公开(公告)号：US20080167679A1

公开(公告)日：2008-07-10

申请号：US11620648

申请日：2007-01-06

申请人： John E. Papp

发明人： John E. Papp

IPC分类号： A61M29/00 ,  B21C37/08

CPC分类号： A61F2/013 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00336 ,  A61B2017/00526 ,  A61B2017/00867 ,  A61B2017/2212 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008 ,  Y10T29/5116

摘要： A cage and sleeve assembly for an embolic filtering device used to filter embolic particles from a body vessel has a strut assembly that is movable between an unexpanded position and an expanded position. Struts having strut ends at the respective ends form a cage. The strut ends are initially made from linear elastic nitinol, and a series of spot or laser or other types of welds then secure the strut ends in the sleeve assembly. In one approach, the ends of the strut ends are welded to form a tube. In another approach, the strut ends are welded onto a sleeve. The strut ends may optionally have ends that are partial cylinders, and the partial cylinders are welded onto a cylindrical sleeve. Effects from the welding, such as changing linear elastic nitinol to superelastic nitinol, are contained within a heat-effected zone, and do not extend into areas of the structure that typically bend during use.

摘要翻译： 用于用于从身体血管过滤栓塞颗粒的栓塞过滤装置的笼和套筒组件具有可在未扩张位置和扩张位置之间移动的支柱组件。 在相应端部具有支柱端的支柱形成笼。 支柱端部最初由线弹性镍钛诺制成，并且一系列点或激光或其他类型的焊缝然后将支柱端部固定在套筒组件中。 在一种方法中，支柱端的端部被焊接以形成管。 在另一种方法中，将支柱端部焊接到套筒上。 支柱端可以可选地具有作为部分圆柱体的端部，并且部分圆柱体焊接到圆柱形套筒上。 来自焊接的影响，例如将线性弹性镍钛诺改变为超弹性镍钛诺，被包含在受热区域内，并且不延伸到在使用期间通常弯曲的结构区域。

公开(公告)号：US20140046431A1

公开(公告)日：2014-02-13

申请号：US13584678

申请日：2012-08-13

申请人： John E. Papp ,  Syed Faiyaz Ahmed Hossainy ,  Michael Ngo ,  Chad Abunassar ,  Boris Anukhin ,  Mikael Trollsas ,  Lewis B. Schwartz

发明人： John E. Papp ,  Syed Faiyaz Ahmed Hossainy ,  Michael Ngo ,  Chad Abunassar ,  Boris Anukhin ,  Mikael Trollsas ,  Lewis B. Schwartz

IPC分类号： A61F2/89

CPC分类号： A61F2/915 ,  A61F2/86 ,  A61F2/89 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/826 ,  A61F2002/9155 ,  A61F2002/91591 ,  A61F2210/00 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2240/001 ,  B29C35/0805 ,  B29C65/64 ,  B29C66/1248 ,  B29C66/71 ,  B29C2035/0838 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2031/7534

摘要： Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.

公开(公告)号：US20120073733A1

公开(公告)日：2012-03-29

申请号：US13090164

申请日：2011-04-19

申请人： Michael H. Ngo ,  Mikael Trollsas ,  John E. Papp ,  Hung T. Nguyen ,  Dudley Jayasinghe ,  Ron Farnbach ,  Gregory C. Orr ,  Joshua Smith ,  Yongjin Xie ,  Yu-Chun Ku

发明人： Michael H. Ngo ,  Mikael Trollsas ,  John E. Papp ,  Hung T. Nguyen ,  Dudley Jayasinghe ,  Ron Farnbach ,  Gregory C. Orr ,  Joshua Smith ,  Yongjin Xie ,  Yu-Chun Ku

IPC分类号： B29C65/02

CPC分类号： A61F2/844 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61F2210/0071 ,  A61F2230/0054 ,  A61F2230/0056 ,  B23K26/361 ,  B23K26/362 ,  B23K26/402 ,  B23K2103/42 ,  B23K2103/50 ,  B29C49/0073 ,  B29C49/08 ,  B29C55/26 ,  B29C2049/0089 ,  B29C2793/0009 ,  B29K2067/046 ,  B29L2031/753 ,  B29L2031/7534 ,  Y10T156/1002

摘要： Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.

摘要翻译： 描述了通过球囊导管进行支架制备的方法。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架结构具有包括不对称或对称闭孔的图案，以及连接这种闭孔的连接。

公开(公告)号：US20110245908A1

公开(公告)日：2011-10-06

申请号：US12752983

申请日：2010-04-01

申请人： John E. Papp

发明人： John E. Papp

IPC分类号： A61F2/82 ,  B23Q1/00 ,  B05D7/00

CPC分类号： B23Q3/062 ,  A61F2/82 ,  B05D1/002 ,  B05D1/02

摘要： An apparatus and method for applying a coating composition to a stent. A mandrel for supporting the stent has one or more drive pins and other supporting structure that loosely supports the stent, in an unstable position. The support permits freedom of movement of the stent relative to the mandrel to cause the stent to frequently re-position itself over the mandrel during a spraying process. When a coating composition is applied, the stent randomly or periodically moves about relative to the mandrel due to intermittent contact between the stent and the rotating mandrel and fluidic forces applied through the sprayed coating composition.

摘要翻译： 一种将涂料组合物施用于支架的装置和方法。 用于支撑支架的心轴具有在不稳定位置松散地支撑支架的一个或多个驱动销和其它支撑结构。 该支撑件允许支架相对于心轴的移动自由度，使得支架在喷涂过程中自动频繁地重新定位在心轴上。 当施加涂料组合物时，支架随着或周期性地相对于心轴移动，这是由于支架和旋转心轴之间的间歇接触以及通过喷涂组合物施加的流体力。

公开(公告)号：US20090093875A1

公开(公告)日：2009-04-09

申请号：US12112935

申请日：2008-04-30

申请人： Kent C. B. Stalker ,  Winnette S. McIntosh ,  Dudley S. Jayasinghe ,  Gregory C. Orr ,  John E. Papp ,  Lewis B. Schwartz

发明人： Kent C. B. Stalker ,  Winnette S. McIntosh ,  Dudley S. Jayasinghe ,  Gregory C. Orr ,  John E. Papp ,  Lewis B. Schwartz

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2/06 ,  A61F2002/91541 ,  A61F2002/91583 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/08

摘要： A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 ug/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.

摘要翻译： 药物洗脱支架可以包括具有亲脂和/或亲水元件的聚合物涂层的支架体。 具有抑制细胞增殖的生物活性的药物可以设置在聚合物涂层中。 药物可以以大于或等于约150μg/ cm 2的量存在于聚合物中。 聚合物涂层和药物被配置为配合以便当支架设置在体腔中时与组织形成扩散路径，使得药物优先地通过穿过体腔的体液扩散到组织中，使得最大系统 药物的血液浓度小于约40ng / ml。

公开(公告)号：US06656202B2

公开(公告)日：2003-12-02

申请号：US09896142

申请日：2001-06-29

申请人： John E. Papp ,  Anuja Patel ,  Kent B. Stalker ,  Christopher Tarapata

发明人： John E. Papp ,  Anuja Patel ,  Kent B. Stalker ,  Christopher Tarapata

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0065 ,  A61F2230/0067

摘要： A system for enabling the insertion and removal of an embolic protection device, for capturing and retaining embolic debris which may be created during the performance of a therapeutic interventional procedure in a stenosed or occluded region of a blood vessel. The system, in an embodiment thereof, enables the device to be snap-fitted so as to engage the distal end of a guide wire, to be pre-formed for expansion thereof so as to seal off the inner surface of a blood vessel, to inhibit the forming of a gap therein, for inhibiting embolic material from passing therethrough, and to be foreshortened to enable insertion thereof through confined spaces. The system, in another embodiment thereof, enables expandable material to be formed into an expandable configuration of an embolic protection device for capturing embolic material, which is capable of sealing off the inner surface of the blood vessel.

公开(公告)号：US4560212A

公开(公告)日：1985-12-24

申请号：US597674

申请日：1984-04-06

申请人： John E. Papp ,  Anthony S. Reed

发明人： John E. Papp ,  Anthony S. Reed

IPC分类号： A47B88/493 ,  F16C29/04 ,  A47B88/00

CPC分类号： A47B88/10 ,  A47B2088/0444 ,  A47B2210/0032 ,  A47B2210/0035 ,  A47B2210/0059 ,  A47B2210/0081

摘要： A precision ball bearing slide mechanism having a removable inner member. The slide is a three part slide having an outer, an intermediate and an inner slide member. A latch which holds the intermediate slide member in a locked out position is disclosed herein. This latch is released when the inner slide member is retracted.

摘要翻译： 具有可拆卸内部构件的精密滚珠轴承滑动机构。 滑块是具有外部，中间和内部滑动构件的三部分滑动件。 此处公开了将中间滑动构件保持在锁定位置的闩锁。 当内部滑动构件缩回时，该闩锁被释放。

公开(公告)号：US10111767B2

公开(公告)日：2018-10-30

申请号：US12916349

申请日：2010-10-29

申请人： John E. Papp

发明人： John E. Papp

IPC分类号： A61F2/958 ,  A61F2/97 ,  B29C63/42 ,  B29C61/06 ,  A61F2/966 ,  B29C65/56 ,  B29C65/68 ,  B29C65/00 ,  B29L28/00 ,  B29L31/00 ,  B29C47/00

摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold. The sheath is removed before the medical device is implanted within the body.

公开(公告)号：US09254212B2

公开(公告)日：2016-02-09

申请号：US13441756

申请日：2012-04-06

申请人： John E. Papp ,  Hung T. Nguyen ,  Justin K. Elerath ,  Dion I. Herabadi ,  Michael T. Martins ,  Kirsten S. King ,  Scott H. Mueller ,  Coeta K. Peloquin ,  Stephen D. Pacetti

发明人： John E. Papp ,  Hung T. Nguyen ,  Justin K. Elerath ,  Dion I. Herabadi ,  Michael T. Martins ,  Kirsten S. King ,  Scott H. Mueller ,  Coeta K. Peloquin ,  Stephen D. Pacetti

IPC分类号： A61F2/06 ,  A61F2/958 ,  A61F2/966 ,  A61F2/82

CPC分类号： A61F2/958 ,  A61F2/844 ,  A61F2/91 ,  A61F2/915 ,  A61F2/966 ,  A61F2002/826 ,  A61F2002/9583 ,  A61F2210/0076 ,  A61F2250/0019 ,  A61F2250/0039

摘要： Segmented scaffolds composed of disconnected scaffold segments are delivered to an implant site on a delivery balloon. The segments are crimped to the balloon and separated from each other by gaps. When the balloon is inflated the gaps between the disconnected scaffold segments stays constant Pillowed or banded balloons are used to deliver the segments.

摘要翻译： 由断开的支架段组成的分段支架被输送到输送球囊上的植入部位。 这些片段被卷曲到球囊并且通过间隙彼此分离。 当气球膨胀时，断开的支架段之间的间隙保持不变。使用枕形或带状气球来递送段。

公开(公告)号：US09011513B2

公开(公告)日：2015-04-21

申请号：US13467660

申请日：2012-05-09

申请人： Michael Bialas ,  John E. Papp ,  John Simpson ,  Wouter Erik Roorda ,  Matt Gillick ,  Michael L. Green ,  David P. Strauss ,  Duane M. DeMore ,  Robert P. Barbier ,  Marc Gianotti

发明人： Michael Bialas ,  John E. Papp ,  John Simpson ,  Wouter Erik Roorda ,  Matt Gillick ,  Michael L. Green ,  David P. Strauss ,  Duane M. DeMore ,  Robert P. Barbier ,  Marc Gianotti

IPC分类号： A61F2/84 ,  A61F2/966

CPC分类号： A61F2/966 ,  A61F2/958 ,  A61F2/962 ,  A61F2002/011 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61M25/09 ,  A61M25/10184 ,  A61M25/10185 ,  A61M2025/0183

摘要： Catheter for delivery of a medical device such as a stent or filter includes an inner tubular member and an outer tubular member movable relative to the inner tubular member. The outer tubular member is disposed at the distal end of the inner tubular member. The inner tubular member includes a fluid lumen defined therein, the fluid lumen having a fluid flow port directed to the exterior surface of the inner tubular member. A pressure chamber is defined by the inner tubular member, the outer tubular member, a proximal seal and a distal seal, and is in fluid communication with the fluid flow port, wherein fluid introduced through the fluid flow port and into the pressure chamber applies a force on the proximal seal to move the outer tubular member in a proximal direction allowing the medical device constrained by the outer tubular member to be released.

摘要翻译： 用于输送诸如支架或过滤器的医疗装置的导管包括内部管状构件和可相对于内部管状构件移动的外部管状构件。 外部管状构件设置在内部管状构件的远端。 内部管状构件包括限定在其中的流体腔，流体腔具有指向内部管状构件的外表面的流体流动口。 压力室由内部管状构件，外部管状构件，近侧密封件和远端密封件限定，并且与流体流动端口流体连通，其中通过流体流动端口引入并进入压力室的流体施加 在近侧密封件上的力沿近端方向移动外部管状构件，允许由外部管状构件约束的医疗装置被释放。