公开(公告)号：US20240339225A1

公开(公告)日：2024-10-10

申请号：US18748589

申请日：2024-06-20

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Jacob N. WOHLSTADTER ,  Michael VOCK ,  Charles M. CLINTON ,  George SIGAL

IPC: G16H50/80 ,  G01N21/76 ,  G06Q50/40 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67 ,  G16H50/20

CPC classification number: G16H50/80 ,  G01N21/76 ,  G06Q50/40 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67 ,  G16H50/20

Abstract: Provided herein are systems, methods, and apparatuses for providing a real-time global bio-surveillance and response solution. The systems and apparatuses may include one or more sentinel subsystems and one or more surge subsystems that each include a real-time, cloud-based, distributed, interconnected set of hardware, software, and/or firmware for comprehensive surveillance, complete detection, and immediate response various to biological, chemical, and/or bio-chemical anomalies, for example, a new or emerging pathogen or other health condition.

公开(公告)号：US20240094233A1

公开(公告)日：2024-03-21

申请号：US18354382

申请日：2023-07-18

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Jacob N. WOHLSTADTER ,  Manish KOCHAR ,  Peter J. BOSCO ,  Ian D. CHAMBERLIN ,  Bandele JEFFREY-COKER ,  Eric M. JONES ,  Gary I. KRIVOY ,  Don E. KRUEGER ,  Aaron H. LEIMKUEHLER ,  Pei-Ming WU ,  Kim-Xuan NGUYEN ,  Pankaj OBEROI ,  Louis W. PANG ,  Jennifer PARKER ,  Victor PELLICIER ,  Nicholas SAMMONS ,  George SIGAL ,  Michael L. VOCK ,  Stanley T. SMITH ,  Carl C. STEVENS ,  Rodger D. OSBORNE ,  Kenneth E. PAGE ,  Michael T. WADE ,  Jon WILLOUGHBY ,  Lei WANG ,  Xinri CONG ,  Kin NG

IPC: G01N35/00 ,  B01L3/00 ,  B01L9/00 ,  F24F11/30 ,  G06K7/14 ,  G06Q10/087 ,  G06Q10/10 ,  G16H10/40 ,  G16H40/40 ,  G16H40/67

CPC classification number: G01N35/0099 ,  B01L3/50853 ,  B01L9/523 ,  F24F11/30 ,  G06K7/1413 ,  G06Q10/087 ,  G06Q10/10 ,  G16H10/40 ,  G16H40/40 ,  G16H40/67 ,  B01L2200/143 ,  B01L2300/021 ,  G01N2035/00356 ,  G05B2219/40269 ,  H04B1/3827

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

公开(公告)号：US20240003925A1

公开(公告)日：2024-01-04

申请号：US18323082

申请日：2023-05-24

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Manish KOCHAR ,  Peter J. BOSCO ,  Ian D. CHAMBERLIN ,  Bandele JEFFREY-COKER ,  Eric M. JONES ,  Gary I. KRIVOY ,  Aaron H. LEIMKUEHLER ,  Pei-Ming WU ,  Kim-Xuan NGUYEN ,  Pankaj OBEROI ,  Louis W. PANG ,  Jennifer PARKER ,  Victor PELLICIER ,  Nicholas SAMMONS ,  George SIGAL ,  Jacob N. WOHLSTADTER ,  Michael L. VOCK ,  Stanley Todd SMITH ,  Carl C. STEVENS ,  Rodger D. OSBORNE ,  Kenneth E. PAGE ,  Michael T. WADE ,  Jon WILLOUGHBY ,  Lei WANG ,  Don E. KRUEGER

IPC: G01N35/00 ,  B01L3/00 ,  B01L9/00 ,  G16H40/67 ,  G16H10/40 ,  G16H40/40 ,  F24F11/30 ,  G06K7/14 ,  G06Q10/087 ,  G06Q10/10

CPC classification number: G01N35/0099 ,  B01L3/50853 ,  B01L9/523 ,  G16H40/67 ,  G16H10/40 ,  G16H40/40 ,  F24F11/30 ,  G06K7/1413 ,  G06Q10/087 ,  G06Q10/10 ,  B01L2200/143 ,  B01L2300/021 ,  G01N2035/00356 ,  G05B2219/40269 ,  H04B1/3827

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

公开(公告)号：US20230175043A1

公开(公告)日：2023-06-08

申请号：US17607731

申请日：2020-04-30

Applicant: Meso Scale Technologies, LLC.

Inventor： John KENTEN ,  Sudeep KUMAR ,  Galina NIKOLENKO ,  Laukik SARDESAI ,  Alexander K. TUCKER-SCHWARTZ ,  George SIGAL ,  Seth Beebe HARKINS ,  Robert UMEK ,  Timothy J. BREAK ,  Laure MOLLER

IPC: C12Q1/6825

CPC classification number: C12Q1/6825 ,  C12Q1/6837 ,  C12Q2600/16

Abstract: Oligonucleotides, methods and kits are provided for detecting, identifying or quantifying one or more target analytes in a sample as well as methods for immobilizing oligonucleotides onto a support surface.

公开(公告)号：US20230061508A1

公开(公告)日：2023-03-02

申请号：US17887191

申请日：2022-08-12

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Scott DOWDELL ,  Nicholas CARBONE ,  Charles CLINTON ,  Mark BILLADEAU ,  Manish KOCHAR ,  Nicholas FOX-LYON ,  Alexander TUCKER-SCHWARTZ ,  George SIGAL ,  Gisbert SPIELES ,  Jules VANDERSARL ,  Jacob WOHLSTADTER ,  Aaron LEIMKUEHLER ,  Jeffrey PETTINGILL ,  Leo TABAKIN ,  Bandele JEFFREY-COKER

IPC: B01L3/00 ,  G01N27/49 ,  G01N27/403 ,  G01N27/327

Abstract: Electrochemical cells and methods for their production are provided. In particular, multi-well assay plates including multi-electrode wells are provided. The multi-electrode wells contain multiple electrodes that are electrically isolated from one another, permitting the various electrodes of the various wells to be addressed in any suitable combination.

公开(公告)号：US20220373554A1

公开(公告)日：2022-11-24

申请号：US17813722

申请日：2022-07-20

Applicant: Meso Scale Technologies, LLC.

Inventor： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC: G01N33/58 ,  G01N21/66

Abstract: The present disclosure provides compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the disclosure relates to an assay composition for detecting Ituninescence, which comprises an alkyl diethanolamine, for example, N-butyldiethanolamnine (BDEA). In emodiments, the assay composition comprises 2-dihutylaminoethanol (BDAE),

公开(公告)号：US20220357318A1

公开(公告)日：2022-11-10

申请号：US17813965

申请日：2022-07-21

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit AGHVANYAN ,  Eli N. GLEZER ,  John KENTEN ,  George SIGAL ,  Martin STENGELIN ,  David ROUTENBERG

IPC: G01N33/543 ,  C12Q1/6832 ,  C12Q1/6837 ,  C12Q1/6844

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

公开(公告)号：US20220018846A1

公开(公告)日：2022-01-20

申请号：US17264489

申请日：2019-12-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC: G01N33/58 ,  G01N21/66

Abstract: The present disclosure provides compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the disclosure relates to an assay composition for detecting luminescence, which comprises an alkyl diethanolamine, for example, N-butyldiethanolamine (BDEA). In embodiments, the assay composition comprises 2-dibutylaminoethanol (BDAE).

公开(公告)号：US20190277855A1

公开(公告)日：2019-09-12

申请号：US16420724

申请日：2019-05-23

Applicant: Meso Scale Technologies, LLC

Inventor： Charles M. CLINTON ,  Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Sandor L. KOVACS ,  Sudeep M. KUMAR ,  George SIGAL ,  Carl STEVENS ,  Michael VOCK

IPC: G01N33/58 ,  G01N21/66 ,  G01N33/53 ,  G01N35/02 ,  B67B7/00 ,  G01N35/10 ,  G01N21/64

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20190187060A1

公开(公告)日：2019-06-20

申请号：US16270062

申请日：2019-02-07

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Charles M. CLINTON ,  Eli N. GLEZER ,  Sharon WEST ,  George SIGAL ,  Carl STEVENS ,  Michael L. VOCK

IPC: G01N21/76 ,  G01N35/02 ,  G01N21/69 ,  G01N35/00

CPC classification number: G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N35/1079 ,  G01N2035/0425 ,  Y10T436/114165

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.