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    Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts
    34.
    发明授权
    Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts 有权
    使用烷氧基醇催化剂通过二硅烷甲酰化芳族杂环

    公开(公告)号：US09556080B2

    公开(公告)日：2017-01-31

    申请号：US14972653

    申请日：2015-12-17

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： Anton Toutov ,  Wenbo Liu ,  Brian M. Stoltz ,  Robert H. Grubbs ,  Kerry Betz ,  David P. Schuman

    IPC: C07B47/00 ,  C07F7/08 ,  C07D209/12

    CPC classification number: C07B47/00 ,  C07D209/12 ,  C07F5/04 ,  C07F7/0827

    Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates, said system consisting essentially of a mixture of (a) at least one organodisilane and (b) at least alkoxide base, preferably a potassium alkoxide base, and said methods comprising contacting a quantity of the organic substrate with a mixture consisting essentially of (a) at least one organodisilane and (b) at least one alkoxide base, preferably a potassium alkoxide, under conditions sufficient to silylate the heteroaromatic substrate.

    Abstract translation: 本发明描述了用于甲硅烷基化杂芳族有机底物的化学系统和方法，所述系统基本上由（a）至少一种有机硅烷和（b）至少烷氧基，优选烷醇钾碱的混合物组成，所述方法包括使 基本上由（a）至少一种有机硅烷和（b）至少一种醇盐碱，优选烷氧基钾，在足以使所述杂芳族底物甲硅烷基化的条件下混合的混合物的有机底物的量。

    Palladium-catalyzed decarbonylation of fatty acid anhydrides for the production of linear alpha olefins
    35.
    发明授权
    Palladium-catalyzed decarbonylation of fatty acid anhydrides for the production of linear alpha olefins 有权
    用于生产线性α-烯烃的钯催化脱脂脂肪酸酐

    公开(公告)号：US09440891B2

    公开(公告)日：2016-09-13

    申请号：US14091466

    申请日：2013-11-27

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： Yiyang Liu ,  Brian M. Stoltz ,  Robert H. Grubbs ,  Alexey Fedorov ,  Kelly E. Kim

    IPC: C07C1/24 ,  C07C1/207

    CPC classification number: C07C1/24 ,  C07C1/2078 ,  C07C2531/24 ,  C07C2531/30 ,  C07C11/02

    Abstract: The present invention is directed to methods of forming olefins, especially linear alpha olefins from fatty acids or anhydrides, each method comprising: contacting an amount of precursor carboxylic acid anhydride with a palladium catalyst comprising a bidentate bis-phosphine ligand in a reaction mixture so as to form an olefin in a product with the concomittant formation and removal of CO and water from the reaction mixture, either directly or indirectly, wherein the reaction mixture is maintained with a sub-stoichiometric excess of a sacrificial carboxylic acid anhydride, an organic acid, or both, said sub-stoichiometric excess being relative to the amount of the precursor carboxylic acid anhydride. The precursor carboxylic acid anhydride may be added to the reaction mixture directly or formed in situ by the reaction between at least one precursor carboxylic acid with a stoichiometric amount of the sacrificial acid anhydride.

    Abstract translation: 本发明涉及从脂肪酸或酸酐形成烯烃，特别是直链α-烯烃的方法，每种方法包括：将一定量的前体羧酸酐与包含二齿双膦配体的钯催化剂反应在反应混合物中，以便 在直接或间接从反应混合物中伴随形成和除去CO和水的产物中形成烯烃，其中反应混合物用亚化学计量过量的牺牲羧酸酐，有机酸， 或两者，所述亚化学计量过量相对于前体羧酸酐的量。 可以将前体羧酸酐直接加入到反应混合物中或通过至少一种前体羧酸与化学计量的牺牲酸酐之间的反应原位形成。

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