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公开(公告)号：US20090252828A1
公开(公告)日：2009-10-08
申请号：US12263886
申请日：2008-11-03
Applicant: Luis G. Cascao-Pereira , James T. Kellis, JR. , Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Vivek Sharma , Andrew Shaw , Jayarama K. Shetty , Donald E. Ward
Inventor： Luis G. Cascao-Pereira , James T. Kellis, JR. , Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Vivek Sharma , Andrew Shaw , Jayarama K. Shetty , Donald E. Ward
CPC classification number: C11D3/38681 , C11D3/386 , C12N9/2417 , D06M16/003
Abstract: Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and kits related thereto.
Abstract translation: 公开了包含α-淀粉酶变体的组合物，其具有α-淀粉酶活性，并且相对于其来源的亲本AmyS样α-淀粉酶表现出改变的性质。 组合物包含另外的酶如植酸酶。 还公开了使用组合物的方法和与其相关的试剂盒。
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42.发明授权公开(公告)号：US07592157B2
公开(公告)日：2009-09-22
申请号：US11848213
申请日：2007-08-30
Applicant: Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
Inventor： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
CPC classification number: C12N15/80 , C07K14/811
Abstract: Described herein are protease inhibitors, variants thereof and methods for their production.
Abstract translation: 本文描述的是蛋白酶抑制剂，其变体及其制备方法。
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公开(公告)号：US20090117642A1
公开(公告)日：2009-05-07
申请号：US12263631
申请日：2008-11-03
Applicant: Scott D. Power , Sandra W. Ramer , Andrew Shaw
Inventor： Scott D. Power , Sandra W. Ramer , Andrew Shaw
IPC: C12N9/28
CPC classification number: C11D3/38681 , C11D3/386 , C12N9/2417 , D06M16/003
Abstract: Disclosed are compositions comprising variants of a parent G. stearothermophilus alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and kits related thereto.
Abstract translation: 公开了包含具有α-淀粉酶活性的亲代嗜热脂肪芽孢杆菌α-淀粉酶的变体的组合物，并且相对于从其衍生的亲本AmyS样α-淀粉酶表现出改变的性质。 组合物包含另外的酶如植酸酶。 还公开了使用组合物的方法和与其相关的试剂盒。
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44.发明授权公开(公告)号：US07429475B2
公开(公告)日：2008-09-30
申请号：US11698326
申请日：2007-01-26
Applicant: Benjamin Bower , Frits Goedegebuur , Kathleen A. Clarkson , Scott D. Power
Inventor： Benjamin Bower , Frits Goedegebuur , Kathleen A. Clarkson , Scott D. Power
CPC classification number: C12N9/16
Abstract: DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.
Abstract translation: 提供了编码具有从青霉，镰刀霉，腐质霉和Emericicella分离的植酸酶活性的酶的DNA。 还提供了分离编码具有植酸酶活性的酶的DNA从具有这种DNA的生物中分离的DNA的方法，将DNA转化为合适的宿主生物体，转化的DNA的表达和在饲料中使用表达的植酸酶蛋白作为补充 。
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45.发明授权Bacterial expression of bowman-birk protease inhibitors and variants thereof 有权Bowman-birk蛋白酶抑制剂及其变体的细菌表达公开(公告)号：US07413877B2
公开(公告)日：2008-08-19
申请号：US10984514
申请日：2004-11-08
Applicant: Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott D. Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
Inventor： Katherine Collier , Grant Ganshaw , Hans De Nobel , Scott D. Power , Anita Van Kimmenade , Marc Kolkman , Jeffrey Miller , Brian Schmidt , Gudrun Vogtentanz , David Estell
CPC classification number: C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
Abstract: The present invention provides compositions and methods related to the expression of Bowman-Birk protease inhibitors and variants thereof in bacterial species. The present invention further provides fusion nucleic acids, vectors, fusion polypeptides, and processes for obtaining the Bowman-Birk protease inhibitors.
Abstract translation: 本发明提供了与细菌种中Bowman-Birk蛋白酶抑制剂及其变体的表达相关的组合物和方法。 本发明还提供了融合核酸，载体，融合多肽以及获得Bowman-Birk蛋白酶抑制剂的方法。
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Patent Agency Ranking
46.发明授权公开(公告)号：US09090887B2
公开(公告)日：2015-07-28
申请号：US12479416
申请日：2009-06-05
Applicant: William A Cuevas , Sang-Kyu Lee , Sandra W Ramer , Andrew Shaw , Amr R Toppozada , David E Estell , Louise Wallace , Regina Chin , Carol A Requadt , Scott D Power , Michael J Pepsin
Inventor： William A Cuevas , Sang-Kyu Lee , Sandra W Ramer , Andrew Shaw , Amr R Toppozada , David E Estell , Louise Wallace , Regina Chin , Carol A Requadt , Scott D Power , Michael J Pepsin
CPC classification number: C12N9/2417 , A21D8/042 , C12N9/2408 , C12P7/14 , C12P19/02 , C12P19/14 , G01N11/00 , Y02E50/17
Abstract: Alpha-amylases from Bacillus subtilis (AmyE), variants thereof, nucleic acids encoding the same, and host cells comprising the nucleic acids are provided. Methods of using AmyE or variants thereof are disclosed, including liquefaction and/or saccharification of starch. Such methods may yield sugars useful for ethanol production or high fructose corn syrup production. In some cases, the amylases can be used at low pH, in the absence of calcium, and/or in the absence of a glucoamylase.
Abstract translation: 提供了来自枯草芽孢杆菌（AmyE）的α-淀粉酶，其变体，编码它们的核酸和包含核酸的宿主细胞。 公开了使用AmyE或其变体的方法，包括淀粉的液化和/或糖化。 这样的方法可能产生可用于乙醇生产或高果糖玉米糖浆生产的糖。 在一些情况下，淀粉酶可以在低pH，不存在钙的情况下和/或不存在葡糖淀粉酶的情况下使用。
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公开(公告)号：US09084734B2
公开(公告)日：2015-07-21
申请号：US11919717
申请日：2006-04-25
Applicant: Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
Inventor： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
IPC: A61K8/02 , A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
CPC classification number: A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
Abstract: The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. IN alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
Abstract translation: 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或毛发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。
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公开(公告)号：US08841107B2
公开(公告)日：2014-09-23
申请号：US13132881
申请日：2009-12-11
Applicant: Scott D. Power , Andrew Shaw
Inventor： Scott D. Power , Andrew Shaw
CPC classification number: C12N9/2417 , C07K2319/00 , G06F19/12 , G06F19/16
Abstract: Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ? amylase. The sequence similarity between the two amylase sequences may be less than 60%. Conserving the wild-type 3D structure in the hybrid facilitates obtaining enzymatically active amylases. In one embodiment, one or both amylase sequences contribute residues to the B domain, resulting in particularly advantageous properties. For instance, replacement of the Ca2+ binding site in the B domain of the Termamyl-like ?-amylase with a B domain sequence of an archae ? amylase that does not bind Ca2+ can produce a hybrid that is fully active in the absence of Ca2+.
Abstract translation: 提供杂交α-淀粉酶，其与野生型类戊酰样α-淀粉酶（例如芽孢杆菌淀粉酶）全部或部分共享保守的3D结构。 在杂交体中，类戊酰样α-淀粉酶的N末端部分被来自古细菌的序列替代 淀粉酶。 两个淀粉酶序列之间的序列相似性可以小于60％。 在杂交中保护野生型3D结构有助于获得酶活性淀粉酶。 在一个实施方案中，一个或两个淀粉酶序列向B结构域贡献残基，导致特别有利的性质。 例如，用具有古细菌的B结构域序列的Termamyl样α-淀粉酶的B结构域中的Ca 2+结合位点的替换 不结合Ca2 +的淀粉酶可以产生在不存在Ca 2+的情况下完全活性的杂交体。
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公开(公告)号：US20130065829A1
公开(公告)日：2013-03-14
申请号：US13609116
申请日：2012-09-10
Applicant: Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
Inventor： Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
IPC: C07K14/415 , A61P17/00 , A61K38/16
CPC classification number: C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
Abstract: The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein is BBI.
Abstract translation: 本发明提供用于治疗增殖性疾病的肽和负载肽。 在特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白是BBI。
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50.发明申请公开(公告)号：US20110086408A1
公开(公告)日：2011-04-14
申请号：US12933752
申请日：2009-03-20
Applicant: Scott D. Power , Robert M. Caldwell , Suzanne E. Lantz , Edmund A. Larenas
Inventor： Scott D. Power , Robert M. Caldwell , Suzanne E. Lantz , Edmund A. Larenas
CPC classification number: C12P19/14 , A61N1/05 , A61N1/0573 , A61N1/086 , A61N1/37 , C12N9/2437 , C12N9/2477 , C12N9/248 , C12P19/02 , C12P19/12 , C12Y301/01072 , C12Y301/01073 , C12Y302/01001 , C12Y302/01003 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01022 , C12Y302/01037 , C12Y302/01055 , C12Y302/01074 , C12Y302/01078 , C12Y302/01091 , C12Y302/01131 , C12Y302/01136 , Y10T29/49117
Abstract: Described are compositions and methods relating to cellulase/hemicellulase enzyme blends for improving the enzymatic hydrolysis of cellulosic and hemicellulosic materials, as commonly found in biomass
Abstract translation: 描述了与纤维素酶/半纤维素酶共混物相关的组合物和方法，用于改进纤维素和半纤维素材料的酶水解，如通常在生物质
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