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    RECONFIGURABLE CHEMICAL PROCESS SYSTEMS
    31.
    发明申请
    RECONFIGURABLE CHEMICAL PROCESS SYSTEMS 有权
    可重构化学工艺系统

    公开(公告)号：US20120094366A1

    公开(公告)日：2012-04-19

    申请号：US13314170

    申请日：2011-12-07

    Applicant: Lester F. LUDWIG

    Inventor： Lester F. LUDWIG

    IPC: C12M1/36 ,  B01L99/00 ,  C12M1/38 ,  B01J8/00 ,  C12M1/00 ,  G01N33/48 ,  G05B1/00

    CPC classification number: B01J19/0093 ,  B01J2219/00835 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00905 ,  B01J2219/00986 ,  B01J2219/00997 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L9/52 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  B01L2400/086 ,  G01N35/0092 ,  Y10T436/12

    Abstract: Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or smallscale chemical manufacturing.

    Abstract translation: 用于软件可重构化学过程系统的系统和方法可用于广泛的应用。 实施例可以包括内部过程的软件控制，用溶剂清洁内部元件的自动化设备，用于清除和干燥气体的规定以及多任务操作。 在一个实施例系列中，实现了灵活的软件可重新配置的多用途可复用“片上实验室”或“嵌入式化学处理器”，其可以促进广泛的应用，仪器和设备。 通过使用一般架构，单一设计可以经济地大规模制造，并且易于适应不同的专业应用。 可以使用清洁和清洁规定来促进设备的再利用，或者可以在再循环或未回收处理之前用于净化。 在其他实施例中，可以实现灵活的软件可重新配置的多用途可重复使用的实验室玻璃器皿设置，从而在分析，合成或小规模化学制造中发生重复，复杂或低级任务的有才华的实验室人员。

    Microfluidic reactor having an annular reaction chamber
    32.
    发明申请
    Microfluidic reactor having an annular reaction chamber 审中-公开
    具有环形反应室的微流控反应器

    公开(公告)号：US20120071647A1

    公开(公告)日：2012-03-22

    申请号：US13322819

    申请日：2010-05-12

    Applicant: Oliver Lade ,  Arno Steckenborn

    Inventor： Oliver Lade ,  Arno Steckenborn

    IPC: C07H5/02 ,  B01J19/00

    CPC classification number: B01J19/0093 ,  B01F13/0059 ,  B01F13/1013 ,  B01F13/1016 ,  B01J47/11 ,  B01J2219/00788 ,  B01J2219/00835 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00918 ,  B01J2219/0093

    Abstract: A microfluidic reactor has a reaction chamber which is configured as an annular channel. It is provided that segments have been formed in the annular channel such that a sequence of inlets and outlets (allows an alternation between the process fluids (A and B) to take place. Furthermore, particles which circulate in the annular channel and can be used, for example, for the adsorption and desorption of ions may be provided in the annular channel. In this way, the ions concerned can, for example, be extracted from the process fluid (A) and transferred into the process fluid (B). In a method, the reactor can be used for example for the purpose of obtaining 18F− ions from water enriched therewith and feeding them to a solvent such as acetonitrile. In the further course of the method, the 18F− ions can be used for producing a radiopharmaceutical (for example FDG).

    Abstract translation: 微流体反应器具有构造为环形通道的反应室。 提供了在环形通道中形成段，使得入口和出口的顺序（允许处理流体（A和B）之间的交替发生），此外，在环形通道中循环并可以使用的颗粒 例如，可以在环形通道中提供离子的吸附和解吸，以此方式，例如可以从工艺流体（A）中提取离子并将其转移到工艺流体（B）中。 在一种方法中，反应器可以用于例如从富含水的水中获得18F离子并将其送入溶剂如乙腈中，在该方法的进一步过程中，18F-离子可用于生产 放射性药物（例如FDG）。

    Dose Synthesis Mosule for Biomaker Generator System
    33.
    发明申请
    Dose Synthesis Mosule for Biomaker Generator System 有权
    用于生物发生器系统的剂量合成Mosule

    公开(公告)号：US20110070160A1

    公开(公告)日：2011-03-24

    申请号：US12565544

    申请日：2009-09-23

    Applicant: Ronald Nutt ,  Anthony M. Giamis ,  Aaron McFarland

    Inventor： Ronald Nutt ,  Anthony M. Giamis ,  Aaron McFarland

    IPC: G21C1/00 ,  A61K51/04

    CPC classification number: A61K51/0491 ,  B01J19/004 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905

    Abstract: A microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, one (1) unit dose of a radiopharmaceutical biomarker for use in positron emission tomography (PET). The radiopharmaceutical production system includes a reaction vessel that receives a radioisotope from an accelerator or other radioisotope generator. Organic and aqueous reagents are introduced into the reaction vessel, and the mixture is heated to synthesize a solution of a pre-selected radiopharmaceutical. The radiopharmaceutical solution is purified by passing the solution through a solid phase extraction column and a filter. The synthesis process produces per run a quantity of radiopharmaceutical approximately equal to, but not less than, one (1) unit dose of a radiopharmaceutical, reducing waste and allowing for the production of radiopharmaceutical on an as-needed basis. The synthesis process allows for the production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between the synthesis of the radiopharmaceutical and the administration of that radiopharmaceutical, thereby minimizing the loss of active isotopes through decay and allowing the production of lesser amounts of radioisotopes overall.

    Abstract translation: 一种微流体放射性药物生产系统和用于在正电子发射断层摄影（PET）中使用的放射性药物生物标志物的大约一个但不少于一个单位剂量的放射性药物生物标志物合成的方法。 放射性药物生产系统包括从加速器或其他放射性同位素发生器接收放射性同位素的反应容器。 将有机和含水试剂引入反应容器中，并加热混合物以合成预先选择的放射性药物的溶液。 通过使溶液通过固相萃取柱和过滤器来纯化放射性药物溶液。 合成过程每次产生大约等于但不小于一（1）个单位剂量的放射性药物的放射性药物的量，减少浪费并允许根据需要生产放射性药物。 合成过程允许在现场生产标记放射性药物并且靠近给予患者的单位剂量的位置。 现场按需要的小剂量放射性药物的生产减少放射性药物的合成和放射性药物的给药之间的时间，从而通过衰减使活性同位素的损失最小化，并允许整体产生较少量的放射性同位素。

    Fluid flow conducting module
    38.
    发明授权
    Fluid flow conducting module 失效
    流体流动传导模块

    公开(公告)号：US07314060B2

    公开(公告)日：2008-01-01

    申请号：US11112467

    申请日：2005-04-23

    Applicant: Jyh-Jain Chen ,  Jhy-Wen Wu

    Inventor： Jyh-Jain Chen ,  Jhy-Wen Wu

    IPC: B01F5/00

    CPC classification number: F15D1/14 ,  B01F5/061 ,  B01F5/0646 ,  B01F5/0654 ,  B01F13/0059 ,  B01F2005/0621 ,  B01J2219/00858 ,  B01J2219/00905 ,  B01L3/5027 ,  B01L2200/0636 ,  F16K99/0001 ,  F16K99/0021 ,  F16K99/0028 ,  F16K99/0057 ,  F16K2099/0084 ,  Y10S366/01 ,  Y10T137/87249 ,  Y10T137/87281

    Abstract: Disclosed is a fluid flow conducting module comprising two or more inlets, one or more outlets, and a chamber that has a first and second blocks therein. Further, the chamber has a gradually wider section in the middle, and two convergent ends. One convergent end is connected to the inlets, and the other convergent end is connected to the outlets. The first block has an acute angle in the front, and is placed close to the first convergent end and the inlets. The second block has a convex surface in the front, and is placed close to the second convergent end. The fluids are injected into the chamber through the inlets, flow through the chamber, and conducted towards one or more outlets for further collection and analysis. This fluid flow conducting module has a wide range of flow speed and a simple structure. It can be used in a wide range of applications, such as cell culture, cell reaction to medicine or bio-chemical detection.

    Abstract translation: 公开了一种包括两个或更多个入口，一个或多个出口和在其中具有第一和第二块的室的流体流动传导模块。 此外，室在中间具有逐渐变宽的部分，并且两个收敛端部。 一个收敛端连接到入口，另一个收敛端连接到出口。 第一块在前部具有锐角，并且靠近第一收敛端和入口放置。 第二块在前部具有凸面，并且靠近第二会聚端放置。 流体通过入口注入到腔室中，流过腔室，并且朝向一个或多个出口传导以进一步收集和分析。 该流体流动传导模块具有宽的流速范围和简单的结构。 它可用于广泛的应用，如细胞培养，细胞对药物的反应或生物化学检测。

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