公开(公告)号：US20040019314A1

公开(公告)日：2004-01-29

申请号：US10312386

申请日：2002-12-26

Inventor： Annalisa Delnevo

IPC: A61M037/00 ,  G01N021/51 ,  C02F001/44

CPC classification number: G01N21/05 ,  A61M1/3639 ,  A61M1/3641 ,  A61M1/3669 ,  A61M1/367 ,  A61M2230/207

Abstract: A fitting (1) for a blood circulating circuit (4) of a dialysis machine has a first ans a second mouth (8, 9) for connecting the fitting (1) to a first ans a second portion (2, 3) of the blood circulating circuit (4) respectively; the fitting (1) defining a third portion (10) of the blood circulating circuit (4) by means of a tuby (6) by which to determine the absorption of electromagnetic waves by the blood, and by means of a chamber (7) having a wall (15) movable as a function of the pressure of the blood.

Abstract translation: 用于透析机的血液循环回路（4）的配件（1）具有用于将配件（1）连接到第一和第二部分（2,3）的第一和第二口（8,9） 血液循环回路（4） 配件（1）通过管（6）限定血液循环回路（4）的第三部分（10），通过该管（6）确定血液对电磁波的吸收，并借助于腔室（7） 具有可以作为血液压力的函数移动的壁（15）。

公开(公告)号：US6061590A

公开(公告)日：2000-05-09

申请号：US868283

申请日：1997-06-03

Applicant: Nikolai M. Krivitski

Inventor： Nikolai M. Krivitski

IPC: A61B5/0275 ,  A61B8/06 ,  A61M1/16 ,  A61M1/36 ,  A61B6/00

CPC classification number: A61M1/367 ,  A61B5/0275 ,  A61B8/065 ,  A61M1/16 ,  A61M1/3669 ,  A61M2230/20

Abstract: A method and apparatus for identifying a central blood volume and monitoring changes in the central blood volume during hemodialysis to assist in predicting an onset of intradialytic morbid events. A method of determining a central blood volume mean transit time in a patient system having the central volume and a tubing portion includes measuring a system mean transit time through the tubing portion and the central volume; calculating a tubing portion mean transit time corresponding to passage of an indicator through the tubing portion; adjusting the measured system mean transit time in response to the calculated tubing portion mean transit time to produce the central volume mean transit time and calculating a central volume by multiplying the central volume mean transit time by the cardiac output. This technology can be used not only in hemodialysis, but in intensive care units or during the surgery with extracorporeal circulation systems.

Abstract translation: 一种用于识别中央血容量并监测血液透析期间中心血液体积变化的方法和装置，以帮助预测体内病态​​发作的发作。 确定具有中心体积和管道部分的患者系统中的中心血容量平均转运时间的方法包括测量通过管部分和中心体积的系统平均通过时间; 计算管道部分平均通过时间，其对应于通过管道部分的指示器通过; 根据计算的管道部分平均通过时间来调整测量的系统平均通过时间，以产生中心体积平均通过时间，并通过将中心体积平均通过时间乘以心输出量来计算中心体积。 该技术不仅可用于血液透析，还可用于重症监护室或手术期间体外循环系统。

公开(公告)号：US5902336A

公开(公告)日：1999-05-11

申请号：US732852

申请日：1996-10-15

Applicant: Gary J. Mishkin

Inventor： Gary J. Mishkin

IPC: A61F2/01 ,  A61F2/06 ,  A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  A61M27/00 ,  A61F2/02 ,  A61F2/04 ,  A61M1/00 ,  A61M37/00

CPC classification number: A61M1/34 ,  A61F2/064 ,  A61F2/01 ,  A61M1/1678 ,  A61M1/3669 ,  A61M2205/3523 ,  A61M27/002

Abstract: An implantable ultrafiltration device for removing low to medium molecular weight solutes and fluids from the blood of a patient experiencing renal failure, the device including: a pump having an inlet and an outlet; a first component for forming a first fluid flow path between the patient's vascular system and the pump inlet; a filter interposed in the first fluid flow path, the filter being permeable to water and substantially impermeable to blood cells and proteins; and a second component for forming a second fluid flow path between the pump outlet and the patient's bladder, wherein the pump, the first and second components, and the filter are all constructed to be surgically implanted in the patient's body. For removing unwanted fluids from the blood of a patient experiencing renal failure the first component is connected in the vascular system of the patient and the second component is implanted in the patient's bladder or ureter; and the pump is then operated to cause fluid to flow through the filter at a controlled rate in order to maintain the volume of the blood in the vascular system and total body volume at a selected value. The infusion of peritoneal solution free of osmotic agents can also be carried out in conjunction with conventional hemodialysis or with operation of the implanted device.

Abstract translation: 一种用于从经历肾衰竭的患者的血液中去除低分子量至中等分子量溶质和流体的可植入超滤装置，所述装置包括：具有入口和出口的泵; 用于在患者血管系统和泵入口之间形成第一流体流路的第一部件; 过滤器插入在第一流体流动路径中，过滤器可渗透水分，并且基本上不可渗透血细胞和蛋白质; 以及用于在所述泵出口和所述患者膀胱之间形成第二流体流路的第二部件，其中所述泵，所述第一和第二部件以及所述过滤器都构造成被外科植入患者体内。 为了从患有肾衰竭的患者的血液中除去不想要的液体，第一组分连接在患者的血管系统中，第二组分被植入患者膀胱或输尿管; 然后操作泵以使流体以受控的速率流过过滤器，以便将血液系统中的血液的体积和总体积保持在选定的值。 输注不含渗透剂的腹膜溶液也可以与常规血液透析或植入装置的操作一起进行。

公开(公告)号：US5510716A

公开(公告)日：1996-04-23

申请号：US332647

申请日：1994-11-01

Applicant: George W. Buffaloe, IV ,  Francis T. Ogawa ,  James M. Brugger

Inventor： George W. Buffaloe, IV ,  Francis T. Ogawa ,  James M. Brugger

IPC: G01N27/06 ,  A61M1/14 ,  A61M1/16 ,  A61M1/36 ,  G01F1/704 ,  G01F1/708 ,  G01N27/02 ,  G01N33/487 ,  G01R27/02 ,  B01D61/32

CPC classification number: G01F1/7088 ,  A61M1/16 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3653 ,  A61M1/3658 ,  A61M1/3669 ,  G01F1/7046 ,  G01F1/708

Abstract: A differential conductivity recirculation monitor quantitatively determines the degree of recirculation in a fistula by comparing the conductivity of blood entering the fistula to the conductivity of blood being withdrawn from the fistula. A discrete quantity of a high conductivity marker fluid is injected into the blood entering the fistula, altering the conductivity of the blood entering the fistula. The altered conductivity blood enters the fistula and, if recirculation is present, co-mingles with blood in the fistula, altering the conductivity of the blood ion the fistula in proportion to the degree of recirculation. Blood withdrawn from the fistula has an altered conductivity related to the degree of recirculation. Quantitative values of the conductivity of the altered conductivity blood entering the fistula and the conductivity of the blood being withdrawn from the fistula are measured and a difference determined. The determined difference between the conductivities is used to determine a quantitative measurement of the degree of recirculation in the fistula.

Abstract translation: 差分电导率再循环监测器通过比较进入瘘的血液的电导率与从瘘管抽取的血液的电导率来定量地确定瘘管中的再循环程度。 将离散量的高电导率标记液注入进入瘘管的血液中，改变进入瘘管的血液的电导率。 改变的电导率血液进入瘘管，并且如果存在再循环，则与瘘管中的血液共混，改变与再循环程度成比例的血液离子瘘的电导率。 从瘘管中取出的血液与再循环程度相关的导电性改变。 测量进入瘘的改变的导电性血液的导电性的定量值和从瘘管取出的血液的电导率，并确定差异。 电导率之间的确定差异用于确定瘘管再循环程度的定量测量。

公开(公告)号：US3957197A

公开(公告)日：1976-05-18

申请号：US571814

申请日：1975-04-25

Applicant: Walter K. Sartory ,  John W. Eveleigh

Inventor： Walter K. Sartory ,  John W. Eveleigh

IPC: B04B1/02 ,  A61M1/36 ,  G01N27/06 ,  G01N33/483 ,  G01N33/487 ,  G01N33/49 ,  B04B11/02

CPC classification number: A61M1/3693 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3669 ,  A61M1/3696 ,  G01N33/491 ,  B04B2005/0464

Abstract: A method and apparatus for operating a continuous flow blood separation centrifuge are provided. The hematocrit of the entrant whole blood is continuously maintained at an optimum constant value by the addition of plasma to the entrant blood. The hematocrit of the separated red cells is monitored to indicate the degree of separation taking place, thereby providing a basis for regulating the flow through the centrifuge.

Abstract translation: 提供了一种用于操作连续流血分离离心机的方法和装置。 通过向进入的血液添加血浆，进入全血的血细胞比容连续保持在最佳的恒定值。 监测分离的红细胞的血细胞比容，以指示发生的分离程度，从而为调节通过离心机的流量提供依据。

公开(公告)号：US09943633B2

公开(公告)日：2018-04-17

申请号：US15190553

申请日：2016-06-23

Applicant: Medtronic, Inc.

Inventor： Daniel C. Sigg ,  Sarah Anne Audet ,  Tommy D. Bennett ,  Dwight H. Warkentin

IPC: A61M37/00 ,  A61M1/34 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61M1/3403 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3406 ,  A61M1/341 ,  A61M1/36 ,  A61M1/3669 ,  A61M2205/18 ,  A61M2205/33 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/20 ,  A61M2230/201 ,  A61M2230/30 ,  A61M2230/65

Abstract: A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.

公开(公告)号：US09399091B2

公开(公告)日：2016-07-26

申请号：US12571127

申请日：2009-09-30

Applicant: Daniel C. Sigg ,  Sarah Anne Audet ,  Tommy D. Bennett ,  Dwight H. Warkentin

Inventor： Daniel C. Sigg ,  Sarah Anne Audet ,  Tommy D. Bennett ,  Dwight H. Warkentin

IPC: A61M37/00 ,  A61M1/34 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61M1/3403 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3406 ,  A61M1/341 ,  A61M1/36 ,  A61M1/3669 ,  A61M2205/18 ,  A61M2205/33 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/20 ,  A61M2230/201 ,  A61M2230/30 ,  A61M2230/65

Abstract: A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.

Abstract translation: 包括生理传感器和超滤单元的医疗装置系统感测患者的生理信号，并使用生理信号计算患者的流体状况测量。 根据响应于流体状态测量而建立的治疗递送控制参数将超滤治疗递送给患者。

公开(公告)号：US08105277B2

公开(公告)日：2012-01-31

申请号：US12438822

申请日：2007-08-31

Applicant: Tobias Gröber ,  Christoph König

Inventor： Tobias Gröber ,  Christoph König

IPC: A61M5/00

CPC classification number: A61M1/3656 ,  A61B5/053 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/15074 ,  A61B5/150755 ,  A61B5/150961 ,  A61B5/153 ,  A61B5/155 ,  A61M1/3669 ,  A61M5/158 ,  A61M2005/1588 ,  A61M2205/13 ,  A61M2205/3317 ,  A61N1/05

Abstract: The present invention relates to a device for creating a vascular access for extracorporeal blood treatment including an electrically conductive puncture needle with a proximal endpiece, a distal endpiece, and a base body made of electrically non-conductive material into which the distal endpiece is inserted. In a properly arranged vascular access, the base body, including an electrically conductive contact element, lies on the skin of the patient, when the puncture needle is located within the vessel of the patient. A disconnection or dislocation is detected by the impedance between the electrically conductive puncture needle and the electrically conductive contact element being measured and compared to a limit value. If the impedance measured is within predetermined limits, this indicates a properly arranged vascular access. A disconnection or dislocation of the puncture needle leads to a strong variation in the impedance.

Abstract translation: 本发明涉及一种用于产生用于体外血液处理的血管通路的装置，包括具有近端件的导电穿刺针，远端件和由非导电材料制成的基体，远端件插入其中。 在正确布置的血管通路中，当穿刺针位于患者的血管内时，包括导电接触元件的基体位于患者的皮肤上。 通过导电穿刺针和被测量的导电接触元件之间的阻抗来检测断开或脱位，并将其与极限值进行比较。 如果测量的阻抗在预定的限度内，则表示正确布置的血管通路。 穿刺针的断开或脱位导致阻抗的强烈变化。

公开(公告)号：US20100016809A1

公开(公告)日：2010-01-21

申请号：US12438822

申请日：2007-08-31

Applicant: Tobias Gröber ,  Christoph König

Inventor： Tobias Gröber ,  Christoph König

IPC: A61M5/00 ,  G01R27/08

CPC classification number: A61M1/3656 ,  A61B5/053 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/15074 ,  A61B5/150755 ,  A61B5/150961 ,  A61B5/153 ,  A61B5/155 ,  A61M1/3669 ,  A61M5/158 ,  A61M2005/1588 ,  A61M2205/13 ,  A61M2205/3317 ,  A61N1/05

Abstract: The present invention relates to a device for creating a vascular access for extracorporeal blood treatment using an extracorporeal blood treatment device, wherein the device for creating the vascular access has an electrically conductive puncture needle with a proximal endpiece and distal endpiece, and a base body that is made of electrically non-conductive material and into which the distal endpiece of the puncture needle is inserted. In the case of a properly arranged vascular access, the base body, which includes an electrically conductive contact element, lies on the skin of the patient, when the puncture needle is located within the vessel of the patient. A disconnection or dislocation is detected by the impedance between the electrically conductive puncture needle and the electrically conductive contact element being measured and compared to a limit value. If the impedance measured is within predetermined limits, this indicates a properly arranged vascular access. A disconnection or dislocation of the puncture needle leads to a strong variation in the impedance, which indicates that the vascular access is not properly arranged.

Abstract translation: 本发明涉及一种使用体外血液处理装置创建用于体外血液处理的血管通路的装置，其中用于产生血管通路的装置具有带有近端件和远端件的导电穿刺针，以及基体， 由不导电材料制成，并且穿刺针的远端件插入其中。 在正确布置的血管通路的情况下，当穿刺针位于患者的血管内时，包括导电接触元件的基体位于患者的皮肤上。 通过导电穿刺针和被测量的导电接触元件之间的阻抗来检测断开或脱位，并将其与极限值进行比较。 如果测量的阻抗在预定的限度内，则表示正确布置的血管通路。 穿刺针的断开或脱位导致阻抗的强烈变化，这表明血管通路未正确布置。

公开(公告)号：US07537687B2

公开(公告)日：2009-05-26

申请号：US11246385

申请日：2005-10-07

Applicant: Masahiro Toyoda ,  Yasushi Takakuwa

Inventor： Masahiro Toyoda ,  Yasushi Takakuwa

IPC: C02F1/44 ,  A61M1/16

CPC classification number: A61M1/367 ,  A61M1/3656 ,  A61M1/3669 ,  A61M2205/13

Abstract: A hemodialysis device includes a hemodialysis device main body including an arterial blood circuit, venous blood circuit, blood pump, dialyzer, dialysate inlet and outlet lines, voltage adding device, electric potential measuring device, and monitoring device monitoring the needle when it is detached from the patient based on an electric potential measured by the electric potential measuring device. One electrode of the voltage adding device is attached between an arterial blood needle in the arterial blood circuit and the pump, and another electrode is attached to the dialysate outlet line. The hemodialysis device allows the precise detection of a needle that is detached from a patient taking a blood hemodialysis treatment by monitoring a voltage difference at a predetermined position while providing voltage to the blood flowing in the blood circuit. The device also allows the suppression of an increase in production cost for a disposable blood circuit.

Abstract translation: 血液透析装置包括：血液透析装置主体，包括动脉血液回路，静脉血液回路，血液泵，透析器，透析液入口和出口管线，加压装置，电位测量装置，以及监测装置，当针脱离时 所述患者基于由所述电位测量装置测量的电位。 电压添加装置的一个电极被安装在动脉血液回路中的动脉血针和泵之间，另一个电极连接到透析液出口管线。 血液透析装置允许通过在向血液回路中流动的血液提供电压的同时监视预定位置处的电压差来精确检测与进行血液透析治疗的患者分离的针。 该装置还允许抑制一次性血液回路的生产成本的增加。