公开(公告)号：US12239443B2

公开(公告)日：2025-03-04

申请号：US17571723

申请日：2022-01-10

Applicant: Medtronic MiniMed, Inc.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/158 ,  A61M5/172 ,  G01N27/02 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G08B21/18

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US12082929B2

公开(公告)日：2024-09-10

申请号：US17135766

申请日：2020-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/158 ,  A61M5/172 ,  G01N27/02 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M2005/1726

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20220133179A1

公开(公告)日：2022-05-05

申请号：US17571723

申请日：2022-01-10

Applicant: Medtronic MiniMed, Inc.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  G01R35/00 ,  A61B5/1486 ,  A61B5/00 ,  A61M5/142 ,  A61M5/158 ,  G01N33/49 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/0538 ,  A61B5/1473 ,  G01N27/02 ,  G01N27/416 ,  G01N33/66 ,  G01N33/96 ,  A61B5/0537 ,  A61M5/172

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20220095965A1

公开(公告)日：2022-03-31

申请号：US17546159

申请日：2021-12-09

Applicant: Medtronic MiniMed, Inc.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  A61B5/00 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61B5/1459 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/0537 ,  G01N33/66 ,  A61M5/172 ,  G01N27/02 ,  A61B5/0538 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10660555B2

公开(公告)日：2020-05-26

申请号：US16419624

申请日：2019-05-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  A61B5/00 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61B5/1459 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/053 ,  G01N33/66 ,  A61M5/172 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20200077930A1

公开(公告)日：2020-03-12

申请号：US16216838

申请日：2018-12-11

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/145 ,  C12Q1/00 ,  A61B5/1486 ,  G01N27/327

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US20190269355A1

公开(公告)日：2019-09-05

申请号：US16419624

申请日：2019-05-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/053 ,  G01R35/00 ,  G01N33/66 ,  G01N27/416 ,  A61B5/00 ,  G01N33/96 ,  G01N33/49 ,  G01N27/02 ,  A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  A61B5/1486 ,  A61M5/158 ,  A61B5/1459 ,  A61B5/1473

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10321865B2

公开(公告)日：2019-06-18

申请号：US15816559

申请日：2017-11-17

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Raghavendhar Gautham ,  Ning Yang ,  Rajiv Shah

IPC: A61B5/00 ,  A61B5/145 ,  G01N27/02 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/053 ,  G01N33/49 ,  G01N33/66 ,  G01N27/416 ,  G01R35/00 ,  A61M5/158 ,  A61M5/142 ,  A61M5/172 ,  G01N33/96

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10188326B2

公开(公告)日：2019-01-29

申请号：US15272225

申请日：2016-09-21

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: G01N27/327 ,  C12Q1/00 ,  A61B5/145 ,  A61B5/1486

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US10172544B2

公开(公告)日：2019-01-08

申请号：US15701775

申请日：2017-09-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/172 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.