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    BAB-type tri-block copolymer comprising polylactic acid (A) and polyethylene glycol (B), method for producing same, and drug delivery system using same
    31.
    发明授权
    BAB-type tri-block copolymer comprising polylactic acid (A) and polyethylene glycol (B), method for producing same, and drug delivery system using same 有权
    包含聚乳酸（A）和聚乙二醇（B）的BAB型三嵌段共聚物，其制备方法和使用其的药物递送系统

    公开(公告)号：US09125944B2

    公开(公告)日：2015-09-08

    申请号：US14343862

    申请日：2011-10-31

    申请人： Kyung Taek Oh ,  Jeong Min Yun

    发明人： Kyung Taek Oh ,  Jeong Min Yun

    IPC分类号： A61K47/34 ,  A61K9/10 ,  C08G81/00 ,  C08G65/08 ,  C08G63/664 ,  A61K9/107

    CPC分类号： A61K47/34 ,  A61K9/1075 ,  C08G63/664 ,  C08G65/08 ,  C08G65/332 ,  C08G81/00 ,  C08L2203/02

    摘要： Provided are a BAB-type tri-block copolymer including a polylactic acid (A) that is a hydrophobic block and polyethylene glycol (B) that is a hydrophilic block, a method of preparing the BAB-type tri-block copolymer including synthesizing a polylactic acid (A)-polyethylene glycol (B) di-block copolymer by a ring opening polymerization of a lactic acid monomer using a hydroxyl group of polyethylene glycol (B) as a polymerization initiator; and synthesizing a BAB-type tri-block copolymer by reacting the AB-type di-block copolymer with polyethylene glycol (B) including at least one carboxyl group at one or more terminals thereof in the presence of a coupling agent and a catalyst, and a drug delivery system using the BAB-type tri-block copolymer.

    摘要翻译： 提供了包含作为亲水性嵌段的疏水性嵌段的聚乳酸（A）和聚乙二醇（B）的BAB型三嵌段共聚物，制备BAB型三嵌段共聚物的方法，包括合成聚乳酸 通过使用聚乙二醇（B）的羟基作为聚合引发剂的乳酸单体的开环聚合来制备酸（A） - 聚乙二醇（B）二嵌段共聚物; 并通过使AB型二嵌段共聚物与其一端或多端含有至少一个羧基的聚乙二醇（B）在偶联剂和催化剂存在下反应合成BAB型三嵌段共聚物，以及 使用BAB型三嵌段共聚物的药物递送系统。

    Crosslinkable curing super-branched polyester and cured product and preparation method thereof
    37.
    发明授权
    Crosslinkable curing super-branched polyester and cured product and preparation method thereof 有权
    可交联固化超支化聚酯和固化产物及其制备方法

    公开(公告)号：US08912246B2

    公开(公告)日：2014-12-16

    申请号：US13885399

    申请日：2010-11-15

    申请人： Mingdong Yu ,  Zhi Chen

    发明人： Mingdong Yu ,  Zhi Chen

    IPC分类号： C08G61/04 ,  C08G63/06 ,  C08G83/00 ,  C08G63/664 ,  C08G63/91

    CPC分类号： C08G63/664 ,  C08G63/06 ,  C08G63/912 ,  C08G83/005

    摘要： A crosslinkable curing super-branched polyester and the cured product and the preparation method thereof are disclosed. The super-branched polyester has high refractive index and comprises a compound represented by the following structural formula (I). In the formula (I), HBP is the backbone of the super-branched polyester; both a and b are positive integers; the sum of a and b is less than or equal to n; n is more than or equal to 10 and less than 80. In the super-branched polyester, A is represented by formula (II) and N is represented by formula (III), wherein R is methyl or hydrogen atom; the mole ratio of N relative to the total mole of A and N is more than 30 mol %, and the ratio of the total mole of A and N relative to the product of the total mole of HBP backbone and n is more than 0.5 and less than or equal to 1.

    摘要翻译： 公开了一种可交联固化的超支化聚酯和固化产物及其制备方法。 超支化聚酯具有高折射率，并且包含由以下结构式（I）表示的化合物。 在式（I）中，HBP是超支化聚酯的主链; a和b都是正整数; a和b的和小于或等于n; 在超支化聚酯中，A由式（II）表示，N由式（III）表示，其中R是甲基或氢原子; N相对于A和N的总摩尔数的摩尔比大于30mol％，A和N的总摩尔数相对于HBP主链和n的总摩尔数的乘积的比率大于0.5， 小于或等于1。