公开(公告)号：US20240348015A1

公开(公告)日：2024-10-17

申请号：US18612461

申请日：2024-03-21

Applicant: California Institute of Technology

Inventor： Alireza Marandi ,  Luis M. Ledezma ,  Louise E. Schul ,  Selina Zhou

IPC: H01S5/183 ,  H01S5/04 ,  H01S5/20

CPC classification number: H01S5/18327 ,  H01S5/041 ,  H01S5/2018

Abstract: A device including a chip including a photonic integrated circuit comprising an external cavity for a source of electromagnetic radiation; the source of electromagnetic radiation attached to a top surface of the chip, the source comprising a semiconductor active region comprising, or coupled to, an output for the electromagnetic radiation, wherein the output is oriented to emit the electromagnetic radiation into the top surface in an emission direction that is inclined with respect to a plane of propagation of the electromagnetic radiation in the external cavity; and a coupler coupling the active region to the external cavity via the top surface to integrate the external cavity with the active region. The coupler partially couples the electromagnetic radiation outputted from the active region to the external cavity, and feedback from the external cavity to the active region.

公开(公告)号：US20240345150A1

公开(公告)日：2024-10-17

申请号：US18632116

申请日：2024-04-10

Applicant: California Institute of Technology

Inventor： Jacob W. Kooi ,  Goutam Chattopadhyay ,  Austin Minnich

IPC: G01R29/26 ,  G01K7/00 ,  H01P3/00 ,  H03F7/00

CPC classification number: G01R29/26 ,  G01K7/00 ,  H01P3/003 ,  H03F7/00 ,  H03F2200/294

Abstract: A variable temperature load (VTL) or noise source including a grounded coplanar waveguide (GCPW) comprising a first metallization patterned on a fused quartz substrate, the first metallization comprising a first end for connecting to a coaxial connector and a second end for connecting to a coplanar waveguide (CPW); the CPW coupled to a 50 ohm termination and comprising a second metallization patterned on a top surface of a crystal quartz substrate; a temperature sensing diode thermally coupled to the crystal quartz substrate and the second metallization; and a heater resistor coupled to the crystal quartz substrate via contact metallization.

公开(公告)号：US20240337665A1

公开(公告)日：2024-10-10

申请号：US18335819

申请日：2023-06-15

Applicant: Regeneron Pharmaceuticals, Inc. ,  California Institute of Technology

Inventor： Heather Agnew ,  Bert Tsunyin Lai ,  Suresh Mark Pitram ,  Blake Farrow ,  James R. Heath ,  David Bunck ,  Jingxin Liang ,  Arundhati Nag ,  Samir Das

IPC: G01N33/68 ,  C07K7/06 ,  C07K14/54

CPC classification number: G01N33/6869 ,  C07K7/06 ,  C07K14/54

Abstract: The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

公开(公告)号：US20240336956A1

公开(公告)日：2024-10-10

申请号：US18625726

申请日：2024-04-03

Applicant: California Institute of Technology ,  Molecular Instruments

Inventor： Harry MT Choi ,  Chun Hao R. Chen ,  Mike C. Liu ,  Aneesh Acharya ,  Sheldon Zhu ,  Niles A. Pierce

IPC: C12Q1/682 ,  C12Q1/6818 ,  C12Q1/6841

CPC classification number: C12Q1/682 ,  C12Q1/6818 ,  C12Q1/6841

Abstract: The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.

公开(公告)号：US12110601B2

公开(公告)日：2024-10-08

申请号：US17894674

申请日：2022-08-24

Applicant: California Institute of Technology

Inventor： Cody E. Finke

IPC: C25B1/22 ,  B09C1/08 ,  C02F1/66 ,  C04B2/10 ,  C05B11/08 ,  C09K17/02 ,  C25B1/02 ,  C25B9/17 ,  H01M8/0656

CPC classification number: C25B1/22 ,  B09C1/08 ,  C02F1/66 ,  C04B2/10 ,  C05B11/08 ,  C09K17/02 ,  C25B1/02 ,  C25B9/17 ,  H01M8/0656

Abstract: A method for producing a cement material wherein 1) a first acid is reacted with a first cement precursor to form a second cement precursor, and 2) the second cement precursor is converted to a cement material. The first cement precursor includes one or more of Ca, Si, or Al, and the reaction with the first acid produces a second cement precursor that includes one or more of Ca, Si, or Al, and the conjugate base of the first acid. The second step can be performed by thermally converting the second cement precursor to a cement material by sintering or thermally decomposing the second cement precursor at a temperature in the range of 500 to 2000° C. The first step can be performed in the presence of water as a wet slurry. The concentration of the first acid can be greater than 20% by weight.

公开(公告)号：US12102477B2

公开(公告)日：2024-10-01

申请号：US18128998

申请日：2023-03-30

Applicant: California Institute of Technology

Inventor： Alaina Ann Brinley Rajagopal ,  Aditya Rajagopal

IPC: A61B8/00 ,  A61B8/08 ,  A61B8/14 ,  G01S15/89

CPC classification number: A61B8/0891 ,  A61B8/14 ,  A61B8/40 ,  A61B8/4236 ,  A61B8/4472 ,  G01S15/895

Abstract: An ultrasound measurement device includes: a processing device and multiple ultrasound sensors that capture tomographic information of a physiological structure. The ultrasound sensors include a first ultrasound sensor including a first transducer having a first frequency response with a first resonant frequency, and a second ultrasound sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits an ultrasound signal that is reflected by the physiological structure to create a reflected ultrasound signal, the first transducer generates a first received signal from the reflected ultrasound signal, the second transducer generates a second received signal from the reflected ultrasound signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.

公开(公告)号：US20240315665A1

公开(公告)日：2024-09-26

申请号：US18734823

申请日：2024-06-05

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Sumner L. Norman ,  Claire Rabut ,  Whitney S. Griggs ,  Richard A. Andersen ,  Mikhail G. Shapiro ,  Charles Liu

IPC: A61B8/00 ,  A61F2/28

CPC classification number: A61B8/4209 ,  A61F2/2875

Abstract: A cranial implant that facilitates functional ultrasound imaging is disclosed. The example cranial implant replaces a section of a skull. The cranial implant in includes a support section shaped to replace a removed section of the skull. The implant includes a window of sonolucent material allowing functional ultrasound imaging through an ultrasound probe on the window. The window is shaped to allow access to a region of interest in the brain from the ultrasound probe.

公开(公告)号：US20240302104A1

公开(公告)日：2024-09-12

申请号：US18664167

申请日：2024-05-14

Applicant: California Institute of Technology

Inventor： Weibo Chen ,  Benjamin I. Furst ,  Scott N. Roberts

IPC: F28D15/02 ,  F28D15/04

CPC classification number: F28D15/0241 ,  F28D15/04

Abstract: Systems and methods for thermal management using separable heat pipes and methods of manufacture thereof. Various embodiments provide a porous insert that can be used to join or connect heat pipes. Further embodiments provide thermal management systems that are modular, expandable, reparable, by allowing for joining of evaporators, condensers, and adiabatic sections via porous inserts. Various embodiments allow for two-phase thermal management systems, where liquid and gaseous phases can be transported simultaneously. Certain embodiments incorporate heat generating components with embedded evaporators and/or condensers. Many embodiments are additively manufactured, including via 3D printing.

公开(公告)号：US20240287259A1

公开(公告)日：2024-08-29

申请号：US18427583

申请日：2024-01-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Julia A. KORNFIELD ,  Ming-Hsin WEI

IPC: C08G83/00 ,  C08G61/08 ,  C08K5/00 ,  C08L101/02 ,  C08L101/08 ,  C10L1/16 ,  C10L1/195 ,  C10L1/236 ,  C10L10/02 ,  C10L10/08 ,  F17D1/17

CPC classification number: C08G83/005 ,  C08G61/08 ,  C08G83/00 ,  C08G83/008 ,  C08K5/0008 ,  C08L101/02 ,  C08L101/025 ,  C08L101/08 ,  C10L1/1658 ,  C10L1/195 ,  C10L1/236 ,  C10L10/02 ,  C10L10/08 ,  F17D1/17 ,  C08F2438/01 ,  C08G2261/132 ,  C08G2261/1644 ,  C08G2261/3323 ,  C08G2261/418 ,  C08G2261/63 ,  C08G2261/64 ,  C08G2261/72 ,  C10L2230/22 ,  C10L2250/04

Abstract: Described herein are associative polymers capable of controlling a physical and/or chemical property of non-polar compositions and related compositions, methods and systems. Associative polymers herein described have a non-polar backbone and functional groups presented at ends of the non-polar backbone, with a number of the functional groups presented at the ends of the non-polar backbone formed by associative functional groups capable of undergoing an associative interaction with another associative functional group with an association constant (k) such that the strength of each associative interaction is less than the strength of a covalent bond between atoms and in particular less than the strength of a covalent bond between backbone atoms.

公开(公告)号：US20240269668A1

公开(公告)日：2024-08-15

申请号：US18486054

申请日：2023-10-12

Applicant: California Institute of Technology

Inventor： Vishal Maingi

IPC: B01L3/00 ,  G01N33/68 ,  G01N33/92

CPC classification number: B01L3/502 ,  G01N33/68 ,  G01N33/92 ,  B01L2200/02 ,  B01L2300/0832 ,  G01N2333/705

Abstract: Systems and methods for assessment of lipid membrane-associated molecules are described. Generally, a system can comprise a scaffold with a molecule attached thereon. The scaffold can comprise a plurality of hydrophobic seeds to form a liposome. The molecule attached to the scaffold can integrate into the formed liposome and then be released from the scaffold. The kinetics, dynamics, and interactions of the molecule within the liposome can be detected or monitored.