公开(公告)号：US20100068227A1

公开(公告)日：2010-03-18

申请号：US12227250

申请日：2007-05-11

Applicant: Krishna Murthy Ella ,  Victor Jerusha Augustus Harshavardhan Gutla ,  Krishna Mohan Vadrevu ,  Smita Suneel Singhania

Inventor： Krishna Murthy Ella ,  Victor Jerusha Augustus Harshavardhan Gutla ,  Krishna Mohan Vadrevu ,  Smita Suneel Singhania

IPC: A61K39/15 ,  A61K39/12 ,  A61P31/12 ,  A61P37/04 ,  A61P31/14

CPC classification number: A61K39/15 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/55505 ,  C12N7/00 ,  C12N2720/12334

Abstract: The present invention relates to a composition comprising a viral antigen, a first protein and a second protein. Optionally, the composition also comprises three different disaccharaides, or, optionally, the composition comprises a primary sugar and at least one, preferably two secondary sugars. The present invention also relates to the use of a viral antigen, a first protein and a second protein for the manufacture of a composition, preferably a vaccine. The present invention furthermore relates to a method of treatment or prevention of virus associates diseases in humans. Moreover, the present invention relates to a method of adapting a virus to a suitable cell-line. The invention is also useful for the production of virus suspensions suitable for making stable, live/inactivated, monovalent and/or polyvalent, liquid/lyophilized rotavirus vaccine compositions for oral and/or nasal or any other suitable route of administration in human.

Abstract translation: 本发明涉及包含病毒抗原，第一蛋白质和第二蛋白质的组合物。 任选地，组合物还包含三种不同的糖苷，或者任选地，组合物包含初级糖和至少一种，优选两种二级糖。 本发明还涉及病毒抗原，第一蛋白质和第二蛋白质用于制备组合物，优选疫苗的用途。 本发明还涉及治疗或预防人类疾病病毒相关疾病的方法。 此外，本发明涉及使病毒适应于合适的细胞系的方法。 本发明还可用于生产适用于制备用于口服和/或鼻或其它合适的人类给药途径的稳定，活/灭活的单价和/或多价液体/冻干轮状病毒疫苗组合物的病毒悬浮液。

公开(公告)号：US20080302476A1

公开(公告)日：2008-12-11

申请号：US11760465

申请日：2007-06-08

Applicant: Govind Bommi ,  Krishna Murthy Bommi

Inventor： Govind Bommi ,  Krishna Murthy Bommi

IPC: B29C65/14

CPC classification number: B29C65/3612 ,  B01D2201/291 ,  B29C65/344 ,  B29C65/3444 ,  B29C65/3448 ,  B29C65/3476 ,  B29C65/364 ,  B29C65/3644 ,  B29C65/3656 ,  B29C65/3676 ,  B29C65/4815 ,  B29C65/4875 ,  B29C65/489 ,  B29C65/5057 ,  B29C65/72 ,  B29C66/112 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/131 ,  B29C66/3034 ,  B29C66/53421 ,  B29C66/5344 ,  B29C66/71 ,  B29C66/727 ,  B29C66/7461 ,  B29C66/80 ,  B29C66/81431 ,  B29C66/8322 ,  B29K2305/00 ,  B29K2305/02 ,  B29K2309/02 ,  B29L2031/14 ,  C02F1/283 ,  C02F2201/006 ,  B29K2027/06 ,  B29K2023/06 ,  B29K2023/12

Abstract: A bonding method for a filtration unit for bonding a polymeric end cap to a porous filter element body includes providing a polymeric end cap of a filtration unit, providing a porous filter element body and positioning a hot melt adhesive element and a metal element between the porous filter element body and the end cap. A pressure is applied between the porous filter element body and the end cap and an electromagnetic field is induced at the metal element. The hot melt adhesive is melted and flows between the end cap and the porous filter element body and a bond is formed between the porous filter element body and the end cap.

Abstract translation: 用于将聚合物端盖接合到多孔过滤元件主体的过滤单元的粘合方法包括提供过滤单元的聚合端盖，提供多孔过滤元件体并将热熔粘合剂元件和金属元件定位在多孔 过滤元件主体和端盖。 在多孔过滤元件体和端盖之间施加压力，并且在金属元件处引起电磁场。 熔融粘合剂熔化并在端盖和多孔过滤元件主体之间流动，并且在多孔过滤器元件主体和端盖之间形成结合。

公开(公告)号：US20080300420A1

公开(公告)日：2008-12-04

申请号：US12159667

申请日：2006-05-17

Applicant: Ghatambu Sethuram Chittoor ,  Rajaram Bapat Uday ,  Jayamani Munuamy ,  Naga Venkata Satya Prasanna Anjaneya Radha Krishna Murthy Muppidi

Inventor： Ghatambu Sethuram Chittoor ,  Rajaram Bapat Uday ,  Jayamani Munuamy ,  Naga Venkata Satya Prasanna Anjaneya Radha Krishna Murthy Muppidi

IPC: C07C253/30

CPC classification number: C07C255/54 ,  C07C279/22 ,  C07C2601/02

Abstract: A process to prepare (2E)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide (Entacapone) eliminating corrosive acids in the purification, with more than 99.5% purity with a Z-isomer content of less than 0.1% comprising condensation of e,4-Dihydroxy{5-nitrobensaldehyde with N,N-diethyl cyanoacetamide in the presence of a base selected from cyclic and acyclic secondary amines and a mixture of solvents, to obtain a crude product, stirring the crude product in a halogenated solvent, filtering and finally crystallization of polymorph A of Entacapone in a solvent.

Abstract translation: 制备（2E）-2-氰基-3-（3,4-二羟基-5-硝基苯基）-N，N-二乙基-2-丙烯酰胺（恩他卡朋）在净化中消除腐蚀性酸的方法，超过99.5％ 纯度，Z-异构体含量小于0.1％，包括e，4-二羟基{5-硝基苯甲醛与N，N-二乙基氰基乙酰胺在选自环状和无环仲胺的碱的存在下和溶剂混合物的缩合， 得到粗产物，在卤化溶剂中搅拌粗产物，过滤并最终在溶剂中结晶Entacapone的多晶型A.

公开(公告)号：US06657082B2

公开(公告)日：2003-12-02

申请号：US09046740

申请日：1998-03-24

Applicant: Balakrishnan Srinivasa ,  Mahajan Shankar Shivram ,  Chaphekar Gopal Moreshwar ,  Gupte Milind Yeshwant ,  Kulkarni Mohan Parshuram ,  Bandarupalli Radha Krishna Murthy

Inventor： Balakrishnan Srinivasa ,  Mahajan Shankar Shivram ,  Chaphekar Gopal Moreshwar ,  Gupte Milind Yeshwant ,  Kulkarni Mohan Parshuram ,  Bandarupalli Radha Krishna Murthy

IPC: C07C33502

CPC classification number: C07C335/02

Abstract: The present invention relates to an improved process for the preparation of thiourea. The object of the present invention is to provide an improved process for the preparation of Thiourea using Calcium Cyanamide, carbon dioxide and hydrogen sulphide. The process of the present invention comprises passing a mixture of Carbon dioxide and hydrogen sulphide into a slurry formed by addition of major part of calcium cyanamide charge into water using constant stirring, maintaining alkaline pH at a temperature ranging between ambient to 80° C., stopping the addition of hydrogen sulphide, continuing the slow passing of carbon dioxide and addition of remaining part of calcium cyanamide charge and retaining the reaction mass to complete the secondary reactions to form the product for a period ranging from 2-5 hours and continuing passing of carbon dioxide at an increased rate for effecting decomposition of Ca(SH)2 for a period of 1.6 to 6 hours, stopping the addition of carbon dioxide separating thiourea solution, treating the separated solution with activated carbon, removing the carbon by conventional methods, separating the product formed by conventional methods and drying the product at a temperature between 50-70° C. to obtain the product.

Abstract translation: 本发明涉及一种制备硫脲的改进方法。 本发明的目的是提供使用氰氨化钙，二氧化碳和硫化氢制备硫脲的改进方法。 本发明的方法包括将二氧化碳和硫化氢的混合物通过使用恒定搅拌将大部分氰氨基氰加入到水中而形成的浆液中，将碱性pH保持在环境温度至80℃之间， 停止加入硫化氢，继续缓慢通入二氧化碳，加入剩余部分的氰氨胺电荷，并保留反应物质以完成二次反应，形成产物2-5小时，并持续通过 二氧化碳以升高的速度使Ca（SH）2分解1.6至6小时，停止加入二氧化碳分离硫脲溶液，用活性炭处理分离的溶液，通过常规方法除去碳，分离 该产品通过常规方法形成并在50-70℃的温度下干燥产物以获得产品 uct。

公开(公告)号：US06224560B1

公开(公告)日：2001-05-01

申请号：US09151914

申请日：1998-09-11

Applicant: Gopala Krishna Murthy Gazula ,  John J. Godleski

Inventor： Gopala Krishna Murthy Gazula ,  John J. Godleski

IPC: A61B508

CPC classification number: A61B5/087

Abstract: A flow restrictor is applied to a respiration-channeling device such as a tracheostomy tube, a mouthpiece, or a face mask. The flow restrictor creates a pressure differential which varies with volume flow rate. A pressure reading is taken on either side of the flow restrictor in the respiration-channeling device and from this, a volume flow rate is determined. A data acquisition device is used to derive further pulmonary function parameters from the volume flow rate.

Abstract translation: 流量限制器应用于诸如气管造口管，口器或面罩之类的呼吸引导装置。 限流器产生随体积流量变化的压力差。 在呼吸引导装置中的限流器的任一侧进行压力读数，由此确定体积流量。 数据采集​​装置用于从体积流量推导出进一步的肺功能参数。

公开(公告)号：US20180107624A1

公开(公告)日：2018-04-19

申请号：US15404217

申请日：2017-01-12

Applicant: Krishna Murthy Janagani ,  Shivesh Kumar Dubey ,  Seshendra Muchukota

Inventor： Krishna Murthy Janagani ,  Shivesh Kumar Dubey ,  Seshendra Muchukota

IPC: G06F13/42 ,  G06F13/40

CPC classification number: G06F13/4282 ,  G06F13/4022

Abstract: Exemplary embodiments of the present disclosure are directed towards a system and methods employed for signal reception by providing programmable and switchable line terminations a universal serial bus physical layer. The system comprising at least one switching unit comprising at least two receiver pad units configured to provide programmable and switchable line terminations for signal reception in the universal serial bus physical layer. The switching unit further comprises at least one current mode logic switching unit interfaced with the receiver pad units. The system further comprises two pairs of receiver pads connected to the receiver pad units configured to receive a plurality of speed signals from at least four transmission units. The receiver pad units are enabled to route the plurality of speed signals to at least one input of a receive amplifier through the current mode logic switching unit.

公开(公告)号：US09711162B2

公开(公告)日：2017-07-18

申请号：US13539380

申请日：2012-06-30

Applicant: Nitish Krishna Murthy ,  Takahiro Unno ,  Edwin R. Cole

Inventor： Nitish Krishna Murthy ,  Takahiro Unno ,  Edwin R. Cole

IPC: G10L21/00 ,  G10L15/00 ,  H03G3/00 ,  G10L21/0208 ,  G10L15/20 ,  G10L25/78 ,  G10L25/84

CPC classification number: G10L21/0208 ,  G10L15/20 ,  G10L25/78 ,  G10L25/84 ,  H03G3/001

Abstract: A method of environmental noise compensation a speech audio signal is provided that includes estimating a fast audio energy level and a slow audio energy level in an audio environment, wherein the speech audio signal is not part of the audio environment, and applying a gain to the speech audio signal to generate an environment compensated speech audio signal, wherein the gain is updated based on the estimated slow audio energy level when the estimated fast audio energy level is not indicative of an audio event in the audio environment and the estimated gain is not updated when the estimated fast audio energy level is indicative an audio event in the audio environment.

公开(公告)号：US09137611B2

公开(公告)日：2015-09-15

申请号：US13594401

申请日：2012-08-24

Applicant: Takahiro Unno ,  Nitish Krishna Murthy

Inventor： Takahiro Unno ,  Nitish Krishna Murthy

IPC: G10L21/02 ,  H04R25/00 ,  H04R3/00

CPC classification number: H04R25/405 ,  H04R3/005 ,  H04R2430/03 ,  H04R2499/11

Abstract: In response to a signal failing to exceed an estimated level of noise by more than a predetermined amount for more than a predetermined continuous duration, the estimated level of noise is adjusted according to a first time constant in response to the signal rising and a second time constant in response to the signal falling, so that the estimated level of noise falls more quickly than it rises. In response to the signal exceeding the estimated level of noise by more than the predetermined amount for more than the predetermined continuous duration, a speed of adjusting the estimated level of noise is accelerated.

Abstract translation: 响应于超过预定持续时间超过预定量的估计噪声水平的信号，响应于信号上升和第二时间，根据第一时间常数调整估计噪声水平 响应于信号下降是恒定的，使得估计的噪声水平比其上升更快地下降。 响应于超过预定连续持续时间超过预定量的噪声估计值的信号，加速了估计噪声水平的调整速度。

公开(公告)号：US08754043B2

公开(公告)日：2014-06-17

申请号：US13912103

申请日：2013-06-06

Applicant: Krishna Murthy Ella ,  Srinivas Kannappa Vellimedu

Inventor： Krishna Murthy Ella ,  Srinivas Kannappa Vellimedu

IPC: A61K38/18 ,  C07K14/485

CPC classification number: A61K38/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/10 ,  A61K31/355 ,  A61K31/375 ,  A61K31/555 ,  A61K31/716 ,  A61K31/728 ,  A61K35/14 ,  A61K35/644 ,  A61K36/185 ,  A61K36/886 ,  A61K36/9066 ,  A61K38/1808 ,  A61K38/1858 ,  A61K38/193 ,  A61K45/06 ,  A61K2300/00

Abstract: A composition for treating a wound, wherein the composition can comprise therapeutically effective amount of an epidermal growth factor and a physiologically acceptable agent, wherein the physiologically acceptable agent comprises at least one of a stabilizer, a preservative, a thickening agent, carrier/diluent, and optionally pH regulating agent and humectant.

Abstract translation: 一种用于治疗伤口的组合物，其中所述组合物可包含治疗有效量的表皮生长因子和生理学上可接受的试剂，其中所述生理学上可接受的试剂包括稳定剂，防腐剂，增稠剂，载体/稀释剂， 和任选的pH调节剂和保湿剂。

公开(公告)号：US20130272999A1

公开(公告)日：2013-10-17

申请号：US13912103

申请日：2013-06-06

Applicant: Krishna Murthy Ella ,  Srinivas Kannappa Vellimedu

Inventor： Krishna Murthy Ella ,  Srinivas Kannappa Vellimedu

IPC: A61K38/18 ,  A61K38/19 ,  A61K36/886 ,  A61K36/9066 ,  A61K36/185 ,  A61K45/06 ,  A61K35/14 ,  A61K31/555 ,  A61K31/728 ,  A61K31/716 ,  A61K31/375 ,  A61K31/355 ,  A61K38/50 ,  A61K35/64

CPC classification number: A61K38/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/10 ,  A61K31/355 ,  A61K31/375 ,  A61K31/555 ,  A61K31/716 ,  A61K31/728 ,  A61K35/14 ,  A61K35/644 ,  A61K36/185 ,  A61K36/886 ,  A61K36/9066 ,  A61K38/1808 ,  A61K38/1858 ,  A61K38/193 ,  A61K45/06 ,  A61K2300/00

Abstract: A composition for treating a wound, wherein the composition can comprise therapeutically effective amount of an epidermal growth factor and a physiologically acceptable agent, wherein the physiologically acceptable agent comprises at least one of a stabilizer, a preservative, a thickening agent, carrier/diluent, and optionally pH regulating agent and humectant.

Abstract translation: 一种用于治疗伤口的组合物，其中所述组合物可包含治疗有效量的表皮生长因子和生理学上可接受的试剂，其中所述生理学上可接受的试剂包括稳定剂，防腐剂，增稠剂，载体/稀释剂， 和任选的pH调节剂和保湿剂。