公开(公告)号：US10555973B2

公开(公告)日：2020-02-11

申请号：US15450566

申请日：2017-03-06

申请人： University of Utah Research Foundation

发明人： Jo-Anna Reems ,  Jan Pierce

IPC分类号： A61K9/50 ,  A61K35/50 ,  A61K38/17 ,  A61K31/728 ,  A61K45/06 ,  A61K35/28 ,  A61L27/36 ,  A61L27/26 ,  A61L27/20 ,  A61L27/22 ,  A61L27/54 ,  A61L24/04 ,  A61L24/08 ,  A61L24/10 ,  A61L24/00 ,  A61K38/18 ,  A61K9/00 ,  B01D21/26 ,  A61K9/19

摘要： A therapeutic composition can include an amount of amniotic fluid having a therapeutically effective amount of at least one protein, hyaluronic acid, or both. The therapeutic composition can be substantially free of lanugo, vernix, and cells harvested with the amniotic fluid.

公开(公告)号：US10548924B2

公开(公告)日：2020-02-04

申请号：US14017152

申请日：2013-09-03

申请人： Universidad Autonoma de Madrid ,  TIGENIX, S.A.U.

发明人： Maria Gema Fernandez Miguel ,  Manuel Angel Gonzalez De La Pena ,  Rosa Ana Garcia Castro ,  Mariano Garcia Arranz ,  Damian Garcia-Olmo

IPC分类号： A61L27/38 ,  A61L27/36 ,  A61K35/35 ,  A61L24/10 ,  C12N5/0775 ,  A61B17/16 ,  A61K45/06 ,  A61L24/00 ,  A61B17/32 ,  A61K35/12

摘要： Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.

公开(公告)号：US10456507B2

公开(公告)日：2019-10-29

申请号：US14765592

申请日：2014-03-05

申请人： Aesculap AG

发明人： Christof Merckle ,  Erich Odermatt

IPC分类号： A61L24/00 ,  A61L24/10 ,  A61L31/14 ,  A61L31/16 ,  A61B18/14 ,  A61L31/04 ,  B05D1/00 ,  B05D1/16 ,  A61B18/00 ,  A61B17/00

摘要： A tissue fusion agent includes a supporting element and a flock material. A surgical system includes the tissue fusion agent and a tissue fusion instrument. A method of producing the tissue fusion agent includes a) coating a supporting element with an adhesive, and b) flocking the adhesive-coated supporting element with a flock material while the adhesive is moist, adhesive or tacky, or after activation of the adhesive.

公开(公告)号：US10441675B2

公开(公告)日：2019-10-15

申请号：US15494622

申请日：2017-04-24

申请人： Cook Medical Technologies LLC

发明人： Alan George Brownlee ,  Christopher Malcolm Elvin

IPC分类号： C08J3/24 ,  A61L24/02 ,  A61L24/00 ,  C09J189/00 ,  A61L24/10

摘要： A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photoactivate the photoactivatable metal-ligand complex; thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.

公开(公告)号：US20190255214A1

公开(公告)日：2019-08-22

申请号：US16401644

申请日：2019-05-02

申请人： Baxter International Inc.

发明人： Ronald Dieck ,  Ian J. Handley ,  Neil Winterbottom ,  Joanna Wong

IPC分类号： A61L24/10 ,  A61L24/04 ,  A61L31/04

摘要： Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

公开(公告)号：US20190184056A1

公开(公告)日：2019-06-20

申请号：US15844450

申请日：2017-12-15

申请人： MANAR M. JAMAL

发明人： MANAR M. JAMAL

IPC分类号： A61L24/00 ,  A61L24/02 ,  A61L27/38 ,  A61L27/36 ,  A61L27/12 ,  A61L27/10 ,  A61L27/02 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L24/10 ,  A61L27/24 ,  A61C13/15 ,  A61F2/28 ,  A61C8/02

CPC分类号： A61L24/0036 ,  A61C8/0006 ,  A61C19/003 ,  A61F2/2857 ,  A61F2002/2835 ,  A61F2002/3093 ,  A61F2250/0081 ,  A61L24/0005 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/02 ,  A61L24/102 ,  A61L27/025 ,  A61L27/10 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/12 ,  A61L2430/34

摘要： A method comprising the steps of applying an adhesive composition to a substrate bone repair region. The adhesive composition comprises a porous, biocompatible, biodegradable, resorbable, non-toxic, and polymerizable composition. The substrate bone repair region comprises a bone structure, implant or device surface, or tooth surface. The adhesive composition is cured to provide a polymerized adhesive composition resulting in repairing or augmenting the substrate bone repair region. The adhesive composition may be mixed with a bone graft material before application. The adhesive composition may be additionally applied to a barrier membrane that is placed over the substrate bone repair region where the adhesive composition or combination of adhesive composition and bone graft material is applied.

公开(公告)号：US20190175786A1

公开(公告)日：2019-06-13

申请号：US16213792

申请日：2018-12-07

申请人： Brian S. COHEN ,  Anthony A. ROMEO ,  Jed JOHNSON ,  Devan OHST

发明人： Brian S. COHEN ,  Anthony A. ROMEO ,  Jed JOHNSON ,  Devan OHST

IPC分类号： A61L27/26 ,  A61L27/54 ,  A61L27/12 ,  A61L27/10 ,  A61L27/36 ,  A61L24/10

摘要： The instant disclosure is directed to methods of treating articular or hyaline cartilage damage or injury using biocompatible electrospun polymer fibers. Methods are also directed to treating arthritis, particularly osteoarthritis or rheumatoid arthritis, using biocompatible electrospun polymer fibers. Such methods may involve placing a patch comprising at least one electrospun polymer fiber in physical communication with the damaged cartilage. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers.

公开(公告)号：US20190134260A1

公开(公告)日：2019-05-09

申请号：US16095317

申请日：2017-04-18

申请人： NIPRO CORPORATION

发明人： Yusuke Nakamura ,  Yoshikatsu Sugahara ,  Kazuhisa Matsuda

IPC分类号： A61L24/04 ,  A61L24/10 ,  A61L24/00 ,  A61L24/08

摘要： A sheet-like hemostatic material is provided with: an adhesive layer which serves as an affixing surface to a bleeding site and which is formed from at least poly-γ-glutamic acid (γ-PGA); and a covering layer which is a sheet formed from at least one biodegradable material (covering material) other than γ-PGA, and which serves as an opposite surface to the affixing surface. At least one of the adhesive layer and the covering layer is a single sheet. If the adhesive layer is a single sheet, the adhesive layer should be a sponge-like sheet, and if the adhesive layer is a partial layer, the adhesive layer should be a sponge-like sheet or a nonporous layer. Alternatively, in another sheet-like hemostatic material, a sheet which is formed from at least poly-γ-glutamic acid (γ-PGA) and to which at least one of a saccharide and collagen has been added is provided as the adhesive layer.

公开(公告)号：US20190133685A1

公开(公告)日：2019-05-09

申请号：US16195121

申请日：2018-11-19

申请人： Arizona Board of Regents on behalf of Arizona State University

发明人： Kaushal Rege ,  Huang-Chiao Huang

IPC分类号： A61B18/20 ,  A61L24/10 ,  A61K38/18 ,  A61K38/19 ,  A61L24/00 ,  A61N5/06 ,  A61K41/00 ,  A61B18/18 ,  A61K38/39

摘要： Disclosed herein are methods of connecting disrupted tissue, tissue repair, treating colorectal disorder and tissue welding. The methods comprise using a bioadhesive composition comprising ELP and light absorbing chromophores and irradiating the bioadhesive tissue.

公开(公告)号：US10238693B2

公开(公告)日：2019-03-26

申请号：US15989809

申请日：2018-05-25

申请人： Vivex Biomedical Inc.

发明人： Harry Thomas Temple

IPC分类号： A61K35/32 ,  A61K9/00 ,  A61K9/19 ,  A61B17/88 ,  A61K45/06 ,  A61L24/00 ,  A61L24/10 ,  A61L27/36 ,  A61L27/54 ,  A61B17/70 ,  A61F2/44 ,  A61B17/56

摘要： The present invention provides a novel way to replenish the disc using retooled disc compositions to repair degenerative discs. There is no better source of proteoglycans than the actual disc material (6) itself. To this end, there has been developed a technique to remove the nucleus pulposus and retool the morphology of the nucleus pulposus to create a powder material (10) that is dry and can be stored at room temperature for long periods of time. This powder (10) can then be reconstituted with a variety of fluids, the most suitable being normal saline or lactated ringers to form a flowable mixture (20).