公开(公告)号：US20180169138A1

公开(公告)日：2018-06-21

申请号：US15886978

申请日：2018-02-02

Applicant: Cytosorbents Corporation

Inventor： Humayra Begum Ali ,  Thomas D. Golobish ,  Vincent J. Capponi ,  Phillip P. Chan ,  Wei Tai Young ,  Andrew Robert Scheirer

IPC: A61K31/765 ,  A61K9/00

CPC classification number: A61K31/765 ,  A61K9/0053 ,  A61K31/75 ,  A61K31/79 ,  A61P1/00 ,  A61P1/04 ,  A61P1/06

Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).

公开(公告)号：US20170296574A1

公开(公告)日：2017-10-19

申请号：US15635517

申请日：2017-06-28

Applicant: CytoSorbents Corporation

Inventor： Phillip P. Chan ,  Wei-Tai Young ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Humayra Begum Ali

IPC: A61K31/745 ,  A61K9/16 ,  A61K9/50 ,  C08J9/26 ,  B01J20/26 ,  B01J20/30 ,  A61K9/00 ,  B01J20/28 ,  C08F212/36

CPC classification number: A61K31/745 ,  A61K9/0053 ,  A61K9/16 ,  A61K9/50 ,  A61K31/74 ,  A61K31/75 ,  A61K47/58 ,  B01J20/261 ,  B01J20/28004 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/3064 ,  C08F212/36 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2207/10 ,  C08J2325/02 ,  Y02A50/406 ,  Y02A50/411

Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.

公开(公告)号：US12076474B2

公开(公告)日：2024-09-03

申请号：US16614838

申请日：2018-05-21

Applicant: CYTOSORBENTS CORPORATION

Inventor： Phillip Chan

IPC: B01D15/00 ,  A61K31/717 ,  A61M1/36 ,  A61M31/00 ,  B01J20/24 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  B01J20/32

CPC classification number: A61M1/362 ,  A61K31/717 ,  A61M1/3679 ,  A61M1/3687 ,  A61M31/00 ,  B01J20/24 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28069 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/28092 ,  B01J20/3078 ,  B01J20/3282

Abstract: The present invention concerns methods of treating a patient suffering from a traumatic brain injury (TBI), comprising contacting said patient's blood with a sorbent for an inflammatory mediator and kits for performing such treatments.

公开(公告)号：US11752250B2

公开(公告)日：2023-09-12

申请号：US14230108

申请日：2014-03-31

Applicant: CytoSorbents Corporation

Inventor： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

IPC: A61M1/36 ,  A61M1/34 ,  A61M1/02 ,  B01J20/28 ,  B01J20/32 ,  A01N1/02 ,  B01J20/26

CPC classification number: A61M1/3679 ,  A01N1/02 ,  A01N1/0215 ,  A61M1/0272 ,  A61M1/34 ,  A61M1/36 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28092 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3285 ,  B01J2220/62

Abstract: The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.

公开(公告)号：US11040061B2

公开(公告)日：2021-06-22

申请号：US15769361

申请日：2016-10-21

Applicant: CYTOSORBENTS CORPORATION

Inventor： Thomas Golobish ,  Maryann Gruda ,  Tamaz Guliashvili ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vi Dan ,  Wei-Tai Young ,  Vincent Capponi ,  Phillip Chan

IPC: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165 ,  B01J20/26 ,  B01J39/20 ,  B01J20/28 ,  A61M1/36 ,  A61M5/14

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

公开(公告)号：US20210106743A1

公开(公告)日：2021-04-15

申请号：US16497982

申请日：2018-03-22

Applicant: CYTOSORBENTS CORPORATION

Inventor： Wei-Tai YOUNG ,  Tamaz GULIASHVILI ,  Andrew SCHEIRER ,  Josh VICHARE ,  Timothy KOVACS ,  Maryann GRUDA ,  Thomas GOLOBISH ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61M1/34 ,  A61M1/36

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

公开(公告)号：US10946040B2

公开(公告)日：2021-03-16

申请号：US16424747

申请日：2019-05-29

Applicant: Cytosorbents Corporation

Inventor： Phillip P. Chan ,  Wei-Tai Young ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Humayra Begum Ali

IPC: A61K31/745 ,  A61K31/74 ,  A61K31/75 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C08F212/36 ,  C08J9/26 ,  A61K47/58

Abstract: The present invention concerns methods of administering a therapeutically effective dose of a sorbent for an inflammatory mediator to a patient where the inflammatory mediator is one or more of enzymes, cytokines, prostaglandins, eicosanoids, leukotrienes, kinins, complement, coagulation factors, endotoxins, enterotoxins, lipopolysaccharide, cell fragments, bile salts, fatty acids, phospholipids, interferon and immunomodulatory antibodies, biologics or drugs.

公开(公告)号：US20200254170A1

公开(公告)日：2020-08-13

申请号：US16639371

申请日：2018-08-21

Applicant: Vincent CAPPONI ,  Paul ROBERTSON ,  CytoSorbents Corporation

Inventor： Vincent CAPPONI ,  Paul ROBERTSON

IPC: A61M1/34 ,  A61M1/36

Abstract: The invention relates to a removable cap for a blood filter cartridge useful in facilitating dispersal of whole blood in the cartridge. The cartridge has a removable cap on at least one and preferably both of its input and output ends. The caps comprise an annular flange means having attached thereto an outer annular wall and an annular inner wall. The annular inner wall defining a cavity covered by a conical, concave filter mesh. The end cap also comprises a channel means positioned under the cavity and a part of said flange means, for reception of any fluid which passes through said concave filter mesh.

公开(公告)号：US20190201867A1

公开(公告)日：2019-07-04

申请号：US16303232

申请日：2017-05-18

Applicant: CYTOSORBENTS CORPORATION

Inventor： Tamaz GULIASHVILI ,  Thomas GOLOBISH ,  Maryann GRUDA ,  Pamela O'SULLIVAN ,  Andrew SCHEIRER ,  Vincent CAPPONI ,  Phillip CHAN ,  Wei-Tai YOUNG

IPC: B01J20/26 ,  B01D15/34 ,  A61M1/36 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61K31/745

CPC classification number: B01J20/261 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/745 ,  A61M1/3679 ,  B01D15/125 ,  B01D15/34 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/3208 ,  B01J20/3231 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US20180303870A1

公开(公告)日：2018-10-25

申请号：US15769361

申请日：2016-10-21

Applicant: CYTOSORBENTS CORPORATION

Inventor： Thomas GOLOBISH ,  Maryann GRUDA ,  Tamaz GULIASHVILI ,  Pamela O'SULLIVAN ,  Andrew SCHEIRER ,  Vi DAN ,  Wei-Tai YOUNG ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165

CPC classification number: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M1/3679 ,  A61M5/14 ,  A61M5/165

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.