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31.发明授权Method and apparatus for testing self-commutative electric power conversion device 失效自交换电力转换装置的测试方法及装置
公开(公告)号：US5376881A
公开(公告)日：1994-12-27
申请号：US950126
申请日：1992-09-24
申请人： Kazutoshi Takahashi
发明人： Kazutoshi Takahashi
摘要： A method and an apparatus for testing a self-commutative electric power conversion device, capable of verifying the maximum voltage stress and the maximum current stress in the main circuit of the device by using a testing facility equipped with the power source and the load having relatively small capacities. The pulse shaped turn on and turn off signals are supplied to the switching elements in the self-commutative electric power conversion device, such that a load current having a desired current level for testing flows though an inductive load connected to an AC output side of the self-commutative electric power conversion device having the DC capacitor charged to a desired voltage level for testing. Then, voltage and current waveforms in the self-commutative electric power conversion device are measured, while the pulse shaped turn on and turn off signals are supplied to the switching elements, to verify an operation of the self-commutative electric power conversion device under voltage stress and current stress.
摘要翻译： 一种用于测试自交换电力转换装置的方法和装置，其能够通过使用配备有电源的测试设备和具有相对的负载来验证装置的主电路中的最大电压应力和最大电流应力 容量小。 将脉冲形状的导通和关闭信号提供给自换电力转换装置中的开关元件，使得具有用于测试的期望电流电平的负载电流通过连接到该交流输出侧的电感负载 具有将所述直流电容器充电至期望电压电平进行测试的自交换电力转换装置。 然后，测量自换向电力转换装置中的电压和电流波形，同时向开关元件提供脉冲形导通和关断信号，以验证自换电功率转换装置在电压下的操作 压力和电流应力。
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公开(公告)号：US4370067A
公开(公告)日：1983-01-25
申请号：US147006
申请日：1980-05-06
申请人： Ryoji Iwakura , Tatsuo Nitta , Kazutoshi Takahashi
发明人： Ryoji Iwakura , Tatsuo Nitta , Kazutoshi Takahashi
CPC分类号： G04G99/00 , G04F5/06 , G04G13/023 , G04G3/022 , G04G9/0047
摘要： An electronic timepiece in which an operating state of a timepiece circuit is controlled by a control circuit composed of a counter responsive to clock pulses from the timepiece circuit, a digital/analog converter for converting a digital output signal from the counter to an analog output signal, a potentiometer adapted to generate an analog input signal, and a comparator for comparing the analog output signal and the analog input signal to generate an output signal which is applied to the counter to control the same by which a control signal is generated to control the operating state of the timepiece.
摘要翻译： 一种电子表，其中时钟电路的操作状态由响应于来自时钟电路的时钟脉冲的计数器组成的控制电路控制;数模转换器，用于将来自计数器的数字输出信号转换为模拟输出信号 ，适于产生模拟输入信号的电位器，以及用于比较模拟输出信号和模拟输入信号以产生输出信号的比较器，该输出信号被施加到计数器以控制产生控制信号的控制信号， 手表的运行状态。
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33.发明授权Method for selecting reduced differentiation resistance human induced pluripotent stem cells 有权选择降低分化能力的人诱导多能干细胞的方法公开(公告)号：US08932857B2
公开(公告)日：2015-01-13
申请号：US13704584
申请日：2011-06-15
CPC分类号： C12N5/0081 , C12N5/0696 , C12N2501/15 , C12N2501/155
摘要： The present invention provides a method for selecting human induced pluripotent stem (iPS) cells which can be safely used for transplantation. That is, the present invention provides a method for selecting human iPS cells having reduced differentiation resistance, comprising the steps of: (1) inducing differentiation of human iPS cells; (2) detecting remaining undifferentiated cells after the step (1); and (3) selecting human iPS cells whose rate of remaining undifferentiated cells detected in step (2) is equivalent to or not more than that of control cells.
摘要翻译： 本发明提供了可以安全地用于移植的人诱导多能干细胞（iPS）细胞的选择方法。 也就是说，本发明提供了选择具有降低的分化阻力的人iPS细胞的方法，包括以下步骤：（1）诱导人iPS细胞的分化; （2）在步骤（1）之后检测剩余的未分化细胞; 和（3）选择在步骤（2）中检测到的剩余未分化细胞的速率等于或不超过对照细胞的人iPS细胞。
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公开(公告)号：US20130183757A1
公开(公告)日：2013-07-18
申请号：US13824087
申请日：2011-11-04
IPC分类号： C12N15/01
CPC分类号： C12N15/01 , C12N5/0696 , C12N9/12 , C12N9/18 , C12N15/86 , C12N2501/405 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/999
摘要： Provided is a method of improving the efficiency of iPS cell establishment, comprising bringing one or more factors selected from the group consisting of proteins belonging to cyclin D family and nucleic acids that encode the same into contact with a somatic cell, in the step of nuclear reprogramming of the somatic cell. Also provided are a method of producing an iPS cell comprising the step of bringing the factor(s) and nuclear reprogramming substance(s) into contact with a somatic cell, an iPS cell comprising a nucleic acid that encodes a protein belonging to cyclin D family that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate.
摘要翻译： 本发明提供了提高iPS细胞建立效率的方法，其包括在核苷酸步骤中使从属于细胞周期蛋白D家族的蛋白质中选出的一个或多个因子和编码其的核酸与体细胞接触 体细胞重编程。 还提供了一种生产iPS细胞的方法，包括使因子和核重编程物质与体细胞接触的步骤，iPS细胞包含编码属于细胞周期蛋白D家族的蛋白质的核酸 可以通过生产iPS细胞的方法获得，以及通过强迫iPS细胞分化的体细胞产生的方法。
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公开(公告)号：US20120217158A1
公开(公告)日：2012-08-30
申请号：US13503816
申请日：2010-10-22
申请人： Kazutoshi Takahashi , Junichi Nitta
发明人： Kazutoshi Takahashi , Junichi Nitta
CPC分类号： C22C1/0458 , B22F3/14 , B22F3/24 , B22F2998/10 , C23C14/3414 , B22F3/02 , B22F3/10
摘要： A method of manufacturing a titanium-containing sputtering target is disclosed, with the method being capable of reducing the frequency of occurrence of abnormal discharge caused by lattice defects. A first metal powder containing a high melting point metal and a second metal powder containing titanium are manufactured. Subsequently, a mixed powder of the first metal powder and the second metal powder is sintered at a temperature of 695° C. or higher, and then heat-treated at a temperature of 685° C. or lower. After the sintering, the sintered body is heat-treated at a temperature of 685° C. or lower, thereby decreasing plate-like structures (lattice defects) in a sintered phase. Accordingly, it is possible to obtain a titanium-containing sputtering target with which abnormal discharge occurs less frequently.
摘要翻译： 公开了一种制造含钛溅射靶的方法，该方法能够降低由晶格缺陷引起的异常放电的发生频率。 制造含有高熔点金属的第一金属粉末和含钛的第二金属粉末。 随后，将第一金属粉末和第二金属粉末的混合粉末在695℃或更高的温度下烧结，然后在685℃或更低的温度下进行热处理。 烧结后，烧结体在685℃以下的温度下进行热处理，从而降低烧结相中的板状结构（晶格缺陷）。 因此，可以获得不频繁发生异常放电的含钛溅射靶。
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公开(公告)号：US20120141175A1
公开(公告)日：2012-06-07
申请号：US13291338
申请日：2011-11-08
申请人： Shigeru Fujiwara , Satoshi Kinouchi , Ryota Saeki , Shoko Shimmura , Kazutoshi Takahashi , Toshihiro Sone , Takafumi Amano
发明人： Shigeru Fujiwara , Satoshi Kinouchi , Ryota Saeki , Shoko Shimmura , Kazutoshi Takahashi , Toshihiro Sone , Takafumi Amano
IPC分类号： G03G15/20
CPC分类号： G03G15/6573 , G03G15/6585 , G03G15/6591
摘要： An image forming apparatus according to an embodiment includes: an image erasing section including a first member which has an elastic layer and heats a recording medium having a thermally decolorizable toner image on the toner image side and a second member which erases the toner image by allowing the recording medium in cooperation with the first member; an image forming section which transfers a thermally decolorizable toner image onto the recording medium on which the toner image is erased to form an unfixed toner image; and an image fixing section including a third member which does not have an elastic layer and heats the recording medium on the unfixed toner image side and a fourth member which fixes the unfixed toner image by allowing the recording medium in cooperation with the third member.
摘要翻译： 根据实施例的图像形成装置包括：图像擦除部分，包括具有弹性层的第一部件，并且在调色剂图像侧加热具有热可脱色调色剂图像的记录介质，以及通过允许调色剂图像来擦除调色剂图像的第二部件 记录介质与第一个成员协作; 将热可脱色调色剂图像转印到其上清除调色剂图像的记录介质上以形成未定影的调色剂图像的图像形成部分; 以及图像定影部，其包括不具有弹性层的第三构件，并且对未定影的调色剂像侧加热记录介质;以及第四构件，其通过允许记录介质与第三构件协作来固定未定影的调色剂图像。
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37.发明授权Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 有权通过编码Oct3 / 4的逆转录病毒载体进行体细胞重编程。 Klf4，c-Myc和Sox2公开(公告)号：US08129187B2
公开(公告)日：2012-03-06
申请号：US12656907
申请日：2010-02-18
CPC分类号： C07K14/4702 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2740/15043
摘要： The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
摘要翻译： 本发明涉及具有重新编程分化的体细胞以产生诱导多能干细胞（iPS）细胞的作用的核重编程因子。 本发明还涉及上述iPS细胞，产生和维持iPS细胞的方法，以及使用iPS细胞的方法，包括筛选和测试方法以及干细胞治疗方法。 本发明还涉及通过诱导上述iPS细胞的分化衍生的体细胞。
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38.发明授权Laser exposure device and optical axis adjustment method in laser exposure device 有权激光曝光装置中的激光曝光装置和光轴调整方法公开(公告)号：US08054326B2
公开(公告)日：2011-11-08
申请号：US12477961
申请日：2009-06-04
IPC分类号： B41J2/44
CPC分类号： G03G15/04072 , G03G15/0435
摘要： In a laser exposure device according to the present invention, a positioning pin, which is formed in a lens holder supporting a lens system, is inserted through an elongated hole for restriction of a board holder supporting a laser diode. An eccentric cam is inserted into an elongated hole for rotation movement formed in a board holder and a circular hole for rotation movement which is formed in the lens holder and which faces the elongated hole for rotation movement. An eccentric cam is inserted into an elongated hole for slide movement formed in the board holder and a circular hole for slide movement which is formed in the lens holder and which faces the elongated hole for slide movement. The eccentric cams are rotated to relatively move the board holder and lens holder with respect to each other to thereby establish alignment between the optical axes of the laser diode and lens system. In a state where the eccentric cams are fitted into the elongated holes, the board holder and lens holder are fixed to each other by screws.
摘要翻译： 在根据本发明的激光曝光装置中，形成在支撑透镜系统的透镜支架中的定位销被插入通过长孔以限制支撑激光二极管的板支架。 偏心凸轮被插入到用于旋转运动的长孔中，形成在板保持器中的旋转运动和用于旋转运动的圆形孔，其形成在透镜保持器中并面向用于旋转运动的细长孔。 偏心凸轮被插入到用于滑动运动的细长孔中，形成在板保持器中，并且用于滑动运动的圆形孔形成在透镜保持器中并面对用于滑动运动的长孔。 偏心凸轮旋转以相对于彼此相对地移动板保持器和透镜保持器，从而在激光二极管和透镜系统的光轴之间建立对准。 在将偏心凸轮装配到细长孔中的状态下，通过螺钉将板保持器和透镜保持器彼此固定。
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公开(公告)号：US20110242260A1
公开(公告)日：2011-10-06
申请号：US13072404
申请日：2011-03-25
CPC分类号： H04N1/02815 , B41J2/451 , H04N1/02845 , H04N1/02855 , H04N1/02865 , H04N1/02895
摘要： An optical head includes a light-emitting substrate that emits light, a lens that focuses the light emitted from the light-emitting substrate, a holder that hold the light-emitting substrate and the lens, and a drive circuit that includes an electric element fixed to at least one of the lens and the holder and drives the light-emitting substrate.
摘要翻译： 光头包括发光的发光基板，对从发光基板发射的光进行聚焦的透镜，保持发光基板和透镜的保持器以及驱动电路，该驱动电路包括固定的电气元件 到所述透镜和所述保持器中的至少一个并驱动所述发光基板。
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公开(公告)号：US20110223669A1
公开(公告)日：2011-09-15
申请号：US12672042
申请日：2009-06-26
CPC分类号： C12N5/0696 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/11 , C12N2510/00
摘要： The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells, comprising inhibiting the p53 function in the step of somatic cell nuclear reprogramming. The inhibition of p53 function is achieved by bringing a substance selected from the group consisting of (1) chemical inhibitors of p53, (2) dominant negative mutants of p53 and nucleic acids that encode the same, (3) siRNAs and shRNAs against p53 and DNAs that encode the same, and (4) p53 pathway inhibitors, into contact with a somatic cell, and the like. The present invention also provides an agent for improving the efficiency of establishment of iPS cells, the agent comprising an inhibitor of p53 function, particularly (1) chemical inhibitors of p53, (2) dominant negative mutants of p53 and nucleic acids that encode the same, (3) siRNAs and shRNAs against p53 and DNAs that encode the same, and (4) p53 pathway inhibitors. The present invention further provides a method of producing an iPS cell, comprising bringing a nuclear reprogramming substance and an inhibitor of p53 function into contact with a somatic cell.
摘要翻译： 本发明提供了提高诱导多能干细胞（iPS）细胞的建立效率的方法，包括抑制体细胞核重编程步骤中的p53功能。 通过使选自（1）p53的化学抑制剂，（2）p53的显性失活突变体和编码其的核酸，（3）siRNA和shRNA的物质与p53和 编码相同的DNA，（4）p53途径抑制剂，与体细胞接触等。 本发明还提供了用于提高iPS细胞的建立效率的试剂，该试剂包含p53功能的抑制剂，特别是（1）p53的化学抑制剂，（2）p53的显性失活突变体和编码其的核酸 ，（3）针对p53的siRNA和shRNA，编码相同的DNA，以及（4）p53途径抑制剂。 本发明还提供了一种制备iPS细胞的方法，包括使核重编程物质和p53功能抑制剂与体细胞接触。
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