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公开(公告)号:US12141659B2
公开(公告)日:2024-11-12
申请号:US18300658
申请日:2023-04-14
Inventor: Gil Semo , Ziv Aqua , Oded Melamed , Dan Charash , Serge Rosenblum , Barak Dayan
IPC: G06N10/40
Abstract: A quantum computing system, method and computer readable medium involve a vacuum chamber, an atom source input associated with the vacuum chamber, a Photonic Integrated Circuit (PIC) having an interaction region configured to interact with an atom from the atom source, a coupling location for atom positioning, a trapping laser for trapping the atom in the coupling location, an excitation laser for manipulating an electronic state or a nuclear state of the atom, a waveguide for guiding input light to the coupling location, and an output channel for directing quantum light generated at the coupling location, out of the vacuum chamber as a resource for quantum computing. The coupling location is associated with the PIC, and the interaction region of the PIC is arranged for at least partial exposure to the vacuum.
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公开(公告)号:US12139522B2
公开(公告)日:2024-11-12
申请号:US16769867
申请日:2018-12-04
Applicant: THE MEDICAL RESEARCH INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor: Zelig Eshhar , Tova Waks , Anat Globerson Levin , Naamit Deshet-Unger , Moran Rawet Slobodkin , Dan Grisaru , Ben Zion Katz , Ido Laskov
IPC: C07K14/725 , A61K35/17 , C07K16/28 , C07K16/32 , A61K38/00
Abstract: The present invention provides T-cells modified to express at least two chimeric antigen receptors, wherein one of the CARs binds specifically to an antigen selected from CD138, HER2 and CD24 and another CAR binds specifically a different antigen selected from CD 138, HER2 and CD24. Further, the invention provides pharmaceutical compositions comprising these CAR T-cells and their use in treatment of cancer, in particular, ovarian cancer, DNA constructs encoding said CARs and methods for preparation of T-cells expressing said CARs.
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公开(公告)号:US20240338586A1
公开(公告)日:2024-10-10
申请号:US18299821
申请日:2023-04-13
Inventor: Gil SEMO , Ziv AQUA , Oded MELAMED , Dan CHARASH , Serge ROSENBLUM , Barak DAYAN
Abstract: A quantum computing system, method, and computer readable medium involves initializing a state of a resonator-coupled quantum emitter having at least four levels arranged in an N-configuration, the N-configuration having a first ground state, a second ground state, a first excited state and a second excited state. A frequency of a first transition between the first ground state and the first excited state is tuned, a frequency of a second transition between the second ground state and the second excited state is tuned, and a frequency of a third transition between the second ground state and the first excited state is tuned. A plurality of photons are fed at a frequency corresponding to the frequency of the second transition, thereby entangling the plurality of photons to the resonator-coupled quantum emitter. Likewise, a photon at a frequency corresponding to the frequency of at least one of the first transition or the third transition is fed, thereby mapping a state of the resonator-coupled quantum emitter into a photon.
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公开(公告)号:US12091445B2
公开(公告)日:2024-09-17
申请号:US16611859
申请日:2018-05-09
Inventor: Guy Patchornik , Irishi N. N. Namboothiri , Mordechai Sheves , Assaf Howard , Margalit (Maggie) Cohen
CPC classification number: C07K16/065 , C07K1/14 , C07K16/36 , C11D9/22
Abstract: A method of isolating an antibody is disclosed. The method comprises contacting a hydrophobic chelator, a non-ionic detergent and metal ions so as to generate an aggregate comprising the hydrophobic chelator, the detergent and the metal ions; and contacting the aggregate with a medium comprising the antibody under conditions that allow partitioning of the antibody into the aggregate. Kits for isolating the antibody are also disclosed.
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公开(公告)号:US20240247315A1
公开(公告)日:2024-07-25
申请号:US18577231
申请日:2022-07-21
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SHEBA IMPACT LTD.
Inventor: Shaul Shalev Itzkovitz , Keren Bahar Halpern , Adi Egozi , Shomron Silan Ben-Horin , Bella Ungar , Shani Ben-Moshe
IPC: C12Q1/6883
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/158
Abstract: A method of diagnosing an inflammatory bowel disease (IBD) of a subject is disclosed. The method comprises analyzing the RNA expression level of particular human gene in a fecal RNA sample of the subject, wherein when the expression level is above a predetermined amount it is indicative of the inflammatory bowel disease.
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公开(公告)号:US12046371B2
公开(公告)日:2024-07-23
申请号:US18123435
申请日:2023-03-20
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Eran Segal , Eran Elinav
CPC classification number: G16H50/20 , G06N20/00 , G16H10/60 , G16H20/60 , G16H50/70 , G16H70/00 , Y02A90/10
Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.
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公开(公告)号:US12031138B2
公开(公告)日:2024-07-09
申请号:US16362897
申请日:2019-03-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Ron Milo , Niv Antonovsky , Elad Noor , Arren Bar-Even , Yehudit Zohar , Lior Zelcbuch , Shmuel Gleizer , Shira Amram
IPC: C12N15/70 , C07K14/195 , C07K14/245 , C12N1/20 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90
CPC classification number: C12N15/70 , C07K14/195 , C07K14/245 , C12N1/20 , C12N9/0006 , C12N9/1025 , C12N9/1205 , C12N9/88 , C12N9/90 , C12Y101/01049 , C12Y203/03009 , C12Y207/01011 , C12Y207/01019 , C12Y401/01039 , C12Y402/01011 , C12Y504/02
Abstract: A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.
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公开(公告)号:US20240150744A1
公开(公告)日:2024-05-09
申请号:US18281341
申请日:2022-03-10
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor: Asaph AHARONI , Prashant SONAWANE , Adam JOZWIAK , Paula BERMAN , Luis DE-HARO
CPC classification number: C12N9/93 , C12N15/8243 , C12P17/182
Abstract: The present invention provides polynucleotide sequences derived from Helichrysum umbraculigerum and encoding a protein or a plurality thereof belonging to the acyl activating enzyme (AAE) family. Further provided are an artificial nucleic acid molecule including the polynucleotide, a transgenic cell, tissue, or plant including same. Further provided are method for synthesizing an acyl coenzyme A (CoA).
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公开(公告)号:US11972324B2
公开(公告)日:2024-04-30
申请号:US18299807
申请日:2023-04-13
Inventor: Gil Semo , Ziv Aqua , Oded Melamed , Dan Charash , Serge Rosenblum , Barak Dayan
Abstract: Generating photonic graph states includes positioning a plurality of quantum emitters at a plurality of coupling sites associated with a plurality of cavities and initializing a state of a quantum emitter qubit associated with each of the plurality of quantum emitters. Photonic qubits are transmitted toward the plurality of the quantum emitters a first instance transmission for generating an entangling gate between the photonic qubits and the quantum emitter qubit in order to entangle the quantum emitter qubit and the photonic qubits. Following the first instance transmission, photonic qubits are transmitted toward the plurality of quantum emitters in a one second instance transmission for generating a SWAP gate between the photonic qubits and the quantum emitter qubits to map the quantum emitter qubits to photonic qubits.
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公开(公告)号:US11957102B2
公开(公告)日:2024-04-16
申请号:US17859053
申请日:2022-07-07
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor: Asaph Aharoni , Prashant Sonawane , Maxim Itkin
CPC classification number: A01H6/82 , C12N9/1059 , C12N15/8218 , C12N15/8243 , C12N15/8247
Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.
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