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公开(公告)号：US20230399457A1
公开(公告)日：2023-12-14
申请号：US18251144
申请日：2020-10-30
Applicant: Agency for Science, Technology and Research
Inventor： Peili Teo , Jiayi Guo , Yew Chin Teo , Eun Ju Park
IPC: C08G61/08
CPC classification number: C08G61/08 , C08G2261/122 , C08G2261/1426 , C08G2261/1432 , C08G2261/3342 , C08G2261/418
Abstract: There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.
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公开(公告)号：US20230391789A1
公开(公告)日：2023-12-07
申请号：US18144641
申请日：2023-05-08
Applicant: Agency for Science, Technology and Research
Inventor： Vikrant Arun ADSOOL
IPC: C07D491/08 , C07D215/233 , C07D401/12 , C07D451/06 , C07D451/14
CPC classification number: C07D491/08 , C07D215/233 , C07D401/12 , C07D451/06 , C07D451/14
Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.
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公开(公告)号：US11806368B2
公开(公告)日：2023-11-07
申请号：US16875486
申请日：2020-05-15
Applicant: Agency for Science, Technology and Research
Inventor： Lawrence Stanton , Padmapriya Sathiyanathan , Simon Cool , Victor Nurcombe , Rebekah M. Samsonraj
IPC: A61K35/28 , C12Q1/6881 , A61K35/545 , C12N5/0775
CPC classification number: A61K35/28 , A61K35/545 , C12N5/0662 , C12N5/0663 , C12Q1/6881 , C12Y205/01018 , C12Q2600/158
Abstract: A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.
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公开(公告)号：US20230326442A1
公开(公告)日：2023-10-12
申请号：US18022975
申请日：2021-08-04
Applicant: Agency for Science, Technology and Research
Inventor： Kui YAO , Siao Li LIEW , Shuting CHEN , Sze Yu TAN , Rogério SALLOUM , Hong YAN , Lei ZHANG , Szu Cheng LAI
IPC: G10K11/165 , C09D7/61 , C09D7/40 , C09D5/24 , C09D163/00 , C09D137/00 , C09D123/08 , C09D113/00
CPC classification number: G10K11/165 , C09D7/61 , C09D7/70 , C09D5/24 , C09D163/00 , C09D137/00 , C09D123/0853 , C09D113/00 , C09D7/69
Abstract: A composite coating material for passive vibration damping is provided. The composite coating material includes a polymer matrix, and a piezoelectric ceramic filler and an electrically conductive filler dispersed in the polymer matrix. Particles of the piezoelectric ceramic filler have an average particle size of greater than about 100 microns (μm).
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公开(公告)号：US20230271255A1
公开(公告)日：2023-08-31
申请号：US18014066
申请日：2021-07-09
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Pei WANG et al. , Cheng Cheh Dennis TAN , Kaixin Vivian LIN , Kwang Boon Desmond LAU , Wei Hock Gary TEH
CPC classification number: B22F10/28 , B22F1/09 , B22F9/04 , B22F9/08 , B22F10/37 , B22F10/38 , B22F2009/047 , B22F2301/052 , B22F2301/205
Abstract: The present disclosure generally relates to a method of fabricating a graded metallic structure by additive manufacturing and the graded metallic structure thereof. The method comprises preparing a material powder in a supply container, the material powder is partitioned into a plurality of longitudinal volumes and comprises different metallic powders, performing an additive manufacturing process comprising supplying layers of the material powder from the supply container, displacing the layers of material powder to a fabrication platform and fusing the layers of material powder on the fabrication platform to form the graded metallic structure, wherein at least one longitudinal volume has a varying transverse cross-sectional area and at least one longitudinal volume has a varying longitudinal cross-sectional area, such that the fused metallic powders in the graded metallic structure are graded along the longitudinal and the transverse. This method is proven to be effective to make graded metal parts with composition gradients in two dimensions.
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Patent Agency Ranking
公开(公告)号：US20230268332A1
公开(公告)日：2023-08-24
申请号：US18006921
申请日：2021-07-09
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Gongyue TANG , Kazunori YAMAMOTO , Xiaowu ZHANG
IPC: H01L25/18 , H01L23/495 , H01L23/367 , H01L23/427 , H01L23/00 , H01L25/00
CPC classification number: H01L25/18 , H01L23/3672 , H01L23/427 , H01L23/49537 , H01L24/32 , H01L24/83 , H01L25/50 , H01L2224/32245 , H01L2224/83801
Abstract: Abstract: Various embodiments may relate to a power module package. The power module package may include a power module including a first lead frame, a second lead frame, and at least one chip at least partially between the first lead frame and the second lead frame. The power module package may also include a first heat spreader attached to the first lead frame. The power module package may further include a second heat spreader also attached to the first lead frame such that the first lead frame, the first heat spreader and the second heat spreader form an enclosure defining a cavity containing the at least one chip. The enclosure may include an inlet configured to allow a cooling medium to flow into the cavity and an outlet configured to allow the cooling medium to flow out of the cavity.
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467.发明公开公开(公告)号：US20230257736A1
公开(公告)日：2023-08-17
申请号：US18009377
申请日：2021-06-11
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Wei Leong Chew , Choong Tat Keng , Ke Guo , Daryl Lim
IPC: C12N15/10
CPC classification number: C12N15/1082 , C12N15/1065
Abstract: Disclosed is a method for assessing the transduction efficiency and/or specificity of vectors at single cell level.
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公开(公告)号：US20230257457A1
公开(公告)日：2023-08-17
申请号：US18172773
申请日：2023-02-22
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE. LTD. , NATIONAL UNIVERSITY OF SINGAPORE
Inventor： Tr Kanaga Sabapathy , David P. Lane , Le-Ann Hwang , Xin Yu Koh , Liew Oi Wah
CPC classification number: C07K16/18 , A61P35/00 , A61K49/0058 , A61K39/00 , A61K2039/505 , C07K2317/34 , C07K2317/24 , A61K2039/552 , A61K2039/80 , A61K2039/575
Abstract: The invention relates to methods for producing an antibody which is specific for a mutant p53 polypeptide over wildtype p53 polypeptide, comprising using as an immunogen a peptide or polypeptide comprising: (i) an antigen sequence, comprising an amino acid sequence of the mutant p53 polypeptide including the mutation and at least one amino acid immediately adjacent to the mutation, and (ii) a scaffold sequence for providing the antigen sequence in a solvent-accessible configuration. Also provided are antibodies produced by such methods, and uses thereof.
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469.发明公开公开(公告)号：US20230243030A1
公开(公告)日：2023-08-03
申请号：US18012412
申请日：2021-06-28
Applicant: Agency for Science, Technology and Research
Inventor： Henry Medina Silva , Dongzhi Chi , Shi Wun Tong , Jianwei Chai , Shijie Wang
IPC: C23C16/02 , C23C14/18 , C23C14/08 , C23C16/448 , C23C16/30 , C23C16/455 , C23C16/46 , C23C14/58 , C23C28/00 , H01L21/02
CPC classification number: C23C16/0281 , C23C14/083 , C23C14/185 , C23C14/5866 , C23C16/46 , C23C16/305 , C23C16/4482 , C23C16/45523 , C23C28/322 , C23C28/3455 , H01L21/0242 , H01L21/02568 , H01L21/02614
Abstract: A method for forming a transition metal dichalcogenide monolayer, which includes depositing a transition metal, a transition metal oxide, or a mixture thereof, on a substrate, introducing a chalcogen precursor to the transition metal, the transition metal oxide, or the mixture thereof, in the presence of an etching gas and a carrier gas at a first temperature, to form a transition metal dichalcogenide on the substrate from the transition metal, the transition metal oxide, or the mixture thereof, and subliming the transition metal dichalcogenide on the substrate in the presence of a pulsating supply of a vapor of the chalcogen precursor to form the transition metal dichalcogenide monolayer at a second temperature, wherein the vapor of the chalcogen precursor comprises a chalcogen vapor.
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公开(公告)号：US20230228741A1
公开(公告)日：2023-07-20
申请号：US17763572
申请日：2020-09-23
Inventor： Jonathan Michael BLACKBURN , Arif ANWAR , Nurul H. RUTT , Anis LARBI , Olivier Nicolas Felix CEXUS , Bernett LEE , Jesus Felix Bayta VALENZUELA , Christopher MONTEROLA , Victor TONG
IPC: G01N33/50 , G01N33/564 , G01N33/68
CPC classification number: G01N33/5091 , G01N33/564 , G01N33/6875 , G01N2333/70596 , G01N2800/00
Abstract: A method for determining the health status of an elderly individual by testing the sample extracted from the individual for the presence of biomarkers, the bio markers being autoantibodies to antigens comprising MAPK13, CD96, FKBP3, PPM1A, PHLDA1, GLRX3, FEN1 and AURKA, wherein the antigens may further comprise one or more of UBE2I, AAK1, YARS, ASPSCR1, CASP10, FHOD2, TCL1A and MAP4, wherein PHLDA1 and CD96 correspond to healthy, AURKA, FEN1, CASP10 and AAK1 correspond to intermediate health, and UBE2I, YARS, ASPSCR1, FHOD2, TCL1A, MAP4, MAPK13, FKBP3, PPM1A and GLRX3 correspond to unhealthy.
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