利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

83 条记录 (耗时 0.037 秒)

    Method of the solid phase synthesis of pyrrole-imidazole polyamide
    31.
    发明授权
    Method of the solid phase synthesis of pyrrole-imidazole polyamide 失效
    吡唑咪唑聚酰胺的固相合成方法

    公开(公告)号：US07067622B2

    公开(公告)日：2006-06-27

    申请号：US10481275

    申请日：2002-02-27

    申请人： Hiroshi Sugiyama ,  Hirokazu Iida ,  Isao Saito ,  Takashi Saito

    发明人： Hiroshi Sugiyama ,  Hirokazu Iida ,  Isao Saito ,  Takashi Saito

    IPC分类号： C07K1/02

    CPC分类号： C07D403/14

    摘要： It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.

    摘要翻译： 本发明提供一种制备吡咯 - 咪唑聚酰胺的方法，其中可以方便地合成较长的吡咯 - 咪唑聚酰胺，并且可以容易地转移肽（蛋白质）。 根据该方法，可以在其末端从固相载体上切割出具有羧酸酯基的吡咯 - 咪唑聚酰胺，从而可以直接转移各种官能团，并且能够精确地区分DNA序列。 一种合成吡咯 - 咪唑聚酰胺的方法，其特征在于使用肽合成仪通过固相Fmoc法进行自动合成; 通过该方法得到的具有羧基的吡咯 - 咪唑聚酰胺; 具有在上述吡咯 - 咪唑聚酰胺末端转移到羧基中的DNA烷基化剂的吡咯 - 咪唑聚酰胺; 特征在于使用上述化合物的序列特异性DNA烷基化方法。

    Interstrand crosslinking agents for DNA and compounds therefor
    32.
    发明授权
    Interstrand crosslinking agents for DNA and compounds therefor 失效
    Interstrand交联剂用于DNA及其化合物

    公开(公告)号：US06946455B2

    公开(公告)日：2005-09-20

    申请号：US10030678

    申请日：2001-05-01

    申请人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Hirokazu Iida ,  Isao Saito

    发明人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Hirokazu Iida ,  Isao Saito

    IPC分类号： C12N15/00 ,  A61K31/407 ,  A61P35/00 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00 ,  C12N15/01 ,  C12N15/09 ,  A61K31/33 ,  A01N43/38 ,  A01N43/90 ,  A61K31/44 ,  C07D209/56

    CPC分类号： C07D487/04 ,  C07D487/10

    摘要： Compounds represented by the general formula (I): which two DNA strands can be interstrand-crossliked: A-L-B-X-B-L-A  (I) wherein B represents a chemical structure capable of recognizing the nucleotide sequence of DNA; A represents a chemical structure capable of binding to one of the bases of DNA; L represents a linker by which the chemical structures of A and B can be linked to each other; X represents a spacer by which the A-L-B components can be linked to each other. A method of interstrand-crosslinking DNA by using these compounds; and medicinal compositions containing interstarand-crosslinking agents of DNA.

    摘要翻译： 由通式（I）表示的化合物：两个DNA链可以是交联的：<？in-line-formula description =“In-line Formulas”end =“lead”？> ALBXBLA（I） line-formula description =“In-line Formulas”end =“tail”？>其中B表示能识别DNA核苷酸序列的化学结构; A表示能够结合DNA的一个碱基的化学结构; L表示A和B的化学结构可以彼此连接的连接体; X表示可以将A-L-B成分彼此连接的间隔物。 通过使用这些化合物进行链间交联DNA的方法; 以及含有星际交联剂的DNA的药物组合物。

    Benzodeazaadenine derivative base and electronic material containing the same
    33.
    发明申请
    Benzodeazaadenine derivative base and electronic material containing the same 失效
    苯并恶唑衍生物基质和含有它们的电子材料

    公开(公告)号：US20050142554A1

    公开(公告)日：2005-06-30

    申请号：US10508138

    申请日：2002-08-15

    申请人： Isao Saito ,  Akimitsu Okamoto ,  Kazuo Tanaka

    发明人： Isao Saito ,  Akimitsu Okamoto ,  Kazuo Tanaka

    IPC分类号： C07H19/14 ,  C07H19/04 ,  C07H19/22 ,  C07H19/23 ,  C07H21/04 ,  H01L51/30 ,  C12Q1/68 ,  C12M1/34

    CPC分类号： C07H21/04 ,  B82Y10/00 ,  C07H19/04 ,  C07H19/22 ,  C07H19/23 ,  H01L51/0072 ,  H01L51/0093

    摘要： A nucleic acid base for hole transportation in DNAs which does not cause oxidative decomposition; and an artificial DNA molecule which can realize effective hole transportation in DNAs while maintaining the double spiral structure of the DNAs. Provided are: a nucleic acid which contains a benzodeazaadenine derivative base represented by the general formula (I): (wherein R1, R2, R3, R4, R5, and R6 each independently represents hydrogen, amino, mono (lower alkyl) amino, di (lower alkyl) amino, hydroxy, lower alkoxy, halogeno, cyano, mercapto, lower alkylthio, or aryl; and R7 and R8 each independently represents hydrogen or a group bonded to phosphoric acid); and a polynucleotide comprising the nucleic acid.

    摘要翻译： DNA不会引起氧化分解的空穴传输核酸碱基; 以及能够在保持DNA的双螺旋结构的同时实现DNA中有效空穴传输的人造DNA分子。 提供：含有由通式（I）表示的苯并恶唑腺苷衍生物碱的核酸：其中R 1，R 2，R 3， R 3，R 5，R 5和R 6各自独立地表示氢，氨基，单（低级烷基）氨基，二（低级 烷基）氨基，羟基，低级烷氧基，卤代，氰基，巯基，低级烷硫基或芳基; R 7和R 8各自独立地表示氢或键合到 磷酸）; 和包含该核酸的多核苷酸。

    Magnetic reproducing apparatus with head positioning circuit
    36.
    发明授权
    Magnetic reproducing apparatus with head positioning circuit 失效
    带磁头定位电路的磁性重放装置

    公开(公告)号：US4825311A

    公开(公告)日：1989-04-25

    申请号：US385934

    申请日：1982-06-07

    申请人： Isao Saito

    发明人： Isao Saito

    IPC分类号： H04N5/7826 ,  G11B5/588 ,  G11B5/592 ,  G11B21/10

    CPC分类号： G11B5/592 ,  G11B5/588

    摘要： A magnetic reproducing apparatus comprises two rotary magnetic heads mounted on respective bimorphs, the heads being displaceable in the transverse direction relative to recorded tracks on a magnetic tape is response to control voltages applied to the respective bimorphs to effect correct scanning of the tracks, a pulse generator for generating a first pulse signal of frequency dependent on the transport speed of the tape, a first counter for counting the pulses of the first pulse signal to produce a first count output each time a head completes scanning of a track, a second counter which, starting from the first count output, counts the pulses of a second pulse signal which has a frequency which is an integral multiple of the frequency of the first pulse signal and produces a second count output, and a circuit to derive from the second count output control voltages for supply to the bimorphs to preset the positions of the heads relative to the tracks each time a head is to start scanning a track. The apparatus further comprises a third counter for counting the pulses of the first pulse signal to produce a respective third count output corresponding to each scan of a track by a head, a subtractor to derive a difference output from each third count output and the immediately preceding third count output, and an adder to add the difference output to the second count output prior to supply to the circuit for deriving the control voltage, whereby the control voltages are modified in dependence on acceleration or deceleration of the transport speed of the tape.

    摘要翻译： 磁性重放装置包括安装在相应的双压电晶片上的两个旋转磁头，磁头相对于磁带上记录的磁道在横向方向上可移动，对施加于相应双压电体的控制电压的响应是对磁道的正确扫描，脉冲 发生器，用于根据磁带的传输速度产生频率的第一脉冲信号;第一计数器，用于对每个磁头完成磁道扫描的第一脉冲信号的脉冲进行计数以产生第一计数输出;第二计数器， 从第一计数输出开始，对具有作为第一脉冲信号的频率的整数倍的频率的第二脉冲信号的脉冲进行计数，并产生第二计数输出，以及从第二计数输出 用于供应双压电晶片的控制电压，以便在每次头部开始扫描时预设头部相对于轨道的位置 一条轨道。 该装置还包括第三计数器，用于对第一脉冲信号的脉冲进行计数，以产生对应于由磁头对磁道的每次扫描相应的相应的第三计数输出;减法器，用于导出从每个第三计数输出和紧接在前的 第三计数输出，以及加法器，用于在提供给用于导出控制电压的电路之前将差分输出加到第二计数输出，由此根据带的传输速度的加速或减速来修改控制电压。

    Anti-depressant imidazoles
    39.
    发明授权
    Anti-depressant imidazoles 失效
    抗抑郁咪唑

    公开(公告)号：US4533669A

    公开(公告)日：1985-08-06

    申请号：US469548

    申请日：1983-02-25

    申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

    CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： An anti-depressant imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts. These compounds are useful as agents for treating depression and depressive states.

    摘要翻译： 一种下式的抗抑郁咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基， 杂环氨基，卤素或者其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，单 - 或二 - 低级烷基氨基烷基，未取代的苯基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基，苯基氨基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基氨基）。 及其药学上可接受的酸加成盐。 这些化合物可用作治疗抑郁和抑郁状态的药剂。