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公开(公告)号：US20180223293A1
公开(公告)日：2018-08-09
申请号：US15750334
申请日：2016-08-05
申请人： LONZA LTD
CPC分类号： C12N15/815 , C12N1/16 , C12N2830/001 , C12P21/00 , C12P21/02
摘要： An isolated and/or artificial pG1-x promoter, which is a functional variant of the carbon source regulatable pG1 promoter of Pichia pastoris identified by SEQ ID 1, which pG1-x promoter consists of or comprises at least a part of SEQ ID 1 with a length of at least 293 bp, characterized by the following promoter regions: a) at least one core regulatory region comprising the nucleotide sequences SEQ ID 2 and SEQ ID 3; and b) a non-core regulatory region, which is any region within the pG1-x promoter sequence other than the core regulatory region; wherein the pG1-x promoter comprises at least one mutation in any of the promoter regions and a sequence identity of at least 80% in SEQ ID 2 and SEQ ID 3, and a sequence identity of at least 50% in any region other than SEQ ID 2 or SEQ ID 3; and further wherein the pG1-x promoter is characterized by the same or an increased promoter strength and induction ratio as compared to the pG1 promoter, wherein the promoter strength is at least 1.1-fold increased in the induced state as compared to the pG1 promoter, and/or the induction ratio is at least 1.1-fold increased as compared to the pG1 promoter.
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32.发明申请公开(公告)号：US20180163118A1
公开(公告)日：2018-06-14
申请号：US15838464
申请日：2017-12-12
申请人： Lonza Ltd.
发明人： Kevin Janak , Steven Colby
CPC分类号： C09K8/38 , C07F7/0834 , C09K8/035 , C09K8/58 , C09K8/594 , C09K8/703 , C09K8/86 , C09K8/94 , C09K2208/20 , C09K2208/22 , C09K2208/28 , C09K2208/32 , E21B43/122 , E21B43/16 , E21B43/34
摘要： A composition containing a quaternary organosilane foaming agent capable of foaming various liquids in order to remove the liquids from subterranean wells is described. For instance, the composition can be used to remove hydrocarbon condensate liquids from a gas well or an oil well. Of particular advantage, the composition can foam liquids containing substantial amounts of hydrocarbons.
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公开(公告)号：US20180162903A1
公开(公告)日：2018-06-14
申请号：US15836683
申请日：2017-12-08
申请人： LONZA LTD
发明人： Paul Pease , Wilburn Miller , Jesse Cobb , Anthony Castagnaro , Andrew Harris
CPC分类号： C07K1/34 , B01D61/00 , B01D61/14 , B01D61/22 , B01D63/02 , C07K1/36 , C07K16/065 , C07K16/08 , G01N30/28
摘要： Disclosed are methods and devices for the optimization of virus removal from solutions. A method of filtering a process fluid comprising a product includes allowing some of the process fluid to flow from a first reservoir to a viral filter; adding a chase fluid to the process fluid in the first reservoir to form a composite fluid; and allowing the composite fluid to flow from the first reservoir to the viral filter to produce eluent. In some embodiments, flow of fluid across the viral filter is sufficient to avoid significant impairment to viral removal until a preselected event, occurs. In some embodiments, flow of fluid from the first reservoir across the viral filter is maintained in the absence of an interruption or slowing of flow of duration or magnitude sufficient to impair viral removal to a level below a log-reduction value of the viral filter.
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公开(公告)号：US20180094231A1
公开(公告)日：2018-04-05
申请号：US15285656
申请日：2016-10-05
申请人： Lonza Ltd.
发明人： Michael Mietzner , Jim Heimbach , Andrew Harris
IPC分类号： C12M1/12
摘要： Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein. In some embodiments, a biopharmaceutical processing equipment can include a vessel having a surface that is configured to contact proteinaceous processing material, wherein the surface has a pre-commissioning surface roughness of greater than about 20 Ra Max (μin).
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公开(公告)号：US20180037861A1
公开(公告)日：2018-02-08
申请号：US15667387
申请日：2017-08-02
申请人： LONZA LTD
发明人： Tristan Wilkins
摘要： A method for delivering a processing solution includes providing a concentrated processing solution in a bioprocess container, the concentrated processing solution being produced at a first site. The method also includes combining the concentrated processing solution with a biopolymer containing solution produced in a bioreactor at a second site different from the first site. In some embodiments, the processing solution is a buffer for processing products of cells cultured in a bioreactor. A system and a pharmaceutical production facility for carrying out the method is also provided.
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36.发明申请公开(公告)号：US20170326520A1
公开(公告)日：2017-11-16
申请号：US15533839
申请日：2015-12-09
申请人： Lonza Ltd
CPC分类号： B01J10/00 , B01F5/064 , B01F5/0647 , B01F13/0059 , B01J19/02 , B01J2219/0277 , B01L3/502746 , B01L2400/086 , C07C51/412 , C07C201/12
摘要： A fluid mixing structure (10) for mixing at least two fluidic components has a flow inlet port and a flow outlet port and comprises a contraction zone (12), an expansion zone (14), and a retention zone (16), arranged in this order in an inflow direction (IFD) of a fluid flow to flow through said fluid mixing structure (10) and being composed of said at least two fluidic components, and a flow splitter (32) arranged In a space (30) formed by said expansion zone (14) and said retention zone (16) to split said fluid flow in a first sub fluid flow and a second sub fluid flow flowing in a first flow path and a second flow path, respectively, formed in the fluid mixing structure, and to mix said first and second sub fluid flows within said space (30) to generate and discharge a homogenized fluid flow, wherein said flow splitter (32) is arranged and configured to let any flow element of each of said first and second sub fluid flows prior to their mixing have a non-zero average flow component in said inflow direction (IFD).
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公开(公告)号：US20160280767A1
公开(公告)日：2016-09-29
申请号：US15077350
申请日：2016-03-22
申请人： LONZA LTD. , GLAXO GROUP LIMITED
发明人： Rajesh G. BERI , Brian HADLEY , Jim HEIMBACH , Allan MAXWELL , Robert George GERBER , Valerie CANNING
CPC分类号： C07K16/00 , C07K2317/14 , C07K2317/41 , C12P21/005
摘要： The present disclosure provides methods for improving batch-to-batch consistency of proteins produced by eukaryotic cells, as well as proteins produced thereby.
摘要翻译： 本公开提供了用于改善由真核细胞产生的蛋白质的批次间连续性以及由此产生的蛋白质的方法。
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公开(公告)号：US20160220466A1
公开(公告)日：2016-08-04
申请号：US15010180
申请日：2016-01-29
申请人： Lonza Ltd.
CPC分类号： A61K8/4973 , A45D7/06 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/46 , A61K2800/40 , A61Q5/04 , A61Q5/06
摘要： A hair treatment composition is described that contains an acetoacetylated compound. The acetoacetylated compound, for instance, can be a bis acetoacetylated compound. In one embodiment, for instance, the acetoacetylated compound comprises a bis acetoacetate or a bis acetoacetamide. In one embodiment, the hair treatment composition can be used to straighten hair. The composition is also well suited for decreasing hair frizz. The acetoacetylated compound is capable of crosslinking hair fibers upon the application of heat.
摘要翻译： 描述了含有乙酰乙酰化化合物的头发处理组合物。 乙酰乙酰化的化合物例如可以是二乙酰乙酰化的化合物。 在一个实施方案中，例如，乙酰乙酰化的化合物包含双乙酰乙酸酯或双乙酰乙酰胺。 在一个实施方案中，头发处理组合物可用于矫正头发。 该组合物也适用于减少头发卷曲。 乙酰乙酰化化合物能够在施加热量时交联毛发纤维。
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公开(公告)号：US20160128920A1
公开(公告)日：2016-05-12
申请号：US14898810
申请日：2014-06-27
申请人： LONZA LTD
发明人： Volker Ranft
摘要： A synergistic preservative composition comprises sorbic acid or a salt thereof, benzyl alcohol, and a mixture of (i) 1,2-propanediol and/or 1,3-propanediol, and (ii), 4-butanediol and/or 1,3-butanediol. The composition is particularly suited for the preservation of cosmetics and personal care products.
摘要翻译： 协同防腐剂组合物包含山梨酸或其盐，苄醇和（i）1,2-丙二醇和/或1,3-丙二醇的混合物，和（ii）4-丁二醇和/或1,3 丁二醇。 该组合物特别适用于保存化妆品和个人护理产品。
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公开(公告)号：US09296718B2
公开(公告)日：2016-03-29
申请号：US14471682
申请日：2014-08-28
申请人： Lonza Ltd
发明人： Christian Noti , Guixian Hu , Barry Jackson
IPC分类号： C07D319/00 , C07D319/06 , C07C67/03 , C07C67/32 , C07C67/05 , C07C67/297 , C07D207/34 , C07D239/42
CPC分类号： C07D319/06 , C07C67/03 , C07C67/05 , C07C67/297 , C07C67/32 , C07D207/34 , C07D239/42 , C07C69/716
摘要： The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl (4R,6S)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate (BHA), Rosuvastatin and Atorvastatin.
摘要翻译： 本发明公开了一种从Meldrum酸衍生物制备6-氯-3,5-二氧代己酸叔丁酯的方法及其用于制备（4R，6S） - （6-羟甲基-2,2-二甲基 - 二甲基-1,3-二恶烷-4-基）乙酸酯（BHA），罗苏伐他汀和阿托伐他汀。
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