公开(公告)号：US08672145B2

公开(公告)日：2014-03-18

申请号：US13953565

申请日：2013-07-29

Applicant: Fresenius Medical Care Holdings, Inc. ,  The Technion Research and Development Foundation, Ltd.

Inventor： Moris S. Eisen

IPC: B01D15/00 ,  B01D24/00 ,  B01D39/00 ,  B01D61/24

CPC classification number: A61M1/3679 ,  A61M1/1696 ,  B01D15/00 ,  B01J20/20 ,  B01J20/261 ,  B01J20/264 ,  B01J20/265 ,  B01J20/28052 ,  B01J41/00 ,  C08F8/14 ,  C08F8/32 ,  C08F216/06 ,  C08F218/04 ,  C08F218/10 ,  C08F220/06 ,  C08F2800/10 ,  C08F2810/20 ,  C08F16/06 ,  C08F8/50 ,  C08F210/02 ,  C08F120/06 ,  C08F220/54

Abstract: A sorbent polymer is provided that interacts or reacts with aqueous urea to aid the regeneration of a dialysate liquid. The sorbent polymer may include one or more specific functional groups bonded thereto. Such specific functional groups are selected from carboxylic acids, carboxylic acid esters, carboxylates, amides, dicarboxylic acids, dicarboxylic acid esters, and dicer boxylates to produce the desired urea sorbent.

Abstract translation: 提供吸附剂聚合物，其与尿素水相互作用或反应以帮助透析液的再生。 吸附剂聚合物可以包括与其键合的一个或多个特定官能团。 这样的特定官能团选自羧酸，羧酸酯，羧酸酯，酰胺，二羧酸，二羧酸酯和切片剂，以产生所需的脲吸附剂。

公开(公告)号：US20140065402A1

公开(公告)日：2014-03-06

申请号：US14016903

申请日：2013-09-03

Applicant: Technion Research and Development Foundation Ltd.

Inventor： Ran Yosef SUCKEVERIENE ,  Moshe NARKIS

IPC: H01B1/04 ,  H01B13/00

CPC classification number: H01B1/04 ,  B82Y30/00 ,  G06F3/044 ,  H01B1/24 ,  H01B13/0026 ,  H01L51/444 ,  Y10S977/742 ,  Y10S977/783 ,  Y10S977/788 ,  Y10S977/842 ,  Y10S977/897 ,  Y10T428/31663 ,  Y10T428/31765 ,  Y10T428/31786 ,  Y10T428/31993

Abstract: The present invention relates to hybrid electrically conducting systems comprising a matrix of a conducting polymer (polyaniline-PANI), and highly conducting carbonaceous nanoparticles, e.g., carbon nanotubes (CNT) or graphenes. The PANI/carbon nano-composites are prepared by a novel process comprising the steps of (a) polymerizing aniline and carbonaceous nanoparticles by inverse emulsion polymerization conducted under sonication, so as to obtain PANI/carbon nano-composites; (b) de-doping the PANI/carbon nano-composites obtained in step (a); (c) re-doping the PANI/carbon nano-composites obtained in step (b); and (d) forming a film from the re-doped PANI/carbon nano-composites. The PANI/carbon nano-composites are used for the preparation of thin, transparent, and conductive films which can be applied to a variety of substrates and used for commercial applications.

Abstract translation: 本发明涉及包含导电聚合物（聚苯胺-PANI）基质和高导电性碳质纳米颗粒例如碳纳米管（CNT）或石墨烯的混合导电体系。 PANI /碳纳米复合材料通过一种新方法制备，包括以下步骤：（a）通过在超声处理下进行的反相乳液聚合使苯胺和碳质纳米颗粒聚合，以获得PANI /碳纳米复合材料; （b）去掺杂步骤（a）中获得的PANI /碳纳米复合材料; （c）重新掺杂步骤（b）中获得的PANI /碳纳米复合材料; 和（d）从再掺杂的PANI /碳纳米复合材料形成膜。 PANI /碳纳米复合材料用于制备薄，透明和导电膜，可以应用于各种基材并用于商业应用。

公开(公告)号：US08609719B2

公开(公告)日：2013-12-17

申请号：US12582491

申请日：2009-10-20

Applicant: Victor Piryatinsky ,  Bronka Cohen ,  David Lerner ,  Dalia Pinkert ,  Istvan Miskolczi ,  Yaacov Herzig ,  Hugo Gottlieb ,  Marta Weinstock-Rosin

Inventor： Victor Piryatinsky ,  Bronka Cohen ,  David Lerner ,  Dalia Pinkert ,  Istvan Miskolczi ,  Yaacov Herzig ,  Hugo Gottlieb ,  Marta Weinstock-Rosin

IPC: A61K31/13

CPC classification number: C07C271/48 ,  A61K31/27 ,  A61K31/325 ,  C07B2200/07 ,  C07C271/44 ,  C07C2602/08

Abstract: A method for treating an individual who has been identified as having Alzheimer's disease by administering orally to the individual a therapeutically effective amount of ladostigil or a pharmaceutically active salt thereof, wherein the therapeutically effective amount is 70 mg per day, 140 mg per day, or 200 mg per day. Also, a unit dosage form of ladostigil or a pharmaceutically active salt thereof in an amount of 50 mg, 70 mg, 80 mg or 100 mg.

Abstract translation: 治疗已被鉴定为患有阿尔茨海默病的个体的方法，其通过向个体口服施用治疗有效量的前消炎症或其药物活性盐，其中治疗有效量为每天70mg，每天140mg，或 每天200毫克。 而且，剂量为50mg，70mg，80mg或100mg的地斯达格或其药物活性盐的单位剂型。

公开(公告)号：US20130313188A1

公开(公告)日：2013-11-28

申请号：US13953565

申请日：2013-07-29

Applicant: The Technion Research and Development Foundation, LTD. ,  Fresenius Medical Care Holdings, Inc.

Inventor： Moris S. Eisen

IPC: A61M1/36

CPC classification number: A61M1/3679 ,  A61M1/1696 ,  B01D15/00 ,  B01J20/20 ,  B01J20/261 ,  B01J20/264 ,  B01J20/265 ,  B01J20/28052 ,  B01J41/00 ,  C08F8/14 ,  C08F8/32 ,  C08F216/06 ,  C08F218/04 ,  C08F218/10 ,  C08F220/06 ,  C08F2800/10 ,  C08F2810/20 ,  C08F16/06 ,  C08F8/50 ,  C08F210/02 ,  C08F120/06 ,  C08F220/54

Abstract: A sorbent polymer is provided that interacts or reacts with aqueous urea to aid the regeneration of a dialysate liquid. The sorbent polymer may include one or more specific functional groups bonded thereto. Such specific functional groups are selected from carboxylic acids, carboxylic acid esters, carboxylates, amides, dicarboxylic acids, dicarboxylic acid esters, and dicer boxylates to produce the desired urea sorbent.

Abstract translation: 提供吸附剂聚合物，其与尿素水相互作用或反应以帮助透析液的再生。 吸附剂聚合物可以包括与其键合的一个或多个特定官能团。 这样的特定官能团选自羧酸，羧酸酯，羧酸酯，酰胺，二羧酸，二羧酸酯和切片剂，以产生所需的脲吸附剂。

公开(公告)号：US20130259634A1

公开(公告)日：2013-10-03

申请号：US13992884

申请日：2011-12-07

Applicant: Reuben Raz ,  Aviv Rosen

Inventor： Reuben Raz ,  Aviv Rosen

IPC: B64D1/12 ,  B66C1/12 ,  B64D1/22

CPC classification number: B64D1/22 ,  B64D1/12 ,  B65D21/0209 ,  B66C1/12 ,  B66C1/38 ,  F16B45/00

Abstract: An add-on sling-load system (100, 200, 300, 400, 600) capable of being attached to a host that comprises a load (120, 230) provided with at least two slices arranged in a predetermined configuration and preferably a stack and a controlled coupling mechanism (130, 620) configured to attach and release at least one slice from the arranged configuration. The sling load system is used for multiple deliveries.

Abstract translation: 能够附接到主机的附加吊装系统（100,200,300,400,600）包括设置有至少两个切片的负载（120,230），所述至少两个切片以预定配置排列，优选地为堆叠 以及受控耦合机构（130,620），被配置为从所述布置的构造附接和释放至少一个切片。 吊装系统用于多次交货。

公开(公告)号：US08541428B2

公开(公告)日：2013-09-24

申请号：US12438291

申请日：2006-08-22

Applicant: Moshe Gavish ,  Jehuda Arieh Veenman ,  Alex Shterenberg ,  Ilan Marek

Inventor： Moshe Gavish ,  Jehuda Arieh Veenman ,  Alex Shterenberg ,  Ilan Marek

IPC: A01N43/54 ,  A61K31/517 ,  C07D239/72

CPC classification number: C07D239/91 ,  C07D239/90

Abstract: The present invention relates to novel quinoxaline, quinazoline and phthalazine derivatives as well as multimeric derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds for the treatment and prevention of brain damage resulting from brain injury, especially secondary brain damage due to traumatic brain injury (TBI). The compounds of the invention are also useful in treating and preventing neurodegenerative diseases.

Abstract translation: 本发明涉及新颖的喹喔啉，喹唑啉和酞嗪衍生物以及多聚衍生物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物治疗和预防由脑损伤引起的脑损伤的方法，特别是二次 由脑外伤引起的脑损伤（TBI）。 本发明的化合物也可用于治疗和预防神经变性疾病。

公开(公告)号：US20130150261A1

公开(公告)日：2013-06-13

申请号：US13678126

申请日：2012-11-15

Applicant: Technion Research and Development Foundation Ltd. ,  Tel Hashomer Medical Research, Infrastructure and Services Ltd.

Inventor： Hossam Haick ,  Nir Peled

IPC: G01N33/497

CPC classification number: G01N33/497 ,  G01N33/0034 ,  G01N2800/7028

Abstract: The present invention provides a unique profile of volatile organic compounds as breath biomarkers for lung cancer. The present invention further provides the diagnosis, prognosis and monitoring of lung cancer or predicting the response to an anti-cancer treatment through the detection of the unique profile of volatile organic compounds indicative of lung cancer at its various stages.

Abstract translation: 本发明提供挥发性有机化合物作为肺癌呼吸生物标志物的独特特征。 本发明还通过检测其各种阶段的指示肺癌的挥发性有机化合物的独特特征，进一步提供对肺癌的诊断，预后和监测或预测对抗癌治疗的反应。

公开(公告)号：US20130143247A1

公开(公告)日：2013-06-06

申请号：US13817285

申请日：2011-08-17

Applicant: Hossam Haick ,  Nir Peled

Inventor： Hossam Haick ,  Nir Peled

IPC: C12Q1/02 ,  G01N30/00 ,  H01J49/00 ,  C12Q1/48

CPC classification number: C12Q1/025 ,  C12Q1/485 ,  C12Q1/6886 ,  C12Q2600/156 ,  G01N30/00 ,  G01N33/57423 ,  G01N2030/8854 ,  G01N2333/71 ,  G01N2333/82 ,  H01J49/0027 ,  Y10T436/212 ,  Y10T436/214 ,  Y10T436/216 ,  Y10T436/24

Abstract: The present invention provides methods of identifying a genetic abnormality such as mutation in EGFR or KRAS or ALK which is associated with the management of lung cancer or diagnosing, prognosing or monitoring the treatment of pre-cancerous conditions of the lung, such as bronchial dysplasia or atypical alveolar hyperplasia (AAH), through the detection of at least one volatile organic compound indicative of these states.

Abstract translation: 本发明提供鉴定EGFR或KRAS或ALK的突变的遗传异常的方法，其与肺癌的管理相关联或诊断，预后或监测肺的癌前病症的治疗，例如支气管发育不良或 通过检测指示这些状态的至少一种挥发性有机化合物，非典型性肺泡增生（AAH）。

公开(公告)号：US08430810B2

公开(公告)日：2013-04-30

申请号：US12526512

申请日：2008-02-12

Applicant: Noam Hassidov ,  Daniel Glozman ,  Moshe Shoham

Inventor： Noam Hassidov ,  Daniel Glozman ,  Moshe Shoham

IPC: A61B1/01 ,  A61B1/015

CPC classification number: F01B19/00 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/00557 ,  A61B2017/12127 ,  A61B2017/22055 ,  A61B2090/306 ,  A61B2090/3614 ,  A61M25/0122

Abstract: A self-propelled device for locomotion through a lumen, comprising a set of serially arranged inflatable chambers, and incorporating a number of novel aspects. To enable easy insertion and use, the rigidity of the device is increased by means of rigid inserts in the balloons, or by use of stiff springs between segments. The working channel can be attached to the distal chamber of the device, such that it is pulled from the leading end of the device during inflation, rather than being pulled from the trailing end of the device during deflation. Lumen wall inspection or treatment facilities are enabled by means of a camera or treatment arm mounted between two distally positioned balloons, the device is able to provide observation capabilities to the lumen wall, yet without becoming excessively dirty by exposure to the front end of the device, as in prior art camera units.

Abstract translation: 一种用于通过内腔运动的自推进装置，包括一组串联布置的可充气室，并且结合了许多新颖的方面。 为了易于插入和使用，通过气球中的刚性插入件或通过在段之间使用刚性弹簧来增加装置的刚性。 工作通道可以附接到装置的远端腔室，从而在充气期间从工具的前端拉出工作通道，而不是在放气期间从装置的后端拉出。 腔壁检查或治疗设施通过安装在两个远端定位的气球之间的相机或治疗臂来实现，该装置能够向管腔壁提供观察能力，而不会通过暴露于装置的前端而变得过分脏 ，如在现有技术的相机单元中。

公开(公告)号：US08366630B2

公开(公告)日：2013-02-05

申请号：US12994177

申请日：2009-05-27

Applicant: Hossam Haick ,  Peng Gang

Inventor： Hossam Haick ,  Peng Gang

IPC: A61B5/08

CPC classification number: G01N33/497 ,  B82Y15/00 ,  G01N27/02 ,  G01N27/04 ,  G01N27/22 ,  G01N27/414 ,  G01N33/0034 ,  G01N33/0047 ,  G01N2033/4975

Abstract: The present invention provides a system for measuring biomarker analytes indicative of various diseases comprising an array of sensors sensitive to volatile organic compounds. Particularly, the system is composed of a random network of single-walled carbon nanotubes (SWCNTs) coated with non-polar small organic molecules in conjunction with learning and pattern recognition algorithms. Methods of discriminating between breath samples of healthy individuals and of lung cancer patients are disclosed.

Abstract translation: 本发明提供了一种用于测量指示各种疾病的生物标志物分析物的系统，其包括对挥发性有机化合物敏感的传感器阵列。 特别地，该系统由结合学习和模式识别算法的非极性小有机分子涂覆的单壁碳纳米管（SWCNT）的随机网络组成。 公开了健康个体和肺癌患者呼吸样本之间的区别方法。