公开(公告)号：US11275259B2

公开(公告)日：2022-03-15

申请号：US17304691

申请日：2021-06-24

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Nabin Joshi ,  Arkady Selenow ,  Steven Ali ,  Stefan Bauer ,  Jean-Noël Fehr ,  Moritz Haeberli ,  Patrizia Weber ,  Julien Sauvet ,  Amitava Gupta

IPC: G02C7/02 ,  G02C7/04 ,  G02C7/06 ,  A61B3/00 ,  A61F9/00 ,  G02C11/04

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US11209672B1

公开(公告)日：2021-12-28

申请号：US17301537

申请日：2021-04-06

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Gordon Frederick MacCabee ,  Ferry Widjaja ,  Amitava Gupta

IPC: G02C11/00 ,  G02C7/04 ,  A61N5/06

Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

公开(公告)号：US10959613B1

公开(公告)日：2021-03-30

申请号：US16947728

申请日：2020-08-13

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Stephan Wyder ,  Philip M. Buscemi ,  Matthias Pfister ,  Alexander Holzer

IPC: A61B3/10 ,  G01B9/02 ,  A61B3/12

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.

公开(公告)号：US09957224B2

公开(公告)日：2018-05-01

申请号：US13887243

申请日：2013-05-03

Applicant: Acucela Inc.

Inventor： Claes Olof Bavik ,  Susan Hayes Henry ,  Ryo Kubota ,  Vladimir A. Kuksa

IPC: A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C215/08 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

CPC classification number: C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US20160151369A1

公开(公告)日：2016-06-02

申请号：US14776675

申请日：2014-03-11

Applicant: ACUCELA INC.

Inventor： Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Ryo Kubota

IPC: A61K31/505 ,  A61K31/4409 ,  A61K31/4406 ,  A61K31/4465 ,  A61K31/445 ,  A61K31/44 ,  A61K31/343 ,  A61K31/341 ,  A61K31/351 ,  A61K31/382

CPC classification number: C07D335/02 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/505 ,  C07D207/08 ,  C07D207/09 ,  C07D207/26 ,  C07D209/08 ,  C07D209/14 ,  C07D211/22 ,  C07D211/26 ,  C07D211/60 ,  C07D211/76 ,  C07D211/96 ,  C07D213/30 ,  C07D213/38 ,  C07D233/64 ,  C07D233/96 ,  C07D239/26 ,  C07D279/02 ,  C07D307/12 ,  C07D307/14 ,  C07D307/80 ,  C07D307/81 ,  C07D309/04 ,  C07D309/06 ,  C07D311/04 ,  C07D311/58 ,  C07D333/12 ,  C07D333/16 ,  C07D333/20

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US09133154B2

公开(公告)日：2015-09-15

申请号：US14205117

申请日：2014-03-11

Applicant: Acucela Inc.

Inventor： Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Ryo Kubota

IPC: C07D309/06 ,  C07D213/38 ,  C07D335/02 ,  C07D211/26 ,  C07D211/76 ,  C07D307/81 ,  C07D307/14 ,  C07D279/02 ,  C07D311/58 ,  C07D207/09 ,  C07D239/26 ,  C07D333/20 ,  C07D209/14

CPC classification number: C07D335/02 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/505 ,  C07D207/08 ,  C07D207/09 ,  C07D207/26 ,  C07D209/08 ,  C07D209/14 ,  C07D211/22 ,  C07D211/26 ,  C07D211/60 ,  C07D211/76 ,  C07D211/96 ,  C07D213/30 ,  C07D213/38 ,  C07D233/64 ,  C07D233/96 ,  C07D239/26 ,  C07D279/02 ,  C07D307/12 ,  C07D307/14 ,  C07D307/80 ,  C07D307/81 ,  C07D309/04 ,  C07D309/06 ,  C07D311/04 ,  C07D311/58 ,  C07D333/12 ,  C07D333/16 ,  C07D333/20

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US20140323530A1

公开(公告)日：2014-10-30

申请号：US14226665

申请日：2014-03-26

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Thomas L. Little ,  Ryo Kubota

IPC: C07D335/02 ,  C07D309/06 ,  C07D213/38 ,  C07D333/20 ,  C07C215/20 ,  C07C217/74

CPC classification number: A61K31/382 ,  A61K31/138 ,  A61K31/165 ,  A61K31/351 ,  C07C211/27 ,  C07C213/00 ,  C07C215/20 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/72 ,  C07C217/74 ,  C07C219/22 ,  C07C225/16 ,  C07C225/18 ,  C07C233/18 ,  C07C235/34 ,  C07C235/54 ,  C07C237/20 ,  C07C237/38 ,  C07C237/40 ,  C07C257/14 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07C323/29 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D213/30 ,  C07D213/38 ,  C07D309/06 ,  C07D333/16 ,  C07D333/20 ,  C07D335/02

Abstract: Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Abstract translation: 提供的是胺衍生物化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和失调症的方法，例如年龄相关性黄斑变性和Stargardt氏病。

公开(公告)号：US12085786B2

公开(公告)日：2024-09-10

申请号：US18314996

申请日：2023-05-10

Applicant: ACUCELA INC.

Inventor： Philip M. Buscemi ,  Ryo Kubota

IPC: G02C7/04 ,  G02B27/01 ,  G02C7/14

CPC classification number: G02C7/04 ,  G02B27/017 ,  G02C7/14 ,  G02B2027/0178 ,  G02C2202/24

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

公开(公告)号：US11974807B2

公开(公告)日：2024-05-07

申请号：US18040186

申请日：2021-08-10

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Stephan Wyder ,  Philip M. Buscemi ,  Matthias Pfister ,  Cyril Stoller

IPC: A61B3/10 ,  G01B9/02091

CPC classification number: A61B3/102 ,  G01B9/02091

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.

公开(公告)号：US11777340B2

公开(公告)日：2023-10-03

申请号：US17904450

申请日：2021-02-19

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Patrizia Weber ,  Marco Burgener ,  Jonas Butscher ,  Praveenth Sanmugarajah ,  Hans Bernhard ,  Amitava Gupta

IPC: H02J50/10 ,  H02J50/40 ,  A45C11/00 ,  A45C15/00 ,  G02C7/04 ,  G02C11/00 ,  H02J7/00

CPC classification number: H02J50/10 ,  A45C11/005 ,  A45C15/00 ,  G02C7/04 ,  G02C11/10 ,  H02J7/0013 ,  H02J7/0044 ,  H02J50/40

Abstract: A contact lens charging case comprises a container sized and shaped to receive an electronic contact lens (“eCL”) and charging coil to couple to a coil of the eCL. In some embodiments, the charging coil comprises a diameter larger than a diameter of the coil of the eCL, so as to decrease sensitivity of the location and orientation of the eCL in the container and improve coupling between the coils. In some embodiments, the charging coil is dimensioned so as to extend at least partially around the container that receives the eCL.