公开(公告)号：US20210229098A1

公开(公告)日：2021-07-29

申请号：US17229086

申请日：2021-04-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Thomas Fischer ,  Eloisa Lopez-Calle ,  Sascha Lutz ,  Josef Roedl ,  Juergen Spinke ,  Pamela Espindola ,  Thomas Manuel Keller ,  Thomas Dolbinow ,  Sabrina Adler ,  Erik Beiersdorf ,  Domenik Wensorra

IPC: B01L3/00 ,  G01N35/00

Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.

公开(公告)号：US10330693B2

公开(公告)日：2019-06-25

申请号：US15132915

申请日：2016-04-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Peter Kupser ,  Norbert Oranth ,  Juergen Spinke ,  Thorsten Brueckner ,  Timo Klein

IPC: B01L3/02 ,  G01N35/10 ,  G01F11/02 ,  B01L3/00 ,  G01N35/00 ,  A61M5/142 ,  A61M5/168

Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.

公开(公告)号：US10307757B2

公开(公告)日：2019-06-04

申请号：US15833476

申请日：2017-12-06

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10

Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. Capillary action next to the side walls is greater than in the central region. A circular arc about the rotational axis passes through a duct entrance in the aliquoting chamber and a duct exit in the metering chamber. The cartridge has a downstream fluidic element which is part of a fluidic structure for processing a biological sample into the processed biological sample. A valve connects the metering chamber to the fluidic element, which is fluidically connected to the fluidic structure. The fluidic structure receives the biological sample and has a measurement structure for enabling measurement of the processed biological sample.

公开(公告)号：US10241124B2

公开(公告)日：2019-03-26

申请号：US15092806

申请日：2016-04-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Manfred Augstein ,  Nadine Losleben ,  Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke

IPC: C12M1/00 ,  G01N35/10 ,  B01L3/02 ,  G01F11/08 ,  B01L3/00 ,  G01N35/00

Abstract: A method of performing a measurement of an analyte in a sample using an automatic analyzer is provided. The automatic analyzer comprises: a cartridge for dispensing a fluid, a measurement unit for performing the measurement, a sample holder for receiving the sample, and a pump for pumping the fluid out of the cartridge and into the sample holder. The cartridge comprises: a rigid portion, a flexible bladder, and an outlet. The rigid portion comprises an opening, which is connected to an inner cavity. The flexible bladder seals the opening to form a fluid chamber from the inner cavity. The fluid chamber is at least partially filled with the fluid. The pump is connected to the outlet. The method comprises: placing the sample into the sample holder, controlling the pumping of the fluid from the cartridge into the sample holder, and performing the measurement of the analyte using the measurement unit.

公开(公告)号：US20180221872A1

公开(公告)日：2018-08-09

申请号：US15943093

申请日：2018-04-02

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N35/00 ,  G01N35/10 ,  G01N1/38

CPC classification number: B01L3/50273 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/04 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N1/38 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00247 ,  G01N2035/00257 ,  G01N2035/1032 ,  G01N2035/1034

Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.

公开(公告)号：US10031053B2

公开(公告)日：2018-07-24

申请号：US15208211

申请日：2016-07-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm

IPC: G01N1/38 ,  B01F1/00 ,  B01F13/00 ,  B01F3/00 ,  B01F15/02 ,  B01F15/04 ,  B01L3/00 ,  G01N21/07

CPC classification number: G01N1/38 ,  B01F1/0022 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01F15/0404 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0409 ,  B01L2400/0688 ,  G01N21/07 ,  G01N2001/386 ,  Y10T436/25

Abstract: A microfluidic element for thoroughly mixing a liquid with a reagent used for the analysis of the liquid for an analyte contained therein and a method thereof are disclosed. The microfluidic element has a substrate and a channel structure. The channel structure includes an elongate mixing channel and an output channel. The mixing channel has an inlet opening and an outlet opening, and is implemented to mix the reagent contained therein with the liquid flowing through the inlet opening into the mixing channel. The outlet opening of the mixing channel is in fluid communication to the output channel. The outlet opening is positioned closer to the middle of the length of the mixing channel than the inlet opening.

公开(公告)号：US10018644B2

公开(公告)日：2018-07-10

申请号：US15006476

申请日：2016-01-26

Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Technologies Corporation

Inventor： Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke ,  Terumi Tamura ,  Taku Sakazume ,  Kyoko Imai

IPC: B01L3/00 ,  G01N35/10 ,  B01L3/02

CPC classification number: G01N35/1002 ,  B01L3/0268 ,  B01L3/0286 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/082 ,  G01N35/1009

Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid. The reservoir chamber has a fluid outlet. The cartridge further comprises a controllable dispenser component for dispensing a dispensing volume of the fluid from the reservoir chamber. The dispenser component is connected to the fluid outlet of the reservoir. The cartridge further comprises a single compressible fluid pump with a single elastic pumping element and a conduit extending from the fluid pump towards the fluid outlet. The fluid pump discharges a mixing volume of the fluid from the conduit into the reservoir chamber upon compression of the elastic pumping element. The mixing volume depends on the degree of compression of the elastic pumping element. The fluid pump sucks in the mixing volume from the reservoir into the conduit upon decompression of the elastic pumping element.

公开(公告)号：US10016758B2

公开(公告)日：2018-07-10

申请号：US15352689

申请日：2016-11-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz

IPC: G01N1/38 ,  G01N35/00 ,  B01L3/00 ,  G01N35/10

CPC classification number: B01L3/50273 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N1/38 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00237 ,  G01N2035/00257 ,  G01N2035/1032 ,  G01N2035/1034

Abstract: An automatic analyzer cartridge spinnable around a rotational axis has a fluid chamber for receiving a fluid, an aliquoting chamber, a duct connecting the fluid chamber and the aliquoting chamber, a downstream fluidic element, a siphon for siphoning the fluid from the aliquoting chamber to the downstream fluidic element, a fluidic structure for processing a biological sample into the processed biological sample, and a measurement structure for enabling measurement of the processed biological sample. The siphon has a siphon entrance in the aliquoting chamber and a siphon exit in the downstream fluidic element, wherein the siphon has a bend, wherein the bend is the portion of the siphon closest to the rotational axis, wherein the siphon entrance starts at the bend, wherein the siphon entrance extends to a lower portion of the aliquoting chamber. This enables multiple aliquots of fluid to be removed from the aliquoting chamber by the siphon.

公开(公告)号：US09808801B2

公开(公告)日：2017-11-07

申请号：US15343389

申请日：2016-11-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Thomas Dolbinow

IPC: G01N21/07 ,  G01N35/00 ,  B01L3/00 ,  G01N35/10

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2300/041 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/0858 ,  B01L2300/087 ,  B01L2300/16 ,  B01L2400/0409 ,  B01L2400/0683 ,  G01N35/00069 ,  G01N35/1079

Abstract: A cartridge for an automatic analyzer, formed from a cover and carrier structure, is operable for rotation about an axis and has at least one container with at least one reservoir containing at least one fluid. Each container may rotate about the axis within a cavity and relative to the carrier structure. A piercing structure opens a seal of each reservoir when the container rotates relative to the carrier structure. Each container and each cavity has a frictional element that mate and cause friction. Each container has an engaging surface which mates with an engaging surface of a rotational actuator that applies torque to rotate and open the container via the piercing structure. A fluidic structure of the cartridge processes a biological sample into a processed biological sample and enables via a measurement structure measurement of the processed biological sample. A duct is between the cavity and the fluidic structure.

公开(公告)号：US20200038858A1

公开(公告)日：2020-02-06

申请号：US16599673

申请日：2019-10-11

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N35/10 ,  G01N35/00 ,  G01N1/38

Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.