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31.发明公开公开(公告)号：US20240335392A1
公开(公告)日：2024-10-10
申请号：US18580703
申请日：2022-07-21
Inventor： Kenneth Craig Kent , Liang-Wang Guo , Bowen Wang , Takuro Shirasu , Shaoqin Gong , Yi Zhao
IPC: A61K9/51 , A61K31/517 , A61P9/14
CPC classification number: A61K9/5176 , A61K9/5146 , A61K31/517 , A61P9/14
Abstract: In one aspect, the disclosure relates to nanoclusters comprising cores comprising self-assembled unimolecular nanoparticles and biomimetic membrane coatings surrounding the cores, methods of making the same, and methods of treating and preventing restenosis using same. In some embodiments, the nanoclusters can contain an anti-restenotic drug. In one embodiment, the polymers and/or copolymers of the unimolecular nanoparticles can contain a hydrophobic group such as, for example, a phenylboronic ester. In a further embodiment, the biomimetic membrane can localize the nanoclusters at sites of vascular damage, at which time reactive oxygen species (ROS) at the sites of vascular damage cleave the hydrophobic groups from the polymers and/or copolymers, increasing hydrophilicity of the polymers and/or copolymers and allowing for greater tissue penetration of the de-clustered nanoclusters and nanoparticles.
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公开(公告)号：US20240228931A9
公开(公告)日：2024-07-11
申请号：US17769549
申请日：2020-10-12
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Inkyu Lee , Juhwan Lee , Michael Phillips , David Gamm , Shaoqin Gong
IPC: C12M1/12 , C12N5/0793
CPC classification number: C12M25/14 , C12N5/062 , C12N2533/30
Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.
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公开(公告)号：US20230170273A1
公开(公告)日：2023-06-01
申请号：US17938378
申请日：2022-10-06
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Huilong Zhang , Shaoqin Gong
IPC: H01L23/367 , H01L29/66 , H01L29/778 , H01L23/522
CPC classification number: H01L23/3672 , H01L23/367 , H01L23/5226 , H01L29/778 , H01L29/66431
Abstract: Flexible transistors and electronic circuits incorporating the transistors are provided. The flexible transistors promote heat dissipation from the active regions of the transistors while preserving their mechanical flexibility and high-frequency performance. The transistor designs utilize thru-substrate vias (TSVs) beneath the active regions of thin-film type transistors on thin flexible substrates. To promote rapid heat dissipation, the TSVs are coated with a material having a high thermal conductivity that transfers heat from the active region of the transistor to a large-area ground.
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公开(公告)号：US20210343618A1
公开(公告)日：2021-11-04
申请号：US16862825
申请日：2020-04-30
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Huilong Zhang , Shaoqin Gong
IPC: H01L23/367 , H01L23/522 , H01L29/778 , H01L29/66
Abstract: Flexible transistors and electronic circuits incorporating the transistors are provided. The flexible transistors promote heat dissipation from the active regions of the transistors while preserving their mechanical flexibility and high-frequency performance. The transistor designs utilize thru-substrate vias (TSVs) beneath the active regions of thin-film type transistors on thin flexible substrates. To promote rapid heat dissipation, the TSVs are coated with a material having a high thermal conductivity that transfers heat from the active region of the transistor to a large-area ground.
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公开(公告)号：US11096899B2
公开(公告)日：2021-08-24
申请号：US16562133
申请日：2019-09-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Zachary Scott Morris , Mingzhou Ye , Ravi Bhasker Patel , Paul M. Sondel
Abstract: Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.
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Patent Agency Ranking
公开(公告)号：US10676363B2
公开(公告)日：2020-06-09
申请号：US15901352
申请日：2018-02-21
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Qifeng Zheng
IPC: H01G11/36 , H01B1/04 , B82Y30/00 , C01B32/198 , C01B32/23 , H01M4/133 , H01G11/56 , H01M4/131 , H01G11/38 , H01G11/62 , H01G11/86 , H01G11/42
Abstract: Electrically conductive aerogel films, electrodes composed of the electrically conductive aerogel films, and supercapacitors incorporating the electrodes are provided. The aerogel films include reduced graphene oxide particles in combination with metal oxynitride fibers. By including cellulosic nanofibrils in the aerogels, the films can be made mechanically flexible and free-standing.
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公开(公告)号：US10668017B2
公开(公告)日：2020-06-02
申请号：US15674293
申请日：2017-08-10
Applicant: Wisconsin Alumni Research Foundation
Inventor： K. Craig Kent , Shaoqin Gong , Xudong Shi , Guojun Chen , Lian-Wang Guo
IPC: A61K9/107 , A61K31/436 , A61K47/34 , A61K9/06 , A61K9/51
Abstract: The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle. The hydrogel may be a di-or tri-block copolymer comprising one block of poly(ethylene glycol) (PEG) and one or two blocks of poly(lactic-co-glycolic acid) (PLGA). The unimolecular micelle may include three domains: a dendritic polymer core, hydrophobic block polymers (e.g., PVL, PVCL, and/or PCL) attached to the core and PEG attached to the hydrophobic block polymers.
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公开(公告)号：US10378876B2
公开(公告)日：2019-08-13
申请号：US15171990
申请日：2016-06-02
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Zhenqiang Ma , Yunming Wang , Hongyi Mi
Abstract: Piezoresistive composite materials comprising electrically conductive particles in a polymeric phase change material are provided. Also provided are strain sensors incorporating the composites and methods for detecting mechanical strain using the composites.
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39.发明授权公开(公告)号：US10044085B2
公开(公告)日：2018-08-07
申请号：US15098636
申请日：2016-04-14
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Yei Hwan Jung , Juhwan Lee , Shaoqin Gong
Abstract: Stretchable high frequency transmission lines and high-frequency filters comprising the transmission lines are provided. The transmission lines provide low power loss, even at microwave and millimeter wave frequencies. The transmission lines are thin and flexible and can be stretched without a significant degradation of their scattering parameters. As a result, the transmission lines have applications as interconnects in stretchable and flexible integrated circuits (IC) and circuit device components, such as flexible transistors and flexible diodes.
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公开(公告)号：US09834714B2
公开(公告)日：2017-12-05
申请号：US15093857
申请日：2016-04-08
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Zhenqiang Ma , Yunming Wang , Hongyi Mi
CPC classification number: C09K5/14 , H01L27/305 , H01L51/0049 , H01L51/42 , H01L51/44 , Y02E10/549 , Y02P70/521
Abstract: Composite materials comprising electrically conductive particles in a form-stable phase change materials (PCMs) are provided. Also provided as radiation sensors incorporating the composites and methods for detecting radiation using the composites. The PCMs comprise crosslinked polyether polyol that undergoes a reversible solid-solid phase change upon heating. Prior to the phase change, the crosslinked polyether polyol comprises microscopic crystalline domains. When the PCM is heated beyond its phase transition temperature these microscopic crystalline domains melt. However, the form-stable PCMs retain their solid form at the macroscopic level.
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