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公开(公告)号：US11667906B2
公开(公告)日：2023-06-06
申请号：US14950771
申请日：2015-11-24
Applicant: Corning Incorporated
Inventor： Stephen Joseph Caracci , Ye Fang , Ann MeeJin Ferrie , Yan Jin , Lingyan Wang , Yue Zhou
Abstract: Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media.
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公开(公告)号：US11111470B2
公开(公告)日：2021-09-07
申请号：US17039218
申请日：2020-09-30
Applicant: CORNING INCORPORATED
Inventor： Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral
Abstract: A packed-bed bioreactor system for culturing cells is provided, the system including a cell culture vessel having at least one interior reservoir, an inlet fluidly connected to the reservoir, and an outlet fluidly connected to the reservoir; and a cell culture matrix disposed in the reservoir. The cell culture matrix includes a structurally defined multi-layered substrate for adhering cells thereto, and each layer of the multi-layered substrate has a physical structure and a porosity that are substantially regular and uniform.
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公开(公告)号：US20190326039A1
公开(公告)日：2019-10-24
申请号：US16391866
申请日：2019-04-23
Applicant: Corning Incorporated
Inventor： Ann MeeJin Ferrie , Yan Jin , Lingyan Wang , Yue Zhou
Abstract: Magnetic particles have a particle size of 500 nm of less and include a core and a polymer coating that surrounds and encapsulates the core. The core includes a metal, metal alloy, or metal oxide of at least one metal such as B, Mg, Al, Mn, Co, Ni, Cu, Fe Sm, Ln, Yb, Dy, Gd or Er and Nb. The magnetic core is polycrystalline particles which are superspin glass magnetic materials having coercivity greater than zero and magnetic remenance greater than zero at room temperature. Magnetic moment of these superspin glass magnetic materials at low field show increasing with temperature over room temperature. An in situ hydrolysis/precipitation method from precursor metal salts is used to form the polymer-encapsulated magnetic particles.
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公开(公告)号：US20180151278A1
公开(公告)日：2018-05-31
申请号：US15520581
申请日：2015-10-23
Applicant: CORNING INCORPORATED
Inventor： Ann MeeJin Ferrie , Yan Jin , Lingyan Wang , Yue Zhou
CPC classification number: H01F1/12 , C12N15/1013 , H01F1/0054 , H01F1/20 , H01F1/344 , H01F1/36
Abstract: Magnetic particles (100) have a particle size (134) of 500 nm or less and include a core (110) and a polymer coating (120) that surrounds and encapsulates the core (110). The core (110) includes a metal, metal alloy, or metal oxide of at least one metal such as B, Mg, Al, Mn, Co, Ni, Cu, Fe Sm, Yb, Dy, Gd or Er and Nb. The magnetic core (100) is a polycrystalline particle and is a superspin glass magnetic material, having a coercivity greater than zero and a magnetic remenance greater than zero at room temperature. Above room temperature and at low field, the magnetic moment of these superspin glass magnetic materials increases with temperature. An in situ hydrolysis/precipitation method from precursor metal salts is used to form the polymer-encapsulated magnetic particles (100).
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公开(公告)号：US20160145600A1
公开(公告)日：2016-05-26
申请号：US14950771
申请日：2015-11-24
Applicant: Corning Incorporated
Inventor： Stephen Joseph Caracci , Ye Fang , Ann MeeJin Ferrie , Yan Jin , Lingyan Wang , Yue Zhou
Abstract: Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media.
Abstract translation: 磁性微载体珠具有1至1000微米的粒度，并且包括复合芯和围绕并封装芯的聚合物涂层。 复合芯包括嵌入在难消化的聚合物基质内的磁性颗粒。 该涂层是可消化或消化不良的聚合物，其在细胞培养期间促进细胞与珠表面的粘附。 可以使用磁力在细胞培养过程中搅动微载体珠，以及将珠与培养的细胞或加工的生物培养基分离。
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Patent Agency Ranking
36.发明申请METHOD FOR FORMING A SCRATCH RESISTANT CRYSTALLIZED LAYER ON A SUBSTRATE AND ARTICLE FORMED THEREFROM 有权在基板上形成耐蚀刻结晶层的方法及其形成的制品公开(公告)号：US20160083863A1
公开(公告)日：2016-03-24
申请号：US14853191
申请日：2015-09-14
Applicant: CORNING INCORPORATED
CPC classification number: C30B13/00 , C03C17/25 , C03C2217/214 , C03C2218/113 , C03C2218/116 , C03C2218/32 , C23C18/1216 , C23C18/1241 , C23C18/1245 , C23C18/1254 , C23C18/1295 , C30B29/20
Abstract: A crystallized layer can be formed on a substrate from a precursor layer deposited on a surface of the substrate. The precursor layer can be an oxide, a nitride, a carbide, or an oxynitride. The process for forming the crystallized layer includes melting the precursor layer formed on the surface of the substrate by localized topical heating of the precursor layer and then cooling the melted precursor layer so that it crystallized to form a scratch resistant crystallized layer. The scratch resistant crystallized layer can have a hardness of 15 GPa or greater.
Abstract translation: 结晶层可以从沉积在基板的表面上的前体层形成在基板上。 前体层可以是氧化物，氮化物，碳化物或氧氮化物。 形成结晶层的方法包括通过局部局部加热前体层熔化形成在基材表面上的前体层，然后冷却熔融的前体层，使其结晶形成耐划伤的结晶层。 耐刮擦结晶层的硬度可以为15GPa以上。
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公开(公告)号：US20240336883A1
公开(公告)日：2024-10-10
申请号：US18746891
申请日：2024-06-18
Applicant: CORNING INCORPORATED
Inventor： Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Lori Eileen Romeo
CPC classification number: C12M25/14 , C12M23/02 , C12M23/20 , C12M23/44 , C12M25/04 , C12M29/10 , C12M29/26 , C12M41/26 , C12M25/02 , C12N5/0068 , C12N5/0602 , C12N2513/00 , C12N2533/30 , C12N2533/40 , C12N2533/90 , C12N2535/00
Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
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公开(公告)号：US20240254421A1
公开(公告)日：2024-08-01
申请号：US18289446
申请日：2022-05-02
Applicant: CORNING INCORPORATED
Inventor： Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Lori Eileen Romeo
Abstract: A fixed-bed bioreactor system (300) is provided that includes a vessel with a media inlet (310), a media outlet (312), and an interior cavity disposed between and in fluid communication with the media inlet and media outlet; a cell culture substrate disposed in the interior cavity between the media inlet and the media outlet in a packed-bed configuration, the cell culture substrate having a plurality of porous disks (308) in a stacked arrangement; and a harvesting volume (2010,2020) to hold a fluid, the harvesting volume being in fluid communication with the interior cavity, wherein each of the plurality of porous disks comprises a surface configured to culture cells thereon. The harvesting volume can be inside or outside of the vessel.
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39.发明公开公开(公告)号：US20240240128A1
公开(公告)日：2024-07-18
申请号：US18586065
申请日：2024-02-23
Applicant: CORNING INCORPORATED
Inventor： Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Lori Eileen Romeo
CPC classification number: C12M25/14 , C12M23/02 , C12M23/20 , C12M23/44 , C12M25/04 , C12M29/10 , C12M29/26 , C12M41/26 , C12M25/02 , C12N5/0068 , C12N5/0602 , C12N2513/00 , C12N2533/30 , C12N2533/40 , C12N2533/90 , C12N2535/00
Abstract: A cell culture matrix for a perfusion-flow fixed-bed reactor is provided. The cell culture matrix includes a substrate having a porous sheet for adhering cells thereto. The sheet has a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate, arrayed in a regular pattern, and passing through the thickness of the substrate. The porous sheet is wound into a cylindrical shape having a plurality of wound layers, and the cell culture matrix does not include a spacer material or physical barrier between the plurality of wound layers of the substrate.
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公开(公告)号：US11920117B2
公开(公告)日：2024-03-05
申请号：US17869419
申请日：2022-07-20
Applicant: CORNING INCORPORATED
Inventor： Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Lori Eileen Romeo
CPC classification number: C12M25/14 , C12M23/02 , C12M23/20 , C12M23/44 , C12M25/04 , C12M29/10 , C12M29/26 , C12M41/26 , C12M25/02 , C12N5/0068 , C12N5/0602 , C12N2513/00 , C12N2533/30 , C12N2533/40 , C12N2533/90 , C12N2535/00
Abstract: A cell culture matrix for a perfusion-flow fixed-bed reactor is provided. The cell culture matrix includes a substrate having a porous sheet for adhering cells thereto. The sheet has a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate, arrayed in a regular pattern, and passing through the thickness of the substrate. The porous sheet is wound into a cylindrical shape having a plurality of wound layers, and the cell culture matrix does not include a spacer material or physical barrier between the plurality of wound layers of the substrate.
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