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39 条记录 (耗时 0.038 秒)

    Methods for non-thermal application of gas plasma to living tissue
    31.
    发明授权
    Methods for non-thermal application of gas plasma to living tissue 有权
    气体等离子体对生物体组织非热应用的方法

    公开(公告)号：US08521274B2

    公开(公告)日：2013-08-27

    申请号：US11911479

    申请日：2006-04-25

    申请人： Alexander F. Gutsol ,  Alexander Fridman ,  Gennady Friedman ,  Gregory Fridman ,  Manjula Balasubramanian

    发明人： Alexander F. Gutsol ,  Alexander Fridman ,  Gennady Friedman ,  Gregory Fridman ,  Manjula Balasubramanian

    IPC分类号： A61N1/06

    CPC分类号： A61B18/042 ,  A61N1/40 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2240/20 ,  H05H2245/122

    摘要： Method for the non-thermal treatment of human or animal tissue with high-voltage electrical discharge plasma is disclosed. The disclosed method employs current through plasma and through tissue not for the purpose of heating the tissue, but instead to maintain the plasma proximate to the tissue being treated. Also disclosed is a method of limiting the current through plasma and through tissue to minimize tissue heating by placement of an insulator or semiconductor between an electrode and tissue resulting in generation of a high-voltage discharge similar to a dielectric barrier discharge. The disclosed non-thermal plasma treatment can be employed to promote coagulation of blood, sterilization, disinfection, re-connection of tissue, and treatment of tissue disorders without causing significant thermal tissue damage.

    摘要翻译： 公开了用高压放电等离子体对人体或动物组织进行非热处理的方法。 所公开的方法采用电流通过等离子体和通过组织而不是用于加热组织的目的，而是将血浆保持在靠近待治疗组织的位置。 还公开了一种限制通过等离子体和通过组织的电流的方法，以通过在电极和组织之间放置绝缘体或半导体来最小化组织加热，导致产生类似于电介质阻挡放电的高压放电。 所公开的非热等离子体处理可用于促进血液凝结，消毒，消毒，组织再连接，以及治疗组织疾病而不引起明显的热组织损伤。

    NANO DISCHARGES IN LIQUIDS
    34.
    发明申请
    NANO DISCHARGES IN LIQUIDS 有权
    纳米在液体中的排放

    公开(公告)号：US20110251604A1

    公开(公告)日：2011-10-13

    申请号：US13055998

    申请日：2009-08-19

    申请人： David Staack ,  Alexander Fridman ,  Alexander Gutsol ,  Yury Gogotsi ,  Gennady Friedman

    发明人： David Staack ,  Alexander Fridman ,  Alexander Gutsol ,  Yury Gogotsi ,  Gennady Friedman

    IPC分类号： A61B18/00 ,  H01J7/00 ,  B05D1/04 ,  G01J3/30 ,  B82Y99/00

    CPC分类号： A61B18/042 ,  A61B2018/00125 ,  B82Y15/00 ,  G01N21/67 ,  G01N27/68

    摘要： The present invention is direct to a nano-probe corona tool and uses thereof. A nano-probe corona tool is disclosed having a tip with a diameter in the nano-scale, typically around 100 nm. The nano-probe corona tool is constructed of electrically conductive material. On the other end of the tool, a pulsed voltage source outputs a pulsed voltage to generated a pulsed electrical potential at the tip. The pulsed electrical potential at the tip causes a plasma discharge corona to occur. Uses of the corona discharge include, but are not limited to, optical emission spectroscopy, in the enhancement of deposition of coatings and nanoscale welding, e.g., nanotube or nanowires to a contact pad and welding two nanowires together, and in nanoscale surgery. For example, a nano-probe comprising CNTs may be inserted into cell membranes. The resulting corona discharge may be used to destroy tumors within the cell.

    摘要翻译： 本发明直接涉及纳米探针电晕工具及其应用。 公开了纳米探针电晕工具，其具有直径在纳米级的尖端，通常为约100nm。 纳米探针电晕工具由导电材料构成。 在工具的另一端，脉冲电压源输出脉冲电压以在尖端产生脉冲电位。 尖端处的脉冲电位导致发生等离子体放电电晕。 电晕放电的使用包括但不限于光学发射光谱法，用于增强涂层的沉积和纳米尺度焊接，例如纳米管或纳米线到接触焊盘，并将两个纳米线焊接在一起，以及在纳米级手术中。 例如，可以将包含CNT的纳米探针插入细胞膜。 所产生的电晕放电可用于破坏细胞内的肿瘤。

    Magnetically-Controllable Delivery System for Therapeutic Agents
    36.
    发明申请
    Magnetically-Controllable Delivery System for Therapeutic Agents 审中-公开
    用于治疗药物的磁控制递送系统

    公开(公告)号：US20100204674A1

    公开(公告)日：2010-08-12

    申请号：US12763925

    申请日：2010-04-20

    申请人： Zachary G. Forbes ,  Benjamin B. Yellen ,  Kenneth A. Barbee ,  Gennady Friedman

    发明人： Zachary G. Forbes ,  Benjamin B. Yellen ,  Kenneth A. Barbee ,  Gennady Friedman

    IPC分类号： A61M37/00 ,  A61B19/00

    CPC分类号： A61L31/14 ,  A61F2/82 ,  A61F2210/009 ,  A61L27/50 ,  A61L31/022 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/30 ,  A61N2/00

    摘要： A magnetic delivery system for delivering a magnetizable particle to a location in a body, the device includes a magnetizable object implanted in the body, wherein the magnetizable object includes a plurality of segments distributed throughout the magnetizable object and wherein the segments are configured to provide a magnetic gradient for attracting the magnetizable particle and an external source of a magnetic field capable of (i) magnetizing the magnetizable particle and (ii) increasing a degree of magnetization of the magnetizable object and thereby creating the magnetic gradient. A drug delivery system including the magnetic delivery system and a magnetizable particle associated with a therapeutic agent and/or a cell. A cell delivery system based on the magnetic delivery system and a magnetizable particle associated with a cell. A method of using the magnetic delivery system for delivery of a therapeutic agent and/or a cell to a targeted location in a body.

    摘要翻译： 一种用于将可磁化颗粒输送到身体中的位置的磁性传送系统，该装置包括植入体内的可磁化物体，其中可磁化物体包括分布在整个可磁化物体上的多个区段，并且其中该区段被配置成提供 用于吸引可磁化颗粒的磁梯度和能够（i）磁化可磁化颗粒的磁场的外部源，和（ii）增加可磁化物体的磁化程度，从而产生磁梯度。 药物递送系统，包括磁性递送系统和与治疗剂和/或细胞相关联的可磁化颗粒。 基于磁传递系统的细胞递送系统和与细胞相关联的可磁化颗粒。 一种使用磁性递送系统将治疗剂和/或细胞输送到体内目标位置的方法。

    Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof
    37.
    发明申请
    Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof 审中-公开
    治疗配方及其治疗系统的磁性梯度靶向和螯合

    公开(公告)号：US20090216320A1

    公开(公告)日：2009-08-27

    申请号：US12297971

    申请日：2007-04-20

    申请人： Robert J. Levy ,  Ivan Alferlev ,  Michael Chorny ,  Ilia Fishbein ,  Gennady Friedman ,  Boris Polyak ,  Darryl Williams

    发明人： Robert J. Levy ,  Ivan Alferlev ,  Michael Chorny ,  Ilia Fishbein ,  Gennady Friedman ,  Boris Polyak ,  Darryl Williams

    IPC分类号： A61M37/00 ,  A61N2/00 ,  A61F2/82

    CPC分类号： A61K9/0009 ,  A61B2017/00876 ,  A61B2017/00893 ,  A61K9/0019 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/624 ,  A61L2400/12 ,  A61N2/002 ,  A61N2/06

    摘要： A therapeutic system and a method that uses stents, and/or other implantable devices (104) for local delivery of a therapeutic agent is disclosed. A therapeutic formulation (102) may include particles of a biocompatible magnetic or magnetizable material that carry the therapeutic agent, or magnetically responsive cells. The therapeutic formulation (102) is intravenously administered to a mammalian subject. A portion of the formulation (102) is delivered to the proximity of a device (104) implanted in the vascular system of the subject by externally generating a magnetic field gradient (106) on the implantable device (104). The portion of the therapeutic formulation (102) not delivered to the proximity of the implantable device (104) is removed from the vascular system. The method allows for the repeated administration of the same or different therapeutic agent, and further, has the option of locally injecting, or alternatively, peripherally administering, the therapeutic agent.

    摘要翻译： 公开了一种治疗系统和使用支架的方法，和/或用于局部递送治疗剂的其它可植入装置（104）。 治疗剂（102）可以包括携带治疗剂或磁反应性细胞的生物相容性磁性或可磁化材料的颗粒。 将治疗制剂（102）静脉内施用于哺乳动物受试者。 制剂（102）的一部分通过在可植入装置（104）上外部产生磁场梯度（106）而输送到植入受试者的血管系统中的装置（104）附近。 从血管系统中去除未被输送到可植入装置（104）附近的部分治疗剂（102）。 该方法允许相同或不同的治疗剂的重复给药，此外，还可以选择局部注射或替代地外周施用治疗剂。

    CONTROL OF MUCUS MEMBRANE BLEEDING WITH COLD PLASMA
    38.
    发明申请
    CONTROL OF MUCUS MEMBRANE BLEEDING WITH COLD PLASMA 有权
    用冷等离子体处理薄膜的控制

    公开(公告)号：US20090054896A1

    公开(公告)日：2009-02-26

    申请号：US12175756

    申请日：2008-07-18

    申请人： Gregory Fridman ,  Alexander Fridman ,  Alexander Gutsol ,  Gennady Friedman ,  David Staack ,  Richard Joseph Hamilton

    发明人： Gregory Fridman ,  Alexander Fridman ,  Alexander Gutsol ,  Gennady Friedman ,  David Staack ,  Richard Joseph Hamilton

    IPC分类号： A61B18/18

    CPC分类号： A61B18/042 ,  A61B2018/00982

    摘要： The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-thermal plasma is generated, the second electrode being human tissue, blood, etc. To reduce the likelihood of an arc being generated, potentially causing tissue damage or pain, the first electrode is partially encapsulated by a dielectric. The non-thermal plasma is applied to the area of bleeding for treatment.

    摘要翻译： 本文描述了使用非热等离子体来治疗粘液膜出血。 使用具有从电源接收交流电位的第一电极的装置产生非热等离子体。 当放置在靠近组织的适当位置时，产生非热等离子体，第二电极是人体组织，血液等。为了减少产生电弧的可能性，可能导致组织损伤或疼痛，第一电极 被电介质部分封装。 将非热等离子体施加到出血处理区域。