-
公开(公告)号：US20080274131A1
公开(公告)日：2008-11-06
申请号：US12010107
申请日：2008-01-18
Applicant: Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
Inventor： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
CPC classification number: A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
Abstract translation: 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
-
公开(公告)号：US20080095738A1
公开(公告)日：2008-04-24
申请号：US11664716
申请日：2005-10-05
Applicant: Martin Bachmann , Patrik Maurer , Edwin Meijerink , Katrin Schwarz , Karl Proba
Inventor： Martin Bachmann , Patrik Maurer , Edwin Meijerink , Katrin Schwarz , Karl Proba
IPC: A61K39/39 , A61K39/00 , A61P29/00 , A61P37/00 , A61K39/385
CPC classification number: A61K39/0013 , A61K39/0005 , A61K39/0006 , A61K39/0011 , A61K39/39 , A61K2039/5258 , A61K2039/55511 , A61K2039/55516 , A61K2039/55583 , A61K2039/57 , A61K2039/6075 , C12N2740/16211 , C12N2795/18123
Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly produced in a host, and wherein the amount of host RNA with secondary structure comprised by the VLP is at most 20% of the amount of host RNA with secondary structure originally comprised by the VLP; and wherein the VLP and the at least one antigen are linked with one another. The invention also provides methods for producing the compositions of the invention. The compositions of the invention are useful in the production of vaccines for the treatment of diseases, disorders and conditions. Furthermore, the compositions of the invention are particularly useful to efficiently induce strong antibody responses against the antigen within the indicated context while lowering or eliminating unwanted T cell responses.
Abstract translation: 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含RNA噬菌体的病毒样颗粒（VLP）和至少一种抗原的组合物，其中VLP在宿主中重组产生，并且其中由VLP包含的具有二级结构的宿主RNA的量为 最多20％的具有二级结构的宿主RNA的量最初由VLP组成; 并且其中所述VLP和所述至少一种抗原彼此连接。 本发明还提供了制备本发明组合物的方法。 本发明的组合物可用于生产用于治疗疾病，病症和病症的疫苗。 此外，本发明的组合物特别可用于在降低或消除不想要的T细胞应答的同时在指定的上下文中有效地诱导针对抗原的强抗体应答。
-
公开(公告)号：US20070128219A1
公开(公告)日：2007-06-07
申请号：US11601687
申请日：2006-11-20
Applicant: Martin Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
Inventor： Martin Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
IPC: A61K39/395 , A61K39/12
CPC classification number: C12N7/00 , A61K39/00 , A61K39/0005 , A61K39/35 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K14/5409 , C07K16/24 , C07K16/40 , C07K2317/34 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N2795/18122 , C12N2795/18123 , Y02A50/412
Abstract: The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
Abstract translation: 本发明提供包含AP205病毒样颗粒（VLP）和抗原的组合物。 本发明还提供了一种制备与AP205 VLP结合的抗原或抗原决定簇的方法。 与抗原结合的AP205 VLP可用于产生用于诱导免疫应答的组合物，其可用于预防或治疗疾病，病症或病症，包括感染性疾病，过敏，癌症，药物成瘾，中毒，并有效诱导自身特异性 免疫应答，特别是抗体应答。
-
公开(公告)号：US20070117129A1
公开(公告)日：2007-05-24
申请号：US11589321
申请日：2006-10-30
Applicant: Martin Bachmann , Patrik Maurer , Gunther Spohn
Inventor： Martin Bachmann , Patrik Maurer , Gunther Spohn
CPC classification number: A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
Abstract translation: 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。 更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
-
35.发明申请公开(公告)号：US20060251677A1
公开(公告)日：2006-11-09
申请号：US10550518
申请日：2004-03-25
Applicant: Martin Bachmann , Andreas Cornelius , Vania Manolova , Patrik Maurer , Edwin Meijerink , Karl Proba , Katrin Schwarz
Inventor： Martin Bachmann , Andreas Cornelius , Vania Manolova , Patrik Maurer , Edwin Meijerink , Karl Proba , Katrin Schwarz
CPC classification number: C12N15/117 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/5258 , A61K2039/55561 , A61K2039/6075 , C07K14/005 , C07K14/4748 , C07K2319/00 , C12N2310/18 , C12N2710/20022 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2740/16222 , C12N2740/16234 , C12N2760/10022 , C12N2760/10034 , C12N2795/18122 , C12N2795/18123 , Y02A50/467
Abstract: The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
-
Patent Agency Ranking
公开(公告)号：US20050002742A1
公开(公告)日：2005-01-06
申请号：US10728181
申请日：2003-12-04
Applicant: Martin Bachmann
Inventor： Martin Bachmann
CPC classification number: B05B7/1459 , B65G53/28
Abstract: In a piston metering pump for supplying the atomizer of a powder coating machine, the vacuum generated in the pump chamber during the suction movement of the piston is reduced in controlled fashion by introducing transport air in order to reduce the powder throughput.
Abstract translation: 在用于供应粉末涂布机的雾化器的活塞计量泵中，在活塞抽吸运动期间在泵室中产生的真空通过引入输送空气以受控的方式减少，以便降低粉末生产量。
-
公开(公告)号：US08344111B2
公开(公告)日：2013-01-01
申请号：US12745537
申请日：2008-09-11
Applicant: Martin Bachmann , Monika Bauer , Roger Beerli , Patrik Maurer
Inventor： Martin Bachmann , Monika Bauer , Roger Beerli , Patrik Maurer
IPC: C07K16/00 , A61K39/395
CPC classification number: C07K16/00 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92
Abstract: The invention relates to recombinantly produced human monoclonalantibodies which are specifically binding nicotine and to nucleic acids encoding the same. The invention further relates to the use of such antibodies in the treatment of nicotine addiction.
Abstract translation: 本发明涉及重组产生的特异性结合尼古丁的人单克隆抗体和编码该烟碱的核酸。 本发明还涉及这种抗体在治疗尼古丁成瘾中的用途。
-
公开(公告)号：US20110081371A1
公开(公告)日：2011-04-07
申请号：US12654758
申请日：2009-12-30
Applicant: Martin Bachmann
Inventor： Martin Bachmann
IPC: A61K39/12 , C07K7/14 , A61K38/08 , A61P9/12 , A61P9/00 , A61P9/10 , A61P9/04 , A61P13/12 , A61P7/04 , A61P37/04
CPC classification number: A61K39/0005 , A61K38/00 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6031 , A61K2039/6075 , A61K2039/627 , C07K5/1021 , C07K7/14 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/26 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
Abstract: The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the renin-activated angiotensin system.
Abstract translation: 本发明提供了哺乳动物肽激素血管紧张素原，血管紧张素I和血管紧张素II的肽衍生物的缀合物，其通过将肽衍生物偶联到载体，特别是病毒样颗粒（VLP）而呈现在重复的支架中。 本发明还提供了产生这种缀合物的方法，以及所得到的免疫原缀合物的免疫治疗用途，用于治疗和预防与肾素激活的血管紧张素系统相关的病症。
-
公开(公告)号：US20100119540A1
公开(公告)日：2010-05-13
申请号：US12594650
申请日：2008-04-18
Applicant: Martin Bachmann , Patrik Maurer , Philipp Muller , Thomas Pfister , Wolfgang Renner
Inventor： Martin Bachmann , Patrik Maurer , Philipp Muller , Thomas Pfister , Wolfgang Renner
IPC: A61K39/385
CPC classification number: A61K39/0013 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/55505
Abstract: This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibody responses in a vaccinated subject. The invention further provides a method for prevention or treatment of a disease by inducing hapten-specific antibodies in a subject comprising administering into said subject a composition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto.
Abstract translation: 本发明涉及疫苗接种和治疗或预防疾病领域。 特别地，本发明涉及通过在接种疫苗的受试者中诱导半抗原特异性抗体应答来治疗或预防疾病。 本发明还提供了通过在受试者中诱导半抗原特异性抗体来预防或治疗疾病的方法，所述方法包括向所述受试者施用包含RNA噬菌体的病毒样颗粒和至少一种与其连接的半抗原的组合物。
-
公开(公告)号：US07666408B2
公开(公告)日：2010-02-23
申请号：US11540969
申请日：2006-10-02
Applicant: Martin Bachmann
Inventor： Martin Bachmann
CPC classification number: A61K39/0005 , A61K38/00 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6031 , A61K2039/6075 , A61K2039/627 , C07K5/1021 , C07K7/14 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/26 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
Abstract: The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the renin-activated angiotensin system.
Abstract translation: 本发明提供了哺乳动物肽激素血管紧张素原，血管紧张素I和血管紧张素II的肽衍生物的缀合物，其通过将肽衍生物偶联到载体，特别是病毒样颗粒（VLP）而呈现在重复的支架中。 本发明还提供了产生这种缀合物的方法，以及所得到的免疫原缀合物的免疫治疗用途，用于治疗和预防与肾素激活的血管紧张素系统相关的病症。
-
-
-
-
-
-
-
-
-
Search Results
47
records
(took 0.038 seconds)
