公开(公告)号：US07291768B2

公开(公告)日：2007-11-06

申请号：US10630636

申请日：2003-07-30

Applicant: Su-May Yu

Inventor： Su-May Yu

IPC: C12N15/29 ,  C12N15/82 ,  C12N15/87 ,  A01H5/00

CPC classification number: C12N15/8217 ,  C07K14/415

Abstract: A pure polypeptide containing an amino acid sequence at least 70% identical to SEQ ID NO:7, 8, or 9. The polypeptide regulates expression of a gene in a cell. Also disclosed is an isolated nucleic acid characterized in that it hybridizes under stringent conditions to SEQ ID NO:1, 2, or 3, or a complementary sequence thereof. Also within the scope of the invention are a transformed cell or a transgenic plant containing such a nucleic acid and a method of identifying a compound that modulates the activity of the polypeptide.

Abstract translation: 含有与SEQ ID NO：7,8或9至少70％相同的氨基酸序列的纯多肽。该多肽调节基因在细胞中的表达。 还公开了分离的核酸，其特征在于其在严格条件下与SEQ ID NO：1,2或3或其互补序列杂交。 也在本发明的范围内的是含有这种核酸的转化细胞或转基因植物以及鉴定调节多肽活性的化合物的方法。

公开(公告)号：US20070231339A1

公开(公告)日：2007-10-04

申请号：US11549215

申请日：2006-10-13

Applicant: Alice Yu ,  John Yu ,  Kuo-I Lin ,  Wen-Bin Yang ,  Chi-Huey Wong

Inventor： Alice Yu ,  John Yu ,  Kuo-I Lin ,  Wen-Bin Yang ,  Chi-Huey Wong

IPC: A61K38/16 ,  A61K39/00 ,  C12N5/02

CPC classification number: A61K36/074 ,  A61K39/39 ,  A61K2039/57 ,  C12N5/0639 ,  C12N2500/74

Abstract: Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.

Abstract translation: 通过与含有来自灵芝的含岩藻糖的糖蛋白部分的组合物的接触，公开了可用于从CD14 + +单核细胞增加树突状细胞成熟的方法。 提取物也可用于增加树突状细胞或CD19 + B细胞中细胞因子或趋化因子的产生。 此外，来自灵芝的含岩藻糖的糖蛋白部分可以施用于被鉴定为需要增加的免疫球蛋白，细胞因子或趋化因子产生的受试者。

公开(公告)号：US20070190254A1

公开(公告)日：2007-08-16

申请号：US11351399

申请日：2006-02-10

Applicant: Tahsin Chow ,  Kew-Yu Chen ,  Jiunn-Jye Hwang

Inventor： Tahsin Chow ,  Kew-Yu Chen ,  Jiunn-Jye Hwang

IPC: B05D3/02 ,  C07C49/00

CPC classification number: C07C49/665 ,  C07C4/16 ,  C07C35/44 ,  C07C43/188 ,  C07C2603/90 ,  C07C15/20

Abstract: A novel soluble pentacene (C22H14) precursor 6,13-dihydro-6,13-methanopentacene-15-one, a method for its production and intermediates therefor as well as pentacene films and coated surfaces. Thermolysis of the precursor at 150° C. to 350° C. induces an expulsion of carbon monoxide to generate pentacene in high yield. The high solubility of the precursor compound, as well as its production of non-contaminated pentacene, makes it an excellent material in the application of organic thin film transistors on surfaces.

Abstract translation: 一种新颖的可溶并五苯（C 22 H 14）前体6,13-​​二氢-6,13-​​甲基多烯-15-酮，其制备方法及其中间体为 以及并五苯膜和涂层表面。 在150℃至350℃下热分解前体引起一氧化碳的排出，以高产率生成并五苯。 前体化合物的高溶解度以及其未污染并五苯的生产使其成为在表面上应用有机薄膜晶体管的优异材料。

公开(公告)号：US07217784B2

公开(公告)日：2007-05-15

申请号：US10449531

申请日：2003-05-29

Applicant: Shu-Mei Liang ,  Jeng-Hwan Wang ,  Jeng-Jer Shieh

Inventor： Shu-Mei Liang ,  Jeng-Hwan Wang ,  Jeng-Jer Shieh

IPC: A61K38/00

CPC classification number: A61K39/135 ,  A61K38/162 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/552 ,  A61K2039/55566 ,  C07K1/1136 ,  C07K14/005 ,  C12N2770/32122 ,  C12N2770/32134

Abstract: A pure, water-soluble polypeptide containing one or more monomers of a VP1 protein of a foot-and-mouth disease virus; or a pure, water-insoluble polypeptide comprising two or more monomers of a VP1 protein of a foot-and-mouth disease virus. Also disclosed are a vaccine containing the polypeptide, a method of producing the polypeptide, and a method of inducing an immune response in a subject by administering to the subject an effective amount of the polypeptide.

Abstract translation: 含有一种或多种口蹄疫病毒VP1蛋白单体的纯水溶性多肽; 或包含口蹄疫病毒的VP1蛋白质的两种或更多种单体的纯的水不溶性多肽。 还公开了含有多肽的疫苗，产生多肽的方法以及通过向对象施用有效量的多肽来在受试者中诱导免疫应答的方法。

公开(公告)号：US20070105814A1

公开(公告)日：2007-05-10

申请号：US11534204

申请日：2006-09-21

Applicant: Kuo-Feng Hua ,  Hsien-Yeh Hsu ,  Chi-Huey Wong

Inventor： Kuo-Feng Hua ,  Hsien-Yeh Hsu ,  Chi-Huey Wong

IPC: A61K31/715 ,  A01N43/04

CPC classification number: A61K36/074

Abstract: The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing the secretion of IL-1 by a monocyte, for increasing the secretion of IL-1Ra by a monocyte, for increasing the secretion of IL-1Ra by a macrophage, for increasing expression of TLR4 on the surface of a macrophage, for increasing expression of CD14 on the surface of macrophage, for increasing the uptake and clearance of lipopolysaccharide (LPS) by a LPS-stimulated macrophage, and for increasing lipopolysaccharide (LPS)-stimulated activation of at least one of ERK, JNK, and p38 in a macrophage. The methods of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Ganoderma lucidum.

Abstract translation: 本公开提供了增加脂多糖诱导的巨噬细胞分泌IL-1的方法，用于增加哺乳动物中IL-1的血清水平，以增加哺乳动物中IL-1受体拮抗剂（IL-1Ra）的血清水平 用于增加单核细胞分泌IL-1，增加单核细胞分泌IL-1Ra，增加巨噬细胞分泌IL-1Ra，增加巨噬细胞表面TLR4的表达，为 增加巨噬细胞表面CD14的表达，增加LPS刺激的巨噬细胞对脂多糖（LPS）的吸收和清除，并增加脂多糖（​​LPS）刺激ERK，JNK和p38中的至少一种的活化 巨噬细胞 本公开的方法涉及从灵芝向哺乳动物和免疫细胞施用含岩藻糖的糖蛋白部分。

公开(公告)号：US20070072247A1

公开(公告)日：2007-03-29

申请号：US11469270

申请日：2006-08-31

Applicant: Chie-Huey Wong ,  Shie-Liang Hsieh ,  Tsui-Ling Hsu ,  Shih-Chin Cheng ,  Szu-Ting Chen

Inventor： Chie-Huey Wong ,  Shie-Liang Hsieh ,  Tsui-Ling Hsu ,  Shih-Chin Cheng ,  Szu-Ting Chen

IPC: G01N33/567 ,  C07H21/04 ,  C12P21/04 ,  C07K16/46

CPC classification number: C07K16/2851 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/56972 ,  G01N33/56983 ,  G01N2333/18 ,  G01N2500/02 ,  Y02A50/53

Abstract: The disclosure provides fusion proteins comprising a carbohydrate recognition domain of an innate immunity receptor and a heterologous polypeptide. The fusion proteins of the disclosure may be used, for example, to fingerprint polysaccharide compositions and to purify polysaccharide compositions. Polysaccharide compositions include those isolated from Ganoderma lucidum (Reishi). The methods and reagents of the disclosure may also be used to identify innate immunity receptors and cell types that bind to polysaccharide compositions (including polysaccharide compositions associated with pathogens), whereupon modulators of the identified receptors can then be obtained. The fusion proteins also may be used to inhibit the interaction between a polysaccharide composition and an innate immunity receptor on a cell surface. The methods and reagents of the disclosure are used in one example to determine that the DLVR1 innate immunity receptor on macrophages interacts with Dengue virus (DV), and that DLVR1 is responsible for DV-mediated secretion of proinflammatory cytokines from macrophages. The disclosure also provides DVLR1 antibodies that prevent the secretion of proinflammatory cytokines by DV-infected macrophages.

Abstract translation: 本公开提供了包含先天免疫受体的碳水化合物识别结构域和异源多肽的融合蛋白。 本公开的融合蛋白可以用于例如指纹多糖组合物和纯化多糖组合物。 多糖组合物包括从灵芝（Reishi）分离的那些。 本公开的方法和试剂也可用于鉴定结合多糖组合物（包括与病原体相关的多糖组合物）的先天免疫受体和细胞类型，于是可以获得鉴定的受体的调节剂。 融合蛋白也可用于抑制多糖组合物和细胞表面上的先天免疫受体之间的相互作用。 在一个实例中使用本公开的方法和试剂来确定巨噬细胞上的DLVR1先天免疫受体与登革热病毒（DV）相互作用，并且DLVR1负责来自巨噬细胞的DV介导的促炎细胞因子的分泌。 本公开还提供DVLR1抗体，其防止DV感染的巨噬细胞分泌促炎细胞因子。

公开(公告)号：US20070025590A1

公开(公告)日：2007-02-01

申请号：US11355013

申请日：2006-02-16

Applicant: Wen-Liang Hwang ,  Jeng-Nan Tzeng ,  I-Liang Chern

Inventor： Wen-Liang Hwang ,  Jeng-Nan Tzeng ,  I-Liang Chern

IPC: G06K9/00

CPC classification number: G06T1/005 ,  G06T2201/0052 ,  H04K1/00

Abstract: The present invention discloses an asymmetric watermarking technology, which is particularly resistant to projection attack. The asymmetric watermark embedding technology of this invention comprises the following steps: Analyze an original image φo to obtain its watermarking space W. Divide said watermarking space W to obtain two orthogonal subspaces g and h. Select an embedding key G, which is a matrix and which columns form bases of subspace g. Calculate a matrix H, HTG=0. Columns of matrix H form bases of subspace h. Calculate detecting key D: D=GT+BHT; wherein B is a matrix. Obtain a watermark w and embed said watermark w into said original image φo to obtain a watermarked image φw, as follows: φw=φo+Gw wherein D φo=mo is not a 0 vector.

Abstract translation: 本发明公开了一种非对称水印技术，特别适用于投射攻击。 本发明的非对称水印嵌入技术包括以下步骤：分析原始图像文件以获得其水印空间W.将所述水印空间W除以获得两个正交子空间g和h。 选择一个嵌入密钥G，它是一个矩阵，哪个列以子空间g为基础。 计算矩阵H，H T G = 0。 矩阵H的列形成子空间h的基础。 计算检测键D：<？in-line-formula description =“In-line Formulas”end =“lead”？> D = G + BH <？in-line-formula description =“In-line Formulas”end =“tail”？>其中B是一个矩阵。 获取水印w并将所述水印w嵌入到所述原始图像文件中以获得水印图像文件，如下所示：<？in-line-formula description =“ 在线公式“end =”lead“？> phi > Gw <？in-line-formula description =”In-line Formulas“end = “尾”？>其中D phi不是0矢量。

公开(公告)号：US07164010B1

公开(公告)日：2007-01-16

申请号：US11237160

申请日：2005-09-28

Applicant: Chia-Ching Chang ,  Lou-Sing Kan ,  Shang-Fan Lee ,  Ken-Wen Sun

Inventor： Chia-Ching Chang ,  Lou-Sing Kan ,  Shang-Fan Lee ,  Ken-Wen Sun

IPC: C07K14/825 ,  A61K38/00

CPC classification number: C07K14/825 ,  A61K38/00

Abstract: A highly magnetically aligned metallothionein (MT) containing manganese (Mn) and cadmium (Cd) has been synthesized. The metallotionein has a formula of Mnx Cd7−x MT with x being in the range of 1 to 6. Its size and biological functions are similar as those of the native metallothionein as tested by dynamic light scattering, UV, and CD spectroscopic experimental methods. Its maximum magnetic moment per formula unit, in saturation field, is estimated to be 19.46 μB, and persists from 277 to 330 K.

Abstract translation: 已经合成了含有锰（Mn）和镉（Cd）的高磁性排列的金属硫蛋白（MT）。 金属线性蛋白具有x x在1至6范围内的Mn xS x 7 x x MT的配方。其尺寸和生物学功能类似于天然 通过动态光散射，UV和CD光谱实验方法测试金属硫蛋白。 在饱和场中，每个公式单位的最大磁矩估计为19.46微米/秒，并且仍然在277至330K。

公开(公告)号：US07135183B1

公开(公告)日：2006-11-14

申请号：US10213257

申请日：2002-08-06

Applicant: Yuan-Yuan Wang ,  Kay-Hooi Khoo ,  Shui-Tein Chen ,  Chun-Cheng Lin ,  Chi-Huey Wong ,  Chun-Hung Lin ,  Hong-Sen Chen ,  Yow-Fu Tsai

Inventor： Yuan-Yuan Wang ,  Kay-Hooi Khoo ,  Shui-Tein Chen ,  Chun-Cheng Lin ,  Chi-Huey Wong ,  Chun-Hung Lin ,  Hong-Sen Chen ,  Yow-Fu Tsai

IPC: A01N65/00 ,  A61K9/00 ,  A61K47/00 ,  A23K1/17

CPC classification number: A61K36/074 ,  A23L33/105

Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.

Abstract translation: 本发明提供了药用活性提取物和级分，以及通过从灵芝植物组分的组织提取和分馏成分的方法及其制备方法。 这些活性提取物和级分可用于抑制肿瘤生长，调节免疫应答和增加造血活性。

公开(公告)号：US07119331B2

公开(公告)日：2006-10-10

申请号：US10726071

申请日：2003-12-01

Applicant: Huan-Cheng Chang ,  Wen-Ping Peng ,  Yong Cai

Inventor： Huan-Cheng Chang ,  Wen-Ping Peng ,  Yong Cai

IPC: B01D59/44

CPC classification number: H01J49/424 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6441

Abstract: A nanoparticle ion detector includes an ion trap that receives charged particles ejected from a mass selection device. A laser beam illuminates the particles to induce fluorescence, which is detected by the photon detector. Particles are periodically dumped from the ion trap. A mass spectrum of the charged particles can be obtained by comparing signals from the photon detector with the particle ejection characteristics of the mass selection device.

Abstract translation: 纳米颗粒离子检测器包括接收从质量选择装置喷射的带电粒子的离子阱。 激光束照射颗粒以诱导荧光，其由光子检测器检测。 颗粒定期从离子阱中倾倒出来。 通过将来自光子检测器的信号与质量选择装置的粒子喷射特性进行比较，可以获得带电粒子的质谱。