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    Apparatuses, methods, systems, and computer-readable media for fluid potential artifact correction in reagent delivery systems
    32.
    发明授权
    Apparatuses, methods, systems, and computer-readable media for fluid potential artifact correction in reagent delivery systems 有权

    公开(公告)号：US11169111B2

    公开(公告)日：2021-11-09

    申请号：US16362367

    申请日：2019-03-22

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Chiu Tai Andrew Wong ,  Todd Rearick ,  John Donohue

    IPC: G01N27/414 ,  G16B30/00

    Abstract: A method for correcting nucleotide incorporation signals for fluid potential effects or disturbances arising in nucleic acid sequencing-by-synthesis includes: disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, the template polynucleotide strands having a sequencing primer and a polymerase bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed through a fluid manifold, the fluid manifold comprising passages for flowing nucleotide species and a branch passage for flowing a solution, the branch passage comprising a reference electrode and a sensing electrode; obtaining a plurality of nucleotide incorporation signals corresponding to the plurality of defined spaces, the nucleotide incorporation signals having a signal intensity related to a number of nucleotide incorporations; and correcting at least some of the plurality of nucleotide incorporation signals for fluid potential effects or disturbances.

    WINDOWED SEQUENCING
    33.
    发明申请
    WINDOWED SEQUENCING 审中-公开

    公开(公告)号：US20200332358A1

    公开(公告)日：2020-10-22

    申请号：US16866653

    申请日：2020-05-05

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Mark MILGREW ,  Jonathan SCHULTZ ,  Chris PAPALIAS ,  Kim JOHNSON

    IPC: C12Q1/6874 ,  G16B30/00

    Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors.

    Apparatuses, methods, systems, and computer-readable media for fluid potential artifact correction in reagent delivery systems
    34.
    发明授权
    Apparatuses, methods, systems, and computer-readable media for fluid potential artifact correction in reagent delivery systems 有权

    公开(公告)号：US10416112B2

    公开(公告)日：2019-09-17

    申请号：US14853026

    申请日：2015-09-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Chiu Tai Andrew Wong ,  Todd Rearick ,  John Donohue

    IPC: C12Q1/68 ,  G06F19/22 ,  G01N27/414

    Abstract: A method for correcting nucleotide incorporation signals for fluid potential effects or disturbances arising in nucleic acid sequencing-by-synthesis includes: disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, the template polynucleotide strands having a sequencing primer and a polymerase bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed through a fluid manifold, the fluid manifold comprising passages for flowing nucleotide species and a branch passage for flowing a solution, the branch passage comprising a reference electrode and a sensing electrode; obtaining a plurality of nucleotide incorporation signals corresponding to the plurality of defined spaces, the nucleotide incorporation signals having a signal intensity related to a number of nucleotide incorporations; and correcting at least some of the plurality of nucleotide incorporation signals for fluid potential effects or disturbances.

    System for reducing noise in a chemical sensor array
    35.
    发明授权
    System for reducing noise in a chemical sensor array 有权

    公开(公告)号：US10404249B2

    公开(公告)日：2019-09-03

    申请号：US15984947

    申请日：2018-05-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jeremy Jordan ,  Todd Rearick

    IPC: G06F1/04 ,  H03K3/00 ,  H04N5/222 ,  H03K17/16 ,  G01N27/414 ,  H03K19/003 ,  G06F1/06 ,  G06F1/26

    Abstract: A system including a power supply and a clock circuitry to generate a plurality of clock signals. Each clock signal is synchronous with a primary clock signal. First, second, and third clock signals of the plurality of clock signals are asynchronous to each other. The system further includes a plurality of switches. Each switch of the plurality of switches is communicatively coupled to the power supply and the clock circuitry. A first switch of the plurality of switches receives the first clock signal, a second switch of the plurality of switches receives the second clock signal, and a third switch of the plurality of switches receives the third clock signal.

    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS
    36.
    发明申请
    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS 审中-公开

    公开(公告)号：US20170293713A1

    公开(公告)日：2017-10-12

    申请号：US15498591

    申请日：2017-04-27

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick

    IPC: G06F19/12 ,  C12Q1/68 ,  G06F19/22

    Abstract: A method of modeling a background signal when sequencing a polynucleotide strand using sequencing-by-synthesis includes: flowing a series of nucleotide flows onto a reactor array having multiple reaction confinement regions, one or more copies of the polynucleotide strand being located in a loaded reaction confinement region of the reactor array, the loaded reaction confinement region being located in a vicinity of one or more neighboring reaction confinement regions that may or may not be loaded; receiving output signals from the reactor array; and modeling a background signal for the loaded reaction confinement region using the received output signals and a model adapted to account at least for an exchange of ions between the one or more neighboring reaction confinement regions and a headspace adjacent the loaded reaction confinement region and the one or more neighboring reaction confinement regions.

    System for reducing noise in a chemical sensor array
    38.
    发明授权
    System for reducing noise in a chemical sensor array 有权
    用于降低化学传感器阵列噪声的系统

    公开(公告)号：US08552771B1

    公开(公告)日：2013-10-08

    申请号：US13867959

    申请日：2013-04-22

    Applicant: Life Technologies Corporation

    Inventor： Jeremy Jordan ,  Todd Rearick

    IPC: H03L7/00

    CPC classification number: H03K17/162 ,  G01N27/4145 ,  G06F1/06 ,  G06F1/26 ,  H03K19/00346

    Abstract: A method including receiving an output signal from a sensor array, providing power to the sensor array and to the first analog-to-digital converter, generating a plurality of clock signals that are synchronous with a primary clock signal, providing a first clock signal of the plurality to the first analog-to-digital converter and providing a second clock signal of the plurality to the first switcher. The first clock signal is asynchronous with the second clock signal.

    Abstract translation: 一种方法，包括从传感器阵列接收输出信号，向传感器阵列和第一模 - 数转换器提供电力，产生与主时钟信号同步的多个时钟信号，提供第一时钟信号 所述多个至所述第一模数转换器，并将所述多个第二时钟信号提供给所述第一切换器。 第一个时钟信号与第二个时钟信号是异步的。

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