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公开(公告)号：US11079896B2
公开(公告)日：2021-08-03
申请号：US16061531
申请日：2016-10-27
Applicant: EMD Millipore Corporation
Inventor： Laurelle Sciola , Paul John Ricketts , Susan Colt
IPC: G06F3/0481 , G06F16/58 , G16B50/30 , G06F30/20 , G06F3/0482 , G06F3/0484
Abstract: Instrumenting or modeling a bio-manufacturing process is disclosed. A data store holds information regarding one or more bio-manufacturing processes. For each process, the data store information includes workflow steps and per step indications of required equipment, services and consumables according to best practice and/or experts. A videographic user interface enables user interactive input regarding a subject bio-manufacturing process from the data store. The user-interface presents a model representation of deployment of the subject bio-manufacturing process. The user interactively navigates and makes selections in the displayed model representation. The user selections include certain bio-manufacturing products, equipment and services from an image database. The images from the image database enable the views of the model representation to appear true to life demonstrating equipment/product layout and physical equipment/computer connections used in the subject bio-manufacturing process. The videographic user interface utilizes various visual effects to guide the user sequentially or logically (and based on best practice and right fit rules) through the steps and pieces of equipment forming the subject bio-manufacturing process.
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公开(公告)号：US20210225462A1
公开(公告)日：2021-07-22
申请号：US17130659
申请日：2020-12-22
Applicant: EMD Millipore Corporation
Inventor： Karol Molga , Piotr Dittwald , Bartosz A. Grzybowski
IPC: G16C20/10
Abstract: By keeping track of lists of specific bonds that are to be preserved, a computer program is able to design synthetic routes to create a target compound that avoid that previously published or patented approaches. This may allow the exploration of lower cost or more efficient methods of creating known compounds, or may allow the synthesis of new compunds without the use of patented compunds. Examples of computer-designed syntheses relevant to medicinal chemistry are provided in which the machine avoids “strategic” disconnections common to industrial patents and/or is forced to use different starting materials.
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403.发明授权公开(公告)号：US11033839B2
公开(公告)日：2021-06-15
申请号：US16208018
申请日：2018-12-03
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US20210170336A1
公开(公告)日：2021-06-10
申请号：US16762688
申请日：2018-11-01
Applicant: EMD Millipore Corporation
Inventor： Elizabeth M. Goodrich , Akshat Gupta , Herbert Lutz
Abstract: Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.
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公开(公告)号：US10940307B2
公开(公告)日：2021-03-09
申请号：US16895521
申请日：2020-06-08
Applicant: EMD Millipore Corporation
Inventor： James Vigna , Joseph Muldoon , John Cieciuch , Robert Langlois
IPC: A61M39/18 , F16L37/36 , F16L37/367 , F16L55/07 , A61M39/26
Abstract: Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.
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Patent Agency Ranking
公开(公告)号：US20210047430A1
公开(公告)日：2021-02-18
申请号：US17088659
申请日：2020-11-04
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Chia-Yun Sun , Melissa Holstein , Kristen Cotoni , Matthew T. Stone , Santosh Rahane
IPC: C07K16/34 , C07K1/22 , B01D15/38 , B01D15/42 , B01D15/20 , B01J20/289 , B01J20/285 , B01J20/32
Abstract: Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability.
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407.发明授权公开(公告)号：US10829289B2
公开(公告)日：2020-11-10
申请号：US15743361
申请日：2016-08-15
Applicant: EMD Millipore Corporation
Inventor： Stephen Proulx , David DeCoste
Abstract: A device for storing, transporting and/or handling a liquid or liquids and methods for using the device are described. The device is suitable for use with sterile or aseptic liquids, particularly with large liquid volumes such as 10-1000 liters or more, and avoids the need for bags, bins and carriers commonly used for storing and transporting large volumes of liquids. The device comprises a coiled tubing. The coiled tubing can be loaded onto a spool to support the coiled tubing. The tubing can be filled, sealed, stored and transported in a more robust manner than previously achieved with bags, bins and carriers.
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公开(公告)号：US10786754B2
公开(公告)日：2020-09-29
申请号：US16058258
申请日：2018-08-08
Applicant: EMD Millipore Corporation
Inventor： Nripen Singh , Kwok-Shun Cheng
Abstract: A process for the primary clarification of feeds, including chemically treated flocculated feeds, containing the target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, using a primary clarification depth filtration device without the use of a primary clarification centrifugation step or a primary clarification tangential flow microfiltration step. The primary clarification depth filtration device contains a porous depth filter having graded porous layers of varying pore ratings. The primary clarification depth filtration device filters fluid feeds, including chemically treated flocculated feeds containing flocculated cellular debris and colloidal particulates having a particle size distribution of approximately about 0.5 μm to 200 μm, at a flow rate of about 10 litres/m2/hr to about 100 litres/m2/hr. Kits and methods of using and making the same are also provided.
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公开(公告)号：US10737266B2
公开(公告)日：2020-08-11
申请号：US16351828
申请日：2019-03-13
Applicant: EMD Millipore Corporation
Inventor： Terry Gaige , Andrew Zayac , Paul Sydlowski , Philip Lee
IPC: G01N21/00 , G01N1/10 , B01L3/00 , A61J1/06 , C23F11/00 , A61L2/00 , C12M3/06 , C12M1/00 , G01N35/00
Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.
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公开(公告)号：US10722602B2
公开(公告)日：2020-07-28
申请号：US16053523
申请日：2018-08-02
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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