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    MEMBRANE FOR USE WITH IMPLANTABLE DEVICES
    41.
    发明申请
    MEMBRANE FOR USE WITH IMPLANTABLE DEVICES 审中-公开
    膜与可植入器件的使用

    公开(公告)号：US20150157248A1

    公开(公告)日：2015-06-11

    申请号：US14619651

    申请日：2015-02-11

    Applicant: DexCom, Inc.

    Inventor： James H. Brauker ,  Mark C. Shults ,  Mark A. Tapsak

    IPC: A61B5/1473 ,  A61B5/145

    CPC classification number: A61B5/14735 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2562/02 ,  A61L31/10 ,  A61L31/14 ,  Y10T428/249921

    Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

    Abstract translation: 本发明提供了一种用于与可植入装置一起使用的生物界面膜，其干扰屏障细胞层的形成，包括： 远离植入装置的第一区域，其中第一结构域支持组织附着并干扰阻挡细胞层形成，以及邻近可植入装置的第二结构域，其中第二结构域对细胞附着有抗性并且对细胞是不可渗透的。 此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。 还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。

    OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES
    42.
    发明申请
    OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES 有权
    用于可植入设备的氧气增强膜系统

    公开(公告)号：US20150057514A1

    公开(公告)日：2015-02-26

    申请号：US14529034

    申请日：2014-10-30

    Applicant: DexCom, Inc.

    Inventor： James R. Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel ,  James H. Brauker

    IPC: A61B5/1486 ,  A61B5/1473

    CPC classification number: A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865

    Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

    Abstract translation: 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

    MEMBRANE FOR USE WITH IMPLANTABLE DEVICES
    43.
    发明申请
    MEMBRANE FOR USE WITH IMPLANTABLE DEVICES 有权
    膜与可植入器件的使用

    公开(公告)号：US20140335343A1

    公开(公告)日：2014-11-13

    申请号：US14341468

    申请日：2014-07-25

    Applicant: DexCom, Inc.

    Inventor： James H. Brauker ,  Mark C. Shults ,  Mark A. Tapsak

    IPC: A61B5/1486 ,  A61L31/14 ,  A61L31/10

    CPC classification number: A61B5/14735 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2562/02 ,  A61L31/10 ,  A61L31/14 ,  Y10T428/249921

    Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

    Abstract translation: 本发明提供了一种用于与可植入装置一起使用的生物界面膜，其干扰屏障细胞层的形成，包括： 远离植入装置的第一区域，其中第一结构域支持组织附着并干扰阻挡细胞层形成，以及邻近可植入装置的第二结构域，其中第二结构域对细胞附着有抗性并且对细胞是不可渗透的。 此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。 还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。

    SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA
    45.
    发明申请
    SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA 有权
    用于处理分析仪传感器数据的系统和方法

    公开(公告)号：US20140257067A1

    公开(公告)日：2014-09-11

    申请号：US14283123

    申请日：2014-05-20

    Applicant: DexCom, Inc.

    Inventor： Paul V. Goode, JR. ,  James H. Brauker ,  Apurv Ullas Kamath ,  James Patrick Thrower

    IPC: A61B5/145 ,  A61B5/00

    CPC classification number: A61B5/14532 ,  A61B5/0015 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7275 ,  A61B5/742 ,  G16H40/40 ,  Y02A90/26

    Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.

    Abstract translation: 用于处理传感器分析数据的系统和方法，包括启动校准，更新校准，评估参考和传感器分析数据的临床可接受性，以及评估传感器校准的质量。 在初始校准期间，在一段时间内评估分析物传感器数据，以确定传感器的稳定性。 可以使用一个或多个匹配的传感器和参考分析物数据对的校准集来校准传感器。 基于新收到的参考分析物数据的纳入标准，可以在评估用于最佳校准的校准集之后更新校准。 基于参考和分析物数据的临床可接受性和传感器校准的质量提供故障安全机制。 算法提供了来自分析物传感器的估计血液分析物数据的优化前瞻性和回顾性分析。

    ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS
    47.
    发明申请
    ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS 审中-公开
    电化学传感器电极系统

    公开(公告)号：US20140001042A1

    公开(公告)日：2014-01-02

    申请号：US14014216

    申请日：2013-08-29

    Applicant: DexCom, Inc.

    Inventor： Peter C. Simpson ,  James R. Petisce ,  Victoria E. Carr-Brendel ,  James H. Brauker

    IPC: G01N27/327

    CPC classification number: G01N27/3274 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/001

    Abstract: The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.

    Abstract translation: 本发明一般涉及用于改进分析物的电化学测量的系统和方法。 优选实施例采用电极系统，包括用于测量被分析物的分析物测量电极或与分析物的酶反应的产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极。 通过辅助电极产生氧气有利地提高了对酶和/或对电极的氧气可利用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。 通过辅助电极的干扰修饰有利地使得它们在分析物 - 测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

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