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公开(公告)号：US10786754B2
公开(公告)日：2020-09-29
申请号：US16058258
申请日：2018-08-08
Applicant: EMD Millipore Corporation
Inventor： Nripen Singh , Kwok-Shun Cheng
Abstract: A process for the primary clarification of feeds, including chemically treated flocculated feeds, containing the target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, using a primary clarification depth filtration device without the use of a primary clarification centrifugation step or a primary clarification tangential flow microfiltration step. The primary clarification depth filtration device contains a porous depth filter having graded porous layers of varying pore ratings. The primary clarification depth filtration device filters fluid feeds, including chemically treated flocculated feeds containing flocculated cellular debris and colloidal particulates having a particle size distribution of approximately about 0.5 μm to 200 μm, at a flow rate of about 10 litres/m2/hr to about 100 litres/m2/hr. Kits and methods of using and making the same are also provided.
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公开(公告)号：US10737266B2
公开(公告)日：2020-08-11
申请号：US16351828
申请日：2019-03-13
Applicant: EMD Millipore Corporation
Inventor： Terry Gaige , Andrew Zayac , Paul Sydlowski , Philip Lee
IPC: G01N21/00 , G01N1/10 , B01L3/00 , A61J1/06 , C23F11/00 , A61L2/00 , C12M3/06 , C12M1/00 , G01N35/00
Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.
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公开(公告)号：US10722602B2
公开(公告)日：2020-07-28
申请号：US16053523
申请日：2018-08-02
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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公开(公告)号：US10656060B2
公开(公告)日：2020-05-19
申请号：US16115762
申请日：2018-08-29
Applicant: EMD Millipore Corporation
Inventor： Phillip Clark , Kurt Greenizen , John Doyle
Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.
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公开(公告)号：US10526572B2
公开(公告)日：2020-01-07
申请号：US15459332
申请日：2017-03-15
Applicant: EMD Millipore Corporation
Inventor： Paul J. Hung , Philip J. Lee
Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.
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Patent Agency Ranking
公开(公告)号：US10472389B2
公开(公告)日：2019-11-12
申请号：US14768254
申请日：2014-03-07
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Melissa Holstein
Abstract: The present invention provides methods for increasing purity of an Fc-containing protein by removing protein aggregates during the Protein A chromatography step used during the purification of the Fc-containing protein.
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公开(公告)号：US20190224626A1
公开(公告)日：2019-07-25
申请号：US16315069
申请日：2017-08-23
Applicant: EMD Millipore Corporation
Inventor： Songhua Liu , Michael Lynch , Ryan Sylvia , Joseph Almasian , Salvatore Giglia , Luc Messier
Abstract: A scaling tool for replicating filtration characteristics of a large-scale filtration device, the scaling tool comprising a housing having a fluid inlet and a fluid outlet, and a filter receiving region in fluid communication with the fluid inlet and the fluid outlet and configured to contain a membrane comprising one or more pleats, the filter receiving region being defined by a rigid wall framework configured to hold the one or more pleats of the membrane and compress the pleats in an amount effective to replicate the filtration performance of the large-scale filtration device. Also disclosed is a methodology for configuring a filter receiving region in a scaling tool.
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公开(公告)号：USD853831S1
公开(公告)日：2019-07-16
申请号：US29641166
申请日：2018-03-20
Applicant: EMD Millipore Corporation
Designer： Joseph Geringer , Stephen G. Hunt , Mikhail Kozlov , Joseph Almasian , Gregory Straeffer
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公开(公告)号：US20190210321A1
公开(公告)日：2019-07-11
申请号：US16352966
申请日：2019-03-14
Applicant: EMD Millipore Corporation
Inventor： David DeCoste , Joseph Cianciolo , Michael Furbush , John Saragosa
IPC: B32B5/02 , B32B27/08 , B32B27/12 , B32B27/32 , B01L3/00 , B32B27/40 , B65D75/58 , B65D65/40 , G01M3/32 , B32B27/34
Abstract: A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.
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公开(公告)号：US20190099717A1
公开(公告)日：2019-04-04
申请号：US16207895
申请日：2018-12-03
Applicant: EMD Millipore Corporation
Inventor： Herbert Lutz , Joseph Parrella , Bala Raghunath
IPC: B01D61/14
Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
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