ,  C07F7/18

CPC分类号： C07D213/30 ,  C07C255/00 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C49/755 ,  C07D215/14 ,  C07D235/12 ,  C07D277/64 ,  C07F7/1856

摘要： The invention relates to an anti-inflammatory or antiallergic composition containing a compound of the formula ##STR1## wherein A is ##STR2## R.sup.1 is aryl which may have cyano or carbamoyl, or heterocyclic group which may have lower alkyl,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is an integer 1 or 2, andn is an integer 1 to 4, or pharmaceutically acceptable salts thereof.

公开(公告)号：US5045553A

公开(公告)日：1991-09-03

申请号：US208071

申请日：1988-06-17

申请人： Yoshio Ueda ,  Takehisa Hata ,  Rinta Ibuki ,  Kazutake Kado ,  Hiroshi Ishikuro

发明人： Yoshio Ueda ,  Takehisa Hata ,  Rinta Ibuki ,  Kazutake Kado ,  Hiroshi Ishikuro

IPC分类号： A61K31/455 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/70 ,  A61K31/44 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12

CPC分类号： A61K9/7053 ,  A61K31/44 ,  A61K47/10 ,  A61K47/12 ,  A61K9/0014 ,  A61K9/7061 ,  A61K9/7084 ,  Y10S514/947

摘要： The present invention relates to a pharmaceutical composition for percutaneous drug absorption which comprises 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and ethanol and/or an unsaturated higher fatty acid and to a composition of matter which comprises ethanol and/or an unsaturated higher fatty acid and is capable of promoting percutaneous absorption of said dihydropyridine compound.

摘要翻译： 一种用于经皮药物吸收的药物组合物，其包括5-异丙基3-氰基-6-甲基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸5-异丙酯和乙醇和/或 不饱和高级脂肪酸。

公开(公告)号：US4963585A

公开(公告)日：1990-10-16

申请号：US310323

申请日：1989-02-14

申请人： Masanori Okamoto ,  Eisaku Tsujii ,  Tsutomu Kaizu ,  Hiroshi Hatanaka ,  Masakuni Okuhara ,  Kozo Sawada ,  Hirokazu Tanaka

发明人： Masanori Okamoto ,  Eisaku Tsujii ,  Tsutomu Kaizu ,  Hiroshi Hatanaka ,  Masakuni Okuhara ,  Kozo Sawada ,  Hirokazu Tanaka

IPC分类号： C12P33/00 ,  C07J63/00 ,  C12P17/06 ,  C12R1/645

CPC分类号： C07J63/008 ,  C12P17/06

摘要： The invention relates to a compound of antimicrobial activity of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkanoyl,R.sup.2 is hydrogen or ##STR2## in which R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen or lower alkanoyl,R.sup.3 is carboxy or a protected carboxy, and pharmaceutically acceptable salt thereof.

公开(公告)号：US4963536A

公开(公告)日：1990-10-16

申请号：US333953

申请日：1989-04-06

申请人： Teruo Oku ,  Eishiro Todo ,  Chiyoshi Kasahara ,  Katsuya Nakamura ,  Hiroshi Kayakiri ,  Masashi Hashimoto

发明人： Teruo Oku ,  Eishiro Todo ,  Chiyoshi Kasahara ,  Katsuya Nakamura ,  Hiroshi Kayakiri ,  Masashi Hashimoto

IPC分类号： C07F9/38 ,  C07F9/58 ,  C07F9/60 ,  C07F9/6506 ,  C07F9/6553

CPC分类号： C07F9/588 ,  C07F9/3873 ,  C07F9/60 ,  C07F9/65067 ,  C07F9/655354

摘要： A compound of the formula: ##STR1## wherein R.sup.1 -A- is a group of the formula: ##STR2## in which R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halo(lower)alkyl, acyl, acylamino and halogen, or lower alkyl which may be substituted with a heterocyclic group optionally substituted with acyl, andX is O or S, andR.sup.2 is hydrogen or lower alkyl, provided that when R.sup.1 is lower alkyl, thenR.sup.1 -A- is a group of the formula: ##STR3## in which R.sup.1 and X are each as defined above, processes for the preparation thereof and pharmaceutical composition comprising the same.

公开(公告)号：US4954496A

公开(公告)日：1990-09-04

申请号：US386232

申请日：1989-07-28

申请人： Teruo Oku ,  Ciyoshi Kasahara ,  Takehiko Ohkawa ,  Masashi Hashimoto

发明人： Teruo Oku ,  Ciyoshi Kasahara ,  Takehiko Ohkawa ,  Masashi Hashimoto

IPC分类号： C07D303/26 ,  A61K31/335 ,  A61K31/336 ,  A61K31/535 ,  A61P9/00 ,  C07D303/22 ,  C07D303/34

CPC分类号： C07D303/22 ,  C07D303/34 ,  Y10S514/825 ,  Y10S514/863 ,  Y10S514/866

摘要： The invention relates to a cyclohexane derivative, useful as an angiogenesis inhibitor, of the formula: ##STR1## wherein R.sup.1 is halomethyl; or arylthiomethyl which may have amino, lower alkoxy or acylamino,R.sup.2 is lower alkoxy,R.sup.3 is ##STR2## or ##STR3## and R.sup.4 is hydrogen, lower alkylcarbamoyl, lower alkylcarbamoyloxy(lower)alkylcarbamoyl, heterocyclic carbonyl or heterocyclic carbamoyl, or salt thereof.

公开(公告)号：US4937265A

公开(公告)日：1990-06-26

申请号：US195133

申请日：1988-05-17

申请人： Toshio Tanaka ,  Yukio Motoyama

发明人： Toshio Tanaka ,  Yukio Motoyama

IPC分类号： A61K31/557 ,  A61P3/08 ,  A61P3/10 ,  A61P25/00

CPC分类号： A61K31/557 ,  Y10S514/866

摘要： An antidiabetic composition which comprises a 7-thiaprostaglandin E.sub.1 represented by the formula ##STR1## wherein R.sup.1 is hydrogen atom, a straight-chain or branched-chain alkyl group or one equivalent of cation, R.sup.2 is hydrogen atom or methyl group, R.sup.3 is a straight-chain or branched-chain alkyl group or a cycloalkyl group, n is 0 or 1, and the asterisk represents an asymmtric carbon atom, which can be administered orally to exhibit the desired activity.

公开(公告)号：US4936918A

公开(公告)日：1990-06-26

申请号：US436953

申请日：1989-11-15

申请人： Takahiro Furuhashi ,  Kazushige Kawada ,  Susumu Tahara ,  Toru Takeuchi ,  Yuji Takahashi ,  Toshikazu Adachi ,  Tsutomu Teraji

发明人： Takahiro Furuhashi ,  Kazushige Kawada ,  Susumu Tahara ,  Toru Takeuchi ,  Yuji Takahashi ,  Toshikazu Adachi ,  Tsutomu Teraji

IPC分类号： C04B24/22 ,  C08G14/06

CPC分类号： C08G14/06 ,  C04B24/22

摘要： The present invention relates to aminoarylsulfonic acid-phenol-formaldehyde condensate and concrete admixture comprising the same for incorporation in cementing composition, for example, concrete, motar, cement paste and the like, for improving slumping characteristics.

公开(公告)号：US4925948A

公开(公告)日：1990-05-15

申请号：US845526

申请日：1986-03-28

申请人： Takao Takaya ,  Hisashi Takasugi ,  Masayoshi Murata ,  Akiteru Yoshioka

发明人： Takao Takaya ,  Hisashi Takasugi ,  Masayoshi Murata ,  Akiteru Yoshioka

IPC分类号： C07D277/20 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D501/20 ,  C07D501/22 ,  C07D501/36 ,  C07D501/59

CPC分类号： C07D277/587

摘要： Compounds of the formula ##STR1## wherein r.sup.1 is amino or protected amino R.sup.2 is cycloalkenyl X is halogen and Y is carboxy or protected carboxy, or salts useful as intermediates for cephalosporin antibiotics.