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    Polynucleotide sequencing
    43.
    发明授权
    Polynucleotide sequencing 有权
    多核苷酸测序

    公开(公告)号：US06833246B2

    公开(公告)日：2004-12-21

    申请号：US10113221

    申请日：2002-03-29

    Applicant: Shankar Balasubramanian

    Inventor： Shankar Balasubramanian

    IPC: C12G168

    CPC classification number: C12Q1/6869 ,  C12Q1/6823 ,  C12Q2521/319

    Abstract: The invention relates to the sequencing of a target polynucleotide sequence, immobilized on a solid support, using the polymerase reaction to extend a suitable primer and characterizing the sequential addition of labelled bases. The present invention further relates to the presence of a polymerase enzyme that retains a 3′ to 5′ exonuclease function, which is induced to remove an incorporated labelled base after detection of incorporation. A corresponding non-labelled base may then be incorporated into the complementary strand to allow further sequence determinations to be made. Repeating the procedure allows the sequence of the complement to be identified, and thereby the target sequence.

    Abstract translation: 本发明涉及使用聚合酶反应扩增合适的引物并表征序列添加标记碱基的固定在固体支持物上的靶多核苷酸序列的测序。 本发明还涉及保留3'至5'外切核酸酶功能的聚合酶的存在，其在检测结合后被诱导去除掺入的标记碱基。 然后可以将相应的未标记的碱基并入互补链中以允许进行进一步的序列测定。 重复该过程允许识别补体序列，从而确定靶序列。

    Incremental block based backup
    46.
    发明授权
    Incremental block based backup 有权
    增量块基备份

    公开(公告)号：US08898407B1

    公开(公告)日：2014-11-25

    申请号：US13250593

    申请日：2011-09-30

    Applicant: Shankar Balasubramanian ,  Vladimir Mandic ,  Sriprasad Bhat Kasargod ,  Anand Raj

    Inventor： Shankar Balasubramanian ,  Vladimir Mandic ,  Sriprasad Bhat Kasargod ,  Anand Raj

    IPC: G06F12/10 ,  G06F12/16

    CPC classification number: G06F11/1453 ,  G06F11/1451 ,  G06F2201/815

    Abstract: A method, article of manufacture, and apparatus for protecting data. In some embodiments, this includes taking a snapshot of a physical volume with a native snapshot program, determining which blocks have changed since a previous snapshot with a change block tracker, creating a child virtual container, populating the child virtual container with the changed blocks, and linking the child virtual container with a parent virtual container.

    Abstract translation: 一种保护数据的方法，制品和装置。 在一些实施例中，这包括使用本地快照程序拍摄物理卷的快照，确定自从具有改变块跟踪器的先前快照以来哪些块已经改变，创建子虚拟容器，用改变的块填充子虚拟容器， 并将子虚拟容器与父虚拟容器进行链接。

    WHOLE BLOOD HEMOLYSIS SENSOR
    47.
    发明申请
    WHOLE BLOOD HEMOLYSIS SENSOR 有权
    全血溶解传感器

    公开(公告)号：US20140262831A1

    公开(公告)日：2014-09-18

    申请号：US14202398

    申请日：2014-03-10

    Applicant: Shankar Balasubramanian ,  Paul D'Orazio

    Inventor： Shankar Balasubramanian ,  Paul D'Orazio

    IPC: G01N27/327

    CPC classification number: G01N27/3272 ,  C12Q1/001 ,  C12Q1/005 ,  C12Q1/26 ,  G01N27/327 ,  G01N27/3271 ,  G01N27/3277

    Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.

    Abstract translation: 本发明涉及溶血传感器，溶血传感器系统和利用溶血传感器或溶血传感器系统来监测或检测样品如全血样品，血浆样品，血清样品或溶血中的溶血的方法 。 溶血传感器响应于细胞外血红蛋白水平，例如全血样品中的细胞外血红蛋白作为检测全血溶血的方法。

    NANO/MICROSCALE VEHICLES FOR CAPTURE AND ISOLATION OF TARGET BIOMOLECULES AND LIVING ORGANISMS
    48.
    发明申请
    NANO/MICROSCALE VEHICLES FOR CAPTURE AND ISOLATION OF TARGET BIOMOLECULES AND LIVING ORGANISMS 有权
    用于捕获和分离目标生物分子和生物有机体的纳诺/微型车辆

    公开(公告)号：US20140045179A1

    公开(公告)日：2014-02-13

    申请号：US13983034

    申请日：2012-01-31

    Applicant: Joseph Wang ,  Shankar Balasubramanian ,  Daniel Kagan ,  Susana Campuzano-Ruiz

    Inventor： Joseph Wang ,  Shankar Balasubramanian ,  Daniel Kagan ,  Susana Campuzano-Ruiz

    IPC: C12Q1/68 ,  G01N1/10

    CPC classification number: C12Q1/6806 ,  B01D15/3885 ,  B01J20/22 ,  B01J20/32 ,  B01J2220/4812 ,  C12M1/268 ,  C12Q1/6834 ,  G01N1/10 ,  G01N33/54313 ,  G01N33/5436 ,  G01N33/54393 ,  G01N33/544

    Abstract: Techniques, systems, devices and materials are disclosed for capturing, isolating and transporting target biomolecules and living organisms. In one aspect, a device includes a tube structured to include a large opening and a small opening that are on opposite ends of the tube, and a tube body connecting the openings and having a cross section spatially reducing in size from the large opening to the small opening, in which the tube includes a layered wall including an inner layer having a catalyst material that is reactive with a fuel fluid to produce bubbles exiting the tube from the large opening to propel the tube to move in the fuel fluid and an external layer formed of a material capable of being functionalized, and a molecular layer functionalized onto the external layer of the tube and structured to attach to a targeted molecule in the fuel fluid.

    Abstract translation: 公开了用于捕获，分离和转运靶生物分子和活生物体的技术，系统，装置和材料。 在一个方面，一种装置包括构造成包括在该管的相对端上的大开口和小开口的管，以及连接开口并具有空间尺寸从大开口至 小开口，其中管包括层状壁，其包括具有催化剂材料的内层，催化剂材料与燃料流体反应，以从大开口产生离开管的气泡，以推动管在燃料流体中移动和外部层 由能够官能化的材料形成，以及分子层，其功能化在管的外层上并被构造成附着到燃料流体中的目标分子上。

    System and method for data protection management in a logical namespace of a storage system environment
    50.
    发明授权
    System and method for data protection management in a logical namespace of a storage system environment 有权
    在存储系统环境的逻辑命名空间中进行数据保护管理的系统和方法

    公开(公告)号：US07734951B1

    公开(公告)日：2010-06-08

    申请号：US11384710

    申请日：2006-03-20

    Applicant: Shankar Balasubramanian ,  K. Uday Kishore

    Inventor： Shankar Balasubramanian ,  K. Uday Kishore

    IPC: G06F11/00

    CPC classification number: G06F11/1435 ,  G06F11/1451

    Abstract: A system and method for data protection in a logical namespace of a storage system environment is provided. An integrated management framework implements a data protection technique that monitors failures in the logical namespace at a managed data object granularity, e.g., a share. In the event of a failure to the data object, e.g., a primary share, the data protection technique enables automatic failover for a link point to the object (primary share) that is protected by a backup copy of the data object, e.g., a secondary share. That is, the data protection technique enables failover from the primary share to a secondary share and corresponding linking of the secondary share to the link point in the logical namespace.

    Abstract translation: 提供了一种用于存储系统环境的逻辑命名空间中的数据保护的系统和方法。 集成管理框架实现数据保护技术，该技术监视管理数据对象粒度（例如共享）的逻辑命名空间中的故障。 在数据对象（例如，主共享）发生故障的情况下，数据保护技术可以实现对由数据对象的备份副本保护的对象（主共享）的链接点的自动故障切换，例如， 次要份额 也就是说，数据保护技术使得能够从主共享到辅助共享的故障切换以及辅助共享与逻辑命名空间中的链接点的对应链接。

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