摘要:
Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要:
Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要:
Various apparatuses and methods for forming integrated circuit packages are described. One aspect of the invention pertains to an integrated circuit package in which one or more integrated circuits are embedded in a substrate and covered with a layer of photo-imageable epoxy. The substrate can be made of various materials, including silicon, quartz and glass. An integrated circuit is positioned within a cavity in the top surface of the substrate. The epoxy layer is formed over the top surface of the substrate and the active face of the integrated circuit. An interconnect layer is formed over the epoxy layer and is electrically coupled with the integrated circuit.
摘要:
Systems and methods for field data gathering and which provide flexible configuration options for a central office. The system, run from, mobile computing devices, provides a free-flowing data gathering experience while only requiring what the central office needs from the field. The central office can configure the system to accept different types of data by way of different data input means available to the mobile computing device. Only the data needed by the central office need be collected by the mobile device operator. The data format is defined by the central office and is uploaded to each of the relevant mobile computing devices for use by the operators. Once each data set has been collected by an operator, the data package with the data set is scheduled for transmission to the central office once a connection with the central office can be made.
摘要:
System and method for version string generation for artifacts in a repository is disclosed. A first source code management server manages first source code versions in a first repository and assigns a first source code version string to each first source code version. A first artifact repository comprises a first artifact built based on one of the first source code versions. A product manager generates a first artifact version string for the first artifact based on the first source code version string of the first source code version used to build the first artifact.
摘要:
System and method for generating meta-data for a product is disclosed. An artifact repository stores first artifacts for building the product. The artifact repository stores first meta-data for one or more of the artifacts in the repository. A build manager builds second artifacts for the product from source code and one or more of the first artifacts based on information in a project script. The build manager is adapted to combine the first meta-data for each of the one or more of the first artifacts used to build the second artifact to form second meta-data for each of the second artifacts.
摘要:
A micro-electromechanical systems (MEMS) relay includes a switch with a first contact region and a second contact region that are vertically separated from each other by a gap. The MEMS relay requires a small vertical movement to close the gap and therefore is mechanically robust. In addition, the MEMS relay has a small footprint and, therefore, can be formed on top of small integrated circuits.
摘要:
Techniques for enabling real-time automated interpretation of clinical narratives are disclosed. The automated interpretation can be achieved by translating narrative text into a clinical terminology-encoded structural representation such as the Systemized Nomenclature of Medicine-Clinical Terms (SNOMED-CT) example of such a clinical terminology. The translation process enables the generation of both pre-coordinated and post-coordinated SNOMED CT concept expressions.
摘要:
Systems and methods for implementing an identity assertion framework to authenticate a user in a federation of security domains are provided. A first security token service (STS) is configured to receive a request for a first token from a consumer and to issue the first token to the consumer. The first STS is associated with a first security domain, and the first token is issued according to a first issuing policy of the first security domain. A service provider within a second security domain receives the first token and makes a determination whether the first token is invalid in the second security domain. A second STS receives the first token from the service provider, determines that the first token was issued by the first STS, and validates the first token according to a federation policy between the first security domain and the second security domain.
摘要:
A method for forming a capacitive micromachined ultrasonic transducer (CMUT) includes forming multiple CMUT elements in a first semiconductor-on-insulator (SOI) structure. Each CMUT element includes multiple CMUT cells. The first SOI structure includes a first handle wafer, a first buried layer, and a first active layer. The method also includes forming a membrane over the CMUT elements and forming electrical contacts through the first handle wafer and the first buried layer. The electrical contacts are in electrical connection with the CMUT elements. The membrane could be formed by bonding a second SOI structure to the first SOI structure, where the second SOI structure includes a second handle wafer, a second buried layer, and a second active layer. The second handle wafer and the second buried layer can be removed, and the membrane includes the second active layer.