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公开(公告)号：US06198952B1
公开(公告)日：2001-03-06
申请号：US09182971
申请日：1998-10-30
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61B50205
CPC分类号： A61B5/1459 , A61B5/14539 , A61N1/056 , A61N1/36557
摘要： An implantable sensor assembly for use with an implantable medical device are disclosed. The sensor assembly preferably includes two or more physiologic sensors coupled to the medical device via a pair of lead conductors, or alternatively an oxygen sensor having certain features. The oxygen sensor permits more accurate and reliable measurement of oxygen saturation in blood masses flowing within the human body.
摘要翻译： 公开了一种用于可植入医疗装置的植入式传感器组件。 传感器组件优选地包括经由一对引线导体或具有某些特征的氧传感器耦合到医疗装置的两个或更多个生理传感器。 氧气传感器可以更精确和可靠地测量人体内血液中的血氧饱和度。
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公开(公告)号：US6106477A
公开(公告)日：2000-08-22
申请号：US221059
申请日：1998-12-28
申请人： Keith A. Miesel , Lee Stylos
发明人： Keith A. Miesel , Lee Stylos
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/08
CPC分类号： A61B5/6876 , A61B5/0215 , A61B5/6884 , A61B5/0031 , A61B5/1459 , A61B5/418
摘要： A system for chronically measuring a physiologic parameter by an implantable device which has several forms is described. At its core a fixture for holding on to a blood vessel and forcing a sensor against a surface of the vessel is taught. Numerous adaptations and uses with various sensors are described.
摘要翻译： 描述了通过具有多种形式的可植入装置长期测量生理参数的系统。 在其核心处，教导了用于保持血管并迫使传感器抵靠血管表面的夹具。 描述了各种传感器的许多适应和使用。
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43.发明授权Implantable medical device for sensing absolute blood pressure and barometric pressure 失效用于感测绝对血压和大气压力的植入式医疗装置
公开(公告)号：US6024704A
公开(公告)日：2000-02-15
申请号：US70310
申请日：1998-04-30
IPC分类号： A61B5/0215 , A61B5/03 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/03 , A61B2560/0257 , A61M1/122 , A61M2205/702
摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.
摘要翻译： 与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。 在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。 在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。 在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室 压力传感器。 大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。 或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。
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公开(公告)号：US10369353B2
公开(公告)日：2019-08-06
申请号：US12359037
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
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公开(公告)号：US09737660B2
公开(公告)日：2017-08-22
申请号：US13217981
申请日：2011-08-25
申请人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
发明人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
CPC分类号： A61M5/16827 , A61M5/14276 , A61M5/1684 , A61M39/223 , A61M2205/3523 , A61M2205/3569 , A61M2210/1003
摘要： A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the valve to open and close the first fluid pathway and to open and close the second fluid pathway.
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公开(公告)号：US09717846B2
公开(公告)日：2017-08-01
申请号：US13561706
申请日：2012-07-30
CPC分类号： A61M5/14276 , A61B5/11 , A61B5/1116 , A61B5/4836 , A61B2562/0219 , A61M2005/14208 , A61M2205/17 , A61M2210/0693 , A61M2210/1053 , A61M2210/1078 , A61M2210/1089 , A61M2230/62 , A61N1/3605 , A61N1/37247
摘要： Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.
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公开(公告)号：US09327117B2
公开(公告)日：2016-05-03
申请号：US13264023
申请日：2010-04-20
CPC分类号： A61N1/36007 , A61B5/053 , A61B5/1116 , A61B5/204 , A61B5/686 , A61B5/6883 , A61B5/7203 , A61B2560/0462 , A61B2562/0219
摘要： This disclosure provides techniques for bladder sensing. In accordance with the techniques described in this disclosure, a device may measure the impedance of a bladder, determine the posture of a patient, and determine a status of the bladder based on the impedance and posture.
摘要翻译： 本公开提供了用于膀胱感测的技术。 根据本公开中描述的技术，装置可以测量膀胱的阻抗，确定患者的姿势，并且基于阻抗和姿势来确定膀胱的状态。
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公开(公告)号：US09044537B2
公开(公告)日：2015-06-02
申请号：US13169092
申请日：2011-06-27
CPC分类号： A61M5/14276 , A61M5/16854 , A61M5/16859 , A61M5/1723 , A61M27/006 , A61M2005/1726 , A61M2025/0003 , A61M2202/0464 , A61M2205/3331 , A61M2205/3344 , A61M2205/3355 , A61M2210/0693 , A61M2230/005 , A61M2230/04 , A61M2230/06 , A61M2230/40 , A61M2230/42 , A61M2230/63
摘要： A method for determining status of an implanted catheter includes acquiring raw pressure data from a pressure sensor of in an implantable infusion device. The pressure sensor is in communication with a lumen of the catheter operably coupled to the infusion device. The catheter has a delivery region, in communication with the lumen, intended to be positioned in a fluid-filled target location of a patient. The method further includes filtering the raw pressure data to remove the DC component, leaving the AC component within a relevant physiological frequency range; rectifying the AC component to produce a rectified pressure signal; calculating a mean magnitude of the rectified signal; and determining whether the mean magnitude is below a predetermined threshold. If the mean magnitude is below the threshold, the catheter is determined to be in a state other than a normal state.
摘要翻译： 用于确定植入导管的状态的方法包括从可植入输注装置中的压力传感器获取原始压力数据。 压力传感器与可操作地连接到输注装置的导管的内腔连通。 导管具有与内腔连通的输送区域，用于定位在患者的流体填充的目标位置。 该方法还包括过滤原始压力数据以去除DC分量，将AC分量留在相关的生理频率范围内; 整流交流分量以产生整流压力信号; 计算整流信号的平均幅度; 以及确定平均幅度是否低于预定阈值。 如果平均值低于阈值，则确定导管处于正常状态以外的状态。
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公开(公告)号：US20130253447A1
公开(公告)日：2013-09-26
申请号：US13426045
申请日：2012-03-21
IPC分类号： A61M5/00
CPC分类号： A61M5/427 , A61M5/14276 , A61M5/46 , A61M2005/1588
摘要： A needle and needle system that aids in determining needle position with respect to an implanted device. The system determines needle position by detecting changes in electrical characteristics and the system further may generate a cue to indicate proper needle placement within an implanted device. Methods for detecting needle position with respect to an implanted infusion device are also disclosed.
摘要翻译： 针和针系统，其有助于相对于植入装置确定针位置。 该系统通过检测电特性的变化来确定针位置，并且该系统还可以产生一个提示，以指示植入装置内适当的针位置。 还公开了相对于植入的输注装置检测针位置的方法。
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公开(公告)号：US08397578B2
公开(公告)日：2013-03-19
申请号：US12793459
申请日：2010-06-03
CPC分类号： G01L9/0072 , G01L19/142 , G01L19/143 , G01L19/147 , H01L2224/48472 , Y10T29/49002 , Y10T29/53265
摘要： The disclosure is directed to a capacitive pressure sensor, and the assembly of a capacitive pressure sensor, that may be used within an implantable medical pump. In one example, a housing ferrule that encloses one capacitive plate and includes at least one protrusion for attaching a support structure of the capacitive plate. The at least one protrusion defines a smaller inner diameter as a reference point for securing the support structure while the ferrule provides a larger inner diameter to allow the support structure to tilt inside the ferrule to orient the capacitive plate into a desired plane. Despite manufacturing irregularities, the capacitive plate can be mounted in the desired plane parallel to another capacitive plate, a diaphragm, mounted to an edge of the ferrule. In another example, an assembly tool provides a stage to orient the capacitive plate and support structure within the ferrule at a desired depth.
摘要翻译： 本公开涉及电容式压力传感器以及可在可植入医疗泵内使用的电容式压力传感器的组件。 在一个示例中，壳体套圈包围一个电容板并且包括用于附接电容板的支撑结构的至少一个突起。 所述至少一个突出部限定较小的内径作为用于固定支撑结构的参考点，同时套圈提供更大的内径以允许支撑结构在套圈内部倾斜以将电容板定向到期望的平面。 尽管制造不规则，但是电容板可以安装在平行于另一个电容板的所需平面中，该电容板安装在套圈的边缘上。 在另一示例中，组装工具提供了将电容板和支撑结构定位在套圈内的阶段，以期望的深度。
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