公开(公告)号：US09296145B2

公开(公告)日：2016-03-29

申请号：US14068226

申请日：2013-10-31

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Kenneth Keilman ,  Dennis D. Jamiolkowski

IPC: A61B17/04 ,  B29C47/00 ,  D01D5/098 ,  A61B17/06 ,  A61L17/12 ,  B29C47/86 ,  B29C47/88 ,  B29K73/00 ,  B29L31/00

CPC classification number: B29C47/0014 ,  A61B17/04 ,  A61B17/06166 ,  A61L17/12 ,  B29C47/0004 ,  B29C47/0061 ,  B29C47/0064 ,  B29C47/0066 ,  B29C47/0088 ,  B29C47/862 ,  B29C47/8805 ,  B29C47/8895 ,  B29K2073/00 ,  B29K2995/0056 ,  B29K2995/006 ,  B29L2031/726 ,  B29L2031/731 ,  B29L2031/753 ,  D01D5/098

Abstract: Novel absorbable monofilament sutures and fibers having unique and improved properties are disclosed including mid-term strength retention post-implantation. Also disclosed is a novel method of manufacturing absorbable monofilament sutures and fibers. The sutures and fibers are extruded from poly(p-dioxanone-co-glycolide) copolymers.

Abstract translation: 公开了新颖的可吸收单丝缝合线和具有独特且改善的性质的纤维，包括植入后的中期强度保留。 还公开了制造可吸收的单丝缝合线和纤维的新方法。 缝合线和纤维从聚（对二恶烷酮 - 共 - 乙交酯）共聚物挤出。

公开(公告)号：US09238094B2

公开(公告)日：2016-01-19

申请号：US13842066

申请日：2013-03-15

Applicant: ETHICON, INC.

Inventor： Sasa Andjelic ,  Benjamin D. Fitz ,  Jianguo Jack Zhou

IPC: C08L67/04 ,  A61L31/06 ,  A61L27/18 ,  C08L69/00 ,  C08L101/16 ,  D01D5/098 ,  D01F6/62 ,  D01F6/68 ,  D01F6/86 ,  B29D7/00 ,  D04H1/56 ,  A61L27/58 ,  A61L31/14 ,  B29C71/00

CPC classification number: A61L31/06 ,  A61L27/18 ,  A61L27/58 ,  A61L31/148 ,  B29C71/00 ,  B29D7/00 ,  C08L67/04 ,  C08L69/00 ,  C08L101/16 ,  C08L2203/02 ,  C08L2205/02 ,  D01D5/0985 ,  D01F6/625 ,  D01F6/68 ,  D01F6/86 ,  D04H1/56 ,  Y10T442/609 ,  C08L2666/18

Abstract: A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.

公开(公告)号：US20150119935A1

公开(公告)日：2015-04-30

申请号：US14068226

申请日：2013-10-31

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Kenneth Keilman ,  Dennis D. Jamiolkowski

IPC: A61B17/04 ,  D01D5/098

CPC classification number: B29C47/0014 ,  A61B17/04 ,  A61B17/06166 ,  A61L17/12 ,  B29C47/0004 ,  B29C47/0061 ,  B29C47/0064 ,  B29C47/0066 ,  B29C47/0088 ,  B29C47/862 ,  B29C47/8805 ,  B29C47/8895 ,  B29K2073/00 ,  B29K2995/0056 ,  B29K2995/006 ,  B29L2031/726 ,  B29L2031/731 ,  B29L2031/753 ,  D01D5/098

Abstract: Novel absorbable monofilament sutures and fibers having unique and improved properties are disclosed including mid-term strength retention post-implantation. Also disclosed is a novel method of manufacturing absorbable monofilament sutures and fibers. The sutures and fibers are extruded from poly(p-dioxanone-co-glycolide) copolymers.

Abstract translation: 公开了新颖的可吸收单丝缝合线和具有独特且改善的性质的纤维，包括植入后的中期强度保留。 还公开了制造可吸收的单丝缝合线和纤维的新方法。 缝合线和纤维从聚（对 - 二恶烷酮 - 共 - 乙交酯）共聚物挤出。

公开(公告)号：US11058792B2

公开(公告)日：2021-07-13

申请号：US16021322

申请日：2018-06-28

Applicant: Ethicon, Inc.

Inventor： Dennis D. Jamiolkowski ,  Christopher DeFelice ,  Sasa Andjelic ,  Brian M. Kelly ,  Marc Wisnudel ,  Daniel Steiger ,  Gaoyuan Gavin Chen

IPC: A61L17/12 ,  A61L17/00 ,  A61L17/14 ,  C08G63/64 ,  A61B17/06 ,  C08G63/08 ,  A61B17/00

Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.

公开(公告)号：US20190176453A1

公开(公告)日：2019-06-13

申请号：US16275664

申请日：2019-02-14

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Dominick Egidio

IPC: B32B37/10 ,  B29C48/08 ,  A61L31/04 ,  B29C48/92 ,  B29C48/00 ,  B32B37/06 ,  B32B27/12 ,  B32B5/02 ,  B29C55/30 ,  A61L31/14 ,  A61K9/70 ,  B32B37/15 ,  B32B27/00 ,  A61L31/10

Abstract: The invention relates to novel processes for the lamination of semi-crystalline, high-melting point, low glass transition polymeric films, which are extruded and subsequently laminated on various thermally sensitive substrates to form laminated medical device constructs in a specific time interval to allow low processing temperatures to avoid polymer film and/or substrate degradation or heat-related distortions. Also disclosed are laminated medical device constructs made from such processes.

公开(公告)号：US10245817B2

公开(公告)日：2019-04-02

申请号：US15267700

申请日：2016-09-16

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Dominick Egidio

IPC: B32B37/10 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14 ,  B29C47/00 ,  B29C55/30 ,  B32B5/02 ,  B32B27/12 ,  B32B37/06 ,  B32B27/00 ,  B32B37/15 ,  A61K9/70 ,  B29C47/92 ,  A61F2/00 ,  B29L31/00 ,  B32B37/00

Abstract: The invention relates to novel processes for the lamination of semi-crystalline, high-melting point, low glass transition polymeric films, which are extruded and subsequently laminated on various thermally sensitive substrates to form laminated medical device constructs in a specific time interval to allow low processing temperatures to avoid polymer film and/or substrate degradation or heat-related distortions. Also disclosed are laminated medical device constructs made from such processes.

公开(公告)号：US10086109B2

公开(公告)日：2018-10-02

申请号：US14728177

申请日：2015-06-02

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Dennis D. Jamiolkowski ,  Jackie Donners ,  Mark Timmer

IPC: A61L24/04 ,  C08J5/18 ,  C08L67/04 ,  A61L24/00 ,  C08G63/08 ,  C08J9/04 ,  C08J9/26 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  A61L31/06 ,  A61L31/14 ,  C08G101/00

Abstract: Absorbable medical devices based on novel foams and films made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. Also disclosed are methods of producing said foams and films, and useful polymer solutions.

公开(公告)号：US20160354510A1

公开(公告)日：2016-12-08

申请号：US14728177

申请日：2015-06-02

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Dennis D. Jamiolkowski ,  Jackie Donners ,  Mark Timmer

IPC: A61L24/04 ,  C08J5/18 ,  C08L67/04 ,  A61L24/00 ,  C08G63/08

CPC classification number: A61L24/046 ,  A61L24/001 ,  A61L24/0036 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  A61L31/06 ,  A61L31/146 ,  A61L31/148 ,  C08G63/08 ,  C08G2101/00 ,  C08J5/18 ,  C08J9/04 ,  C08J9/26 ,  C08J2201/03 ,  C08J2201/0482 ,  C08J2205/02 ,  C08J2300/16 ,  C08J2367/04 ,  C08L67/04

Abstract: Absorbable medical devices based on novel foams and films made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. Also disclosed are methods of producing said foams and films, and useful polymer solutions.

Abstract translation: 公开了基于由具有长期吸收特性的丙交酯和ε-己内酯的半结晶分段共聚物制成的新型泡沫和薄膜的可吸收医疗器械。 还公开了制备所述泡沫和膜以及有用的聚合物溶液的方法。

公开(公告)号：US20150159011A1

公开(公告)日：2015-06-11

申请号：US14533274

申请日：2014-11-05

Applicant: Ethicon, Inc.

Inventor： Dennis D. Jamiolkowski ,  Sasa Andjelic ,  Brian M. Kelly ,  Christopher DeFelice

IPC: C08L67/04 ,  A61L31/14 ,  A61L31/04

CPC classification number: C08L67/04 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00004 ,  A61B2017/00831 ,  A61L17/12 ,  A61L27/18 ,  A61L29/06 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148 ,  C08G63/664 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2205/02 ,  C08L2205/025

Abstract: Novel absorbable polymeric blends having bimodal molecular weight distribution are disclosed. The bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a bimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of unimodal or bimodal molecular weight distribution. Alternately, the bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a unimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of bimodal molecular weight distribution. The novel polymeric bimodal molecular weight blends provide medical devices having improved dimensional stability. Also disclosed are novel absorbable medical devices made from these novel bimodal polymer blends, as well as novel methods of manufacture.

Abstract translation: 公开了具有双峰分子量分布的新型可吸收聚合物共混物。 双峰共混物具有第一组分，其是聚丙交酯聚合物或具有双峰分子量分布的丙交酯和乙交酯的共聚物，以及作为单峰或双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 或者，双峰共混物具有第一组分，其是具有单峰分子量分布的聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及作为双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 新型聚合双峰分子量共混物提供具有改进的尺寸稳定性的医疗装置。 还公开了由这些新型双峰聚合物共混物制成的新型可吸收医疗装置，以及新颖的制造方法。

公开(公告)号：US08575301B2

公开(公告)日：2013-11-05

申请号：US13691434

申请日：2012-11-30

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Tara Zabrosky

IPC: C08G63/08

CPC classification number: A61K8/85 ,  A61K2800/91 ,  A61L31/06 ,  A61Q19/00 ,  C08G63/60 ,  C08L67/00 ,  C08L67/04 ,  C08L2666/22

Abstract: A co-polyester which includes the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol. The co-polyester is injectable and absorbable into animal, such as human, tissue and can be used for facial cosmetic or reconstructive surgery of soft tissue. Another embodiment is directed to a method for preventing adhesion using a co-polyester comprising the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol, and the co-polyester comprises about 40 to 50% by weight of the polycondensation polyester based on the total weight of the co-polyester.