公开(公告)号：US10406629B2

公开(公告)日：2019-09-10

申请号：US15539971

申请日：2015-12-21

申请人： National University Corporation Gunma University

发明人： Shinji Koyama ,  Xiaojuan Ma ,  Tatsunori Tsunetou ,  Tsukasa Akiyama ,  Yohei Tomikawa

IPC分类号： B23K31/02 ,  B23K20/16 ,  B23K1/20 ,  B23K20/02 ,  B23K20/233 ,  B23K20/24 ,  B23K103/10 ,  B23K103/20 ,  B23K103/12

摘要： To provide a method for joining metal members, in which joining can be performed at relatively lower temperature, and deformation caused when joining the metal members can be reduced. The present invention includes a step of joining a plurality of metal members with a sheet sandwiched between the joining surfaces of the plurality of metal members, wherein the sheet is obtained by forming an organic acid metal salt film on the surface of a metal sheet; wherein aluminum or an aluminum alloy is used as the metal members, and a sheet made of any one of zinc, copper and magnesium is used as the metal sheet.

公开(公告)号：US10392249B2

公开(公告)日：2019-08-27

申请号：US15735777

申请日：2016-06-17

申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY ,  NISSHINBO HOLDINGS INC.

发明人： Haruo Kumagai ,  Jun-ichi Ozaki ,  Asao Oya ,  Takafumi Ishii ,  Takuya Maie ,  Rieko Kobayashi ,  Yasuo Imashiro

IPC分类号： C01B3/00 ,  C01B32/00 ,  C01B32/318 ,  C01B32/336 ,  B01J20/20 ,  B01J20/28 ,  G01N24/08

摘要： A hydrogen storage carbon material having a carbon structure suited for hydrogen storage and a production method thereof. The hydrogen storage carbon material according to this embodiment includes a carbon structure which has a ratio of an ultramicropore volume to a micropore volume of 60% or more, and in which stored hydrogen exhibits, in 1H-NMR measurement, a second peak at a position corresponding to a chemical shift of from −2 ppm to −20 ppm with respect to a first peak attributed to gaseous hydrogen.

公开(公告)号：US10385090B2

公开(公告)日：2019-08-20

申请号：US15032623

申请日：2014-09-10

申请人： NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY

发明人： Masayasu Kuwahara

IPC分类号： C07H19/20 ,  C07H19/073 ,  C07H19/10 ,  C12N15/115 ,  C07H19/16 ,  C12N15/10 ,  C07H19/173 ,  C12N15/11

摘要： Disclosed is a nucleoside derivative of formulae (I-1) or a salt thereof: in which R1, R2, R3, R5, A1 to A3, B, X, Y, and k are described herein. Also provided are a 5′-phosphate ester and a 3′-phosphoramidite derivative of the nucleoside derivative and substrate solutions thereof. A polynucleotide is produced using the 5′-phosphate ester or 3′-phosphoramidite derivative of the nucleoside derivative. A library of the produced polynucleotide is used in a method of selecting a nucleic acid aptamer. Further provided is a vesicular endothelial growth factor binding agent of formula (i).

公开(公告)号：US20190169107A1

公开(公告)日：2019-06-06

申请号：US16323299

申请日：2017-02-16

申请人： KANTO DENKA KOGYO CO., LTD. ,  NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY

发明人： Hideki AMII ,  Kazuki KOMODA ,  Masafumi KOBAYASHI ,  Yutaka NAKAMURA ,  Ryusuke OBINATA ,  Akinori HARADA

IPC分类号： C07C29/38 ,  C07C41/30 ,  C07C209/78 ,  C07C231/12

CPC分类号： C07C29/38 ,  C07C31/125 ,  C07C33/46 ,  C07C35/48 ,  C07C41/30 ,  C07C43/23 ,  C07C209/68 ,  C07C209/78 ,  C07C211/48 ,  C07C231/12 ,  C07C233/15

摘要： A simple production process is provided of a perfluoroalkyl compound that uses monohydroperfluoroalkane as a starting material, the perfluoroalkyl compound being an important intermediate of organic electronic materials, medicine, agricultural chemicals, functional polymer materials and the like. With monohydroperfluoroalkane is reacted a base and then a carbonyl compound to produce an alcohol having a perfluoroalkyl group. For example, potassium hydroxide is made to interact with trifluoromethane, and a reaction with a carbonyl compound is induced to produce an alcohol having a trifluoromethyl group.

公开(公告)号：US20180346932A1

公开(公告)日：2018-12-06

申请号：US15779227

申请日：2016-11-25

申请人： NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY

发明人： Izuho HATADA ,  Sumiyo MORITA ,  Takuro HORII

IPC分类号： C12N15/90 ,  C12N5/10 ,  C07K16/18 ,  C12N1/00 ,  C12N9/10 ,  C12N15/11

CPC分类号： C07K16/18 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09

摘要： A DNA methylation editing kit comprises: (1) a fusion protein of inactivated CRISPR-associated endonuclease Cas9 (dCas9) having no nuclease activity and a tag peptide array in which plural tag peptides are linked by linkers, or an RNA or DNA coding therefor; (2) a fusion protein(s) of a tag peptide-binding portion and a methylase or demethylase, or an RNA(s) or DNA(s) coding therefor; and (3) a guide RNA(s) (gRNA(s)) comprising a sequence complementary to a DNA sequence within 1 kb of a desired site of methylation or demethylation, or a DNA(s) expressing the gRNA(s).

公开(公告)号：US10083800B2

公开(公告)日：2018-09-25

申请号：US15022091

申请日：2014-09-03

申请人： AION CO., LTD. ,  NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY

发明人： Hidehiko Tsukada ,  Kimiyasu Onda ,  Hiroshi Miyaji ,  Soshi Shiraishi ,  Yukiko Endo

IPC分类号： H01G11/24 ,  H01G11/34 ,  H01G11/42 ,  H01G11/26 ,  H01G11/50 ,  H01G11/86 ,  C01B32/354 ,  C01B32/336

CPC分类号： H01G11/34 ,  C01B32/336 ,  C01B32/382 ,  H01G11/24 ,  H01G11/26 ,  H01G11/42 ,  H01G11/50 ,  H01G11/86 ,  Y02E60/13

摘要： First, the present invention involves adding a curing catalyst to a phenolic resin, polyvinyl alcohol, a pore-forming agent, and a cross-linking agent, and mixing, casting, heating, and drying the same. Next, the plate-shaped porous phenolic resin obtained thereby which has uniform consecutive macropores having an average pore diameter in the range of 3 to 35 μm and formed in a three-dimensional network pattern is immersed with an organic solvent. Thereafter, this block is extracted and pressure is applied thereto. It is possible to obtain plate-shaped activated carbon for use in an electrode of a power-storage device by carbonizing and activating a block which has undergone this procedure by keeping the same at an increased temperature.

公开(公告)号：US20170215394A1

公开(公告)日：2017-08-03

申请号：US15329477

申请日：2014-07-31

申请人： TRANSGENIC INC. ,  NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY

发明人： Kenichi YAMAMURA ,  Takao IWAWAKI ,  Daisuke OIKAWA ,  Tomoo ISHIKAWA

IPC分类号： A01K67/027 ,  A61K49/00

CPC分类号： A01K67/0278 ,  A01K67/027 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0368 ,  A61K49/0008 ,  C12N15/09

摘要： The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.

公开(公告)号：US20160311845A1

公开(公告)日：2016-10-27

申请号：US15032623

申请日：2014-09-10

申请人： NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY

发明人： Masayasu KUWAHARA

IPC分类号： C07H19/20 ,  C12N15/115 ,  C12N15/10 ,  C07H19/16

CPC分类号： C07H19/20 ,  C07H19/073 ,  C07H19/10 ,  C07H19/16 ,  C07H19/173 ,  C12N15/1048 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/315 ,  C12N2320/51 ,  C12N2330/31

摘要： A nucleoside derivative represented by any of the following formulae (I-1) to (I-6) or a salt thereof: in the formulae (I-1) to (I-6), R1 to R5, A1 to A3, B, X, Y, and k represent the meanings as described in claim 1.

摘要翻译： 在式（I-1）至（I-6）中，R1至R5，A1至A3，B，X，Y和k表示权利要求1中所述的含义。

公开(公告)号：US20150366851A1

公开(公告)日：2015-12-24

申请号：US14766543

申请日：2013-11-26

申请人： TOHOKU UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY ,  FUSO PHARMACEUTICAL INDUSTRIES, LTD.

发明人： Haruhisa Kikuchi ,  Yoshiteru Oshima ,  Toshio Hattori ,  Yuzuru Kubohara ,  Osamu Yamada ,  Jing Zhang ,  Yoshihisa Matsushita ,  Shinya Kida

IPC分类号： A61K31/45 ,  A61K31/4412 ,  A61K31/366

CPC分类号： A61K31/45 ,  A61K31/366 ,  A61K31/4412

摘要： Disclosed herein is an osteopontin production inhibitor capable of preventing a disease resulting from increased production of osteopontin.The osteopontin production inhibitor contains a dictyopyrone derivative or a dihydrodictyopyrone derivative as an active ingredient. The dictyopyrone derivative is preferably a compound represented by Chemical Formula 1 or 2, and the dihydrodictyopyrone derivative is preferably a compound represented by Chemical Formula 3 or 4.

摘要翻译： 本文公开了能够预防由骨桥蛋白生成增加引起的疾病的骨桥蛋白生成抑制剂。 骨桥蛋白生成抑制剂含有二甲基吡喃酮衍生物或二氢二甲基吡喃酮衍生物作为活性成分。 二氯代吡酮衍生物优选为化学式1或2所示的化合物，二氢二甲基吡喃酮衍生物优选为化学式3或化学式4表示的化合物。

公开(公告)号：US20150357639A1

公开(公告)日：2015-12-10

申请号：US14763801

申请日：2013-12-25

申请人： Hide MORIMOTO ,  Shin-ichi TOBISHIMA ,  Yohei SHINDO ,  NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY ,  TOYOTA JIDOSHA KABUSHIKI KAISHA

发明人： Hideyuki MORIMOTO ,  Shin-ichi TOBISHIMA ,  Yohei SHINDO

IPC分类号： H01M4/36 ,  H01M10/0525 ,  H01M4/58

CPC分类号： H01M4/366 ,  C01B25/40 ,  H01G11/06 ,  H01G11/30 ,  H01G11/50 ,  H01M4/13 ,  H01M4/505 ,  H01M4/5825 ,  H01M10/0525 ,  H01M2220/20 ,  H01M2220/30 ,  Y02E60/122 ,  Y02E60/13

摘要： The main object of the present invention is to provide an active material which is used for an electrochemical device utilizing Li ion conduction, and capable of improving cycle stability. The present invention attains the object by providing an active material used for an electrochemical device utilizing Li ion conduction, comprising an active substance capable of absorbing and releasing a Li ion, and an Na ion conductor disposed on the surface of the active substance and having a polyanionic structure.

摘要翻译： 本发明的主要目的是提供一种活性物质，其用于利用Li离子传导的电化学装置，并能够提高循环稳定性。 本发明的目的是提供一种利用Li离子传导的电化学装置的活性物质，其包括能够吸收和释放Li离子的活性物质，以及设置在活性物质表面上的Na离子导体， 聚阴离子结构。