Self-setting absorbable composites and applications thereof
    32.
    发明授权
    Self-setting absorbable composites and applications thereof 有权
    自制可吸收复合材料及其应用

    公开(公告)号:US08034850B2

    公开(公告)日:2011-10-11

    申请号:US11601994

    申请日:2006-11-20

    IPC分类号: A61K6/083 C08K3/32 A61K33/42

    摘要: Self-setting, bioactive, absorbable composites are derived from inorganic phosphate microparticles and a cyanoacrylate matrix of a methoxypropyl cyanoacrylate at a weight to volume ratio of at least 20/80 of microparticles/matrix. The self-setting composites are capable of the controlled release of bone mineralizing ions, antimicrobials, and bone growth promoters. Such composites are useful as bone cements, fillers, and/or substitutes.

    摘要翻译: 自制,生物活性,可吸收的复合材料衍生自无机磷酸盐微粒和氰基丙烯酸甲氧基丙酯的氰基丙烯酸酯基质,体积比至少为20/80微米/基质。 自固化复合材料能够控制骨矿化离子,抗微生物剂和骨生长促进剂的释放。 这样的复合材料可用作骨水泥,填料和/或替代物。

    High strength fibers of l-lactide copolymers, ε-caprolactone, and trimethylene carbonate and absorbable medical constructs thereof
    33.
    发明授权
    High strength fibers of l-lactide copolymers, ε-caprolactone, and trimethylene carbonate and absorbable medical constructs thereof 有权
    1-丙交酯共聚物,ε-己内酯和三亚甲基碳酸酯的高强度纤维及其可吸收的医用结构

    公开(公告)号:US07192437B2

    公开(公告)日:2007-03-20

    申请号:US09862093

    申请日:2001-05-21

    IPC分类号: A61L17/00 A61B17/04 C08G63/08

    摘要: The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably ε-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Surgical sutures made of mono- or multifilament yams of the present copolymers will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.

    摘要翻译: 本发明涉及1-丙交酯和少部分环状单体的结晶共聚物,优选ε-己内酯或三亚甲基碳酸酯或两者。 本共聚物的熔融温度至少为150℃,结晶度至少为20%。 优选的是具有至少1.1dl / g的特性粘度的高分子量共聚物。 各种手术构建体可以由本发明的共聚物形成。 本发明共聚物的单丝或多丝纱线的手术缝合线将在不到三年的时间内生物吸收,术后3周将保持其初始强度的至少50%。

    Peracylated insulin compositions and process for making the same
    35.
    发明授权
    Peracylated insulin compositions and process for making the same 有权
    过酰基化胰岛素组合物及其制备方法

    公开(公告)号:US6162895A

    公开(公告)日:2000-12-19

    申请号:US392416

    申请日:1999-09-09

    摘要: A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain substituent selected from the group consisting of alkyl and alkenyl groups. Most preferably, the cyclic anhydride is succinic anhydride, although glutaric anhydride may also be employed. Preferably, the step of peracylating the protein or polypeptide is performed in the presence of an acid catalyst, most preferably .rho.-toluene sulfonic acid. The resultant modified protein or polypeptide may be employed in numerous applications including drug delivery, absorbable sutures, and thermoplastic films and molded articles.

    摘要翻译: 公开了一种修饰蛋白质或多肽的方法,其包括以下步骤:将蛋白质或多肽分散在基本上非水性的培养基中,并将所述蛋白质或多肽与具有选自以下的碳链取代基的环酸酐进行过酰化:烷基和 烯基。 最优选地,环状酸酐是琥珀酸酐,尽管也可以使用戊二酸酐。 优选地,在酰基化蛋白质或多肽的步骤在酸催化剂,最优选Rho-甲苯磺酸的存在下进行。 所得到的修饰的蛋白质或多肽可用于许多应用,包括药物递送,可吸收缝合线,以及热塑性薄膜和模塑制品。

    Low fiber-loading composites with hybridized fiber/matrix interface
    36.
    发明授权
    Low fiber-loading composites with hybridized fiber/matrix interface 有权
    低纤维加载复合材料与杂化纤维/基质界面

    公开(公告)号:US6069192A

    公开(公告)日:2000-05-30

    申请号:US172334

    申请日:1998-10-13

    摘要: Disclosed are fiber-reinforced composites having untraditionally low fiber loading and a novel form of hybridized interface. Typical examples of fiber-matrix combinations capable of developing such interfaces include surface-phosphonylated ultrahigh molecular weight polyethylene (UHMW-PE) and polypropylene (PP) yarns (or fabric constructs) and epoxy resin, acrylic resin, and cement. For further improvement of the hybridized interface and the overall composite properties, the surface-phosphonylated fiber may be post-treated with reagents that will improve the abridging of the fibers to the matrix through physicochemically hybridized interfaces. Compared with composites having unmodified fiber, those based on modified ones, with or without post-treatment, exhibit a substantial increase in physicomechanical properties at exceptionally low fiber loading, ranging from about 0.1 to 35 percent by weight, preferably from about 0.1 to about 20 percent by weight, most preferably less than 10 percent by weight. Among these properties are maximum tensile strength, fracture toughness, and modulus.

    摘要翻译: 公开了具有非常低的纤维负载和新颖形式的杂化界面的纤维增强复合材料。 能够开发这种界面的纤维 - 基质组合物的典型实例包括表面膦酰化的超高分子量聚乙烯(UHMW-PE)和聚丙烯(PP)纱线(或织物构造)和环氧树脂,丙烯酸树脂和水泥。 为了进一步改善杂交界面和整体复合性质,可以用可以通过物理化学杂交界面改善纤维对基质的桥接的试剂对表面膦酰化的纤维进行后处理。 与具有未改性纤维的复合材料相比,具有或不具有后处理的基于改性纤维的复合材料在非常低的纤维负载下显示出显着增加的物理机械性能,其范围为约0.1至35重量%,优选约0.1至约20 重量百分比,最优选小于10重量%。 这些性能中的最大拉伸强度,断裂韧性和模量。