摘要:
Disclosed is a substance which has a low molecular weight, can be applied in a simpler manner, and has an immunopotentiating activity against cancer and/or a microorganism-mediated infectious disease.An EP4 agonist exhibits an immunopotentiating activity through the activation of a cytotoxic T cell, and is therefore useful for the prevention and/or treatment of cancer or a microorganism-mediated infection disease.
摘要:
A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要:
A memory cell system is provided including a first insulator layer over a semiconductor substrate, a charge trap layer over the first insulator layer, and slot where the charge trap layer includes a second insulator layer having the characteristic of being grown.
摘要:
A silicon carbide single crystal wafer wherein a substrate is cut out at an OFF angle from a (0001) c plane of an α-type silicon carbide single crystal of less than 2° and in an OFF direction in which a deviation from a (11-20) direction is less than 10°, the number of substantially triangular lamination defects exposed from a surface of a wafer which is epitaxial grown on the substrate is less than 4/cm2 over the entire surface of the wafer. The invention provides a producing method of a silicon carbide single crystal wafer capable of enhancing the utility ratio of the bulk silicon carbide single crystal, the element characteristics and the cleavage, as well as a silicon carbide single crystal wafer obtained by such a producing method.
摘要翻译:一种碳化硅单晶晶片,其中从与α(α)的α型碳化硅单晶的(0001)c面成OFF角切割基板,在偏离方向偏离(11 -20)方向小于10°时,从在晶片外延生长的晶片的表面露出的基本上三角形层叠缺陷的数量在晶片的整个表面上小于4 / cm 2。 本发明提供了一种能够提高体积碳化硅单晶的利用率,元素特性和切割的碳化硅单晶晶片的制造方法以及通过这种制造方法获得的碳化硅单晶晶片。
摘要:
An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
摘要:
(1) A preventive and/or a remedy for lower urinary tract diseases such as inflammation in the lower urinary tract, cystitis (interstitial cystitis, etc.) and urethritis; (2) an agent for improving bladder compliance and/or bladder capacity; and (3) an agent for protecting bladder mucosa and/or bladder epithelial cells and/or promoting the regeneration thereof; each containing an EP4 agonist. An EP4 agonist is useful in ameliorating symptoms of lower urinary tract diseases such as (1) frequent urination, (2) urgency of urination, (3) pain in the reproductive organs and/or lower urinary tract (for example, bladder pain, urinary tract pain, vulvar pain, vaginal pain, scrotal pain, perineal pain, pelvic pain, etc.) and/or (4) discomfort in the reproductive organs and/or lower urinary tract. Among all, a selective EP4 agonist is useful as a preventive and/or remedy for lower urinary tract diseases having no side effect.
摘要翻译:(1)下泌尿道疾病如下泌尿道炎症,膀胱炎(间质性膀胱炎等)和尿道炎的预防和/或补救措施; (2)改善膀胱依从性和/或膀胱容量的药剂; 和(3)用于保护膀胱粘膜和/或膀胱上皮细胞和/或促进其再生的药剂; 每个含有EP 4激动剂。 EP 4激动剂可用于改善下尿路疾病的症状,例如(1)尿频,(2)排尿紧急,(3)生殖器官和/或下泌尿道疼痛 (例如,膀胱疼痛,尿路疼痛,外阴疼痛,阴道疼痛,阴囊疼痛,会阴疼痛,骨盆疼痛等)和/或(4)生殖器官和/或下尿路中的不适。 其中,选择性EP 4激动剂可用作不具有副作用的下尿路疾病的预防和/或补救措施。
摘要:
A method of producing a silicon carbide single crystal, having: fixing a seed crystal, including setting a seed crystal on a seed crystal fixing part with interposition of an adhesive; applying a uniform pressure on the entire surface of the seed crystal by contacting a flexible bag which is inflatable and deflatable to the seed crystal by charging a gas into the to flexible bag; hardening the adhesive; and sublimating a silicon carbide powder obtained by calcinating a mixture containing at least a silicon source and a resol xylene resin, having a nitrogen content of 100 mass ppm or less and having a content of each impurity elements of 0.1 mass ppm or less, and re-crystallizing for growing a silicon carbide single crystal.
摘要:
A method of producing a silicon carbide single crystal in which a sublimation raw material 40 is accommodated at the side of vessel body 12 in a graphite crucible 10, placing a seed crystal of a silicon carbide single crystal at the side of cover body 11 of the graphite crucible 10, the sublimation raw material 40 is sublimated by a first induction heating coil 21 placed at the side of sublimation raw material 40, a re-crystallization atmosphere is form by a second induction heating coil 20 placed at the side of cover body 11 so that the sublimation raw material 40 sublimated by the first induction heating coil 21 is re-crystallizable only in the vicinity of the seed crystal of a silicon carbide single crystal, and the sublimation raw material 40 is re-crystallized on the seed crystal of a silicon carbide single crystal, and a silicon carbide single crystal 60 is grown while keeping the whole surface of its growth surface in convex shape through the all growth processes. A high quality silicon carbide single crystal with large diameter excellent in dielectric breakdown property, heat resistance, radiation resistance and the like, suitable for electronic and optical devices and the like, and showing no contamination of polycrystals and polymorphs, no defect of micropipes and the like can be produced efficiently without cracking and the like.
摘要:
An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
摘要翻译:式(I)的N-苯基芳基磺酰胺化合物(R 1)是COOH等; R 2是氢,甲基等; R 3 O >和R 4是甲基和甲基等的组合; R 5是异丙基等; Ar是噻唑基,吡啶基,5-甲基-2-呋喃基 任选被甲基取代; n为0或1),化合物的合成中间体及其制备方法。 式(I)化合物与前列腺素E 2受体结合,特别是EP 1亚型受体,并拮抗它。 蛋白质结合的影响较小,因此具有令人满意的体内活性。 因此,认为可用作止痛剂,解热剂,治疗尿频(尿频)和/或下尿路疾病综合征或抗肿瘤药物的药剂。
摘要:
The present invention relates to an electrorheological fluid which is capable of increasing viscosity under an application of electric potential difference.An electrorheological fluid according to the present invention comprises dielectric particulates dispersed in a highly electrically insulating oily medium, in which the particulates are carbonaceous particulates having an atomic ratio of carbon atoms to hydrogen atoms (C/H) of 1.70-3.50 and an average particle size of from 0.01 to 100 .mu.m, and the oily medium is an electrical insulating oil having a dielectric constant of not less than 3 and a volume resistivity of not less than 10.sup.9 .OMEGA..multidot.cm.