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433 条记录 (耗时 0.047 秒)

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    31.
    发明授权
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
    用于与电力源一起递送治疗剂的内部医疗装置

    公开(公告)号：US08538515B2

    公开(公告)日：2013-09-17

    申请号：US12939363

    申请日：2010-11-04

    申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

    Apparatus for extruding polymers employing microwave energy
    34.
    发明授权
    Apparatus for extruding polymers employing microwave energy 失效
    用于使用微波能量挤出聚合物的装置

    公开(公告)号：US07458798B2

    公开(公告)日：2008-12-02

    申请号：US11563315

    申请日：2006-11-27

    申请人： Jan Weber ,  Scott Schewe

    发明人： Jan Weber ,  Scott Schewe

    IPC分类号： B29C47/86

    CPC分类号： A61M25/1029 ,  A61M25/1027 ,  A61M25/1034 ,  A61M25/1036 ,  B29B13/024 ,  B29C33/06 ,  B29C35/0805 ,  B29C45/14655 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/0033 ,  B29C47/0071 ,  B29C47/86 ,  B29C47/862 ,  B29C47/8835 ,  B29C47/884 ,  B29C47/8895 ,  B29C47/903 ,  B29C47/907 ,  B29C49/0042 ,  B29C49/64 ,  B29C49/66 ,  B29C49/78 ,  B29C49/783 ,  B29C2035/0855 ,  B29C2049/0089 ,  B29C2793/009 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  H05B6/80

    摘要： An apparatus and method for molding balloon catheters is disclosed. The balloon may be molded by providing a polymeric tube within a mold having an interior cavity in the shape of the desired balloon. Microwave energy, which may be generated by a gyrotron, may then be directed toward the mold, to heat the polymeric material without heating the mold. Once heated, pressurized fluid may be injected into the tube to blow the polymeric material against the interior cavity whereupon the material can cool to form the balloon or can be further heatset by additional microwave energy and be cooled to form the balloon. In accordance with one embodiment, microwave energy can also be used without a mold to form a medical device. A polymer extrusion apparatus is disclosed utilizing a microwave energy for heating polymer feedstock material within the extruder tip and die unit just prior to formation of the extrudate product. A cooling bath mechanism, which in one embodiment can also include a cooling tube member having a cooling medium forced therethrough, is also disclosed. An apparatus for preparing polymer disk members, to use as the polymer feedstock material for the microwave extrusion apparatus, is also disclosed. Apparatus for interconnecting and rotating the polymer disk members, the die tip, or the die, or any combination thereof, for creating angularity characteristics in the polymer extrudate, is also disclosed.

    摘要翻译： 公开了一种用于模制球囊导管的装置和方法。 可以通过在具有所需球囊形状的内部空腔的模具内提供聚合物管来模制球囊。 可以由陀螺仪产生的微波能量然后可以被引向模具，以加热聚合材料而不加热模具。 一旦加热，加压流体可以被注入到管中以将聚合物材料吹向内部空腔，由此该材料可以冷却以形成球囊，或者可以通过额外的微波能量进一步热固并被冷却以形成气囊。 根据一个实施例，微波能量也可以在没有模具的情况下用于形成医疗装置。 公开了一种聚合物挤出设备，其利用微波能量来在挤出物产物形成之前在挤出机顶端和模具单元内加热聚合物原料。 还公开了一种冷却浴机构，其在一个实施例中还可以包括具有强制通过其中的冷却介质的冷却管构件。 还公开了一种用于制备用于微波挤出装置的聚合物原料的聚合物盘构件的装置。 还公开了用于互连和旋转聚合物盘构件，模头或模具或其任何组合的装置，用于在聚合物挤出物中产生角度特性。

    Medical devices having inorganic barrier coatings
    40.
    发明授权
    Medical devices having inorganic barrier coatings 有权
    具有无机屏障涂层的医疗器械

    公开(公告)号：US09220818B2

    公开(公告)日：2015-12-29

    申请号：US12501671

    申请日：2009-07-13

    申请人： Torsten Scheuermann ,  Michael Kuehling ,  Jan Weber ,  Dominique Seidel

    发明人： Torsten Scheuermann ,  Michael Kuehling ,  Jan Weber ,  Dominique Seidel

    IPC分类号： A61F2/82 ,  A61K9/22 ,  A61L27/34 ,  A61L31/16 ,  A61L31/08 ,  A61L31/14

    CPC分类号： A61L31/16 ,  A61L31/082 ,  A61L31/146 ,  A61L2300/608 ,  A61L2420/08

    摘要： Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.

    摘要翻译： 具有包含无机材料的阻挡层的医疗装置。 医疗装置具有含有治疗剂的储液器，并且阻挡层设置在贮存器的上方。 在一个方面，阻挡层在医疗装置的一部分处具有对治疗剂的一种渗透性，并且在医疗装置的另一部分具有不同的渗透性。 另一方面，医疗器械的一部分处的储存器中的治疗剂的剂量与医疗器械的另一部分处的储存器中的治疗剂的剂量不同。 在另一方面，生物可再吸收层设置在医疗装置的一个或多个部分的阻挡层之上，其中生物可再吸收层包括生物可再吸收材料。 此外，公开了涂覆医疗装置的方法，其中使用光刻蚀刻工艺形成医疗装置上的阻挡层，其中多个颗粒用作蚀刻掩模。