公开(公告)号：US20080107564A1

公开(公告)日：2008-05-08

申请号：US11550643

申请日：2006-10-18

Applicant: Shmuel Sternberg ,  Kent L. Lurvey ,  Robin G. Pauley ,  Dustin C. Cawthon ,  Ton That Hai ,  Lecon Woo ,  Ashok K. Khanna ,  Birendra K. Lal ,  Michael Tung-Kiung Ling ,  Vadim V. Krongauz ,  Rosa H. Yeh ,  William S. Hoerle ,  Craig L. Sandford

Inventor： Shmuel Sternberg ,  Kent L. Lurvey ,  Robin G. Pauley ,  Dustin C. Cawthon ,  Ton That Hai ,  Lecon Woo ,  Ashok K. Khanna ,  Birendra K. Lal ,  Michael Tung-Kiung Ling ,  Vadim V. Krongauz ,  Rosa H. Yeh ,  William S. Hoerle ,  Craig L. Sandford

IPC: G01N21/78 ,  A61M5/50

CPC classification number: G01N21/78 ,  A61M39/02 ,  A61M39/045 ,  A61M39/16 ,  A61M39/26 ,  A61M2039/1033 ,  A61M2039/1072 ,  A61M2205/583 ,  A61M2205/584 ,  G01N31/22

Abstract: An access device including access site is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

公开(公告)号：US20050158499A1

公开(公告)日：2005-07-21

申请号：US11079767

申请日：2005-03-14

Applicant: Michael Ling ,  William Hurst ,  Lecon Woo ,  Algirdas Bindokas ,  Patrick Ryan ,  Scott Edwards ,  Henk Blom ,  Atul Khare

Inventor： Michael Ling ,  William Hurst ,  Lecon Woo ,  Algirdas Bindokas ,  Patrick Ryan ,  Scott Edwards ,  Henk Blom ,  Atul Khare

IPC: F16L11/04 ,  A61J1/10 ,  A61J1/14 ,  A61L29/12 ,  A61L31/00 ,  B29C35/08 ,  B29C65/04 ,  B32B1/08 ,  B32B25/08 ,  B32B27/08 ,  B32B27/32 ,  C08L23/08 ,  C08L23/12 ,  C08L23/14 ,  C08L51/00 ,  C08L53/02 ,  C08L75/04 ,  C08L77/00 ,  C08L101/00

CPC classification number: C08L23/12 ,  A61L29/126 ,  B29C65/04 ,  B29C66/1122 ,  B29C66/53262 ,  B29C66/71 ,  B29C66/7234 ,  B29C2035/0861 ,  B32B1/08 ,  B32B27/08 ,  B32B27/32 ,  C08L23/0815 ,  C08L23/0869 ,  C08L23/142 ,  C08L51/00 ,  C08L53/02 ,  C08L75/04 ,  C08L77/00 ,  C08L101/00 ,  C08L2314/06 ,  Y10T428/1352 ,  Y10T428/1386 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/31746 ,  Y10T428/31913 ,  Y10T428/31924 ,  Y10T428/31931 ,  C08L2666/24 ,  C08L2666/04 ,  B29C65/00 ,  B29K2079/08 ,  B29K2077/00 ,  B29K2075/02 ,  B29K2075/00 ,  B29K2067/00 ,  B29K2033/12 ,  B29K2033/08 ,  B29K2023/18 ,  B29K2023/14 ,  B29K2023/12 ,  B29K2023/086 ,  B29K2023/083 ,  B29K2023/08 ,  B29K2021/003 ,  B29K2009/00

Abstract: The present invention provides a flowable material container closure assembly having a port tube and a membrane tube. The port tube (I) has a first layer and a second layer, (A) the first layer is a polymer blend of: (1) from about 25% to about 50% by weight of the first layer a first polyolefin selected from the group consisting of polypropylene and polypropylene copolymers, (2) from about 0 to about 50% by weight of the first layer a second polyolefin selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, and butene ethylene copolymers; (3) from about 0% to about 40% by weight of the first layer a radio frequency susceptible polymer selected from the group consisting of polyamides, ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, polyureas, ethylene vinyl acetate copolymers with a vinyl acetate comonomer content from 12%-50% by weight of the copolymer, ethylene methyl acrylate copolymers with methyl acrylate comonomer content from 12%-40% by weight of the copolymer, ethylene vinyl alcohol with vinyl alcohol comonomer content from 12%-70% by mole percent of the copolymer; (4) from about 0% to about 40% of a first thermoplastic elastomer; and (B) the second layer is disposed coaxially within the first layer and is a second thermoplastic elastomer; and the (II) membrane tube is disposed coaxially within the port tube, the membrane tube has an outer layer, a core layer and an inner layer, the outer layer (A) is a polymer blend of: (1) from about 0% to about 60% by weight of the outer layer of a third polyolefin and (2) from about 40% to about 100% by weight of the outer layer of a second component of a third thermoplastic elastomer, the core layer (B) is attached to the outer layer, the core layer is a polymer blend of: (1) from about 35% to about 100% by weight of the core layer of a fourth thermoplastic elastomer and (2) from about 0% to about 65% by weight of the core layer of a fourth polyolefin; and (C) the inner layer is attached to the core layer on a side opposite of the outer layer, the inner layer is a polymer blend of: (1) from about 25% to about 55% by weight of the inner layer a fifth polyolefin, (2) from about 0 to about 50% by weight of the inner layer a sixth polyolefin selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, polybutadiene and butene ethylene copolymers; (3) from about 0% to about 60% by weight of the inner layer a radio frequency susceptible polymer selected from the group consisting of polyamides, ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, polyureas, ethylene vinyl acetate copolymers with a vinyl acetate comonomer content from 12%-50% by weight of the copolymer, ethylene methyl acrylate copolymers with methyl acrylate comonomer content from 12%-40% by weight of the copolymer, ethylene vinyl alcohol with vinyl alcohol comonomer content from 12%-70% by mole percent of the copolymer; (4) from about 0% to about 40% by weight of the inner layer of a fifth thermoplastic elastomer.

公开(公告)号：US20050085785A1

公开(公告)日：2005-04-21

申请号：US10688843

申请日：2003-10-17

Applicant: Sherwin Shang ,  Lecon Woo ,  Tahua Yang ,  Michael Ling ,  Craig Sandford

Inventor： Sherwin Shang ,  Lecon Woo ,  Tahua Yang ,  Michael Ling ,  Craig Sandford

IPC: A61B19/00 ,  C08J5/18 ,  C08L23/00 ,  C08L23/04 ,  C08L23/10

CPC classification number: C08L23/04 ,  C08J5/18 ,  C08J2323/04 ,  C08J2323/10 ,  C08L23/10 ,  Y10T428/1352 ,  C08L2666/06

Abstract: A monolayer film of a polymer blend of a first component selected from the group consisting of an ethylene containing polymer, the first component present in an amount by weight of the film from about 60% to about 1%, the first component having a first melting point temperature determined by DSC, a second component selected from the group consisting of propylene containing polymers and methyl pentene containing polymers, the second component being present in an amount by weight of the film from about 99% to about 40%, the second component having a second melting point temperature determined by DSC; and the film being capable of withstanding steam sterilization at a temperature from about 100° C. to about 130° C.

Abstract translation: 选自由含乙烯的聚合物组成的组的第一组分的聚合物共混物的单层膜，所述第一组分以约60重量％至约1重量％的膜的重量存在，所述第一组分具有第一熔融 由DSC测定的第二组分，选自含丙烯的聚合物和含有甲基戊烯的聚合物的第二组分，第二组分以约99重量％至约40重量％的量存在，第二组分具有 通过DSC测定的第二熔点温度; 并且该膜能够在约100℃至约130℃的温度下耐受蒸汽灭菌。

公开(公告)号：US06576201B1

公开(公告)日：2003-06-10

申请号：US09493848

申请日：2000-01-28

Applicant: Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

Inventor： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

IPC: B01J1908

CPC classification number: A61L2/10 ,  A61L2/0011 ,  A61M1/0281 ,  A61M1/3681 ,  A61M2202/0415 ,  A61M2205/053

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is disposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

Abstract translation: 一种用于在连续流动布置中灭菌治疗流体中的病原体灭活的装置和方法，同时具有辐射剂量均匀性和在装置内的流体的滞留时间分布。 装置（10）包括具有设置在其中的同心圆柱形转子（14）的透射性圆柱形管（12），从而在它们之间提供薄的间隙（16）。 具有流体出口（26）的顶板（18）和具有密封圆柱形管（12）的流体入口（24）的底板（20）。 入口（24）和出口（26）都与薄间隙（16）流体连通。 转子轴（36）轴向设置在圆柱形转子（14）上并与马达（30）连接。 泵提供流过装置（10）的流体。 辐射源通过圆柱形管（12）向流体提供灭菌辐射。 当流体流动时，马达（30）驱动转子（14）以向流体流传递泰勒涡流，流体更接近圆柱形管（12），流体更靠近转子（14）。

公开(公告)号：US06328716B1

公开(公告)日：2001-12-11

申请号：US08642278

申请日：1996-05-03

Applicant: Chuan Qin ,  Patrick T. Ryan ,  Donna L. Rostron ,  Birendra K. Lal ,  Yuanpang S. Ding ,  Susan R. Mizener ,  Lecon Woo ,  Michael T. K. Ling

Inventor： Chuan Qin ,  Patrick T. Ryan ,  Donna L. Rostron ,  Birendra K. Lal ,  Yuanpang S. Ding ,  Susan R. Mizener ,  Lecon Woo ,  Michael T. K. Ling

IPC: A61M500

CPC classification number: A61M39/08

Abstract: The present invention provides a method for using medical tubing for infusing therapeutic fluids to a patient comprising the steps of: providing a medical tubing having a sidewall of a polymeric blend, the blend having a polymeric material in an amount by weight within the range of 99.999%-90.0%, and an additive in an amount by weight within the range of 0.001%-10%, the tubing having been oriented along a longitudinal axis of the tubing to define a oriented diameter that is less than a diameter of the tubing before orienting; and providing fluid under pressure through the tubing to the patient.

Abstract translation: 本发明提供了一种使用用于将治疗流体输注给患者的医用管道的方法，包括以下步骤：提供具有聚合共混物侧壁的医用管道，所述共混物具有重量在99.999范围内的聚合物材料 ％-90.0％，以及重量百分比在0.001％-10％范围内的添加剂，管道已经沿着管道的纵向轴线定向，以限定小于管道直径的定向直径 定向 并在压力下通过管道向患者提供流体。

公开(公告)号：US06303200B1

公开(公告)日：2001-10-16

申请号：US09014217

申请日：1998-01-27

Applicant: Lecon Woo ,  Michael T. K. Ling ,  Patrick Balteau ,  Ying-Cheng Lo ,  Ketan Shah ,  Hénaut J. Eric ,  Yuan-pang Samuel Ding ,  Stanley Westphal ,  Robert Wojnarowski

Inventor： Lecon Woo ,  Michael T. K. Ling ,  Patrick Balteau ,  Ying-Cheng Lo ,  Ketan Shah ,  Hénaut J. Eric ,  Yuan-pang Samuel Ding ,  Stanley Westphal ,  Robert Wojnarowski

IPC: B29D2300

CPC classification number: A61L29/049 ,  C08F287/00 ,  C08L23/10 ,  C08L51/006 ,  C08L53/02 ,  C08L53/025 ,  C08L57/02 ,  Y10T428/139 ,  C08L23/12 ,  C08L2666/02 ,  C08L2666/04 ,  C08L2666/06

Abstract: A steam sterilizable monolayer medical tubing comprising a blend of a melt strength enhancing agent of a homopolymer or copolymer of polypropylene having free-end long chain branches of propylene units, a melt flow index of greater than 10 and in an amount of 1-10% by weight and a second component selected from the group of (i) a selectively hydrogenated block copolymer of a vinyl aromatic hydrocarbon and a conjugated diene and (ii) a selectively hydrogenated block copolymer of a vinyl aromatic hydrocarbon and a conjugated diene to which has been grafted, an alpha, beta-olenfically unsaturated monocarboxylic or dicarboxylic acid reagent.

Abstract translation: 一种蒸汽消毒单层医用管，其包含具有丙烯单元的自由端长支链的聚丙烯均聚物或共聚物的熔体强度增强剂的共混物，熔体流动指数大于10，量为1-10％ 和选自（i）乙烯基芳族烃和共轭二烯的选择性氢化嵌段共聚物和（ii）乙烯基芳族烃和共轭二烯的选择性氢化嵌段共聚物的第二组分，其中已经 接枝的α，β-烯烃不饱和单羧酸或二羧酸试剂。

公开(公告)号：US06297046B1

公开(公告)日：2001-10-02

申请号：US08330717

申请日：1994-10-28

Applicant: Sidney T. Smith ,  David V. Bacehowski ,  William Kolanko ,  Larry Rosenbaum ,  Stephen L. Smith ,  James G. Bender ,  Lecon Woo ,  Michael T. K. Ling

Inventor： Sidney T. Smith ,  David V. Bacehowski ,  William Kolanko ,  Larry Rosenbaum ,  Stephen L. Smith ,  James G. Bender ,  Lecon Woo ,  Michael T. K. Ling

IPC: C12M306

CPC classification number: C12M23/14 ,  C12M23/24

Abstract: A multi-layer, flexible, gas-permeable film (10) suitable for forming a cell culture container (20), the film (10) comprising a first layer (12) composed of a polystyrene having a thickness within the range of 0.0001 inches to about 0.0010 inches and, a second layer (14) adhered to the first layer (12) composed of a polyolefin having a thickness within the range of 0.004 inches to about 0.015 inches.

Abstract translation: 一种适用于形成细胞培养容器（20）的多层柔性透气膜（10），所述膜（10）包括由厚度在0.0001英寸范围内的聚苯乙烯构成的第一层（12） 至约0.0010英寸，以及粘附到由厚度在0.004英寸至约0.015英寸范围内的聚烯烃构成的第一层（12）的第二层（14）。

公开(公告)号：US06255396B1

公开(公告)日：2001-07-03

申请号：US09392912

申请日：1999-09-09

Applicant: Yuan-pang Samuel Ding ,  Chuan Qin ,  Lecon Woo ,  Michael T. K. Ling ,  Sherwin Shang ,  Tahua Yang

Inventor： Yuan-pang Samuel Ding ,  Chuan Qin ,  Lecon Woo ,  Michael T. K. Ling ,  Sherwin Shang ,  Tahua Yang

IPC: C08F800

CPC classification number: C08L23/08 ,  C08L9/00 ,  C08L23/04 ,  C08L23/0815 ,  C08L23/10 ,  C08L23/16 ,  C08L23/20 ,  C08L45/00 ,  C08L2666/04

Abstract: The present invention provides a polymer composition having a first component obtained by copolymerizing a norbornene monomer and an ethylene monomer, the first component being in an amount from about 1-99% by weight of the composition; and a second component of an ethylene and &agr;-olefin copolymer, the &agr;-olefin having 6 carbons, the second component being in an amount from about 99% to about 1% by weight of the composition.

Abstract translation: 本发明提供了一种聚合物组合物，其具有通过使降冰片烯单体和乙烯单体共聚获得的第一组分，第一组分的量为组合物重量的约1-99％; 和乙烯和α-烯烃共聚物的第二组分，所述α-烯烃具有6个碳，第二组分的量为组合物重量的约99％至约1％。

公开(公告)号：US06187400B1

公开(公告)日：2001-02-13

申请号：US09084816

申请日：1998-05-26

Applicant: Lecon Woo ,  Michael T. K. Ling ,  Chuan Qin ,  Birendra K. Lal ,  Yuan-pang S. Ding ,  Donna L. Rostron ,  Susan R. Mizener ,  Patrick T. Ryan

Inventor： Lecon Woo ,  Michael T. K. Ling ,  Chuan Qin ,  Birendra K. Lal ,  Yuan-pang S. Ding ,  Donna L. Rostron ,  Susan R. Mizener ,  Patrick T. Ryan

IPC: A61M100

CPC classification number: A61M39/08 ,  A61L29/041 ,  A61L29/085 ,  A61M5/14228 ,  B29C55/22 ,  B29L2009/00 ,  B29L2031/753 ,  Y10T428/1379 ,  Y10T428/1383 ,  Y10T428/139 ,  Y10T428/1393 ,  C08L31/04 ,  C08L23/12

Abstract: The present invention provides a method of using a medical tubing with a pump for administering measured amounts of a beneficial fluid over time to a patient comprising the steps of providing a tubing having a first layer selected from the group consisting of ethylene homopolymers and ethylene copolymers, wherein the copolymers of ethylene are an ethylene monomer copolymerized with at least one monomer selected from the group consisting of lower alkyl olefins, lower alkyl esters of a carboxylic acid, and lower alkene esters of a carboxylic acid, the lower alkyl and lower alkene having from 3 to 18 carbons, the tubing having been exposed to a sterilization dosage of radiation of from about 15 to about 45 kGys; and pumping fluid through the tubing with the pump.

Abstract translation: 本发明提供了一种使用具有泵的医用管道的方法，用于向患者施用测量量的有益流体，包括以下步骤：提供具有选自乙烯均聚物和乙烯共聚物的第一层的管道， 其中乙烯的共聚物是与选自低级烷基烯烃，羧酸的低级烷基酯和羧酸的低级烯烃中的至少一种单体共聚的乙烯单体，低级烷基和低级烯具有 3至18个碳，所述管已暴露于约15至约45kGys的灭菌剂量的辐射; 并用泵泵送流体通过管道。

公开(公告)号：US5733270A

公开(公告)日：1998-03-31

申请号：US474839

申请日：1995-06-07

Applicant: Michael T. K. Ling ,  Lecon Woo ,  Ying-Cheng Lo ,  Patrick Balteau ,  F. Peluso

Inventor： Michael T. K. Ling ,  Lecon Woo ,  Ying-Cheng Lo ,  Patrick Balteau ,  F. Peluso

IPC: A61L2/20 ,  A61L29/16 ,  A61L31/16 ,  A61M39/16 ,  A61M1/00

CPC classification number: A61M39/162 ,  A61L29/16 ,  A61L2300/106 ,  A61L2300/404 ,  Y10S604/905

Abstract: An improved system and method for providing sterile connections. To this end, a device is provided comprising a body, a chamber defined, at least in part, by a portion of the body, the chamber including an interior having a solid sterilizing agent that can sublimate at ambient conditions, and a member that defines., in part, the chamber and is so constructed and arranged to allow the solid sterilizing agent to release in a rate controlled manner through the member.

Abstract translation: 用于提供无菌连接的改进的系统和方法。 为此，提供了一种装置，其包括主体，至少部分地由主体的一部分限定的室，所述室包括具有可在环境条件下升华的固体灭菌剂的内部，以及限定 部分地，腔室被构造和布置成允许固体灭菌剂以速率控制的方式通过构件释放。