摘要:
Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
摘要:
A security closure for enclosing the top opening of a container includes a cap having a plurality of flexible, independently movable skirt portion segments which are positionable under a rib of the container. A wire engaging the skirt portion segments cooperates with a pivoted lever to move the skirt portion segments into latching position relative to the container and a lock is employed to maintain the wire tightened against the skirt portion segments.
摘要:
A circuit arrangement for the linearization and temperature compensation of capacitive sensor signals is provided which requires few components and wherein the compensated input signal is obtained fast. The arrangement includes: a clock generator; a reference capacitor; a measuring capacitor; a temperature-dependent voltage divider connected between an operating and a reference potential which measures the temperature of the measuring capacitor; an adjusting circuit which acts on the measuring capacitor and the reference capacitor and having a first input connected to the operating potential, a second input connected to the voltage divider, and a third input; an integrating stage connected to the measuring capacitor and the reference capacitor and having its output coupled to the third input of the adjusting circuit, the output being the output of the arrangement. The output signal is ##EQU1## where C.sub.v =(C.sub.m -C.sub.r)/C.sub.m, (C.sub.m -C.sub.r)/(C.sub.m +C.sub.r) , or (C.sub.m -C.sub.r)/C.sub.r ; C.sub.m is the capacitance of the capacitor; C.sub.r is the capacitance of the reference capacitor; U is the operating potential; a.sub.0 is a zero adjustment value; a.sub.1 is a temperature coefficient zero adjustment value; a.sub.2 is a first span adjustment value; a.sub.3 is a temperature coefficient span adjustment value; b.sub.0 is a second span adjustment value; b.sub.1 is a linearization adjustment value, and v.sub.1 is the temperature-dependent resistance ratio of the voltage divider.
摘要:
The arrangement serves for the processing of sensor signals which are furnished by a capacitive sensor which includes a measuring capacitor having a measuring capacitance influenceable by a physical measured quantity to be determined and at least one reference capacitor having a reference capacitance influenceable in another manner and furnishing a measuring effect dependent on the measuring capacitance and the reference capacitance. The arrangement comprises a signal processing circuit which operates by the principle of quantized charge transport by means of switch-capacitor structures and charge balancing at least in time average and which receives the sensor signals representing the measuring effect and furnishes an output signal corresponding to the measuring effect. The first electrodes of the capacitors of the sensor are at a fixed potential and their second electrodes are connectable for performing the charge transport to the first input of an input operational amplifier, the second input of which lies at a reference potential. The reverse charging of the capacitors of the sensor necessary for forming the transported charge packets is effected by switching over the reference potential of the input operational amplifier. This permits a one-sided fixed binding of the sensor capacitors to any desired potential.
摘要:
The present invention relates to systems and methods for model generation. The model is generated by selecting indicators that are relevant to the model, determining a strength score for each of the indicators, ranking the indicators by their strength scores, and bucketizing the indicators. Different permutations of the indicators are then selected for modeling in parallel. The model results are compared, and the ‘best’ model (most historically accurate) is selected for display within a report.
摘要:
The invention relates to a measuring device for measuring at least one property of cells or vesicles, characterized in that is divided into two chambers by a hydrophobic partition having a horizontal opening, these chambers containing electrolyte solution and said opening being closed by a lipid double layer. The invention is characterized in that at least one cell or vesicle contacts the lipid double layer. The invention also relates to methods involving the use of the measuring device and to arrays, measuring chambers and microtitration plates all suited therefor.
摘要:
The present invention is to a safe, biodegradable trace metal binding system that effectively delivers chromium, cobalt, copper, iron, manganese, molybdenum, selenium and zinc to animals. The method of preparing an animal foodstuff composition involves the steps of: providing transgenic algal cells comprising a nucleotide sequence, the nucleotide sequence being capable of expressing a non-native metal-binding protein in the transgenic algal cells; binding the metal-binding protein with at least one metal so as to produce a metal-bound adduct of the metal-binding protein; and admixing the metal-bound adduct with animal foodstuff. The invention is also to a animal foodstuff composition comprising animal foodstuff and transgenic algal cells expressing a non-native metal-binding protein in the transgenic algal cells, such that the transgenic algal cells contain the metal-binding protein and the metal-binding protein being bound to a metal.
摘要:
The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.