公开(公告)号：US20240029840A1

公开(公告)日：2024-01-25

申请号：US18335513

申请日：2023-06-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Luis Suárez Novau

IPC: G16H10/40

CPC classification number: G16H10/40

Abstract: A computer-implemented method of automatically locating and processing test sample(s) from a patient within a laboratory setting 100 is disclosed. The method comprises determining that a test sample has not been processed by any device in the laboratory and the test sample is still within a time period of processing, performing inquiry of historical data of previous non-located test samples maintained in a database for possible locations of non-located test sample, and notifying laboratory operator of a location with a highest probability of test sample location based on the historical data.

公开(公告)号：US11879904B2

公开(公告)日：2024-01-23

申请号：US17507874

申请日：2021-10-22

Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Technologies Corporation

Inventor： Kouhei Nonaka ,  Takamichi Mori ,  Yoichi Aruga ,  Yosuke Horie ,  Andrew McCaughey ,  Alexander Seiler

IPC: G01N35/10 ,  B01L3/02 ,  G01N35/00 ,  B01F31/00

CPC classification number: G01N35/1004 ,  G01N35/1009 ,  B01F31/00 ,  B01L3/0275 ,  G01N2035/00524 ,  G01N2035/00554

Abstract: A method of washing an aspiration probe of an in-vitro diagnostic system is disclosed. The aspiration probe comprises an outer surface and an inner surface forming an inner space for receiving a fluid. The method comprises dipping the aspiration probe into a first wash fluid so that the outer surface is immersed at least in part into the first wash fluid, aspirating an amount of the first wash fluid into the inner space of the aspiration probe, propagating an ultrasonic vibration to the outer surface of the aspiration probe via the first wash fluid, and rinsing the outer surface and the inner surface of the aspiration probe with a second wash fluid. Further, an in-vitro diagnostic method and an in-vitro diagnostic system are disclosed.

公开(公告)号：US20240019453A1

公开(公告)日：2024-01-18

申请号：US18347647

申请日：2023-07-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Artur Tropmann

IPC: G01N35/02 ,  G01N35/04 ,  B01L9/06

CPC classification number: G01N35/02 ,  G01N35/04 ,  B01L9/06 ,  G01N2035/0405 ,  G01N2035/0496

Abstract: A laboratory apparatus for use in a laboratory sample handling system, wherein the apparatus comprises a cap waste disposal catcher, wherein the catcher is designed to catch a laboratory cap removed from a laboratory sample container containing a laboratory sample, and an electric field generator, wherein the generator is designed to generate an electric field to attract a residue of the sample released by the cap to the catcher.

公开(公告)号：US20240013873A1

公开(公告)日：2024-01-11

申请号：US18360278

申请日：2023-07-27

Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Tech Corporation

Inventor： Daniel Laubert ,  Rita Sachse ,  Dennis Aldorf ,  Werner Rapp ,  Ralf Herzog ,  Kenichi Yagi ,  Satoru Chida

IPC: G16H10/40 ,  G06F9/48 ,  G06F9/54

CPC classification number: G16H10/40 ,  G06F9/4881 ,  G06F9/54

Abstract: The present disclosure relates to a computer implemented method of managing sample processing priorities in a diagnostic laboratory comprising at least one sample processing device connected to a host system. The method comprises generating a communication message between the host system and the at least one sample processing device related to a sample processing order received in association with a sample, the message comprising one of at least two priority identifiers (R, S) indicative of respective sample processing priorities from lower priority to higher priority according to the received sample processing order. The method further comprises identifying the sample by the at least one sample processing device and processing the sample by the at least one sample processing device according to the sample processing priority (S, R) in the message. In case of receiving a subsequent request for change of sample processing priority for the sample from a lower priority to a higher priority after transmission of the message and before the sample is processed, the method comprises changing the message and processing the sample as a higher priority sample instead of as a lower priority sample, wherein changing the message comprises changing the lower priority identifier (R) to an identifier (CS) indicative of a change of priority but different from an equivalent higher priority identifier (S) in order to maintain the sample and the sample processing order uniquely identifiable and traceable by both the host system and the at least one sample processing device. A respective system for managing sample processing priorities is herein also disclosed.

公开(公告)号：US20230420240A1

公开(公告)日：2023-12-28

申请号：US18339760

申请日：2023-06-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudia Epping ,  Martin Rempt

IPC: H01J49/26 ,  G01N1/40

CPC classification number: H01J49/26 ,  G01N1/40 ,  G01N2001/4038

Abstract: The present invention relates to a clinical diagnostic system, a method for determining the presence or level of at least one analyte of interest in a biological sample, a kit and the uses thereof for efficiently and/or robust detection of an analyte of interest.

公开(公告)号：US11845733B2

公开(公告)日：2023-12-19

申请号：US17155020

申请日：2021-01-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Hans-Peter Josel ,  Uwe Kobold ,  Christoph Seidel ,  Martin Rempt ,  Andreas Leinenbach ,  Giuseppe Prencipe ,  Silvia Baecher ,  Simon Ferdinand Loibl ,  Anna-Skrollan Geiermann ,  Jelena Milic ,  Nicole Pirkl

IPC: C07D249/04 ,  C07D257/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D471/04 ,  C07D249/06 ,  C07D203/04 ,  G01N30/72

CPC classification number: C07D249/06 ,  C07D203/04 ,  C07D249/04 ,  C07D257/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D471/04 ,  G01N30/72

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

公开(公告)号：US20230381743A1

公开(公告)日：2023-11-30

申请号：US18338633

申请日：2023-06-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Eduardo Silvestre ,  Stephan Hug

IPC: B01J20/28 ,  B01J20/26 ,  B01J20/32 ,  B03C1/01 ,  G01N33/543

CPC classification number: B01J20/28009 ,  B01J20/267 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B03C2201/26 ,  B01J20/3272 ,  B03C1/01 ,  G01N33/54326 ,  B01J20/3282 ,  B01J20/3293 ,  B03C2201/18 ,  B01J20/3234

Abstract: The present disclosure relates to a method of preparing a magnetic particle having a polymer matrix (P) and at least one magnetic core (M), preferably at least two magnetic cores (M), wherein the polymer matrix (P) comprises at least one hypercrosslinked polymer, wherein the method comprises (i) providing at least one magnetic core (M), preferably at least two magnetic cores (M), (ii) providing polymer precursor molecules, (iii) polymerizing the polymer precursor molecules according to (ii) in the presence of the at least one magnetic core (M), thereby forming a particle comprising the at least one magnetic core (M). Further, the present disclosure relates to particles obtained or obtainable by this method as well as to the use of these particles. In a further aspect, the disclosure relates to a method for determining at least one analyte in a fluid sample having the step of contacting of the magnetic particle with a fluid sample having or suspected of having the at least one analyte.

公开(公告)号：US20230324398A1

公开(公告)日：2023-10-12

申请号：US17990903

申请日：2022-11-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Uwe Kobold ,  Hannes Kuchelmeister ,  Heribert Maerz ,  Giuseppe Prencipe ,  Martin Rempt

IPC: G01N33/58

CPC classification number: G01N33/58 ,  G01N2560/00

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

公开(公告)号：US11774395B2

公开(公告)日：2023-10-03

申请号：US17106620

申请日：2020-11-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  C12Q1/006 ,  G01N27/3274

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US20230296623A1

公开(公告)日：2023-09-21

申请号：US18017073

申请日：2021-07-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Torbjoern Omland ,  Ursula-Henrike Wienhues-Thelen ,  Andre Ziegler

IPC: G01N33/68 ,  G01N33/569

CPC classification number: G01N33/6893 ,  G01N33/56983 ,  G01N2800/56

Abstract: The present invention relates to a method for predicting the disease severity in a patient with COVID-19, said method comprising a) determining the level of GDF-15 in a sample from the patient with COVID-19, b) comparing the level determined in step a) to a reference, and predicting the disease severity in a patient with COVID-19. Also encompassed are methods for risk stratification, monitoring of the disease progression and the risk prediction for hospital admission in a patient with COVID-19. Furthermore, methods are provided for predicting the need for intensive care, the risk for thrombosis, pulmonary embolism, hypoxia and mortality in a patient with COVID-19.