APTAMER ASSEMBLIES FOR PROTEIN CROSSLINKING
    33.
    发明公开

    公开(公告)号:US20230382976A1

    公开(公告)日:2023-11-30

    申请号:US18313064

    申请日:2023-05-05

    CPC classification number: C07K14/78 C12N2310/16 C12N15/115

    Abstract: Disclosed herein is the use of DNA aptamer assemblies of varying DNA length, structure, and sequence to both bind to collagen and other ECM proteins, to then act as a biocompatible, degradable, reversible, or permanent 3D crosslinkers between proteins, and to service as a biologically functional material when using the appropriate aptamer sequence. Therefore, disclosed herein are compositions comprising collagen fibers and additional ECM components crosslinked with DNA aptamers. Also disclosed are devices and implants made from or coated with collagen fibers and additional ECM components crosslinked with DNA aptamers. Also disclosed are methods of making collagen fibers. Also disclosed are kits for producing collagen fibers.

    Functionalized cyclic polymers and methods of preparing same

    公开(公告)号:US11814462B2

    公开(公告)日:2023-11-14

    申请号:US17516191

    申请日:2021-11-01

    Inventor: Adam S. Veige

    CPC classification number: C08F4/78

    Abstract: The disclosure provides a method of preparing a functionalized cyclic polymer the method including reacting a metal-alkylidyne compound, metallacycloalkylene compound, or metallacyclopentadiene compound with a plurality of alkynes to form the functionalized cyclic polymer, wherein at least one alkyne comprises a functional group capable of further reacting to form a modified polymer. Also provided is a stereoregular functionalized cyclic polymer prepared by the method of the disclosure.

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