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公开(公告)号：US20240307493A1
公开(公告)日：2024-09-19
申请号：US18738964
申请日：2024-06-10
Inventor： Binfeng Lu , Runzi Sun
IPC: A61K38/20 , A61K39/395 , A61P35/00
CPC classification number: A61K38/20 , A61K39/3955 , A61P35/00
Abstract: The present disclosure relates to the methods of preventing and/or treating cancer including administering IL33 and anti-AREG antibodies or fragments thereof to a subject in need thereof. The present disclosure further provides compositions and kits for performing such methods.
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公开(公告)号：US20240304828A1
公开(公告)日：2024-09-12
申请号：US18654149
申请日：2024-05-03
Inventor： Prashant N. Kumta , Prasad P. Patel , Moni K. Datta , Oleg Velikokhatnyi , Prashanth J. Hanumantha , Ramalinga Kuruba , Shrinath Ghadge
IPC: H01M4/90 , B01J27/135 , B82Y30/00 , H01M4/88 , H01M8/08 , H01M8/1018 , H01M8/1233
CPC classification number: H01M4/9016 , H01M4/881 , H01M4/8825 , H01M8/08 , H01M8/1018 , H01M8/1233 , B01J27/135 , B82Y30/00 , Y02E60/50
Abstract: The invention provides noble metal-free electro-catalyst compositions for use in acidic media, e.g., acidic electrolyte. The noble metal-free electro-catalyst compositions include non-noble metal absent of noble metal. The non-noble metal is non-noble metal oxide, and typically in the form of any configuration of a solid or hollow nano-material, e.g., nano-particles, a nanocrystalline thin film, nanorods, nanoshells, nanoflakes, nanotubes, nanoplates, nanospheres and nanowhiskers or combinations of myriad nanoscale architecture embodiments. Optionally, the noble metal-free electro-catalyst compositions include dopant, such as, but not limited to halogen. Acidic media includes oxygen reduction reaction (ORR) in proton exchange membrane (PEM) fuel cells, and direct methanol fuel cells and oxygen evolution reaction (OER) in PEM-based water electrolysis and metal air batteries, and hydrogen generation from solar energy and electricity-driven water splitting.
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43.发明公开公开(公告)号：US20240299599A1
公开(公告)日：2024-09-12
申请号：US18515076
申请日：2023-11-20
Inventor： Dexing ZENG , Lingyi SUN , Yongkang GAI
IPC: A61K51/08 , A61K9/51 , A61K47/68 , A61K51/10 , C07D255/02 , C07D257/02 , C07K7/06 , C07K7/64 , C07K16/30 , G01N33/50 , G01N33/60
CPC classification number: A61K51/082 , A61K9/51 , A61K47/6893 , A61K51/1027 , C07D255/02 , C07D257/02 , C07K7/06 , C07K7/64 , C07K16/30 , G01N33/5008 , G01N33/60 , C07K2319/00
Abstract: The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery.
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公开(公告)号：US20240299475A1
公开(公告)日：2024-09-12
申请号：US18673024
申请日：2024-05-23
Inventor： Graham F. Hatfull , Carlos Andrés Guerrero , Rebekah Marie Dedrick
CPC classification number: A61K35/76 , A61K9/0019 , A61K9/0073 , A61P31/06
Abstract: Disclosed are pharmaceutical compositions comprising a combination of five or more phages and a pharmaceutically acceptable carrier, as well as methods of treating, reducing, or preventing a disease caused by Mycobacterium tuberculosis in a mammal, methods of treating an antibiotic resistant infection in a mammal, and methods of treating, reducing, or preventing activation of a latent disease caused by M. tuberculosis.
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公开(公告)号：US12070475B2
公开(公告)日：2024-08-27
申请号：US16970861
申请日：2019-02-22
Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education , Ri.MED Foundation
Abstract: Provided herein is a ligament ECM soluble fraction useful for the growth and regrowth of ligament tissue. Methods of preparation of the soluble fractions and use of the soluble fractions in growth or regrowth of ligament tissue also are provided.
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Patent Agency Ranking
公开(公告)号：US20240277778A1
公开(公告)日：2024-08-22
申请号：US18568661
申请日：2022-06-09
Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN
Inventor： Giorgio TRINCHIERI , Amiran Kasanovich DZUTSEV , John Anthony MCCULLOCH , Richard R. RODRIGUES , Diwakar DAVAR , Hassane Mohamed ZAROUR
IPC: A61K35/741 , A61K39/00 , C07K16/28 , C12Q1/04
CPC classification number: A61K35/741 , C07K16/2818 , C12Q1/04 , A61K2039/505 , C07K2317/76 , G01N2800/52
Abstract: Disclosed herein are methods for treating cancer by administering an immune checkpoint inhibitor and modifying an amount of one or more bacteria in an intestine of the subject.
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公开(公告)号：US20240257992A1
公开(公告)日：2024-08-01
申请号：US18578660
申请日：2022-07-14
Inventor： Andrew B. Schwartz , May Yoon PWINT
IPC: H01B7/00 , A61B5/293 , C23C14/04 , C23C14/08 , C23C14/14 , C23C16/04 , C23C16/56 , G06F3/01 , H01B13/00
CPC classification number: H01B7/0009 , A61B5/293 , C23C14/042 , C23C14/081 , C23C14/14 , C23C16/04 , C23C16/56 , G06F3/015 , H01B13/0036 , A61B2562/222
Abstract: Disclosed herein is a method for forming a cable configured to convey neuron signals. The method can include forming two longitudinal halves of the cable and bonding the two longitudinal halves together. Each of the two longitudinal halves can be formed on a respective substrate and includes a plurality of groups of conductive traces each in a respective layer of the respective longitudinal half. Each respective group of the plurality of groups of conductive traces can formed by depositing a respective insulating layer, patterning the respective insulating layer, depositing a respective conductive layer over at least a portion of the patterned insulating layer, patterning the respective conductive layer into the respective group of conductive traces. Each respective layer of the respective longitudinal half can have a width smaller than a layer formed prior to the respective layer, and can have a thickness that is within a range of 2 microns and 10 microns.
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公开(公告)号：US20240257665A1
公开(公告)日：2024-08-01
申请号：US18565421
申请日：2022-08-31
Inventor： Steven L. Orebaugh , James V. Snyder
CPC classification number: G09B23/285 , G09B23/32 , G09B23/34
Abstract: Described are examples of a training simulator for direct laryngoscopy, which reproduce the dynamics of the human airway and hyoid bone movement observed in the human anatomy during movement of the somatic skeleton and direct laryngoscopy procedures. Training simulators can include a skeleton structure having a styloid process analogue, a mandible analogue, and a longitudinally extending column configured to move between an extended state and a flexed state. A suspension chain can extend parallel to the column and be configured to move with the column. The suspension chain can include a hyoid analogue coupled to the styloid process analogue, the mandible analogue, and an anchor point situated along the column of the skeleton structure. Training simulators can also include a glottis analogue, the visibility of which can be greater when the column is in a flexed state, than when the column is in an extended state.
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公开(公告)号：US12036695B2
公开(公告)日：2024-07-16
申请号：US17164474
申请日：2021-02-01
Inventor： Jung-Kun Lee , Ian Nettleship , Ryan W. Read
IPC: C04B35/571 , B28B1/00 , B33Y10/00 , B33Y70/10 , C04B35/56 , C04B35/565 , C04B35/632 , C04B35/64 , C04B37/00
CPC classification number: B28B1/001 , B33Y10/00 , B33Y70/10 , C04B35/5607 , C04B35/5626 , C04B35/565 , C04B35/571 , C04B35/632 , C04B35/64 , C04B37/005 , C04B2235/40 , C04B2235/405 , C04B2235/422 , C04B2235/483 , C04B2235/5454 , C04B2235/6025 , C04B2235/80 , C04B2237/083 , C04B2237/365
Abstract: A bonding tape for joining carbide ceramic structures, wherein the bonding tape comprises: a mixture comprising carbide ceramic particles, preceramic polymer liquid, fine carbon particles and metal nanoparticles that form a eutectic liquid at temperatures below 1400° C.
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50.发明公开公开(公告)号：US20240229168A9
公开(公告)日：2024-07-11
申请号：US18338128
申请日：2023-06-20
Inventor： Asim Ahmed , Radha Duttagupta , Georgios D. Kitsios
IPC: C12Q1/70 , C12Q1/689 , C12Q1/6895 , G01N33/68
CPC classification number: C12Q1/701 , C12Q1/689 , C12Q1/6895 , G01N33/6863 , G01N33/6893 , C12Q1/6874
Abstract: Described herein is a method of detecting secondary infection in a patient, particularly a patient with a primary infection that is a pneumonia, a COVID-19 infection, or a COVID-19 pneumonia. In some cases, the secondary infection is a secondary bacterial infection, e.g., secondary bacterial pneumonia. In some cases, the methods provided herein detect a hyper-inflammatory response or severity of disease, e.g., indicating a severe COVID-19 infection, or provide a risk of death from a disease (e.g., COVID-19). This disclosure also provides method of detecting a localized respiratory infection in a subject by quantifying microbial cell-free nucleic acids (e.g., mdfDNA) from plasma from the subject. In some cases, the subject is not bacteremic when plasma is collected from the subject. This disclosure also provides systems, such as nucleic acid-sequencing systems with increased reliability for detecting secondary infections, particularly in patients with culture-negative pneumonia.
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