Patent search cpc:"A61K31/415" Page 4

31.

发明公开
METHODS OF PERMEABILIZING THE BLOOD BRAIN BARRIER 审中-公开

公开(公告)号：US20230248662A1

公开(公告)日：2023-08-10

申请号：US18190643

申请日：2023-03-27

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN

IPC: A61K31/045 , A61P35/00 , A61K9/00 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K31/4745 , A61K35/17 , A61K39/395 , A61K45/06 , C07K14/705 , C07K16/42

CPC classification number: A61K31/045 , A61P35/00 , A61K9/0019 , A61K9/0043 , A61K9/0078 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K31/4745 , A61K35/17 , A61K39/3955 , A61K45/06 , C07K14/70503 , C07K16/42 , A61K2039/505

Abstract: The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.

32.

发明公开
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 审中-公开

公开(公告)号：US20230233560A1

公开(公告)日：2023-07-27

申请号：US17865220

申请日：2022-07-14

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou

IPC: A61K31/506 , C07D213/82 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64

CPC classification number: A61K31/506 , C07D213/82 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/035 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64

Abstract: The present invention features a compound of formula I:

or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

33.

发明公开
METHODS AND SYSTEMS FOR DEPOSITING ACTIVE INGREDIENTS ON SUBSTRATES 审中-公开

公开(公告)号：US20230233479A1

公开(公告)日：2023-07-27

申请号：US18152394

申请日：2023-01-10

Applicant: Purdue Research Foundation

Inventor： Arun V. GIRIDHAR , Michael HARRIS , Gintaras V. REKLAITIS , Lynne S. TAYLOR , Zoltan K. NAGY , Elcin ICTEN , Frederick FIESSER , Laura HIRSHFIELD

IPC: A61K9/70 , A61K47/10 , A61K31/415 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/635 , A61K47/14 , A61K47/34 , A61K47/38 , B01J4/00 , B01J4/02

CPC classification number: A61K9/7007 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/38 , B01J4/002 , B01J4/02 , B01J4/008 , B01J2204/005 , B01J2204/007

Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluiddispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

34.

发明授权
Charged ion channel blockers and methods for use 有权

公开(公告)号：US11696912B2

公开(公告)日：2023-07-11

申请号：US17099759

申请日：2020-11-16

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole , James Lamond Ellis

IPC: A61K31/4436 , C07D409/12 , A61K45/06 , A61K31/415 , A61K31/4155

CPC classification number: A61K31/4436 , A61K31/415 , A61K31/4155 , A61K45/06 , C07D409/12

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:

The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.

35.

发明公开
Methods for Treating Huntington’s Disease 审中-公开

公开(公告)号：US20230201200A1

公开(公告)日：2023-06-29

申请号：US18111421

申请日：2023-02-17

Applicant: PTC Therapeutics, Inc.

Inventor： Suresh Babu , Anuradha Bhattacharyya , Seongwoo Hwang , Minakshi Jani , Young-choon Moon , Nadiya Sydorenko

IPC: A61K31/506 , A61K31/433 , C07D403/14 , C07D405/14 , C07D401/12 , C07D417/14 , C07D417/04 , C07D487/04 , C07D401/04 , C07D409/14 , C07D487/10 , C07D237/20 , C07D471/10 , C07D413/14 , C07D487/08 , C07D405/12 , C07D403/10 , C07D471/08 , C07D403/12 , C07D417/10 , C07D401/14 , C07D417/12 , A61K31/50 , A61K31/415 , A61P25/28 , A61K31/4439 , A61K31/4709 , A61K31/501 , A61K31/517 , A61K31/5377 , A61K31/5513 , G01N33/68

CPC classification number: A61K31/506 , A61K31/50 , A61K31/415 , A61K31/433 , A61K31/501 , A61K31/517 , A61K31/4439 , A61K31/4709 , A61K31/5377 , A61K31/5513 , A61P25/28 , C07D237/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , G01N33/6896 , G01N2800/2835

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington’s disease.

In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington’s disease.

36.

发明公开
THERAPEUTIC AGENT FOR NON-MOTOR SYMPTOMS ASSOCIATED WITH PARKINSON'S DISEASE 审中-公开

公开(公告)号：US20230149357A1

公开(公告)日：2023-05-18

申请号：US18089752

申请日：2022-12-28

Applicant: Sumitomo Pharma Co., Ltd.

Inventor： Taro KATO , Satoko SHIMIZU

IPC: A61K31/415 , A61P25/22 , A61P25/24 , A61P25/08 , A61K45/06

CPC classification number: A61K31/415 , A61K45/06 , A61P25/08 , A61P25/22 , A61P25/24

Abstract: The purpose of the present invention is to provide: a therapeutic agent or a recurrence preventive agent for serotonergic system- or dopaminergic system-related diseases, in particular, mental dysfunction symptoms and other non-motor symptoms of Parkinson’s disease; and a method for treating the aforesaid symptoms or preventing the recurrence of the same. A compound represented by formula (1) [wherein each symbol is as defined in the description] or a pharmaceutically acceptable salt thereof can exhibit an effect of treating serotonergic system- or dopaminergic system-related diseases, in particular, mental dysfunction symptoms and other non-motor symptoms of Parkinson’s disease and/or an effect of preventing the recurrence of the same.

37.

发明申请
METHODS AND COMPOSITIONS FOR TREATING MIGRAINE AND CONDITIONS ASSOCIATED WITH PAIN 审中-公开

公开(公告)号：US20190216720A1

公开(公告)日：2019-07-18

申请号：US16234069

申请日：2018-12-27

Applicant: Achelios Therapeutics, Inc.

Inventor： Crist J. FRANGAKIS , William BAUER , Wolfgang LIEDTKE

IPC: A61K9/00 , A61K31/635 , A61K31/616 , A61K31/5415 , A61K31/415 , A61K31/407 , A61K31/405 , A61K9/06 , A61K31/14 , A61P25/06 , A61K45/06 , A61K31/192 , A61K47/32 , A61K31/196

CPC classification number: A61K9/0014 , A61K9/06 , A61K31/14 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/5415 , A61K31/616 , A61K31/635 , A61K45/06 , A61K47/32 , A61P25/06 , A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions of a non-steroidal anti-inflammatory drug (NSAIDs) such as, aspirin, diclofenac, ibuprofen, ketoprofen, or naproxen, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The compositions, which can be formulated for topical administration, can provide extended release of the NSAIDs. The compositions of the invention are useful, for example, in the prophylactic treatment or treatment and/or reduction of pain, in the prophylactic treatment or treatment of headaches such as migraine headaches and symptoms of migraine headaches, and in the treatment of temporomandibular disorders (TMD).