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97 条记录 (耗时 0.057 秒)

    COAPTATION ENHANCEMENT IMPLANT, SYSTEM, AND METHOD
    32.
    发明申请
    COAPTATION ENHANCEMENT IMPLANT, SYSTEM, AND METHOD 有权
    加工植入，系统和方法

    公开(公告)号：US20120197388A1

    公开(公告)日：2012-08-02

    申请号：US13099532

    申请日：2011-05-03

    申请人： Alex Khairkhahan ,  Michael D. Lesh

    发明人： Alex Khairkhahan ,  Michael D. Lesh

    IPC分类号： A61F2/24

    CPC分类号： A61F2/246 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/0412 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/048 ,  A61B2017/0649 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2250/0003

    摘要： Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

    摘要翻译： 植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着 血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空 血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。 在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。 阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。 可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

    TRANSCUTANEOUSLY ADJUSTABLE FLUID-FILLED IMPLANTS
    35.
    发明申请
    TRANSCUTANEOUSLY ADJUSTABLE FLUID-FILLED IMPLANTS 审中-公开
    经过可调节的流体填充的植入物

    公开(公告)号：US20100249946A1

    公开(公告)日：2010-09-30

    申请号：US12412830

    申请日：2009-03-27

    申请人： Michael D. Lesh ,  Stewart Kume ,  Randy J. Kesten ,  Geoffrey Willis ,  Leo Centeno ,  Jeff Christian

    发明人： Michael D. Lesh ,  Stewart Kume ,  Randy J. Kesten ,  Geoffrey Willis ,  Leo Centeno ,  Jeff Christian

    IPC分类号： A61F2/02

    CPC分类号： A61F2/0059 ,  A61F2250/0003

    摘要： Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having a self-sealing membrane operably attached to a wall of the implant. The self-sealing membrane provides access for filling the device, and includes a first layer comprising a fabric. The fabric has a first plurality of yarn strands positioned in a first direction, and a second plurality of yarn strands positioned in a second direction. The first and second plurality of yarn strands intersect to form a matrix pattern with cells defined by free spaces between yarn strands. The membrane also includes a first elastomeric material configured to fill the cells as well as form a coating over the first and second plurality of yarn strand, and a second layer comprising a second elastomeric material. The second elastomeric material has a lower durometer than the first elastomeric material. Kits and systems are also disclosed.

    摘要翻译： 公开了可植入组织增强装置，方法和相关联的工具。 所述装置包括可充气体，其具有可操作地附接到所述植入物的壁的自密封膜。 自密封膜提供用于填充装置的通路，并且包括包括织物的第一层。 织物具有沿第一方向定位的第一多根纱线和位于第二方向上的第二多根纱线。 第一和第二多根纱线相交以形成具有由纱线之间的自由空间限定的细胞的矩阵图案。 膜还包括构造成填充细胞并且在第一和第二多根纱线上形成涂层的第一弹性体材料，以及包含第二弹性体材料的第二层。 第二弹性体材料具有比第一弹性体材料低的硬度。 还披露了套件和系统。

    Catheter system and method for delivery of therapeutic compounds to cardiac tissue
    36.
    发明授权
    Catheter system and method for delivery of therapeutic compounds to cardiac tissue 失效
    导管系统和将治疗化合物递送至心脏组织的方法

    公开(公告)号：US07799011B2

    公开(公告)日：2010-09-21

    申请号：US11809022

    申请日：2007-05-30

    申请人： Michael D. Lesh

    发明人： Michael D. Lesh

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0136 ,  A61B17/22 ,  A61B2017/00243 ,  A61B2017/22082 ,  A61B2017/3488 ,  A61B2018/00273 ,  A61B2018/00815 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2090/3784 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0147 ,  A61N7/02

    摘要： This is a method and an apparatus for the treatment or introduction of contrast fluids into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected treatment or contrast fluid to be confined to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.

    摘要翻译： 这是用于将对比流体治疗或引入组织，特别是心脏组织的方法和装置。 所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除 。 这允许所选择的治疗或造影剂被限制在特定部位。 导管还可以包括可视化组件，其包括在身体的远端处的换能器。

    Tissue Augmentation Device
    38.
    发明申请
    Tissue Augmentation Device 审中-公开
    组织增强装置

    公开(公告)号：US20080275569A1

    公开(公告)日：2008-11-06

    申请号：US11575493

    申请日：2005-09-15

    申请人： Michael D. Lesh

    发明人： Michael D. Lesh

    IPC分类号： A61F2/10 ,  A61B17/3209 ,  A61M29/02

    CPC分类号： A61B17/3468 ,  A61B90/02 ,  A61B2017/00539 ,  A61B2017/00747 ,  A61B2017/00792 ,  A61F2/0036 ,  A61F2/0059 ,  A61F2/12 ,  A61F2250/0003

    摘要： A medical device and methods for filling tissue are disclosed. The device has a first configuration for delivery into tissue to be filled and a second configuration in which the device either expands, or is forced to expand within the tissue to be filled. The exterior profile of the expanded device may be customized along its length, to achieve a desired result. The device is adapted to be placed in the skin, and may be used to reduce facial wrinkles or augment facial features such as the lips.

    摘要翻译： 公开了用于填充组织的医疗装置和方法。 该装置具有用于输送到待填充的组织中的第一构造和第二构造，其中该装置在待填充的组织内膨胀或被迫膨胀。 扩展装置的外部轮廓可以沿其长度被定制，以实现期望的结果。 该装置适于放置在皮肤中，并且可用于减少面部皱纹或增加诸如嘴唇的面部特征。