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公开(公告)号：US20080069852A1
公开(公告)日：2008-03-20
申请号：US11625086
申请日：2007-01-19
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46
摘要： The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.
摘要翻译： 本发明涉及用于骨缺损部位以促进新骨生长的多孔复合材料。 本发明的多孔复合材料包括生物相容性聚合物和多种骨源材料，无机材料，骨替代材料或复合材料的颗粒。 在某些实施方案中，使用包括超临界流体（例如超临界二氧化碳）处理的方法制备多孔复合材料。 本发明还公开了使用这些复合材料作为骨空隙填料的方法。
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32.发明申请公开(公告)号：US20080063684A1
公开(公告)日：2008-03-13
申请号：US11934980
申请日：2007-11-05
申请人： John Winterbottom , David Kaes
发明人： John Winterbottom , David Kaes
IPC分类号： A61K35/32
CPC分类号： A61L24/00 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3847 , A61L27/40 , A61L27/446 , A61L27/46 , A61L2430/02 , C08L67/04
摘要： A composite osteoimplant. The osteoimplant includes a polymer and bone-derived particles. The composite is adapted and constructed to be formable during or immediately prior to implantation and to be set after final surgical placement.
摘要翻译： 复合植骨。 骨植入物包括聚合物和骨衍生的颗粒。 该复合材料适于和构造成在植入期间或之前即刻形成，并且在最终手术放置之后被设定。
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33.发明申请Transforaminal lumbar interbody fusion (TLIF) implant, surgical procedure and instruments for insertion of spinal implant in a spinal disc space 审中-公开经椎间孔腰椎间融合术（TLIF）植入物，脊柱植入物插入椎间盘空间的外科手术和器械公开(公告)号：US20050038511A1
公开(公告)日：2005-02-17
申请号：US10912667
申请日：2004-08-05
申请人： Erik Martz , John Kuras , John Winterbottom , Craig Stratton , David Marques , Lawrence Shimp
发明人： Erik Martz , John Kuras , John Winterbottom , Craig Stratton , David Marques , Lawrence Shimp
IPC分类号： A61B17/00 , A61B17/02 , A61B17/16 , A61B17/70 , A61B19/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61F2/30771 , A61B17/1606 , A61B17/1659 , A61B17/1671 , A61B17/1684 , A61B17/7001 , A61B2017/0046 , A61B2017/0256 , A61B2090/062 , A61F2/28 , A61F2/4455 , A61F2/4611 , A61F2/4684 , A61F2002/30131 , A61F2002/30774 , A61F2002/30892 , A61F2002/30904 , A61F2002/4475 , A61F2002/448 , A61F2002/4622 , A61F2002/4628 , A61F2230/0013 , A61F2310/00359
摘要： Various instrumentation, implants and methodology are disclosed for implanting bone implants in the TLIF approach. The implants are preferably cortical bone of various shapes. The instruments include chisels, rasps, trials, inserters, spreaders, adjustors, curettes, rongeurs, and impactors. The instruments have straight and bent shafts. The implants may have recesses or notches in their sides for receipt of a mating insertion instrument. Some of the implants have a threaded hole for receiving a mating threaded stud of an implant insertion instrument. The implants may have saw tooth vertebral gripping surfaces which are lordotic or parallel, may be C-shaped, multi-faceted or annular.
摘要翻译： 公开了在TLIF方法中植入骨植入物的各种仪器，植入物和方法。 植入物优选为各种形状的皮质骨。 仪器包括凿子，锉刀，试验，插入器，吊具，调节器，刮刀，护腿和冲击器。 仪器具有直的和弯曲的轴。 植入物在其侧面可以具有凹口或凹口以接收配合的插入器械。 一些植入物具有用于接收植入物插入器械的配合螺柱的螺纹孔。 植入物可具有锯齿状的脊椎牵引表面，其为脊柱状或平行的，可为C形，多面或环形。
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公开(公告)号：US08740987B2
公开(公告)日：2014-06-03
申请号：US11018853
申请日：2004-12-20
申请人： Perry Geremakis , Jennifer Grasso , David Knaack , Jo-Wen Lin , Lawrence Shimp , Robert Waterman , John Winterbottom
发明人： Perry Geremakis , Jennifer Grasso , David Knaack , Jo-Wen Lin , Lawrence Shimp , Robert Waterman , John Winterbottom
IPC分类号： A61F2/28
CPC分类号： A61L27/3641 , A61B17/06166 , A61B2017/00004 , A61F2/0063 , A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2/4601 , A61F2/4644 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61F2310/00011 , A61F2310/00179 , A61F2310/00359 , A61L27/3608 , A61L27/3633 , A61L27/3645 , A61L27/3804 , A61L27/3843 , B29C67/02
摘要： An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.
摘要翻译： 一种植入体，其包括基本上凝聚的聚集体，其包含骨衍生的颗粒。 粘合性通过机械互锁的成员维持，相邻的骨衍生的颗粒通过与粘合剂的接合，热粘合，化学粘合或其中保留骨衍生的颗粒的基质材料相互粘合。 聚集体成形为一维或二维体。
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公开(公告)号：US08002843B2
公开(公告)日：2011-08-23
申请号：US10771736
申请日：2004-02-04
申请人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Lawrence A. Shimp
发明人： David Knaack , John Winterbottom , David Kaes , Todd Boyce , Lawrence A. Shimp
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译： 生物基聚氨酯及其制备方法。 聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。 形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。
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公开(公告)号：US20110040334A1
公开(公告)日：2011-02-17
申请号：US12914051
申请日：2010-10-28
CPC分类号： A61F2/28 , A61B17/86 , A61F2/30965 , A61F2/4455 , A61F2/446 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30131 , A61F2002/30176 , A61F2002/30354 , A61F2002/30405 , A61F2002/30492 , A61F2002/30578 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30836 , A61F2002/30841 , A61F2002/3085 , A61F2002/30904 , A61F2002/4475 , A61F2002/449 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0054 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00365
摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
摘要翻译： 在手术中使用的植入单元具有由成骨可植入材料制成的主体，并且包括植入部分和保持部分，该部分与植入部分相连并横向延伸。 保持部分附接到邻接的椎体或哺乳动物骨的侧壁，以防止植入部分相对于椎体或哺乳动物骨骼移位，并加速其间的融合。
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公开(公告)号：US07833245B2
公开(公告)日：2010-11-16
申请号：US10483804
申请日：2002-07-12
CPC分类号： A61F2/28 , A61B17/86 , A61F2/30965 , A61F2/4455 , A61F2/446 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30131 , A61F2002/30176 , A61F2002/30354 , A61F2002/30405 , A61F2002/30492 , A61F2002/30578 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30836 , A61F2002/30841 , A61F2002/3085 , A61F2002/30904 , A61F2002/4475 , A61F2002/449 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0054 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00365
摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
摘要翻译： 在手术中使用的植入单元具有由成骨可植入材料制成的主体，并且包括植入部分和保持部分，该部分与植入部分相连并横向延伸。 保持部分附接到邻接的椎体或哺乳动物骨的侧壁，以防止植入部分相对于椎体或哺乳动物骨骼移位，并加速其间的融合。
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38.发明授权Formable and settable polymer bone composite and method of production thereof 有权可成型和可固化聚合物骨复合材料及其制备方法公开(公告)号：US07291345B2
公开(公告)日：2007-11-06
申请号：US10735135
申请日：2003-12-12
申请人： John Winterbottom , David Kaes
发明人： John Winterbottom , David Kaes
CPC分类号： A61L24/00 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3847 , A61L27/40 , A61L27/446 , A61L27/46 , A61L2430/02 , C08L67/04
摘要： A composite osteoimplant. The osteoimplant includes a polymer and bone-derived particles. The composite is adapted and constructed to be formable during or immediately prior to implantation and to be set after final surgical placement.
摘要翻译： 复合植骨。 骨植入物包括聚合物和骨衍生的颗粒。 该复合材料适于和构造成在植入期间或之前即刻形成，并且在最终手术放置之后被设定。
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公开(公告)号：US20070233272A1
公开(公告)日：2007-10-04
申请号：US11758751
申请日：2007-06-06
申请人： Todd Boyce , Lawrence Shimp , Albert Manrique , John Winterbottom
发明人： Todd Boyce , Lawrence Shimp , Albert Manrique , John Winterbottom
CPC分类号： A61F2/28 , A61B17/0401 , A61B17/72 , A61B17/74 , A61B17/80 , A61B17/86 , A61B2017/0409 , A61B2017/0414 , A61B2017/044 , A61C8/0012 , A61C8/0036 , A61F2/2803 , A61F2/2875 , A61F2/30965 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/442 , A61F2/446 , A61F2/4611 , A61F2/4644 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/2871 , A61F2002/2892 , A61F2002/30004 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30143 , A61F2002/30146 , A61F2002/30148 , A61F2002/30153 , A61F2002/30154 , A61F2002/30158 , A61F2002/30225 , A61F2002/30237 , A61F2002/30238 , A61F2002/30261 , A61F2002/30266 , A61F2002/30433 , A61F2002/30561 , A61F2002/30622 , A61F2002/30678 , A61F2002/30785 , A61F2002/3085 , A61F2002/3092 , A61F2002/3095 , A61F2002/30952 , A61F2002/30957 , A61F2002/30962 , A61F2002/30968 , A61F2002/3611 , A61F2002/365 , A61F2002/3686 , A61F2210/0004 , A61F2220/0041 , A61F2230/0006 , A61F2230/0008 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0026 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2250/0071 , A61F2310/00011 , A61F2310/00161 , A61F2310/00173 , A61F2310/00293 , A61F2310/00347 , A61F2310/00365 , A61L27/3608 , A61L27/3641 , A61L27/3683 , A61L27/3691 , A61L27/3839 , A61L27/3847 , A61L31/005 , A61L2430/02
摘要： A load-bearing osteoimplant which comprises a shaped, coherent aggregate of bone particles.
摘要翻译： 一种承重骨植入物，其包括骨形成的，相干的骨颗粒聚集体。
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公开(公告)号：US20070191963A1
公开(公告)日：2007-08-16
申请号：US11625119
申请日：2007-01-19
申请人： John Winterbottom , David Kaes , Deger Tunc , Todd Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
发明人： John Winterbottom , David Kaes , Deger Tunc , Todd Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
摘要翻译： 一种植物复合材料，其包含多种无机材料颗粒，骨替代材料，骨衍生材料或其任何组合; 以及与颗粒结合的聚合物材料。 复合材料可以自然地模塑或流动，或者它可以是可模制的或可设定的。 植入后，可以将复合材料设置成为植入物提供机械强度。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为提供大多数矫形应用所需的机械强度。 本发明还提供了使用和制备可模制和可流动的复合材料的方法。
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